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Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne play crucial roles in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .
6-N-Phthalimidoy hexanoic acid (compound FH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-N-Phthalimidoy hexanoic acid can be combined with carrier proteins and used in antigen design .
4-(N-Phthalimidoyl)butanoic acid (compound FB) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-(N-Phthalimidoyl)butanoic acid can be combined with carrier proteins and used in antigen design .
2-(N-Phthalimidoylmethylthio)acetic acid (MFA) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 2-(N-Phthalimidoylmethylthio)acetic acid can be combined with carrier proteins and used in antigen design .
6-(N-Phthalimidoylmethylthio)hexanoic acid (MFH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-(N-Phthalimidoylmethylthio)hexanoic acid can be combined with carrier proteins and used in antigen design .
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption .
4-Ketobenztriazine-CH2COOH (compound BA) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 4-Ketobenztriazine-CH2COOH can be combined with carrier proteins and used in antigen design .
3-(((1,3-Dioxoisoindolin-2-yl)methyl)thio)propanoic acid (MFP) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 3-(((1,3-Dioxoisoindolin-2-yl)methyl)thio)propanoic acid can be combined with carrier proteins and used in antigen design .
Fmoc-N-Me-His(Trt)-OH (Fmoc-MeHis(Trt)-OH) is a is an amino acid derivative containing amino and carboxyl groups. Fmoc-N-Me-His(Trt)-OH for the synthesis of Fmoc-MeHis (Trt) -Leu-OH .
3-[(4-Oxo-1,2,3-benzotriazin-3-yl)methylthio]propanoic acid (MBP) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 3-[(4-Oxo-1,2,3-benzotriazin-3-yl)methylthio]propanoic acid can be combined with carrier proteins and used in antigen design .
2-[(4-Oxo-1,2,3-benzotriazin-3-yl)oxy]acetic acid (HBA) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 2-[(4-Oxo-1,2,3-benzotriazin-3-yl)oxy]acetic acid can be combined with carrier proteins and used in antigen design .
6-[(4-Oxo-1,2,3-benzotriazin-3-yl)methylthio]hexanoic acid (MBH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-[(4-Oxo-1,2,3-benzotriazin-3-yl)methylthio]hexanoic acid can be combined with carrier proteins and used in antigen design .
YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models .
(Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models .
HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
ZEp is a zearalenone (ZEN) immunohapten activated by conversion of the carboxyl group to the corresponding N-hydroxysuccinimide ester for use in immunoassays .
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.
Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids .
Caerulein, desulfated is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK) .
Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
Quinacillin is a compound that undergoes hydrolysis catalyzed by penicillinase. Quinacillin is irreversibly covalently bound to proteins via its β-lactam carboxyl group .
Hapten Dca is an immunizing hapten. Hapten Dca is activated by a solution of N, N′-disuccinimidyl carbonate. Hapten Dca with a carboxyl functional group is conjugated to proteins .
Chymotrypsin (Chymotrypsin A) (MS grade) is a serine protease produced by the pancreas. Chymotrypsin (MS grade) cleaves protein chains at the carboxyl side of aromatic amino acids .
GK56 is a carboxyl nicotine hapten, which contains a linker attached to the 6-position of nicotine. GK56 conjugates to KLH via carbodiimide-mediated reactions .
Linoleyl alcohol (Standard) is the analytical standard of Linoleyl alcohol. This product is intended for research and analytical applications. Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol .
TLCK-treated Chymotrypsin is a serine protease. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids. TLCK treated to inactivate residual tryspin activity .
Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule .
Copeptin (human) is a diagnostic and prognostic biomarker for cardiovascular disease (CVD). Copeptin (human) is also the carboxyl terminus of the arginine vasopressin (AVP) precursor peptide. Copeptin (human) can be used in the study of cardiovascular disease .
Lysyl endopeptidase, Achromobacter sp (Lys-C) catalyzes carboxyl oxygen exchange reaction. Lysyl endopeptidase has higher substrate binding affinities and higher catalytic rates at the acidic pHs than at the alkaline pHs .
Recombinant Kex2 protease is a membrane-bound, Ca 2+-dependent serine protease. Recombinant Kex2 protease specifically recognize and cleave the carboxyl-terminal peptide bonds of dibasic amino acids .
tert-Butyl methyl adipate is a linker with an methyl ester group and a t-butyl ester. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Cyanine7 carboxylic acid (Cy7 COOH) is a derivative of Cy7 (HY-D0825) dye. Cyanine7 carboxylic acid contains carboxyl groups, which can condense ammonia to form covalent bonds .
Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers .
2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields .
TAMRA-PEG4-t-butyl ester is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm, containing a t-butyl protected carboxyl group which can be deprotected under acidic conditions.
Dextran-COOH is a dextran derivative with carboxyl (–COOH) functional groups introduced into the molecular chain. Dextran-COOH can be covalently coupled with a variety of bioactive molecules, drugs, small molecule ligands, fluorescent probes and other functional materials .
2,6-Dihydroxybenzoic acid is an aromatic compound containing phenolic hydroxyl groups and carboxyl groups, and it is a secondary metabolite of Salicylic acid (HY-B0167). 2,6-Dihydroxybenzoic acid is also present in olive oil wastewater .
t-Butyl 3-(hydroxypropoxyl)-propanoate contains reactive hydroxyl and t-butyl protected carboxyl moieties. The hydroxyl group can react to further derivatize the compound. The t-butyl carbonyl group can be deprotected under acidic conditions.
Sulfo Cy7 bis-COOH is a derivative of Cy7 (HY-D0825) dye containing sulfonate ions. Sulfo Cy7 bis-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand .
Sulfo Cy5 bis COOH is a derivative of Cy5 (HY-D0821) dye containing sulfonate ions. Sulfo Cy5 bis COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .
tert-Butyl 6-hydroxyhexanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Sulfo Cy3 bis COOH is a derivative of Cy3 (HY-D0822) dye containing sulfonate ions. Sulfo Cy3 bis COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
tert-Butyl 7-hydroxyheptanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
BACE1 (485-501) is the carboxyl terminal of BACE1 (Beta-site APP cleaving enzyme 1). BACE1 (485-501) can be used as antigen to produce anti-BACE1-C antibody .
