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Results for "

P21

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (2) Amino Acid Derivatives (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (4) AP-1 (1) Apoptosis (49) Atg8/LC3 (1) Aurora Kinase (1) Autophagy (7) Bacterial (10) Bcl-2 Family (3) BRK (1) c-Myc (3) Caspase (7) CDK (10) Cholinesterase (ChE) (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) Deubiquitinase (6) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (2) DNA/RNA Synthesis (11) Drug Intermediate (1) E1/E2/E3 Enzyme (5) Endogenous Metabolite (14) Epigenetic Reader Domain (2) Farnesyl Transferase (1) Ferroptosis (1) Flavivirus (2) Fluorescent Dye (1) Fungal (5) HDAC (12) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (3) HIV (3) HSP (4) HSV (2) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) MDM-2/p53 (25) MicroRNA (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Mitophagy (1) MMP (2) MyD88 (1) NAMPT (1) NF-κB (12) NO Synthase (1) Notch (1) p38 MAPK (2) PAK (13) Parasite (2) PARP (1) PDGFR (1) PDK-1 (1) Phosphatase (1) PI3K (1) PINK1/Parkin (1) PKC (1) Polo-like Kinase (PLK) (1) Potassium Channel (3) PPAR (9) PROTACs (3) Proteasome (2) PTEN (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (9) Reference Standards (6) Ser/Thr Kinase (1) Sirtuin (2) Small Interfering RNA (siRNA) (6) STAT (1) Toll-like Receptor (TLR) (1) Topoisomerase (4) Tyrosinase (2) VD/VDR (2) VEGFR (1) Virus Protease (2) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (117) Cardiovascular Disease (5) Endocrinology (2) Infection (15) Inflammation/Immunology (23) Metabolic Disease (5) Neurological Disease (9)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	saRNAs (3) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNAs (6)

138

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112780

UC2288 5+ Cited Publications	MDM-2/p53 Apoptosis	Cancer
UC2288 is a potent and orally active *p21* attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 μM .

HY-15681

Senexin A 5+ Cited Publications	CDK	Cancer
Senexin A is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of *p21* transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

HY-103664A

Fmoc-1,6-diaminohexane hydrochloride	Amino Acid Derivatives	Cancer
Fmoc-1,6-diaminohexane hydrochloride is the hydrochloride form of Fmoc-1,6-diaminohexane (HY-103664). Fmoc-1,6-diaminohexane hydrochloride conjugates with monoclonal antibody, and exhibits anticancer activity against p21-deficient cancer .

HY-19635A

G-5555 hydrochloride 5+ Cited Publications	PAK	Cancer
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a K_i of 3.7 nM.

HY-115715

EN219 1 Publications Verification	E1/E2/E3 Enzyme	Cancer
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination .

HY-15542A

FRAX597 5+ Cited Publications	PAK	Cancer
FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC₅₀ of 8, 13 and 19 nM for PAK1, 2 and 3.

HY-177373

P21 saRNA	CDK	Cancer
P21 saRNA is a small activating RNA (saRNA) targeting the *p21* genes. P21 saRNA induce expression of the p21 genes, and targets the p21 promoters at ?322 relative to gene's transcription start site .

HY-P10825

p21PBP	DNA/RNA Synthesis	Cancer
p21PBP, a 20 amino-acid peptide, is an inhibitor of DNA replication. p21PBP specifically binds to purified proliferating cell nuclear antigen (PCNA) in tumour cell extracts. p21PBP is promising for research of cancers .

HY-15681A

Senexin A hydrochloride	CDK	Cancer
Senexin A hydrochloride is an inhibitor of CDK8/19 (IC₅₀: 280 nM, CDK8) and an inhibitor downstream of *p21* transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .

HY-122646

USP7-IN-2	Deubiquitinase MDM-2/p53	Cancer
USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC₅₀ of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of *p21* in multiple cell lines, and can be utilized in cancer research .

