Search Result

Results for "

cytochrome P450 (CYP)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (113) 5-HT Receptor (4) Adenosine Receptor (2) Adrenergic Receptor (2) Aldose Reductase (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (12) Apoptosis (13) Aryl Hydrocarbon Receptor (1) Autophagy (12) Bacterial (10) Calcium Channel (1) Caspase (2) COX (6) Dopamine Receptor (3) Dopamine β-hydroxylase (2) Drug Intermediate (2) Drug Metabolite (27) Endogenous Metabolite (11) ERK (2) Estrogen Receptor/ERR (1) Ferroptosis (3) FGFR (1) Fluorescent Dye (2) Fungal (12) GABA Receptor (3) Glucocorticoid Receptor (1) HBV (1) HCV (3) HCV Protease (3) Heme Oxygenase (HO) (1) Histamine Receptor (1) HIV (4) HMG-CoA Reductase (HMGCR) (1) HSV (1) Influenza Virus (2) Insecticide (1) Isotope-Labeled Compounds (15) Keap1-Nrf2 (1) mAChR (1) Mineralocorticoid Receptor (1) Mitosis (1) Monoamine Oxidase (2) Necroptosis (2) NO Synthase (2) Opioid Receptor (2) p38 MAPK (1) Parasite (5) PKC (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (3) PPAR (9) Pregnane X Receptor (PXR) (1) PROTACs (1) Pyruvate Kinase (1) Quinone Reductase (1) RAR/RXR (5) Reactive Oxygen Species (ROS) (1) Reference Standards (32) Reverse Transcriptase (3) SARS-CoV (6) Serotonin Transporter (2) SGLT (1) Sodium Channel (4) STAT (2) Telomerase (2) Thrombopoietin Receptor (7) Topoisomerase (1) Urotensin Receptor (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (22) Endocrinology (1) Infection (34) Inflammation/Immunology (45) Metabolic Disease (42) Neurological Disease (43)
Click Chemistry:	Alkynes (1)

204

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

(S)-Mephenytoin (+)-Mephenytoin	Cytochrome P450	Neurological Disease
(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism .

(S)-Mephenytoin (Standard) (+)-Mephenytoin (Standard)	Reference Standards Cytochrome P450	Neurological Disease
(S)-Mephenytoin (Standard) is the analytical standard of (S)-Mephenytoin. This product is intended for research and analytical applications. (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism .

Clotrimazole 5+ Cited Publications	Fungal Bacterial Autophagy Antibiotic	Infection Cancer
Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.

6-Hydroxymelatonin	Drug Metabolite Endogenous Metabolite	Neurological Disease Metabolic Disease
6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.

RPR132595A hydrochloride NPC hydrochloride	Drug Metabolite	Cancer
RPR132595A (NPC) hydrochloride is an active metabolite of CPT-11, which is generated by **cytochrome P-450 3A4 (CYP3A4)** and finally excreted through urine .

16,17-EDT	Endogenous Metabolite	Metabolic Disease
16,17-EDT is an oxylipin and a metabolite of adrenic acid formed by the cytochrome P450 (CYP) pathway .

13,14-EDT	Endogenous Metabolite	Metabolic Disease
13,14-EDT is a metabolite of oxylipids and adrenal acid that is formed through the cytochrome P450 (CYP) pathway .

EDDP perchlorate	Drug Metabolite	Others
EDDP perchlorate is an N-desmethyl metabolite of Methadone by intestinal, hepatic, and cytochrome P450 (CYP) 3A4 .

14(15)-EpETE	Cytochrome P450	Metabolic Disease
14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function .

RPR132595A NPC	Drug Metabolite	Cancer
RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by **cytochrome P-450 3A4 (CYP3A4)** and finally excreted through urine .

(±)13,14-EDT	Drug Metabolite	Metabolic Disease
(±)13,14-EDT is an oxylipin and a metabolite of Adrenic acid (HY-W013215) formed via the cytochrome P450 (CYP) pathway.

2-Naphthol 1 Publications Verification	Endogenous Metabolite	Others
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

CYP3A4-IN-1	Cytochrome P450	Infection
CYP3A4-IN-1 (compound 5a) is a potent **cytochrome P450 3A4 (CYP3A4) inhibitor with an IC₅₀** value of 0.085 µM .