TAMRA-PEG8-COOH is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
TAMRA-PEG4-COOH is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
TAMRA-PEG3-COOH is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
IR-825 is a near infrared fluorescent dye.the end of IR-825 has carboxyl COOH active group, and can participate in the reaction to connect other molecules. IR-825 can be widely used in tumor photothermal treatment. .
LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .
Polycarbophil is an orally active hydrophilic polymer. Polycarbophil achieves bioadhesion through hydrogen bonding between carboxyl groups and mucosal surfaces, and prolongs compound retention time and regulates compound release through swelling properties. Polycarbophil relieves constipation and diarrhea .
Tyrosine decarboxylase, Microorganism (TDC) widely exists in plants, insects and different microorganisms, and is often used in biochemical research. Tyrosine decarboxylase is a pyridoxal 5'-phosphate (PLP)-dependent decarboxylase that catalyzes the removal of carboxyl groups from tyrosine to produce tyramine and carbon dioxide .
Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC50 of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase .
(S)-Trolox is an analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects .
Cannabigerorcin is a phenolic compound found in cannabis plants, featuring a diphenol backbone and a terpene side chain. By reacting with radiolabeled methylmagnesium carbonate (MMC), its carboxyl group can be 14C-labeled. Radiolabeled Cannabigerorcin is widely used in research on cannabinoid biosynthesis pathways and metabolic processes .
D-Galacturonic acid (D-galUA) hydrate, as the main component of pectin, is abundantly present in plants. The carboxyl group of D-Galacturonic acid hydrate can bind to metal cations. D-Galacturonic acid hydrate plays an important role in the food industry, pharmaceutical field, and heavy metal removal, among other aspects .
D-Galacturonic acid (D-galUA), as the main component of pectin, is abundantly present in plants. The carboxyl group of D-Galacturonic acid can bind to metal cations. D-Galacturonic acid plays an important role in the food industry, pharmaceutical field, and heavy metal removal, among other aspects .
mPEG-CM (MW 10000) (mPEG-COOH (MW 10000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 10000) can be used for drug delivery .
mPEG-CM (MW 20000) (mPEG-COOH (MW 20000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 20000) can be used for drug delivery .
mPEG-CM (MW 1000) (mPEG-COOH (MW 1000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 1000) can be used for drug delivery .
Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .
mPEG-CM (MW 5000) (mPEG-COOH (MW 5000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 5000) can be used for drug delivery .
mPEG-CM (MW 40000) (mPEG-COOH (MW 40000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 40000) can be used for drug delivery .
PLGA-COOH (MW 80000) (LA/GA 50:50) is a copolymer, which consist of lactic acid (LA)-glycolic acid (GA) with a molar ratio of 50:50, and a carboxyl terminal groups. PLGA-COOH (MW 80000) (LA/GA 50:50) is utilized in drug delivery system for its biocompatibility and biodegradability .
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
Endoproteinase Arg-C is a serine endoproteinase that hydrolyzes peptide bonds on the carboxyl side of arginyl residues and has esterase and amidase activities. Endoproteinase Arg-C can be isolated from Clostridium histolyticum. Endoproteinase Arg-C is of mass spectrometry grade and can be used for peptide mapping, sequence analysis, cell separation .
Poly-L-γ-glutamic acid sodium is a high molecular weight polymer composed of glutamic acid linked by γ-amino and carboxyl groups to form peptide bonds. Poly-L-γ-glutamic acid sodium protects bacteria from bacteriophage infection. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems .
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
AF 594 carboxylic acid is a carboxyl derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 carboxylic acid can form stable covalent bonds through the reaction of carboxylic acid groups with molecules with amino groups .
Hydroxy-PEG12-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Tos-PEG11-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
TAMRA-PEG2-NH2 is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-NH2 contains NH2 groups, which can undergo condensation reactions with carboxyl groups to form covalent bonds.
TAMRA-PEG3-NH2 is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-NH2 contains NH2 groups, which can undergo condensation reactions with carboxyl groups to form covalent bonds.
TAMRA-PEG7-NH2 is a dye derivative of TAMRA (HY-135640) containing 7 PEG units. TAMRA-PEG7-NH2 contains NH2 groups, which can undergo condensation reactions with carboxyl groups to form covalent bonds.
Stearic acid-PEG-CH2CO2H, MW 1000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The terminal carboxyl can react with amine via condensation reaction in the presence of HATU/EDC activator. Reagent grade, for research use only.
1-Butanol, 4-azido-, 1-benzoate (4-Azidobutyl benzoate) is a compound with an ethyl benzoate head and a terminal azide group. The ethyl benzoate protected carboxyl group can be deprotected under acidic conditions. Azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry.
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .
Cy3-PEG-Amine is a derivative of the Cyanine 3 (Cy3) (HY-D0822) dye containing one PEG unit. Cy3-PEG-Amine bears an Amine group, which can react with various functional groups (such as carboxyl, aldehyde, or active esters) to form amide or imine bonds.
AF 430 amine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 amine can form covalent bonds through a condensation reaction between amino groups and molecules containing carboxyl groups. To achieve specific coupling of dye labels and biomolecules .
Amino-PEG11-t-butyl ester is a click chemistry linker containing an amine and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Mal-PEG12-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
XH161-180 is a potent and orally active ubiquitin carboxyl-terminal hydrolase 2 (USP2) inhibitor. XH161-180 decreases the protein of cyclin D and ACE2. XH161-180 shows antiproliferative activity. XH161-180 has the potential for the research of cancer and virus infection depending on ACE2 .
Paclitaxel-2′-succinate NHS ester is a paclitaxel derivative with a succinic acid linker, in which the carboxyl group is activated by the NHS ester. The NHS ester group is highly reactive toward amino or hydroxyl groups and can be used to conjugate with other molecules such as peptides, proteins, antibodies, enzymes or polymers. Paclitaxel-2′-succinate NHS ester can be used in the development of nanomedicines and in the study of cancer therapy .
