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Results for "

antiapoptotic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (10) AMPK (4) Androgen Receptor (1) Antibiotic (1) Apoptosis (92) ASK1 (2) Autophagy (17) Bacterial (5) Bcl-2 Family (34) Bcr-Abl (1) Biochemical Assay Reagents (3) Btk (1) Cadherin (1) Calcium Channel (4) Caspase (23) CDK (4) COX (2) Cytochrome P450 (3) Deubiquitinase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) EGFR (3) Endogenous Metabolite (7) ERK (10) Fatty Acid Synthase (FASN) (3) FLT3 (1) Fungal (1) FXR (3) GCGR (1) Glycosidase (3) HBV (2) HDAC (3) Histone Methyltransferase (1) HIV (1) IAP (6) Imidazoline Receptor (2) Influenza Virus (1) Insulin Receptor (1) Interleukin Related (6) Isotope-Labeled Compounds (1) JAK (2) JNK (8) Keap1-Nrf2 (6) MDM-2/p53 (4) MEK (5) Mitochondrial Metabolism (4) Mitophagy (2) MMP (1) Molecular Glues (1) mTOR (2) Necroptosis (1) NF-κB (20) NOD-like Receptor (NLR) (3) P-glycoprotein (1) p38 MAPK (10) PACAP Receptor (1) PARP (4) PGE synthase (1) Phospholipase (1) PI3K (5) Pim (1) PKA (1) Platelet-activating Factor Receptor (PAFR) (2) PPAR (3) PROTACs (1) PTEN (3) Pyroptosis (3) Raf (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (17) Reference Standards (22) Ser/Thr Protease (1) Sirtuin (2) SOD (1) STAT (3) Survivin (4) Telomerase (2) TNF Receptor (8) Topoisomerase (2) Trk Receptor (1) Tyrosinase (4) Virus Protease (4) Wnt (1)
By Research Areas:	Cancer (88) Cardiovascular Disease (23) Endocrinology (2) Infection (15) Inflammation/Immunology (47) Metabolic Disease (6) Neurological Disease (38)
Oligonucleotides:	Antisense Oligonucleotides (2)

147

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9933

Tauro-β-muricholic acid 4 Publications Verification TβMCA	FXR Apoptosis	Metabolic Disease Cancer
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC₅₀ = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential .

HY-101083

BDA-366	Bcl-2 Family	Cancer
BDA-366 is a potent Bcl2 antagonist (K_i = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .

HY-107599

AEG3482	JNK Apoptosis	Neurological Disease
AEG3482 is a potent *antiapoptotic* compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .

HY-161705

Anti-apoptotic agent 1	Apoptosis	Neurological Disease
Anti-apoptotic agent 1 (Compound B4) exhibits neuroprotective activity and good pharmacokinetic properties. Anti-apoptotic agent 1 inhibits apoptosis, prevents stroke recurrence in photothrombotic rat model .

HY-122267A

cis-Clovamide	Apoptosis	Inflammation/Immunology
cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities .

HY-162137

Hepatoprotective agent-1	Apoptosis	Inflammation/Immunology
Hepatoprotective agent-1 (compound 1b) is a hepatoprotective agenrt. Hepatoprotective agent-1 shows anti-inflammatory, *antiapoptotic* and antifibrotic effects .

HY-W027126

Hepatoprotective agent-2	Apoptosis	Metabolic Disease
Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has *antiapoptotic* activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .

HY-N7697D

Chitoheptaose heptahydrochloride	Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-123244

YC137	Bcl-2 Family Apoptosis	Cancer
YC137 is a potent Bcl-2 antagonist with K_is of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research .

HY-142026

Vitisin A (+)-Vitisin A	NF-κB ERK	Inflammation/Immunology
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .

HY-163764

Bfl-1-IN-4	Bcl-2 Family Apoptosis	Cancer
Bfl-1-IN-4 (Compound 8) is an inhibitor for Bcl-2 associated protein A1 (Bfl-1) with an IC₅₀ of 16.8 μM .

HY-15191B

(S)-Sabutoclax (S)-BI-97C1	Bcl-2 Family	Cancer
(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC₅₀ values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC₅₀ values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer .

HY-N1778

3,4-Dimethoxycinnamic acid O-Methylferulic acid	Reactive Oxygen Species (ROS) Virus Protease	Infection Cancer
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N1778A

(E)-3,4-Dimethoxycinnamic acid (E)-O-Methylferulic acid	Reactive Oxygen Species (ROS) Virus Protease	Infection Cancer
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N1778AR

(E)-3,4-Dimethoxycinnamic acid (Standard) (E)-O-Methylferulic acid (Standard)	Reactive Oxygen Species (ROS) Virus Protease	Infection Cancer
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-177076

Dalvotoclax	Bcl-2 Family	Cancer
Dalvotoclax (Example 8) is a selective inhibitor of BCL-2. Dalvotoclax has good liver microsomal stability. Dalvotoclax inhibits the activity of anti-apoptotic BCL-2 protein and anti-apoptotic BCL-XL protein. Dalvotoclax can be studied in research for B cell leukemia .

HY-143230A

Custirsen sodium OGX-011 sodium	Apoptosis	Cancer
Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-143230

Custirsen OGX-011	Apoptosis	Cancer
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-160108

Bcl-2-IN-17	Bcl-2 Family	Others
Bcl-2-IN-17 is a Bcl2 inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

HY-126157

Linearol	Apoptosis	Inflammation/Immunology
Linearol, a diterpene extracted from Sideritis L. spp. (Lamiaceae), exhibits a diverse array of properties, including potent antioxidant, anti-inflammatory, and anti-apoptotic effects.

HY-N0783

Eupatilin 5+ Cited Publications	PPAR Autophagy	Neurological Disease Inflammation/Immunology Cancer
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-N12669

Curcumin monoglucoside	Bacterial Reactive Oxygen Species (ROS) Apoptosis JNK Caspase	Neurological Disease
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

HY-12305A

(R)-Q-VD-OPh (R)-QVD-OPH; (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone	Apoptosis	Cancer
(R)-Q-VD-OPh ((R)-QVD-OPH) is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible pan-caspase inhibitor with potent antiapoptotic properties.

HY-N3204

Neoechinulin A	Apoptosis	Neurological Disease
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-10397A

MX1013 1 Publications Verification CV1013; Z-VD-FMK	Caspase	Cancer
MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC₅₀ of 30 nM .

HY-103272

iMAC2	Apoptosis	Inflammation/Immunology Cancer
iMAC2 is a potent MAC inhibitor with an IC₅₀ of 28 nM and an LD₅₀ of 15000 nM. iMAC2 shows *anti-apoptotic* effect. iMAC2 blocks cytochrome c release .

HY-P2804

GAPDH, rabbit muscle 1 Publications Verification GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase	Endogenous Metabolite	Others
Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .

HY-W777084

(E)-3,4-Dimethoxycinnamic acid-13C3 (E)-O-Methylferulic acid-¹³C₃	Reactive Oxygen Species (ROS)	Cancer
(E)-3,4-Dimethoxycinnamic acid- ¹³C₃ ((E)-O-Methylferulic acid- ¹³C₃) is the ¹³C-labeled (E)-3,4-Dimethoxycinnamic acid (HY-N1778A). (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-110073

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC₅₀ of 28 nM and a LD₅₀ of 15000 nM. iMAC2 hydrochloride shows *anti-apoptotic* effect. iMAC2 hydrochloride blocks cytochrome c release .

HY-N6077

Thalidezine	AMPK Apoptosis	Cancer
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-160006

PIM-IN-2	Pim	Cancer
PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC₅₀ = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors .

HY-113091

Alpha-Tocotrienol	Apoptosis	Neurological Disease
Alpha-Tocotrienol is a vitamin E analog with anti-apoptotic neuroprotective action and antioxidant properties. Alpha-Tocotrienol prevents oxidative stress-independent apoptotic cell death, DNA cleavage, and nuclear morphological changes .

HY-161254

ATPase-IN-3	Apoptosis MDM-2/p53	Inflammation/Immunology Cancer
ATPase-IN-3 (compound 6) is a ATPase inhibitor. ATPase-IN-3 has Gastroprotective effect in ethanol-induced gastric ulcers by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins .

HY-N6076

Tenuifoliside A	ERK	Neurological Disease
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .

HY-134616

Ulinastatin 2 Publications Verification Uristatin	Ser/Thr Protease Apoptosis	Neurological Disease Inflammation/Immunology
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .

HY-N0783R

Eupatilin (Standard)	Reference Standards PPAR Autophagy	Neurological Disease Inflammation/Immunology Cancer
Eupatilin (Standard) is the analytical standard of Eupatilin. This product is intended for research and analytical applications. Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-W012670

2-Deoxy-L-ribose	Apoptosis	Cancer
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

HY-13264

Degrasyn 15+ Cited Publications WP1130	Deubiquitinase Bcr-Abl Autophagy Apoptosis	Cancer
Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

HY-10087

Navitoclax Maximum Cited Publications 121 Publications Verification ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-P3993

(Gly14)-Humanin (human) 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

HY-N0119

Naringin Dihydrochalcone 2 Publications Verification Naringin DC	NF-κB	Cancer
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-P3993A

(Gly14)-Humanin (human) acetate 14-Glycine-Humanin (human) acetate	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

HY-149017

Apoptosis inducer 7	Apoptosis	Cancer
Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .

HY-152193

ChoKα inhibitor-4	Apoptosis	Cancer
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC₅₀=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression .

HY-N2638

Ilexsaponin A	Apoptosis	Cardiovascular Disease
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through *anti-apoptotic* pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-170763B

(-)-Mcl-1 inhibitor 22	Bcl-2 Family Apoptosis	Cancer
(-)-Mcl-1 inhibitor 22 (compound 38) is an Mcl-1 inhibitor that works by blocking the interaction between Mcl-1 and pro-apoptotic proteins, reducing the anti-apoptotic activity of Mcl-1. (-)-Mcl-1 inhibitor 22 can be used in cancer research .

HY-N1485

Cycloastragenol 5 Publications Verification Astramembrangenin; Cyclosieversigenin	Telomerase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .

HY-N4005

Isoastilbin	Bacterial Tyrosinase	Infection Neurological Disease
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-10087S

Navitoclax-d8 1 Publications Verification	Bcl-2 Family	Cancer
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

Cat. No.	Product Name	Type

HY-Y0396

N-Hydroxyphthalimide

Biochemical Assay Reagents

N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer .

HY-112624K

Dextran T5 (MW 5,000)

Dextran 5; Dextran D5; Dextran T5(MW 4500-5500)

Thickeners

Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-W012670

2-Deoxy-L-ribose	Carbohydrates
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

HY-W145695

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

HY-Y0396R

N-Hydroxyphthalimide (Standard)

Biochemical Assay Reagents

N-Hydroxyphthalimide (Standard) is the analytical standard of N-Hydroxyphthalimide (HY-Y0396). This product is intended for research and analytical applications. N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer .

Cat. No.	Product Name	Target	Research Area

HY-P3993A

(Gly14)-Humanin (human) acetate 14-Glycine-Humanin (human) acetate	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-P1928

Humanin	Bcl-2 Family	Neurological Disease Endocrinology
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging . Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-P3993

(Gly14)-Humanin (human) 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

HY-P6084

RP-220	NOD-like Receptor (NLR) p38 MAPK Apoptosis	Inflammation/Immunology
RP-220 is a renalase peptide targeting NLRP3. RP220 has anti-inflammatory and anti-apoptotic activities. RP220 inhibits renal tubular epithelial cells apoptosis with alkaline insult by activating MAPK signaling pathway. RP220 significantly inhibits NLRP3 expression and reduces macrophage infiltration and kidney tissue damage in acute kidney injury (AKI) mice model. RP-220 can be uses for systemic lupus erythematosus (SLE) and its complication lupus nephritis (LN) research .

HY-P3483

Maxadilan	PACAP Receptor Caspase Apoptosis PKA Interleukin Related TNF Receptor	Cardiovascular Disease Neurological Disease
Maxadilan is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan exhibits anti-apoptotic activity in hADSCs. Maxadilan inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan promotes neural differentiation of human adipose-derived stem cells. Maxadilan can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases ^{[1] [2] [3] [4] [5]}.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9933

Tauro-β-muricholic acid 4 Publications Verification TβMCA	Structural Classification Human Gut Microbiota Metabolites Microorganisms Animals Source classification Endogenous metabolite Steroids	FXR Apoptosis
Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC₅₀ = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential .

HY-N1778

3,4-Dimethoxycinnamic acid O-Methylferulic acid	Infection Structural Classification Securidaca inappendiculata Hassk. Classification of Application Fields Simple Phenylpropanols Source classification Polygalaceae Phenylpropanoids Plants Disease Research Fields	Reactive Oxygen Species (ROS) Virus Protease
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N1778A

(E)-3,4-Dimethoxycinnamic acid (E)-O-Methylferulic acid	Infection Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	Reactive Oxygen Species (ROS) Virus Protease
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N0783

Eupatilin 5+ Cited Publications	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Plants Compositae Disease Research Fields Sindora sumatrana Miq. Cancer	PPAR Autophagy
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-N3204

Neoechinulin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Apoptosis
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-122267A

cis-Clovamide	Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis
cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities .

HY-N7697D

Chitoheptaose heptahydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Reactive Oxygen Species (ROS)
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .

HY-142026

Vitisin A (+)-Vitisin A	Structural Classification Microorganisms Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	NF-κB ERK
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .

HY-N1778AR

(E)-3,4-Dimethoxycinnamic acid (Standard) (E)-O-Methylferulic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Reactive Oxygen Species (ROS) Virus Protease
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-N12669

Curcumin monoglucoside	Apocynaceae Structural Classification Source classification Plants Saccharides Monosaccharides Catharanthus roseus (L.) G. Don	Bacterial Reactive Oxygen Species (ROS) Apoptosis JNK Caspase
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

HY-N6077

Thalidezine	Structural Classification Alkaloids Source classification Nelumbo nucifera Gaertn. Plants Nymphaeaceae Alkaloid Dimers	AMPK Apoptosis
Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .

HY-113091

Alpha-Tocotrienol	Structural Classification Monophenols Animals Source classification Phenols Endogenous metabolite	Apoptosis
Alpha-Tocotrienol is a vitamin E analog with anti-apoptotic neuroprotective action and antioxidant properties. Alpha-Tocotrienol prevents oxidative stress-independent apoptotic cell death, DNA cleavage, and nuclear morphological changes .

HY-N6076

Tenuifoliside A	Triterpenes Structural Classification Monophenols Terpenoids Source classification Polygalaceae Phenols Plants Polygala tenuifolia Willd.	ERK
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .

HY-N0783R

Eupatilin (Standard)	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Source classification Plants Compositae Disease Research Fields Sindora sumatrana Miq. Cancer	Reference Standards PPAR Autophagy
Eupatilin (Standard) is the analytical standard of Eupatilin. This product is intended for research and analytical applications. Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα* agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.*

HY-N0119

Naringin Dihydrochalcone 2 Publications Verification Naringin DC	Structural Classification Classification of Application Fields Source classification Plants Dihydrochalcones Sweeteners Food Research Flavonoids other families Phenols Polyphenols Disease Research Fields Cancer	NF-κB
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-N2638

Ilexsaponin A	Cardiovascular Disease Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Tabernaemontana elegans Stapf	Apoptosis
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through *anti-apoptotic* pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-N1485

Cycloastragenol 5 Publications Verification Astramembrangenin; Cyclosieversigenin	Triterpenes Structural Classification other families Terpenoids Source classification Plants	Telomerase
Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .

HY-N4005

Isoastilbin	Flavanonols Flavonoids other families Source classification Phenols Polyphenols Plants	Bacterial Tyrosinase
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-N13123

Tenacissoside C	Triterpenes Structural Classification Terpenoids Marsdenia tenacissima (Roxb.) Moon Source classification Asclepiadaceae Plants	Apoptosis
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

HY-N0153

Naringin 15+ Cited Publications Naringoside	Structural Classification Citrus × aurantium Linnaeus Flavonoids Classification of Application Fields Leguminosae Flavonones Rutaceae Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Cytochrome P450 Autophagy Mitophagy Endogenous Metabolite
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .

HY-N0153R

Naringin (Standard) Naringoside (Standard)	Structural Classification Citrus × aurantium Linnaeus Classification of Application Fields Source classification Rutaceae Plants Endogenous metabolite Flavonoids Leguminosae Flavonones Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Endogenous Metabolite Cytochrome P450 Mitophagy Autophagy Reference Standards
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .

HY-N0119R

Naringin Dihydrochalcone (Standard) Naringin DC (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Dihydrochalcones	Reference Standards NF-κB
Naringin Dihydrochalcone (Standard) is the analytical standard of Naringin Dihydrochalcone. This product is intended for research and analytical applications. Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

HY-N6967

Levomenol (-)-α-Bisabolol	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	Apoptosis
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N2638R

Ilexsaponin A (Standard)	Aquifoliaceae Triterpenes Structural Classification Terpenoids Source classification Plants Tabernaemontana elegans Stapf	Reference Standards Apoptosis
Ilexsaponin A (Standard) is the analytical standard of Ilexsaponin A. This product is intended for research and analytical applications. Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .

HY-N1485R

Cycloastragenol (Standard) Astramembrangenin (Standard); Cyclosieversigenin (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants	Reference Standards Telomerase
Cycloastragenol (Standard) is the analytical standard of Cycloastragenol. This product is intended for research and analytical applications. Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .

HY-N0321

Caftaric acid trans-Caftaric acid	Structural Classification Microorganisms other families Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields	Others
Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities .

HY-N0619

Mulberroside A 4 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-17473

Embelin 5 Publications Verification Embelic acid; Emberine; NSC 91874	Quinones Structural Classification Classification of Application Fields Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae Disease Research Fields Cancer	IAP NF-κB Apoptosis Autophagy
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-108635

C16-PAF Maximum Cited Publications 29 Publications Verification PAF (C16)	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	p38 MAPK MEK ERK Endogenous Metabolite
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-N6967R

Levomenol (Standard) (-)-α-Bisabolol (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	Reference Standards Apoptosis
Levomenol (Standard) is the analytical standard of Levomenol. This product is intended for research and analytical applications. Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N0106

(Rac)-Salvianic acid A sodium (Rac)-Danshensu sodium; (Rac)-Tanshinol sodium	Structural Classification Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Keap1-Nrf2 NF-κB Mitochondrial Metabolism Apoptosis
(Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases .

HY-N0784

Ginkgolide B 5+ Cited Publications BN-52021	Structural Classification Ginkgoaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Ginkgo biloba Disease Research Fields Cancer	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0619R

Mulberroside A (Standard)	Structural Classification Stilbenes Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	Reference Standards TNF Receptor Interleukin Related Tyrosinase
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0058

4,5-Dicaffeoylquinic acid 5+ Cited Publications Isochlorogenic acid C	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Disease Research Fields	HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N0784R

Ginkgolide B (Standard) BN-52021 (Standard)	Structural Classification Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Ginkgo biloba	Reference Standards Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (Standard) is the analytical standard of Ginkgolide B. This product is intended for research and analytical applications. Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-17473R

Embelin (Standard) Embelic acid (Standard); Emberine (Standard); NSC 91874 (Standard)	Quinones Structural Classification Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae	Reference Standards IAP NF-κB Apoptosis Autophagy
Embelin (Standard) is the analytical standard of Embelin. This product is intended for research and analytical applications. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N0106R

(Rac)-Salvianic acid A sodium (Standard) (Rac)-Danshensu sodium (Standard); (Rac)-Tanshinol sodium (Standard)	Structural Classification Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Phenylpropanoids Plants	Reference Standards Keap1-Nrf2 NF-κB Mitochondrial Metabolism Apoptosis
(Rac)-Salvianic acid A (sodium) (Standard) is the analytical standard of (Rac)-Salvianic acid A (sodium). This product is intended for research and analytical applications. (Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases .

HY-108635R

C16-PAF (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	p38 MAPK MEK ERK Endogenous Metabolite
C16-PAF (Standard) is the analytical standard of C16-PAF. This product is intended for research and analytical applications. C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

HY-N6576

Hellebrigenin	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	p38 MAPK ERK JNK IAP PARP Apoptosis Caspase
Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway (ERK, p38, JNK) and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins (Bcl-2, Bcl-xL) and upregulate pro-apoptotic proteins (Bax, Bak). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers .

HY-N1441

Afzelin 5+ Cited Publications Kaempferol-3-O-rhamnoside	Flavonols Structural Classification Flavonoids Saururaceae Houttuynia cordata Thunb. Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Mitochondrial Metabolism PTEN Autophagy Bacterial
Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Structural Classification Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

HY-N0408R

Picroside II (Standard)	Structural Classification Iridoids Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell	Reference Standards NF-κB Reactive Oxygen Species (ROS) Apoptosis Influenza Virus
Picroside II (Standard) is the analytical standard of Picroside II. This product is intended for research and analytical applications. Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways . Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities .

HY-107738

Guggulsterone 15+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-B1065

Aceglutamide α-N-Acetyl-L-glutamine; N2-Acetylglutamine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Keap1-Nrf2 Akt ASK1 Apoptosis
Aceglutamide (α-N-Acetyl-L-glutamine; N2-Acetylglutamine) is a neuroprotectant that can penetrate the blood-brain barrier. Aceglutamide can enhance the antioxidant systems of glutathione (GSH), thioredoxin (Trx) and Nrf2. Aceglutamide also inhibits ASK1 and TRAF1, activates the Akt/Bcl-2 anti-apoptotic pathway, enhances the activity of antioxidant enzymes and reduces oxidative damage. Aceglutamide can improve neurological deficits after cerebral ischemia, reduce infarct volume, and inhibit neuronal apoptosis, especially substantia nigra dopaminergic neurons. Aceglutamide can reduce cerebral ischemia/reperfusion injury, improve motor dysfunction, and is used in ischemic stroke-related research .

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard) Isochlorogenic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite	Reference Standards HBV Endogenous Metabolite Apoptosis Glycosidase
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N4205

Tetrahydropiperine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn. Cancer	Cytochrome P450
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs<、b>, and an activator of the PI3K/Akt/mTOR<、b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .

HY-107738R

Guggulsterone (Standard)	Triterpenes Structural Classification Terpenoids Plants Burseraceae Commiphora wightii	Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

HY-W040129

Chromomycin A3 1 Publications Verification	Microorganisms Source classification	DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase
Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-N1441R

Afzelin (Standard) Kaempferol-3-O-rhamnoside (Standard)	Flavonols Structural Classification Flavonoids Saururaceae Houttuynia cordata Thunb. Source classification Phenols Polyphenols Plants	Mitochondrial Metabolism PTEN Autophagy Bacterial Reference Standards
Afzelin (Standard) is the analytical standard of Afzelin. This product is intended for research and analytical applications. Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

Cat. No.	Compare	Product Name	Species	Source

HY-P71179

	OLFM4 Protein, Human (HEK293, His) Olfactomedin-4; OLM4; antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD; OLFM4; GW112	Human	HEK293
	OLFM4 protein may promote the proliferation of pancreatic cancer cells by affecting the transition from S phase to G2/M phase, highlighting its role in cancer cell cycle dynamics. In myeloid leukemia cell lines, OLFM4 exhibits dual effects of inhibiting growth and inducing differentiation and apoptosis. OLFM4 Protein, Human (HEK293, His) is the recombinant human-derived OLFM4 protein, expressed by HEK293 , with C-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-W777084

(E)-3,4-Dimethoxycinnamic acid-13C3
(E)-3,4-Dimethoxycinnamic acid- ¹³C₃ ((E)-O-Methylferulic acid- ¹³C₃) is the ¹³C-labeled (E)-3,4-Dimethoxycinnamic acid (HY-N1778A). (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-W707863

Lercanidipine-d3

Lercanidipine-d₃ is the deuterium labeled Lercanidipine (HY-B0612). Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC₅₀ of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research .

Cat. No.	Product Name		Classification

HY-143230A

Custirsen sodium OGX-011 sodium		Antisense Oligonucleotides
Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-143230

Custirsen OGX-011		Antisense Oligonucleotides
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

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antiapoptotic

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