18-HETE	Endogenous Metabolite	Others
18-HETE (compound 3) is a monooxygenase metabolite of cytochrome P450 (CYP450).18- HETE consists of arachidonic acid bearing a hydroxy substituent at position 18 .

7-Methoxy-4-(trifluoromethyl)coumarin MFC	Cytochrome P450 Fluorescent Dye	Others
7-Methoxy-4-(trifluoromethyl)coumarin (MFC) is a fluorescent substrate for **cytochrome P450** and can quantify CYP activity .

Dihydrocubebin (-)-Dihydrocubebin	Cytochrome P450	Others
Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4) .

N-Desmethyl Eletriptan	Cytochrome P450	Metabolic Disease
N-desmethyl Eletriptan is a metabolite of Eletriptan (HY-A0039). It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes.

TUPS	Cytochrome P450	Cancer
TUPS can inhibit the gene expression of epoxide hydrolase (sEH) and cytochrome P450 (CYP). TUPS can be used in cardiovascular disease-related research .

Bifeprofen	Cytochrome P450	Others
Bifeprofen, a **cytochrome P450 2C9 (CYP2C9)** inhibitor, exhibits dose-dependent inhibition (75 μM, 50%) .

trans-Hydroxy Glimepiride	Drug Metabolite	Metabolic Disease
trans-hydroxy Glimepiride is an active metabolite of the sulfonylurea Glimepiride (HY-B0104). It is formed from glimepiride primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9.

Kushenol M	Cytochrome P450	Others
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a **cytochrome P450 (CYP)** inhibitor, with IC₅₀ values of 1.29 μM for CYP3A4 in human liver microsomes .

Promethazine sulfoxide	Histamine Receptor	Neurological Disease
Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296). It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6.

Aripiprazole N1-oxide	Dopamine Receptor	Neurological Disease
Aripiprazole N-oxide is a metabolite of the atypical antipsychotic Aripiprazole (HY-14546). Aripiprazole N-oxide is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.

CYP1B1-IN-1	Cytochrome P450	Cancer
CYP1B1-IN-1 (Compound 9e) is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 0.49 nM .

Tienilic acid 2 Publications Verification Ticrynafen; ANP 3624	Cytochrome P450	Cardiovascular Disease Metabolic Disease
Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro .

Isoglycycoumarin	Cytochrome P450	Metabolic Disease
Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome **P450 2A6 (CYP2A6)** .

CYP1B1-IN-2	Cytochrome P450	Cancer
CYP1B1-IN-2 (compound 9j) is a potent and selective *CYP1B1* (cytochrome P450 1B1) inhibitor, with an IC₅₀ of 0.52 nM .

CYP1B1-IN-5	Cytochrome P450	Cancer
CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 4.7 nM .

8-Hydroxy mirtazapine	5-HT Receptor	Neurological Disease
8-Hydroxy mirtazapine is a metabolite of the antidepressant Mirtazapine (HY-B0352). 8-Hydroxy mirtazapine is formed from mMirtazapine by the cytochrome P450 (CYP) isoform CYP2D6.

21-Hydroxyeplerenone	Mineralocorticoid Receptor	Cardiovascular Disease
21-Hydroxyeplerenone is a major metabolite of the mineralocorticoid receptor antagonist Eplerenone (HY-B0251). 21-Hydroxyeplerenone is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4.

Resorufin methyl ether Methoxyresorufin	Cytochrome P450	Others
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

Hydroxymethyl tolperisone hydrochloride	Drug Metabolite	Neurological Disease
Hydroxymethyl tolperisone hydrochloride is a metabolite of Tolperisone (HY-B1139A). Hydroxymethyl tolperisone hydrochloride is formed from tolperisone primarily by the cytochrome P450 (CYP) isoform CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2.

7-Ethoxycoumarin 7-O-Ethylumbelliferone	Cytochrome P450	Metabolic Disease
7-Ethoxycoumarin is a substrate of cytochrome P450 (CYP450). 7-Ethoxycoumarin has been used for the functional characterization of various CYPs and for the generation of 7-hydroxycoumarin (HY-N0573) .

DLCI-1	Cytochrome P450	Others
DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6) that markedly reduces nicotine self-administration in both male and female mice.

Clotrimazole (Standard)	Reference Standards Fungal Bacterial Autophagy Antibiotic	Infection Cancer
Clotrimazole (Standard) is the analytical standard of Clotrimazole. This product is intended for research and analytical applications. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.