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis .
Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation .
2,3-Dihydroxysuccinic acid (Standard) (Tartaric acid (Standard)) is the analytical standard of 2,3-Dihydroxysuccinic acid (HY-N2436). This product is intended for research and analytical applications. 2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields.
2,6-Dihydroxybenzoic acid (Standard) is the analytical standard of 2,6-Dihydroxybenzoic acid (HY-Y0801). This product is used for research and analytical applications. 2,6-Dihydroxybenzoic acid is an aromatic compound containing phenolic hydroxyl groups and carboxyl groups, and it is a secondary metabolite of Salicylic acid (HY-B0167). 2,6-Dihydroxybenzoic acid is also present in olive oil wastewater .
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
4-Arm PEG-amine (MW 5000) is a PEG Linker. The reactive primary amine or NH2 rapidly react with aldehyde, ketone to form imine. Imine upon further reduction forms secondary amine via reductive amination. Amine reacts with activated carboxyl acid, NHS ester to form stable amide bonds. 4-Arm PEG reagents are useful crosslinking reagent and used for drug delivery .
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
D-Galacturonic acid hydrate (Standard) (D-galUA hydrate (Standard)) is the analytical standard of D-Galacturonic acid hydrate (HY-B1827). This product is intended for research and analytical applications. D-Galacturonic acid (D-galUA) hydrate, as the main component of pectin, is abundantly present in plants. The carboxyl group of D-Galacturonic acid hydrate can bind to metal cations. D-Galacturonic acid hydrate plays an important role in the food industry, pharmaceutical field, and heavy metal removal, among other aspects.
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
Iomeprol intermediate-1 (Standard) is the analytical standard of Iomeprol intermediate-1. This product is intended for research and analytical applications. Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .
Cationic Bovine Serum Albumin is a bovine serum albumin (BSA) modified with excess ethylenediamine, which has enhanced immunogenicity compared to native BSA. Positively charged primary amines block all negatively charged carboxyl groups, making Cationic Bovine Serum Albumin a cationic protein. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .
mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation .
Cy3B amine chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
Cy3B amine chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group in the disodium salt form. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
DPPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG5000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG550 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG350 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG1000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG3000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG350 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG1000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG1000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
1-Adamantylaspartate is a newly developed β-β-1-imidopropionic acid used to synthesize the C-terminal octapeptide of the β subunit of human chorionic gonadotropin (hCG) and the hexadecapeptide of the α subunit of the insulin receptor (30-55) by conventional solution methods and solid phase methods, aiming to inhibit the formation of asparagine during the synthesis of asparagyl peptides. Studies have shown that β-β-1-imidopropionic acid is an effective protector of the β-carboxyl function of aspartic acid residues.
DPPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG3000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .
Iminodiacetic acid is a metal ion chelator targeting Cr 6+, Cd 2+, Ni 2+, and Pb 2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .
18:0 mPEG750 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG3000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
Enitociclib (BAY-1251152; VIP152) is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .
Sulfo-Cy5 amine is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy5 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. The amine functionality of Sulfo-Cy5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Sulfo-Cy3 amine is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
(+)-Enitociclib ((+)-BAY-1251152) is the enantiomer of Enitociclib (HY-103019E) with (+) optical rotation. Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
(±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
(-)-Enitociclib ((R)-Enitociclib) is an enantiomer of Enitociclib (HY-103019E) with an optical rotation of (-). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
1H-Imidazole-4-carboxylic acid is an organic compound containing an imidazole ring and a carboxyl group. 1H-Imidazole-4-carboxylic acid stabilizes specific forms of metal ions through coordination, thus influencing the progress of chemical reactions. 1H-Imidazole-4-carboxylic acid plays an important role in the hydrolysis of phosphate esters catalyzed by lanthanide metals. 1H-Imidazole-4-carboxylic acid can be used to modify dendrimers, changing the surface properties and catalytic performance of materials .
sulfo-Cy7.5 amine is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The amine functionality of sulfo-Cy7.5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy7.5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC50=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .
ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT .
ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation .
ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively .
ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively .
ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines .
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .
4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .
Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .
4-Aminohippuric acid-d4 (p-Aminohippuric acid-d4) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .
FCH Group Screening Library Collection contains about 2,244,487 lead-like compounds for biological screening. This brand new collection comprises polar molecules with pharmacologically important groups such as free carboxylic and amino groups.
Cyanine7 carboxylic acid (Cy7 COOH) is a derivative of Cy7 (HY-D0825) dye. Cyanine7 carboxylic acid contains carboxyl groups, which can condense ammonia to form covalent bonds .
TAMRA-PEG4-t-butyl ester is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm, containing a t-butyl protected carboxyl group which can be deprotected under acidic conditions.
Sulfo Cy7 bis-COOH is a derivative of Cy7 (HY-D0825) dye containing sulfonate ions. Sulfo Cy7 bis-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
Sulfo Cy5 bis COOH is a derivative of Cy5 (HY-D0821) dye containing sulfonate ions. Sulfo Cy5 bis COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
Sulfo Cy3 bis COOH is a derivative of Cy3 (HY-D0822) dye containing sulfonate ions. Sulfo Cy3 bis COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
TAMRA-PEG8-COOH is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
TAMRA-PEG4-COOH is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
TAMRA-PEG3-COOH is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-COOH contains carboxyl groups, which can condense ammonia to form covalent bonds.
IR-825 is a near infrared fluorescent dye.the end of IR-825 has carboxyl COOH active group, and can participate in the reaction to connect other molecules. IR-825 can be widely used in tumor photothermal treatment. .
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
AF 594 carboxylic acid is a carboxyl derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (Ex=594 nm, Em=615 nm). AF 594 carboxylic acid can form stable covalent bonds through the reaction of carboxylic acid groups with molecules with amino groups .