HY-15542B

FRAX486 5+ Cited Publications	PAK	Cancer
FRAX486 is a p21-activated kinase (PAK) inhibitor with IC₅₀s of 14, 33 and 39 nM for PAK1, PAK2 and PAK3, respectively.

HY-19635

G-5555 5+ Cited Publications	PAK	Cancer
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with K_is of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

HY-110315

Ischemin sodium	Apoptosis MDM-2/p53 Epigenetic Reader Domain	Cardiovascular Disease
Ischemin sodium is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits p53-induced *p21* activation with an IC₅₀ value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia) .

HY-N7526R

Naphthazarin (Standard)	Apoptosis	Neurological Disease Cancer
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-143412

MIR002	HDAC DNA/RNA Synthesis Apoptosis	Cancer
MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo .

HY-168443

HTR2A antagonist 1	5-HT Receptor Apoptosis	Cancer
HTR2A antagonist 1 (Compound 15f) is a HTR2A antagonist, with an IC₅₀ of 42.79 nM. HTR2A antagonist 1 induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells via the activation of p53/p21/caspase 3 signaling. HTR2A antagonist 1 has good liver microsomal stability. HTR2A antagonist 1 can be used for the research of colorectal cancer .

HY-123994

Tenovin-D3 hydrochloride	Sirtuin	Cancer
Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner .

HY-15027

5-Aminosalicylic Acid 20+ Cited Publications Mesalamine; 5-ASA; Mesalazine	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-147816

Anticancer agent 70	Mitochondrial Metabolism	Cancer
Anticancer agent 70 (Compound 21), an anticancer agent, exhibits remarkable cytotoxic activity against numerous human cancer cell lines. Anticancer agent 70 results in the G0/G1-cell cycle arrest with a concomitant increase in p53 and p21 protein levels. Anticancer agent 70 leads to ATP depletion and disruption of the mitochondrial membrane potential .

HY-131265

Mesalamine impurity P	PPAR PAK NF-κB	Inflammation/Immunology Cancer
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride Mesalamine-d₃ hydrochloride; 5-ASA-d₃ hydrochloride; Mesalazine-d₃ hydrochloride	Isotope-Labeled Compounds PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-W206016

3-Aminosalicylic acid	Drug Intermediate	Inflammation/Immunology Cancer
3-Aminosalicylic acid is the impurity found during the 5-Aminosalicylic acid (HY-15027) production. 5-Aminosalicylic acid is the agonist for PPARγ and the inhibitor for p21-activated kinase 1 (PAK1) and NF-κB . Crohn's disease, ulcerative proctitis

HY-117513

CEP1612	Proteasome Apoptosis	Cancer
CEP1612 is a dipeptidyl proteasome inhibitor with the IC₅₀ of 60 nM. CEP1612 induces p21(WAF1)and p27(KIP1) expression and cell apoptosis. CEP1612 shows anticancer activity in vivo .

HY-15027S2

5-Aminosalicylic acid-13C6 Mesalamine-¹³C₆; 5-ASA-¹³C₆; Mesalazine-¹³C₆	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology
5-Aminosalicylic acid- ¹³C₆ is the ¹³C labeled 5-Aminosalicylic Acid . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-15027S1

5-Aminosalicylic acid-d3 Mesalamine-d₃; 5-ASA-d₃; Mesalazine-d₃	Isotope-Labeled Compounds Endogenous Metabolite NF-κB PAK PPAR	Inflammation/Immunology Cancer
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-N6725

Sterigmatocystine	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

HY-116926

Deoxynybomycin	Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Apoptosis	Infection Cancer
Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1 .

HY-15027R

5-Aminosalicylic Acid (Standard) Mesalamine (Standard); 5-ASA (Standard); Mesalazine (Standard)	Reference Standards PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-18406

YM-1 tosylate	HSP	Cancer
YM-1 tosylate is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 tosylate induces cell death of HeLa cells and up-regulates the level of p53 and *p21* proteins .