Linderane	Cytochrome P450	Inflammation/Immunology
Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor **cytochrome P450 2C9 (CYP2C9)**. Linderane has the potential to relieve pain and cramp .

Omeprazole sulfone 2 Publications Verification Omeprazole sulphone	Drug Metabolite Cytochrome P450	Others
Omeprazole sulfone is one of the major metabolites of Omeprazole (HY-B0113). Omeprazole sulfone is generated via sulfoxidation mediated by **cytochrome P450 3A4 (CYP3A4)** .

Cobicistat 10+ Cited Publications GS-9350	Cytochrome P450 HIV	Infection Cancer
Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC₅₀s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.

Dafadine-A	Cytochrome P450	Infection Cancer
Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Dafadine-A inhibits the mammalian ortholog of DAF-9 (CYP27A1). Dafadine-A does not inhibits DAF-12 and sterol- and oxysterol-metabolizing P450s .

o-Desmethyl ranolazine CVT-2514; RS-88390	Drug Metabolite	Cardiovascular Disease
o-Desmethyl ranolazine (CVT-2514; RS-88390) is a metabolite of Ranolazine (HY-B0280), formed through metabolism of Ranolazine by enzymes of the cytochrome P450 (CYP) 3A family .

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Cytochrome P450 NO Synthase	Others
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of **cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase** .

Cat. No.	Product Name

HY-L922

MCE Good ADMET Diversity Library

28,153 compounds

A diverse compound library with favorable ADMET properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) is crucial in drug discovery. Early evaluation of ADMET properties allows for the exclusion of molecules with unfavorable profiles at the initial stages, thereby reducing the risk of late-stage development failures, lowering R&D costs, and accelerating optimization of lead compounds. Based on predictions from ADMET-related AI algorithms, the compounds in this library are predicted to exhibit favorable oral bioavailability (F > 30%), reasonable plasma protein binding (PPB < 98%), minimized CYP3A4 inhibition potential (inhibition probability < 50%, CYP3A4 is the most critical drug-metabolizing enzyme in the cytochrome P450 family) , low toxicity profiles, with 140 potentially toxic substructures pre-identified and excluded via substructure searching to eliminate compounds containing hazardous fragments. The diversity library enables broad applicability in high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Type

HY-W027773

7-Methoxy-4-(trifluoromethyl)coumarin MFC	Fluorescent Dyes/Probes
7-Methoxy-4-(trifluoromethyl)coumarin (MFC) is a fluorescent substrate for **cytochrome P450** and can quantify CYP activity .

HY-D0144

Resorufin methyl ether Methoxyresorufin	Chromogenic Substrates
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Chromogenic Substrates
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of **cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase** .

HY-116862

Dibenzylfluorescein

DBF

Fluorescent Dyes/Probes

Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its K_m value of 0.87-1.9 μM (Ex=485 nm，Em=535 nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease .

HY-17356G

Fenofibrate (GMP)

Fluorescent Dye

Fenofibrate (GMP) is Fenofibrate (HY-17356) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

Cat. No.	Product Name	Type

HY-N9934R

(-)-3-Dehydroshikimic acid (Standard) 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)	Biochemical Assay Reagents
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-17356G

Fenofibrate (GMP)

Biochemical Assay Reagents

Species:	Human (4)
Tag:	His (6) SUMO (1) GST (1)
Source:	P. pastoris (1) Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P72164

	CYP21A2 Protein, Human (His) CYP21; 21 OHase; 21-OHase; CA21H ; CAH1; CP21A_HUMAN; CPS1; CYP21A 2; CYP21A2; CYP21B; cytochrome P-450c21; cytochrome P450 21; cytochrome P450 C21B; cytochrome P450 XXI; cytochrome P450; family 21; subfamily A; polypeptide 2; cytochrome P450; subfamily XXIA steroid 21 hydroxylase;	Human	E. coli
	CYP21A2 Protein, a cytochrome P450 monooxygenase, crucially hydroxylates progesterone and 17alpha-hydroxyprogesterone at C-21, yielding vital intermediates for mineralocorticoid and glucocorticoid biosynthesis in adrenal steroidogenesis. This enzymatic process involves molecular oxygen, with NADPH providing essential electrons via cytochrome P450 reductase (CPR). CYP21A2 plays a pivotal role in regulating adrenal cortex hormone production. CYP21A2 Protein, Human (His) is the recombinant human-derived CYP21A2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72163