TAMRA-PEG2-NH2 is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-NH2 contains NH2 groups, which can undergo condensation reactions with carboxyl groups to form covalent bonds.
TAMRA-PEG3-NH2 is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-NH2 contains NH2 groups, which can undergo condensation reactions with carboxyl groups to form covalent bonds.
TAMRA-PEG7-NH2 is a dye derivative of TAMRA (HY-135640) containing 7 PEG units. TAMRA-PEG7-NH2 contains NH2 groups, which can undergo condensation reactions with carboxyl groups to form covalent bonds.
Cy3-PEG-Amine is a derivative of the Cyanine 3 (Cy3) (HY-D0822) dye containing one PEG unit. Cy3-PEG-Amine bears an Amine group, which can react with various functional groups (such as carboxyl, aldehyde, or active esters) to form amide or imine bonds.
AF 430 amine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 amine can form covalent bonds through a condensation reaction between amino groups and molecules containing carboxyl groups. To achieve specific coupling of dye labels and biomolecules .
Cy3B amine chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Cy3B amine chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group in the disodium salt form. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
BP Fluor 488 Cadaverine is a carboxyl/carbonyl reactive building block used widely to modify carboxylic groups in the presence of activators (e.g. EDC or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. BP Fluor 488 dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
Sulfo-Cy5 amine is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy5 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. The amine functionality of Sulfo-Cy5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Sulfo-Cy3 amine is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
sulfo-Cy7.5 amine is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The amine functionality of sulfo-Cy7.5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy7.5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne play crucial roles in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .
Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids .
2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields .
HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
Dextran-COOH is a dextran derivative with carboxyl (–COOH) functional groups introduced into the molecular chain. Dextran-COOH can be covalently coupled with a variety of bioactive molecules, drugs, small molecule ligands, fluorescent probes and other functional materials .
mPEG-CM (MW 10000) (mPEG-COOH (MW 10000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 10000) can be used for drug delivery .
mPEG-CM (MW 20000) (mPEG-COOH (MW 20000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 20000) can be used for drug delivery .
mPEG-CM (MW 1000) (mPEG-COOH (MW 1000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 1000) can be used for drug delivery .
mPEG-CM (MW 5000) (mPEG-COOH (MW 5000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 5000) can be used for drug delivery .
mPEG-CM (MW 40000) (mPEG-COOH (MW 40000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure, which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group. mPEG-CM (MW 40000) can be used for drug delivery .
Poly-L-γ-glutamic acid sodium is a high molecular weight polymer composed of glutamic acid linked by γ-amino and carboxyl groups to form peptide bonds. Poly-L-γ-glutamic acid sodium protects bacteria from bacteriophage infection. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems .
Stearic acid-PEG-CH2CO2H, MW 1000 is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The terminal carboxyl can react with amine via condensation reaction in the presence of HATU/EDC activator. Reagent grade, for research use only.
2,3-Dihydroxysuccinic acid (Standard) (Tartaric acid (Standard)) is the analytical standard of 2,3-Dihydroxysuccinic acid (HY-N2436). This product is intended for research and analytical applications. 2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields.
Cationic Bovine Serum Albumin is a bovine serum albumin (BSA) modified with excess ethylenediamine, which has enhanced immunogenicity compared to native BSA. Positively charged primary amines block all negatively charged carboxyl groups, making Cationic Bovine Serum Albumin a cationic protein. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .
mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies .
DPPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG5000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG550 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG350 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG1000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG3000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG350 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG1000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG1000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG3000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .
18:0 mPEG750 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG3000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
1H-Imidazole-4-carboxylic acid is an organic compound containing an imidazole ring and a carboxyl group. 1H-Imidazole-4-carboxylic acid stabilizes specific forms of metal ions through coordination, thus influencing the progress of chemical reactions. 1H-Imidazole-4-carboxylic acid plays an important role in the hydrolysis of phosphate esters catalyzed by lanthanide metals. 1H-Imidazole-4-carboxylic acid can be used to modify dendrimers, changing the surface properties and catalytic performance of materials .
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption .
Fmoc-N-Me-His(Trt)-OH (Fmoc-MeHis(Trt)-OH) is a is an amino acid derivative containing amino and carboxyl groups. Fmoc-N-Me-His(Trt)-OH for the synthesis of Fmoc-MeHis (Trt) -Leu-OH .
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.
Caerulein, desulfated TFA is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK) .
Caerulein, desulfated is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK) .
Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule .
Copeptin (human) is a diagnostic and prognostic biomarker for cardiovascular disease (CVD). Copeptin (human) is also the carboxyl terminus of the arginine vasopressin (AVP) precursor peptide. Copeptin (human) can be used in the study of cardiovascular disease .
Crustacean cardioactive peptide (CCAP) is a insect cardioregulatory peptides that contmns 9 amino acid, first isolated from the tobacco hawkmoth, Manduca sexta. There are two cystemes at pnsttons 3 and 9 forming a disulfide bridge and the carboxyl-terminns is amldated .
Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan belongs to cell-penetrating peptides (CPPs) .
LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .
BACE1 (485-501) is the carboxyl terminal of BACE1 (Beta-site APP cleaving enzyme 1). BACE1 (485-501) can be used as antigen to produce anti-BACE1-C antibody .
LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .
Antho-RFamide is a neuropeptide isolated from the sea anemone (Anthopleura elegantissima). Antho-RFamide contains a specific carboxyl-terminal sequence, Arg-Phe-NH2, that plays an important role in neural signaling. Antho-RFamide can be used to study the function of neuropeptides in the nervous system of the simplest animals .
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α2bβ3 integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .
MCE Carboxyl Magnetic beads (200 nm, 10 mg/mL) are characterized by superparamagnetism, fast magnetic response, abundant carboxyl functional groups, monodispersity, and submicron scale particle size. Biological ligands (proteins, peptides, oligonucleotides, drug molecules, etc.) can be covalently coupled to the surface of microspheres under the action of special chemical reagents (such as EDC).
Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers .
2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields .
2,6-Dihydroxybenzoic acid is an aromatic compound containing phenolic hydroxyl groups and carboxyl groups, and it is a secondary metabolite of Salicylic acid (HY-B0167). 2,6-Dihydroxybenzoic acid is also present in olive oil wastewater .
D-Galacturonic acid (D-galUA) hydrate, as the main component of pectin, is abundantly present in plants. The carboxyl group of D-Galacturonic acid hydrate can bind to metal cations. D-Galacturonic acid hydrate plays an important role in the food industry, pharmaceutical field, and heavy metal removal, among other aspects .
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
Linoleyl alcohol (Standard) is the analytical standard of Linoleyl alcohol. This product is intended for research and analytical applications. Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol .
D-Galacturonic acid (D-galUA), as the main component of pectin, is abundantly present in plants. The carboxyl group of D-Galacturonic acid can bind to metal cations. D-Galacturonic acid plays an important role in the food industry, pharmaceutical field, and heavy metal removal, among other aspects .
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .
2,3-Dihydroxysuccinic acid (Standard) (Tartaric acid (Standard)) is the analytical standard of 2,3-Dihydroxysuccinic acid (HY-N2436). This product is intended for research and analytical applications. 2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields.
2,6-Dihydroxybenzoic acid (Standard) is the analytical standard of 2,6-Dihydroxybenzoic acid (HY-Y0801). This product is used for research and analytical applications. 2,6-Dihydroxybenzoic acid is an aromatic compound containing phenolic hydroxyl groups and carboxyl groups, and it is a secondary metabolite of Salicylic acid (HY-B0167). 2,6-Dihydroxybenzoic acid is also present in olive oil wastewater .
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
D-Galacturonic acid hydrate (Standard) (D-galUA hydrate (Standard)) is the analytical standard of D-Galacturonic acid hydrate (HY-B1827). This product is intended for research and analytical applications. D-Galacturonic acid (D-galUA) hydrate, as the main component of pectin, is abundantly present in plants. The carboxyl group of D-Galacturonic acid hydrate can bind to metal cations. D-Galacturonic acid hydrate plays an important role in the food industry, pharmaceutical field, and heavy metal removal, among other aspects.
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
Iminodiacetic acid is a metal ion chelator targeting Cr 6+, Cd 2+, Ni 2+, and Pb 2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .
4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .
4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .
The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53. USP7 Protein, Human (His) is the recombinant human-derived USP7, expressed by E. coli , with N-His labeled tag. ,
The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53. USP7 Protein, Human (sf9) is the recombinant human-derived USP7 protein, expressed by Sf9 insect cells , with tag free.
USP5 protein selectively cleaves branched multiubiquitin polymers, favoring 'Lys-48'-linked polyubiquitin disassembly. It exhibits lower affinity for linear and 'Lys-63'-linked polyubiquitin. USP5 knockdown leads to p53/TP53 accumulation, enhancing p53/TP53 transcriptional activity, as unanchored polyubiquitin competes with ubiquitinated p53/TP53 for proteasomal recognition, unlike MDM2. USP5 Protein, Human (sf9, His) is the recombinant human-derived USP5 protein, expressed by Sf9 insect cells , with C-His labeled tag.
The UCHL3 protein is a deubiquitinating enzyme (DUB) that complexly controls cellular ubiquitin levels by processing ubiquitin precursors and ubiquitinated proteins. As a thiol protease, UCHL3 selectively recognizes and hydrolyzes the peptide bond of ubiquitin or the C-terminal glycine of NEDD8, showing a 10-fold preference for Arg and Lys at the P3 position, and has a special preference for "Lys-48" linked ubiquitin chains. affinity. UCHL3 Protein, Rat (His) is the recombinant rat-derived UCHL3 protein, expressed by E. coli , with N-His labeled tag.
Calcitonin Protein, Human (His), is a recombinant human Calcitonin expressed in E. coli with a His tag at the N-terminus. Calcitonin has an effect on decreasing osteoclast activity and has the potential for hypercalcemia research.
Calcitonin Protein, Human (His, solution), is a recombinant human Calcitonin expressed in E. coli with a His tag at the N-terminus. Calcitonin has an effect on decreasing osteoclast activity and has the potential for hypercalcemia research.
UCHL1 Protein, a ubiquitin carboxyl-terminal hydrolase, plays a crucial role in protein degradation and regulation of cellular processes.It is involved in maintaining neuronal integrity and has been linked to neurodegenerative diseases.UCHL1 Protein's potential as a biomarker and therapeutic target in neurodegenerative disorders makes it a subject of intense research in the field of neuroscience.UCHL1 Protein, Mouse (His) is the recombinant mouse-derived UCHL1 protein, expressed by E.coli , with N-His labeled tag.
The UCHL1 protein is a ubiquitin proteolytic enzyme essential for processing ubiquitin precursors and hydrolyzing ubiquitinated proteins. As a thiol protease, it specifically cleaves the C-terminal glycine of ubiquitin. UCHL1 Protein, Rat (His) is the recombinant rat-derived UCHL1 protein, expressed by E. coli , with N-10*His labeled tag.
Carboxyester lipase/CEL protein plays a crucial role in cellular processes as it catalyzes the hydrolysis of a variety of substrates, including cholesterol esters, phospholipids, lysophospholipids, diacylglycerols and triacylglycerols, and lipids of hydroxy fatty acids acid ester. FAHF). Carboxyl Ester Lipase/CEL Protein, Mouse (sf9, His) is the recombinant mouse-derived Carboxyl Ester Lipase/CEL protein, expressed by Sf9 insect cells , with C-His labeled tag.