HY-18399

YM-1 1 Publications Verification	HSP NO Synthase	Cancer
YM-1 is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and *p21* proteins .

HY-151884

FUBP1-IN-2	c-Myc	Cancer
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases *p21* mRNA and protein expression, and depletes intracellular polyamines .

HY-146887

USP7-IN-9	Deubiquitinase Apoptosis	Cancer
USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21 .

HY-126075A

WS-383	E1/E2/E3 Enzyme	Cancer
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .

HY-115715A

EN219-alkyne	Fluorescent Dye	Cancer
EN219-alkyne is an alkyne-functionalized EN219 probe. EN219 (HY-P0287A) is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC₅₀ of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination . EN219-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15027S3

5-Aminosalicylic acid-d3 disodium Mesalamine-d₃ disodium; 5-ASA-d₃ disodium; Mesalazine-d₃ disodium	PPAR NF-κB Endogenous Metabolite PAK Isotope-Labeled Compounds	Inflammation/Immunology
5-Aminosalicylic acid-d₃ disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-118672

HNHA	HDAC MMP HIF/HIF Prolyl-Hydroxylase	Cancer
HNHA is a potent HDAC inhibitor with an IC₅₀ of 100 nM. HNHA arrests the cell cycle at the G1/S phase via p21 induction. HNHA inhibits tumor growth and tumor neovascularization. HNHA may be a potent anti-cancer agent against breast cancer .

HY-W014612

Eugenol acetate Acetyleugenol	Fungal Bacterial Endogenous Metabolite	Infection Inflammation/Immunology Cancer
Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-113471A

(S)-(-)-Perillic acid	Apoptosis Bacterial	Infection Cancer
(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, *p21* and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research .

HY-131031

KCC-07	DNA Alkylator/Crosslinker	Cancer
KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity .

HY-157800

Trilexium TRX-E-009-1	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases *p21* protein expression and induces apoptosis. Trilexium depolymerizes microtubules. Trilexium shows broad anti-cancer activity .

HY-149428

AD4 1 Publications Verification	PROTACs	Cancer
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC₅₀: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .

HY-158210

Wnt/β-catenin-IN-3	Wnt β-catenin MDM-2/p53	Cancer
Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI₅₀s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of *p53-p21* pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells .

HY-125669

XR 3054	Farnesyl Transferase	Cancer
XR 3054 is an inhibitor for Farnesyl Transferase, that inhibits farnesylation of CAAX recognition peptide with IC₅₀ of 50 μM. XR 3054 suppresses the farnesylation of p21 ras and activation of MAP kinase. XR 3054 inhibits the proliferation of prostate cancer cell and colon cancer cell, with IC₅₀ of 8.8-21.4 μM .

HY-160084

2′-Deoxy-4′-thiocytidine	DNA Methyltransferase	Cancer
2′-Deoxy-4′-thiocytidine (T-dCyd) is a novel epigenetic agent. 2′-Deoxy-4′-thiocytidine administrations led to a significant *p21* increase. 2′-Deoxy-4′-thiocytidine can eradicate of tumor cells in the double-mutant xenografts .

HY-114310

VDR agonist 1	VD/VDR Apoptosis	Cancer
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC₅₀ of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 .

HY-126075

WS-383 free base	E1/E2/E3 Enzyme	Cancer
WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC₅₀ of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2 .

HY-110111A

T2AA hydrochloride	DNA/RNA Synthesis	Others
T2AA hydrochloride is a non-peptide small molecule PCNA inhibitor T2 amino alcohol (T2AA) that lacks thyroid hormone activity. T2AA hydrochloride inhibits the interaction of PCNA/PIP-box peptide (IC50=~1 μM) and the interaction of PCNA with full-length p21 protein .

HY-N6725R

Sterigmatocystine (Standard)	Reference Standards DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-P11114

Periplanetasin-4	Bacterial p38 MAPK Reactive Oxygen Species (ROS) Apoptosis Caspase	Inflammation/Immunology
Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and *p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans* ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis .

Cat. No.	Product Name	Target	Research Area

HY-106263B

Tyroserleutide hydrochloride	PTEN PDK-1 MDM-2/p53 Apoptosis Akt	Cancer
Tyroserleutide hydrochloride is a tripeptide isolated from the degradation products of porcine spleen with antitumor activity. Tyroserleutide hydrochloride can upregulate the expression of the tumor suppressor gene PTEN and inhibit the activity of AKT and PDK1. Tyroserleutide hydrochloride inhibits tumor cell proliferation and MDM2 phosphorylation by inhibiting the PI3K/AKT pathway, and also upregulates P21, P27, P53, and induces mitochondrial damage and cell apoptosis .

HY-P10825

p21PBP	DNA/RNA Synthesis	Cancer
p21PBP, a 20 amino-acid peptide, is an inhibitor of DNA replication. p21PBP specifically binds to purified proliferating cell nuclear antigen (PCNA) in tumour cell extracts. p21PBP is promising for research of cancers .

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

HY-P11114

Periplanetasin-4	Bacterial p38 MAPK Reactive Oxygen Species (ROS) Apoptosis Caspase	Inflammation/Immunology
Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and *p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans* ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis .

HY-P10914

D-CopA3	MDM-2/p53 Autophagy	Inflammation/Immunology Cancer
D-CopA3 is the inhibitor for MDM2 and the activator for p53 signaling pathway. D-CopA3 exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO (IC₅₀=15-18 μM), induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of cell cycle inhibitory protein p21Cip1/Waf1, enhances the mucosal barrier function and reduces penetration of inflammatory mediators. D-CopA3 exhibits anti-inflammtory activity in mouse C. difficile toxin A-induced acute enteritis models and DSS (HY-116282)-induced chronic colitis models. D-CopA3 exhibits antitumor efficacy in mouse HCT-116 xenograft models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15027

5-Aminosalicylic Acid Maximum Cited Publications 22 Publications Verification Mesalamine; 5-ASA; Mesalazine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-N6725

Sterigmatocystine	Infection Structural Classification Monophenols Microorganisms Xanthones Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-15027R

5-Aminosalicylic Acid (Standard) Mesalamine (Standard); 5-ASA (Standard); Mesalazine (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Reference Standards PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-W014612

Eugenol acetate Acetyleugenol	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Myrtaceae Phenylpropanoids Plants Syzygium aromaticum Disease Research Fields	Fungal Bacterial Endogenous Metabolite
Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-W014612R

Eugenol acetate (Standard) Acetyleugenol (Standard)	Structural Classification Simple Phenylpropanols Source classification Myrtaceae Phenylpropanoids Plants Syzygium aromaticum	Fungal Bacterial Endogenous Metabolite Reference Standards
Eugenol acetate (Standard) is the analytical standard of Eugenol acetate. This product is intended for research and analytical applications. Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-N4225

Aaptamine 2 Publications Verification	Alkaloids Structural Classification Animals Classification of Application Fields Marine natural products Source classification Quinoline Alkaloids Sponge Disease Research Fields Endocrinology	Adrenergic Receptor Proteasome Cholinesterase (ChE) Bacterial Apoptosis AP-1 NF-κB
Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of *p21* through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects .

HY-W050154

Kojic acid 1 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Parasite Tyrosinase NF-κB CDK
Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC₅₀ of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and *p21* signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

HY-N7526R

Naphthazarin (Standard)	Quinones Structural Classification other families Source classification Phenols Polyphenols Plants Naphthalene Quinones	Apoptosis
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-N6725R

Sterigmatocystine (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Reference Standards DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N13944

Argyrin F	Structural Classification Natural Products Microorganisms Source classification	Apoptosis
Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT). Argyrin F stabilizes p27 ^kip, up-regulated p21 ^waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC) .

HY-N0068

Solasodine 4 Publications Verification Purapuridine; Solancarpidine; Solasodin	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Infection Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Solanaceae Inflammation/Immunology Disease Research Fields	MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis
Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities .

HY-N11692

9-Hydroxyoctadecanoic acid 1 Publications Verification 9-Hydroxystearic acid; 9-HSA	Apocynaceae Structural Classification Strophanthus sarmentosus DC. Ketones, Aldehydes, Acids Source classification Plants	HDAC
9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ∼66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity .

HY-107421

Prostratin 1 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Disease Research Fields Wikstroemia chamaedaphne Meisn.	PKC HIV
Prostratin, a natural terpenoid compound, is a PKC activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-125570

Ginsenoside Rs3	Structural Classification Polysaccharides Source classification Plants Talinaceae Saccharides Talinum paniculatum (Jacq.) Gaertn.	Apoptosis
Ginsenoside Rs3 is a natural diol-type ginseng saponin with anticancer effects. Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells .

HY-N2424

Flavone 2-Phenyl-4-chromone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	CDK Apoptosis Caspase
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as *p21_waf1, PIG3). Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21_waf1,* and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer .

HY-W097625

6-Methoxyflavone	Structural Classification Flavonoids Flavones Thymelaeaceae Source classification Plants Pimelea simplex F.Muell.	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO)
6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the *CCNA2/CDK2/p21CIP*1 signaling pathway in HeLa cells. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases .

HY-122506

Salviolone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	STAT
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .

HY-N0411R

β-Carotene (Standard) Provitamin A (Standard); beta-Carotene (Standard)	Other Terpenoids Structural Classification Immune System Disorder other families Terpenoids Source classification Disease markers Endocrine diseases Plants Endogenous metabolite Cancer	Reference Standards Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
β-Carotene (Standard) is the analytical standard of β-Carotene. This product is intended for research and analytical applications. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

HY-N0411

β-Carotene 2 Publications Verification Provitamin A; beta-Carotene	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Plants Endogenous metabolite Food Research Other Terpenoids Immune System Disorder other families Terpenoids Disease markers Pigments Disease Research Fields Cancer	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

HY-N14903

Oximidine Ⅲ	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Oximidine III is an anti-tumor antibiotic. Oximidine III can selectively inhibit the growth of 3Y1 in rat fibroblasts with degeneration of various tumor genes. Oximidine III inhibits v-H-ras-3Y1, v-src-3Y1 cells and the normal 3Y1 cells with IC₅₀s (nM) of 14, 4.5 and 140, respectively. Oximidine III stops RAS-or SRC-denatured cells at G1 phase of the cell cycle and increases p21WAF1 expression .

HY-N0692

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N0692R

Schisandrol B (Standard) Gomisin-A (Standard); TJN-101 (Standard); Wuweizi alcohol-B (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy
Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N1992R

Theaflavin 3,3'-digallate (Standard) TF-3 (Standard); ZP10 (Standard)	Structural Classification Flavonoids Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Reference Standards Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N1992

Theaflavin 3,3'-digallate 5 Publications Verification TF-3; ZP10	Infection Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

Species:	Human (14) Mouse (1)
Tag:	His (7) SUMO (2) Tag Free (4) GST (5)
Source:	Sf9 insect cells (5) E. coli (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P704204

	CDKN1A Protein, Mouse (His) CDK-interacting protein 1; Melanoma differentiation-associated protein; P21	Mouse	E. coli
	CDKN1A Protein, Mouse (His) is the recombinant mouse-derived CDKN1A protein, expressed by E. coli, with C-6*His tag.