	CYP11B2 Protein, Human (His-SUMO) ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2_HUMAN; CYP11B2; CYPXIB2; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2; cytochrome P450 11B2; mitochondrial; mitochondrial; P-450Aldo; P-450C18; Steroid 18-hydroxylase	Human	E. coli
	CYP11B2 Protein, a cytochrome P450 monooxygenase, synthesizes aldosterone, pivotal for salt and water balance, impacting blood pressure and cardiovascular health. Mechanistically, it orchestrates three oxidative reactions, forming aldosterone, utilizing molecular oxygen and a mitochondrial transfer system. Additionally, CYP11B2 may be involved in the androgen metabolic pathway, expanding its physiological roles. CYP11B2 Protein, Human (His-SUMO) is the recombinant human-derived CYP11B2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P74210

	CYP3A4 Protein, Human (His) cytochrome P450 3A4; CYPIIIA3; CYP3A4; CYP3A3	Human	E. coli
	The CYP3A4 protein, encoded by the CYP3A4 gene, is a key enzyme in drug metabolism and the synthesis of cholesterol, steroids, and lipids. It localizes to the endoplasmic reticulum and is induced by glucocorticoids and certain drugs. CYP3A4 Protein, Human (His) is the recombinant human-derived CYP3A4 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P72049

	CYP51 Protein, Mycobacterium tuberculosis (sf9, His) cyp51; MT0788Lanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; cytochrome P450 51; cytochrome P450-14DM; cytochrome P450-LIA1; Sterol 14-alpha demethylase	Others	Sf9 insect cells
	CYP51 Proteinas is a sterol 14α-demethylase that acts with an unknown physiological substrate and accepts electrons from the iron-sulfur ferredoxin Fdx. In vitro, it catalyzes the C14-demethylation of lanosterol, 24,25-dihydrolanosterol, and obtanyol, showing stereoselectivity in producing 8,14-diene. CYP51 Protein, Mycobacterium tuberculosis (sf9, His) is the recombinant CYP51 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.

HY-P72165

	ERG11 Protein, Saccharomyces cerevisiae (GST) ERG11; CYP51; YHR007CLanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; cytochrome P450 51; cytochrome P450-14DM; cytochrome P450-LIA1; Sterol 14-alpha demethylase	Others	E. coli
	ERG11 Proteinas is a sterol 14α-demethylase, a key enzyme in the ergosterol biosynthetic pathway, particularly in the late pathway that occurs in the endoplasmic reticulum membrane. ERG11 catalyzes the three-step removal of the 14α-methyl group from lanosterol, releasing it as a formate, resulting in the conversion of the sterol into a key intermediate in ergosterol biosynthesis. ERG11 Protein, Saccharomyces cerevisiae (GST) is the recombinant ERG11 protein, expressed by E. coli , with N-GST labeled tag.

HY-P702798

	CYP7A1 Protein, Human (His) cytochrome P450 7A1; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase	Human	E. coli
	CYP7A1 Protein, Human (His) is the recombinant human-derived CYP7A1, expressed by E. coli , with N-6*His labeled tag.

HY-P700629

	CYP102A1 Protein, Priestia megaterium (P. pastoris, His) Bifunctional cytochrome P450; NADPH--P450 reductase; cytochrome P450BM-3; Fatty acid monooxygenase; Flavocytochrome P450 BM3	Others	P. pastoris
	The CYP102A1 protein acts as a fatty acid monooxygenase, catalyzing the hydroxylation of fatty acids at various positions. The protein also exhibits NADPH-dependent reductase activity, promoting electron transfer within its domain. CYP102A1 Protein, Priestia megaterium (P. pastoris, His) is the recombinant CYP102A1 protein, expressed by P. pastoris , with C-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-10882S

Clotrimazole-d5
Clotrimazole-d₅ is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity .

HY-10882S1

Clotrimazole-d10
Clotrimazole-d₁₀ is deuterated labeled Clotrimazole (HY-10882). Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.

HY-Y0110S1

2-Naphthol-d7
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-70013S

Abiraterone-d4
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

HY-B0476S

Phenacetin-d5
Phenacetin-d₅ is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-133091S

7-Ethoxycoumarin-d5
7-Ethoxycoumarin-d₅ is deuterium labeled 7-Ethoxycoumarin. 7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs .

HY-Y0110S

2-Naphthol-d8
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-132545S

RPR132595A-d3
RPR132595A-d₃ is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of Irinotecan (CPT-11), which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .

HY-30151S

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

HY-D0145S

7-Ethoxyresorufin-d5
7-Ethoxyresorufin-d₅ is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase .

HY-B0476S1

Phenacetin-13C
Phenacetin- ¹³C is the ¹³C labeled Phenacetin . Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-133116S

4-Hydroxyatomoxetine-d3
4-Hydroxyatomoxetine-d₃ is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor .

HY-17356S

Fenofibrate-d6
Fenofibrate-d₆ is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride
O-Desmethyltramadol-d6 (hydrochloride) is a deuterated labeled O-Desmethyltramadol (hydrochloride) . O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-10493S

Cobicistat-d8
Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC₅₀ values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules .

HY-17356S2

Fenofibrate-13C6
Fenofibrate-13C6 is a deuterated labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for *CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4*, respectively.

HY-17356S1

Fenofibrate-d4
Fenofibrate-d₄ is the deuterium labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively .

HY-15550S

4'-Hydroxy diclofenac-d4
4'-Hydroxy diclofenac-d₄ is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-132428S

O-Desmethyl Tramadol-d6
O-Desmethyl Tramadol-d₆ is the deuterium labeled O-Desmethyl Tramadol.?O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-B1462S

Chlorzoxazone-d3
Chlorzoxazone-d₃ is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

HY-15550S1

4'-Hydroxy diclofenac-13C6
4'-Hydroxy diclofenac- ¹³C₆ is the ¹³C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-117580S

16α-Hydroxyprednisolone-d3

16α-Hydroxyprednisolone-d₃ is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .

HY-13463BS

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-W707708

N-(4-Ethoxyphenyl)acetamide-2,2,2-d3
N-(4-Ethoxyphenyl)acetamide-2,2,2-d₃ is the deuterium labeled Phenacetin (HY-B0476). Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ (DM-3411 D₈) is a deuterium labeled Brexpiprazole S-oxide (HY-133152). Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM .

HY-B0653AS

Levobupivacaine-d9 hydrochloride

Levobupivacaine-d₉ ((S)-(–)-Bupivacaie-d₉) hydrochloride is deuterium labeled Levobupivacaine hydrochloride (HY-B0653A). Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82091

	Cytochrome P450 1B1 Antibody (YA1836) CYP1B1; cytochrome P450 1B1; CYPIB1	WB, IHC-P, FC	Human, Mouse, Rat
	Cytochrome P450 1B1 Antibody (YA1836) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 1B1.

HY-P82557

	Cytochrome P450 2E1 Antibody (YA2302) CYP2E1; CYP2E; cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; cytochrome P450-J	WB	Human, Mouse, Rat
	Cytochrome P450 2E1 Antibody (YA2302) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 2E1.

HY-P82421

	Cytochrome P450 2C9 Antibody (YA2166) CPC9; CYP2C; CYP2C10; CYP2C9; CYPIIC9; P450 PB1; P450MP	WB, ICC/IF, FC	Human
	Cytochrome P450 2C9 Antibody (YA2166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 2C9.

HY-P82376

	Cytochrome P450 24A1 Antibody (YA2121) CYP24A1; CYP24; 1; 25-dihydroxyvitamin D(3) 24-hydroxylase; mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; cytochrome P450 24A1; cytochrome P450-CC24	WB	Human
	Cytochrome P450 24A1 Antibody (YA2121) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 24A1.

HY-P80547

	Aromatase Antibody (YA611) CYP19A1; ARO1; CYAR; CYP19; cytochrome P450 19A1; Aromatase; CYPXIX; cytochrome P-450AROM; Estrogen synthase	WB, IP	Human, Mouse, Rat
	Aromatase Antibody (YA611) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aromatase.

HY-P83639

	Cytochrome P450 2D6 Antibody (YA3384) CYP2D6; CYP2DL1; cytochrome P450 2D6; CYPIID6; cytochrome P450-DB1; Debrisoquine 4-hydroxylase	WB, IHC-P, ICC/IF, FC	Human
	Cytochrome P450 2D6 Antibody (YA3384) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 2D6.