The USP7 protein is a hydrolase that deubiquitinates multiple targets, including FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. It cooperates with DAXX to enhance the E3 ligase activity of MDM2 and promote ubiquitination and degradation of p53/TP53. USP7 Protein, Human is the recombinant human-derived USP7, expressed by E. coli , with tag Free labeled tag. ,
UCHL3 Protein, a ubiquitin carboxyl-terminal hydrolase, is responsible for protein degradation and regulation of cellular processes. It is prominently expressed in the testes and plays a crucial role in spermatogenesis. UCHL3 Protein's involvement in male fertility and its potential as a therapeutic target in reproductive disorders make it a subject of interest in reproductive medicine. UCHL3 Protein, Human (His) is the recombinant human-derived UCHL3 protein, expressed by E. coli , with C-6*His labeled tag.
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9) is the recombinant human, mouse-derived USP46 protein, expressed by Sf9 insect cells , with tag free.
USP53 protein, a critical element in tight junctions, is essential for the survival of auditory hair cells and the maintenance of hearing function. Although lacking peptidase activity, USP53's importance is highlighted by its interaction with the TJP1:TJP2 heterodimer, suggesting nuanced involvement in the molecular architecture of tight junctions. This interaction emphasizes USP53's potential impact on cellular survival and auditory processes. USP53 Protein, Human is the recombinant human-derived USP53 protein, expressed by E. coli , with tag free.
USP46 Protein, a ubiquitin-specific protease, is involved in the regulation of cellular processes and protein degradation. It has been found to play a critical role in synaptic plasticity and memory formation. USP46 Protein's potential as a therapeutic target in cognitive disorders and its impact on neurological function make it a subject of interest in neuroscience research. USP46 Protein, Human/Mouse (sf9, SUMO) is the recombinant mouse-derived USP46 protein, expressed by Sf9 insect cells , with SUMO labeled tag.
USP50 protein, also known as ubiquitin-specific protease 50, is a protein without peptidase activity. Peptidase activity generally refers to the ability of an enzyme to cleave peptide bonds in proteins. USP50 Protein, Human (sf9) is the recombinant human-derived USP50 protein, expressed by sf9 insect cells , with tag free.
USP53 protein, a critical element in tight junctions, is essential for the survival of auditory hair cells and the maintenance of hearing function. Although lacking peptidase activity, USP53's importance is highlighted by its interaction with the TJP1:TJP2 heterodimer, suggesting nuanced involvement in the molecular architecture of tight junctions. This interaction emphasizes USP53's potential impact on cellular survival and auditory processes. USP53 Protein, Human (His, GST) is the recombinant human-derived USP53 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
USP50 protein, also known as ubiquitin-specific protease 50, is a protein without peptidase activity. Peptidase activity generally refers to the ability of an enzyme to cleave peptide bonds in proteins. USP50 Protein, Human (sf9, GST) is the recombinant human-derived USP50 protein, expressed by sf9 insect cells , with N-GST labeled tag.
BAP1 protein deubiquitinates histone H2A and HCFC1, mediating deubiquitination of H2AK119ub1. It regulates cell growth by deubiquitinating HCFC1 chains and inhibits BRCA1 and BARD1 activity. BAP1 also protects itself from cytoplasmic sequestration and acts as a tumor suppressor. BAP1 Protein, Human is the recombinant human-derived BAP1 protein, expressed by E. coli , with tag free.
BAP1 protein deubiquitinates histone H2A and HCFC1, mediating deubiquitination of H2AK119ub1. It regulates cell growth by deubiquitinating HCFC1 chains and inhibits BRCA1 and BARD1 activity. BAP1 also protects itself from cytoplasmic sequestration and acts as a tumor suppressor. BAP1 Protein, Human (His) is the recombinant human-derived BAP1 protein, expressed by E. coli , with N-6*His labeled tag.
UCHL5 is a highly specific protease that acts as a deubiquitinating enzyme intricately linked to the 19S proteasome subunit, cleaving "Lys-48" linked polyubiquitin chains. Although the INO80 complex is inert, transient interactions between INO80 and the proteasome (facilitated by ADRM1) activate UCHL5. UCHL5 Protein, Human is the recombinant human-derived UCHL5 protein, expressed by E. coli , with tag free.
The USP44 protein is a key deubiquitinase that regulates the spindle assembly checkpoint and prevents premature initiation of anaphase by deubiquitinating CDC20. This stabilizes the MAD2L1-CDC20-APC/C complex and enhances the spindle assembly checkpoint. USP44 Protein, Human is the recombinant human-derived USP44 protein, expressed by E. coli , with tag free.
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human is the recombinant human-derived USP46 protein, expressed by E. coli , with tag free.
USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human is the recombinant human-derived USP21 protein, expressed by E. coli , with tag free.
USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human (GST) is the recombinant human-derived USP21 protein, expressed by E. coli , with N-GST labeled tag.
SCYL3 protein may regulate cell adhesion and migration complexes, suggesting its involvement in cellular processes related to cell motility. Its interaction with the C-terminal domain of EZR/VIL2 suggests a molecular partnership affecting cell adhesion and migration. SCYL3 Protein, Human (sf9, His, GST) is the recombinant human-derived SCYL3 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.
USP14 is a proteasome-associated deubiquitinase that regulates ubiquitin dynamics by releasing ubiquitin from proteins marked for degradation. As a reversible proteasome subunit, USP14 ensures ubiquitin replenishment. USP14 Protein, Human (His) is the recombinant human-derived USP14 protein, expressed by E. coli , with N-6*His labeled tag.
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with tag free.
USP22 protein is a histone deubiquitinating enzyme in the SAGA complex that catalyzes the deubiquitination of histones H2A and H2B and acts as a coactivator. Activators such as MYC facilitate its recruitment to gene promoters, which is critical for transcriptional activation. USP22 Protein, Human (sf9) is the recombinant human-derived USP22 protein, expressed by sf9 insect cells , with tag free.
The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (sf9) is the recombinant human-derived USP28 protein, expressed by sf9 insect cells , with tag free.
USP29 protein, as a deubiquitinating enzyme, plays a crucial role in innate antiviral immunity by mediating "Lys-48" deubiquitination of CGAS. This effect stabilizes CGAS, an important sensor of the cellular response to viral infection, emphasizing the importance of USP29 in regulating CGAS activity. USP29 Protein, Human (sf9) is the recombinant human-derived USP29 protein, expressed by sf9 insect cells , with tag free.