HY-P702747

	PAK4 Protein, Human (His) PAK4; P21 protein (Cdc42/Rac)-activated kinase 4; P21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; P21-activated kinase 4; P21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs	Human	E. coli
	PAK4 is an important serine/threonine kinase that affects cytoskeletal regulation, cell migration, growth, and survival through multiple pathways. Activation triggered by various effectors induces autophosphorylation, targeting proteins such as SSH1 and LIMK1 to regulate cofilin activity and stabilize actin filaments. PAK4 Protein, Human (His) is the recombinant human-derived PAK4, expressed by E. coli , with N-His labeled tag. ,

HY-P77099

	NCKIPSD Protein, Human (His) NCK-interacting protein with SH3 domain; VIP54; WISH; AF3P21; SPIN90	Human	E. coli
	NCKIPSD Protein, vital for stress fiber formation induced by active DRF1, stimulates N-WASP-induced ARP2/3 complex activation, independent of CDC42. Implicated in sarcomere maintenance, myofibril assembly, actin polymerization, and angiogenesis. Associates with vimentin, desmin, NCK, GRB2, and interacts with Helicobacter pylori toxin vacA, FHOD1, FASLG, and TMIGD2, showcasing its diverse cellular interactions. NCKIPSD Protein, Human (His) is the recombinant human-derived NCKIPSD protein, expressed by E. coli , with N-His labeled tag.

HY-P700570

	CDKN1A Protein, Human (GST) CDK-interacting protein 1Melanoma differentiation-associated protein 6 ; MDA-6P21	Human	E. coli
	The CDKN1A protein critically controls cell cycle progression and mediates DNA damage-induced G2 arrest through p53/TP53-dependent and CREB3L1-mediated p53-independent pathways. It inhibits cyclin-dependent kinase activity, blocking cell cycle progression by preventing phosphorylation of key substrates. CDKN1A Protein, Human (GST) is the recombinant human-derived CDKN1A protein, expressed by E. coli , with N-GST labeled tag.

HY-P702748

	PAK5 Protein, Human PAK5; P21 (RAC1) activated kinase 5; PAK7	Human	E. coli
	PAK5 Protein, Human is the recombinant human-derived PAK5, expressed by E. coli , with tag Free labeled tag. ,

HY-P702745

	PAK2 Protein, Human (sf9, GST) PAK2; P21 (RAC1) activated kinase 2; KNO2; PAK65; PAKgamma	Human	Sf9 insect cells
	PAK2 Protein, Human (sf9, GST) is the recombinant human-derived PAK2, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702746

	PAK3 Protein, Human (sf9) PAK3; P21 protein (Cdc42/Rac)-activated kinase 3; bPAK; MRX30; MRX47; OPHN3; hPAK3; CDKN1A; PAK3beta; P21-activated kinase 3; beta-PAK; oligophrenin-3; OTTHUMP00000023856; P21 (CDKN1A)-activated kinase 3; serine/threonine-protein kinase PAK 3; EC 2.7.11.1	Human	Sf9 insect cells
	PAK3 is a serine/threonine kinase that plays a key role in multiple signaling pathways, affecting cytoskeletal dynamics, cell migration, and cell cycle. Its involvement in dendritic spine morphogenesis and synapse formation emphasizes its importance in neuronal processes. PAK3 Protein, Human (sf9) is the recombinant human-derived PAK3, expressed by Sf9 insect cells, with tag Free labeled tag.

HY-P76746

	BCCIP Protein, Human (sf9) BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; TOK1	Human	Sf9 insect cells
	BCCIP proteins contribute to interphase microtubule organization and anchoring as well as spindle pole organization and stability during mitosis. BCCIP protein may induce cell cycle arrest by enhancing CDK2 inhibition and participate in DNA damage repair through homologous recombination with BRCA2. BCCIP Protein, Human (sf9) is the recombinant human-derived BCCIP protein, expressed by Sf9 insect cells, with tag free.