HY-P81245

	Cytochrome P450 1A2 Antibody (YA3505) cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; cytochrome P450 family 1 polypeptide 2; cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); Xenobiotic monooxygenase; P450 1A2.	WB, ICC/IF, FC	Human
	Cytochrome P450 1A2 Antibody (YA3505) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 1A2.

HY-P85566

	Cytochrome P450 17A1 Antibody (YA5258) 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; cytochrome P450 17A1; cytochrome P450 family 17; cytochrome P450 family 17 subfamily A polypeptide 1; cytochrome P450 subfamily XVII; steroid 17 alpha hydroxylase; adrenal hyperplasia; cytochrome P450 XVIIA1; cytochrome P450-C17; cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.	WB	Human
	Cytochrome P450 17A1 Antibody (YA5258) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cytochrome P450 17A1.

HY-P82342

	Cytochrome P450 4A/CYP4A11 Antibody (YA2087) cytochrome P450 family 4 subfamily A member 11; CP4Y; CYP4A2; CYP4AII; CYPIVA11	WB, IHC-P, IP	Human, Mouse, Rat
	Cytochrome P450 4A/CYP4A11 Antibody (YA2087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 4A/CYP4A11.

HY-P80640

	Cytochrome P450 17A1 Antibody (YA786) CPT7; CYP17; P450C17; S17AH; CYP17A1	WB	Human
	Cytochrome P450 17A1 Antibody (YA786) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Cytochrome P450 17A1.

HY-P81244

	CYP2E1 Antibody (YA9212) CYP2E1; CYP2E; cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; cytochrome P450-J	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	CYP2E1 Antibody (YA9212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYP2E1.

HY-P82514

	Cytochrome P450 26A1 Antibody (YA2259) CP26; CYP26; cyp26a1; hP450RAI; P450RAI; P450RAI1	WB, IHC-P	Human, Rat
	Cytochrome P450 26A1 Antibody (YA2259) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 26A1.

HY-P82418

	Cytochrome P450 27A1 Antibody (YA2163) CYP27A1; CYP27; Sterol 26-hydroxylase; mitochondrial; 5-beta-cholestane-3-alpha; 7-alpha; 12-alpha-triol 27-hydroxylase; cytochrome P-450C27/25; cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cytochrome P450 27A1 Antibody (YA2163) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 27A1.

HY-P81223

	CYP11A1 Antibody 1 Publications Verification Cholesterol 20 22 desmolase antibody Cholesterol desmolase antibody; Cholesterol monooxygenase (side chain cleaving) antibody; Cholesterol side chain cleavage enzyme antibody; Cholesterol side chain cleavage enzyme mitochondrial antibody; Cholesterol side-chain cleavage enzyme antibody; CP11A_HUMAN antibody; CYP11A antibody; CYP11A1 antibody; CYPXIA1 antibody; cytochrome P450 11A1 antibody; cytochrome P450 11A1 mitochondrial antibody; cytochrome P450 family 11 subfamily A polypeptide 1 antibody; cytochrome P450 subfamily XIA antibody; cytochrome P450(scc) antibody; cytochrome P450C11A1 antibody; mitochondrial antibody; P450SCC antibody; Steroid 20 22 lyase antibody;	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	CYP11A1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CYP11A1.

HY-P85425

	CYP7A1 Antibody (YA5117) CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; cytochrome P450 7A1	WB	Human, Golden hamster
	CYP7A1 Antibody (YA5117) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CYP7A1.

HY-P82925

	Thromboxane A Synthase Antibody (YA2670) TBXAS1; CYP5; CYP5A1; Thromboxane-A synthase; TXA synthase; TXS; cytochrome P450 5A1	WB	Human, Mouse
	Thromboxane A Synthase Antibody (YA2670) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thromboxane A Synthase.

HY-P84018

	Cytochrome P450 3A4 Antibody (YA3715) HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Cytochrome P450 3A4 Antibody (YA3715) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cytochrome P450 3A4.

HY-P83620

	Cytochrome P450 3A4 Antibody (YA3365) HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; CYP3A4	WB, IHC-P, IP	Human
	Cytochrome P450 3A4 Antibody (YA3365) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 3A4.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-114759

MS-PPOH 1 Publications Verification		Alkynes
MS-PPOH is a potent and selective **cytochrome P450** (CYP) epoxygenase inhibitor . MS-PPOH inhibits *CYP2C8* and *CYP2C9* with IC₅₀s of 15 and 11 μM, respectively . MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

cytochrome P450 (CYP)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products