The USP37 protein is a multifunctional deubiquitinase that regulates critical cellular processes. During the G1/S transition, it deubiquitinates cyclin A, promotes S phase entry, and enhances activity through Ser-628 phosphorylation. USP37 Protein, Human (sf9) is the recombinant human-derived USP37 protein, expressed by sf9 insect cells , with tag free.
The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (sf9) is the recombinant human-derived USP11 protein, expressed by sf9 insect cells , with tag free.
USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human (sf9) is the recombinant human-derived USP10 protein, expressed by sf9 insect cells , with tag free.
The USP47 protein is a ubiquitin-specific protease that deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizes POLB, and regulates base excision repair (BER). In addition to DNA repair, USP47 is an important regulator of cell growth and genome integrity. USP47 Protein, Human (sf9, FLAG) is the recombinant human-derived USP47 protein, expressed by sf9 insect cells , with C-Flag labeled tag.
The USP28 protein serves as a deubiquitinase and plays a key role in the DNA damage response checkpoint and the stability of the MYC proto-oncogene. It selectively deubiquitinates DNA damage pathway proteins such as CLSPN, thereby regulating apoptosis. USP28 Protein, Human (sf9, His) is the recombinant human-derived USP28 protein, expressed by sf9 insect cells , with N-8*His labeled tag.
USP29 protein, as a deubiquitinating enzyme, plays a crucial role in innate antiviral immunity by mediating "Lys-48" deubiquitination of CGAS. This effect stabilizes CGAS, an important sensor of the cellular response to viral infection, emphasizing the importance of USP29 in regulating CGAS activity. USP29 Protein, Human (sf9, FLAG) is the recombinant human-derived USP29 protein, expressed by sf9 insect cells , with N-Flag labeled tag.
The USP37 protein is a multifunctional deubiquitinase that regulates critical cellular processes. During the G1/S transition, it deubiquitinates cyclin A, promotes S phase entry, and enhances activity through Ser-628 phosphorylation. USP37 Protein, Human (sf9, His) is the recombinant human-derived USP37 protein, expressed by sf9 insect cells , with N-8*His labeled tag.
The USP11 protein is a multifunctional protease that selectively removes ubiquitin from target proteins and polyubiquitin chains, thereby hindering their proteasomal degradation. It shows a preference for “Lys-6” and “Lys-63” linked ubiquitin chains and less activity towards other linkages. USP11 Protein, Human (sf9, GST) is the recombinant human-derived USP11 protein, expressed by sf9 insect cells , with N-GST labeled tag.
USP21 protein is a multifunctional deubiquitinase that plays a key role in the regulation of epigenetic transcriptional repression by deubiquitinating histone H2A. As a coactivator, it relieves the inhibition of dimethylation and trimethylation of histone H3 at "Lys-4", thereby regulating transcription initiation. USP21 Protein, Human (356a.a) is the recombinant human-derived USP21, expressed by E. coli , with tag Free labeled tag. ,
The USP47 protein is a ubiquitin-specific protease that deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizes POLB, and regulates base excision repair (BER). In addition to DNA repair, USP47 is an important regulator of cell growth and genome integrity. USP47 Protein, Human (sf9, His, FLAG) is the recombinant human-derived USP47 protein, expressed by sf9 insect cells , with C-Flag, N-8*His labeled tag.
The USP51 protein uniquely regulates the DNA damage response by deubiquitinating the "Lys-14" (H2AK13Ub) and "Lys-16" (H2AK15Ub) residues of histone H2A at double-strand breaks. After DNA damage, USP51 is recruited to chromatin and regulates TP53BP1 and BRCA1 assembly/disassembly, which is critical for DNA repair. USP51 Protein, Human (sf9, His, FLAG) is the recombinant human-derived USP51 protein, expressed by sf9 insect cells , with N-Flag, N-8*His labeled tag.
USP10 is a multifunctional hydrolase that plays a critical regulatory role in a variety of cellular processes. It stabilizes the tumor suppressor p53/TP53 by deubiquitinating the tumor suppressor p53/TP53 in the cytoplasm, thereby counteracting MDM2-mediated degradation. USP10 Protein, Human (sf9, His, GST) is the recombinant human-derived USP10, expressed by sf9 insect cells , with His, GST labeled tag. ,
USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Protein, Human is the recombinant human-derived USP2 protein, expressed by E. coli , with tag free.
USP15 is a hydrolase that complexly regulates cellular processes by deubiquitinating various target proteins in pathways such as TGF-β receptor, NF-κ-B, and RNF41/NRDP1-PRKN. In TGF-β signaling, it promotes R-SMAD deubiquitination or stabilizes TGFBR1, thereby enhancing pathway activity. USP15 Protein, Human (sf9) is the recombinant human-derived USP15 protein, expressed by Sf9 insect cells , with tag free.
USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (sf9) is the recombinant human-derived USP6 protein, expressed by sf9 insect cells , with tag free.
The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates. USP25 Protein, Human is the recombinant human-derived USP25 protein, expressed by E. coli , with tag free.
The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (sf9) is the recombinant human-derived USP16 protein, expressed by sf9 insect cells , with tag free.
USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (sf9, GST) is the recombinant human-derived USP6 protein, expressed by sf9 insect cells , with N-GST labeled tag.
The USP25 protein acts as a deubiquitinating enzyme and plays a key role in the hydrolysis of the ubiquitin moiety conjugated to the substrate. This function enables processing of newly synthesized ubiquitin, recycling of ubiquitin molecules, and editing of polyubiquitin chains, thus preventing proteasomal degradation of substrates. USP25 Protein, Human (His) is the recombinant human-derived USP25 protein, expressed by E. coli , with N-6*His labeled tag.