HY-P76747

	BCCIP Protein, Human (sf9, His-GST) BRCA2 and CDKN1A-interacting protein; P21- and CDK-associated protein 1; TOK1	Human	Sf9 insect cells
	BCCIP proteins contribute to interphase microtubule organization and anchoring as well as spindle pole organization and stability during mitosis. BCCIP protein may induce cell cycle arrest by enhancing CDK2 inhibition and participate in DNA damage repair through homologous recombination with BRCA2. BCCIP Protein, Human (sf9, His-GST) is the recombinant human-derived BCCIP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P700575

	PAK4 Protein, Human (His-SUMO) P21-activated kinase 4 ; PAK-4	Human	E. coli
	PAK4 is an important serine/threonine kinase that affects cytoskeletal regulation, cell migration, growth, and survival through multiple pathways. Activation triggered by various effectors induces autophosphorylation, targeting proteins such as SSH1 and LIMK1 to regulate cofilin activity and stabilize actin filaments. PAK4 Protein, Human (His-SUMO) is the recombinant human-derived PAK4 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P74607

	RAC2 Protein, Human (His) Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; P21-Rac2	Human	E. coli
	The RAC2 protein is a plasma membrane-associated small GTPase that dynamically regulates cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active state, RAC2 regulates secretory function, phagocytosis, and epithelial cell polarization. RAC2 Protein, Human (His) is the recombinant human-derived RAC2 protein, expressed by E. coli , with N-His labeled tag.

HY-P701732

	PAK6 Protein, Human PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; P21-activated kinase 6; PAK-6	Human	E. coli
	PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human is the recombinant human-derived PAK6 protein, expressed by E. coli , with tag free.

HY-P701733

	PAK6 Protein, Human (His) PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; P21-activated kinase 6; PAK-6	Human	E. coli
	PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human (His) is the recombinant human-derived PAK6 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74608

	RAC1 Protein, Human (sf9, GST) Ras-related C3 botulinum toxin substrate 1; P21-Rac1; RAC1; TC25; MIG5	Human	Sf9 insect cells
	The RAC1 protein is a plasma membrane-associated small GTPase that dynamically regulates multiple cellular responses by cycling between an active GTP-bound state and an inactive GDP-bound state. In its active form, RAC1 regulates processes such as secretory function, phagocytosis, cell polarization, neuronal activity, and growth factor-induced membrane ruffle formation. RAC1 Protein, Human (sf9, GST) is the recombinant human-derived RAC1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P71530

	PAK1 Protein, Human (His-SUMO) Serine/threonine-protein kinase PAK 1; Alpha-PAK; P21-activated kinase 1 ; p65-PAK; PAK1	Human	E. coli
	PAK1 is a dynamic protein kinase that plays an important role in multiple intracellular signaling pathways, affecting cytoskeletal dynamics, adhesion, migration, proliferation, apoptosis, mitosis, and vesicle trafficking. Multifunctional PAK1 directly phosphorylates BAD to provide antiapoptotic cell protection. PAK1 Protein, Human (His-SUMO) is the recombinant human-derived PAK1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-15027S

5-Aminosalicylic Acid-d3 hydrochloride
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-15027S1

5-Aminosalicylic acid-d3
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-143704S

5-Aminosalicylic acid-13C6 hydrochloride
5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-15027S2

5-Aminosalicylic acid-13C6
5-Aminosalicylic acid- ¹³C₆ is the ¹³C labeled 5-Aminosalicylic Acid . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .

HY-15027S3

5-Aminosalicylic acid-d3 disodium
5-Aminosalicylic acid-d₃ disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

HY-15027S4

5-Aminosalicylic acid-d7
5-Aminosalicylic acid-d₇ (5-ASA-d₇; Mesalamie-d₇; Mesalazie-d₇) is deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN) .

HY-W014612S

Eugenol acetate-d3
Eugenol acetate-d₃ is the deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis .

HY-W050154S

Kojic acid-13C6

Kojic acid- ¹³C₆ is ¹³C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86368

	p21 Antibody (YA6060) Cyclin-dependent kinase inhibitor 1 ; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21;	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	p21 Antibody (YA6060) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p21.

HY-P80774

	p21 Antibody 2 Publications Verification CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21	WB, ICC/IF	Human, Mouse, Rat
	p21 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to p21.

HY-P80773

	p21 Antibody (YA254) 1 Publications Verification CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21	WB	Human, Mouse
	p21 Antibody (YA254) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p21.