USP15 is a hydrolase that complexly regulates cellular processes by deubiquitinating various target proteins in pathways such as TGF-β receptor, NF-κ-B, and RNF41/NRDP1-PRKN. In TGF-β signaling, it promotes R-SMAD deubiquitination or stabilizes TGFBR1, thereby enhancing pathway activity. USP15 Protein, Human (sf9, GST) is the recombinant human-derived USP15 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
The USP16 protein is a specific deubiquitinase that targets "Lys-120" of histone H2A (H2AK119Ub), a tag associated with epigenetic transcriptional repression. By catalytically removing this ubiquitin moiety, USP16 acts as a coactivator, promoting subsequent phosphorylation of histone H3 (H3S10ph) 'Ser-11' to achieve mitotic chromosome segregation. USP16 Protein, Human (sf9, His) is the recombinant human-derived USP16 protein, expressed by sf9 insect cells , with N-8*His labeled tag.
USP30 protein is anchored on the outer mitochondrial membrane and severely inhibits mitophagy by antagonizing Parkin (PRKN). Hydrolyzing ubiquitin on RHOT1/MIRO1 and target proteins such as TOMM20 and USP30 blocks Parkin-mediated mitophagy, thereby regulating the clearance of damaged mitochondria. USP30 Protein, Human (sf9) is the recombinant human-derived USP30 protein, expressed by sf9 insect cells , with tag free.
USP30 protein is anchored on the outer mitochondrial membrane and severely inhibits mitophagy by antagonizing Parkin (PRKN). Hydrolyzing ubiquitin on RHOT1/MIRO1 and target proteins such as TOMM20 and USP30 blocks Parkin-mediated mitophagy, thereby regulating the clearance of damaged mitochondria. USP30 Protein, Human (sf9, His) is the recombinant human-derived USP30 protein, expressed by sf9 insect cells , with N-8*His labeled tag.
The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human is the recombinant human-derived USP9Y protein, expressed by E. coli , with tag free.
USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Catalytic Domain Protein, Human (His) is the recombinant human-derived USP2 Catalytic Domain protein, expressed by E. coli , with N-6*His labeled tag.
USP48 protein, a deubiquitinase, hydrolyzes ubiquitin bonds at the C-terminal Gly, processing poly-ubiquitin precursors and ubiquitinated proteins. It may regulate NF-kappa-B activation by the TNF receptor superfamily via RELA and TRAF2 interactions. With potential roles at postsynaptic sites, USP48 exhibits multifunctionality, influencing ubiquitin processing and signaling pathways involved in immune response and synaptic function. USP48 Protein, Human (sf9, FLAG) is the recombinant human-derived USP48 protein, expressed by sf9 insect cells , with C-Flag labeled tag.
The USP9Y protein is a multifunctional ubiquitin proteolytic enzyme that performs critical processing of ubiquitin precursors and ubiquitinated proteins. Its multifaceted roles make USP9Y a key regulator of protein turnover, preventing degradation by efficiently removing the ubiquitin moiety. USP9Y Protein, Human (GST) is the recombinant human-derived USP9Y protein, expressed by E. coli , with N-GST labeled tag.
The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human (GST) is the recombinant human-derived USP9X protein, expressed by E. coli , with N-GST labeled tag.
The USP9X protein serves as a deubiquitinase, playing a crucial role in processing ubiquitin precursors and preventing protein degradation. It exhibits specificity in hydrolyzing various polyubiquitin chain linkages, including "Lys-63", "Lys-48", "Lys-29" and "Lys-33". USP9X Protein, Human is the recombinant human-derived USP9X protein, expressed by E. coli , with tag free.
4-Aminohippuric acid-d4 (p-Aminohippuric acid-d4) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .
Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .
USP7 Antibody (YA657) is a non-conjugated and Mouse origined monoclonal antibody about 128 kDa, targeting to USP7 (3E4). It can be used for WB assays with tag free, in the background of Human.
USP28 Antibody (YA1336) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1336), targeting USP28, with a predicted molecular weight of 122 kDa (observed band size: 135 kDa). USP28 Antibody (YA1336) can be used for WB, ICC/IF, FC experiment in human background.
UCHL3 Antibody (YA2811) is a non-conjugated IgG antibody, targeting UCHL3, with a predicted molecular weight of 26 kDa (observed band size: 26 kDa). UCHL3 Antibody (YA2811) can be used for WB experiment in human, mouse, rat background.
USP14 Antibody (YA3328) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3328), targeting USP14, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). USP14 Antibody (YA3328) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.
DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-rela
WB, IHC-P
Human, Mouse, Rat
DRP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 82 kDa, targeting to DRP1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.
USP22 Antibody (YA1334) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1334), targeting USP22, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). USP22 Antibody (YA1334) can be used for WB, ICC/IF, IP, FC experiment in human background.
Calcitonin Antibody is an unconjugated, rabbit-derived, anti-Calcitonin monoclonal antibody. Calcitonin Antibody can be used for: IHC-P expriments in human background without labeling.
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne play crucial roles in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .
Polycarbophil is an orally active hydrophilic polymer. Polycarbophil achieves bioadhesion through hydrogen bonding between carboxyl groups and mucosal surfaces, and prolongs compound retention time and regulates compound release through swelling properties. Polycarbophil relieves constipation and diarrhea .
PLGA-COOH (MW 80000) (LA/GA 50:50) is a copolymer, which consist of lactic acid (LA)-glycolic acid (GA) with a molar ratio of 50:50, and a carboxyl terminal groups. PLGA-COOH (MW 80000) (LA/GA 50:50) is utilized in drug delivery system for its biocompatibility and biodegradability .
5,6-Dichlorobenzimidazole riboside (DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain kinases, including casein kinase II and cell cycle-dependent kinases (CDK). 5, 6-dichlorobenzimidazole riboside has antitumor activity. 5, 6-dichlorobenzimidazole riboside can induce apoptosis .
18:0 mPEG5000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
DPPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG550 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG550 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG750 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG350 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG1000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG3000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG350 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG1000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG5000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG1000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG3000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG1000 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DPPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG3000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:1 PEG350 PE is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
18:0 mPEG750 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG5000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
DMPE-PEG3000 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
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