HY-P80774A

	p21 Antibody (YA3460) CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21	WB, ICC/IF	Human, Mouse, Rat
	p21 Antibody (YA3460) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p21.

HY-P84291

	p21 Antibody (YA3988) P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; P21CIP1	IHC-P, FC, ELISA	Human
	p21 Antibody (YA3988) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p21.

HY-P84292

	p21 Antibody (YA3989) P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; P21CIP1	ICC/IF, FC, ELISA	Human
	p21 Antibody (YA3989) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p21.

HY-P85782

	P21 Antibody (YA5474) Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	P21 Antibody (YA5474) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to P21.

HY-P86562

	P21 Antibody (YA6254) Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; P21;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Rat
	P21 Antibody (YA6254) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P21.

HY-P87164

	p21 Antibody (YA6857) CAP20 antibody; CDK-interacting protein 1 antibody; CDKI antibody; CDKN1 antibody; Cdkn1a antibody; CDN1A_HUMAN antibody; CIP1 antibody; Cyclin Dependent Kinase Inhibitor 1A antibody; Cyclin-dependent kinase inhibitor 1 antibody; Cyclin-dependent kinase inhibitor 1A (P21) antibody; CAP20 antibody; CDK-interacting protein 1 antibody; CDKI antibody; CDKN1 antibody; Cdkn1a antibody; CDN1A_HUMAN antibody; CIP1 antibody; Cyclin Dependent Kinase Inhibitor 1A antibody; Cyclin-dependent kinase inhibitor 1 antibody; Cyclin-dependent kinase inhibitor 1A (P21) antibody; Cyclin-dependent kinase inhibitor 1A (P21, Cip1) antibody; DNA Synthesis Inhibitor antibody; MDA-6 antibody; MDA6 antibody; Melanoma differentiation-associated protein 6 antibody; Melanoma differentiation-associated protein antibody; P21 antibody; P21 protein antibody; P21CIP1 antibody; P21Cip1/Waf1 antibody; P21WAF antibody; PIC1 antibody; SDI1 antibody; SLC12A9 antibody; WAF1 antibody; Wild type p53 activated fragment 1 (WAF1) antibody; Wild type p53 activated fragment 1 antibody; Wildtype p53-activated fragment 1 antibody;	WB, ICC/IF, IHC-P, FC	Mouse
	p21 Antibody (YA6857) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p21.

HY-P87028

	Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Antibody (YA6721) KIAA1142 antibody; P21 activated kinase 4 antibody; P21 Cdc42/Rac1-actiated kinase 4 antibody; P21 protein (Cdc42/Rac) activated kinase 4 antibody; P21(CDKN1A) activated kinase 4 antibody; P21-activated kinase 4 antibody; PAK 4 antibody; PAK-4 antibody; Pak4 antibody; PAK4_HUMAN antibody; KIAA1142 antibody; P21 activated kinase 4 antibody; P21 Cdc42/Rac1-actiated kinase 4 antibody; P21 protein (Cdc42/Rac) activated kinase 4 antibody; P21(CDKN1A) activated kinase 4 antibody; P21-activated kinase 4 antibody; PAK 4 antibody; PAK-4 antibody; Pak4 antibody; PAK4_HUMAN antibody; Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody; Serine threonine kinase PAK 4 antibody; Serine/threonine protein kinase PAK 4 antibody; Serine/threonine protein kinase PAK4 antibody; Serine/threonine-protein kinase PAK 4 antibody; EC 2.7.11.1 antibody; KIAA1264 antibody; MGC26232 antibody; P21 activated kinase 7 antibody; P21 protein (Cdc42/Rac)-activated kinase 7 antibody; P21(CDKN1A) activated kinase 7 antibody; P21-activated kinase 5 antibody; P21-activated kinase 7 antibody; PAK 5 antibody; PAK 7 antibody; PAK-5 antibody; PAK-7 antibody; PAK5 antibody; PAK7 antibody; PAK7_HUMAN antibody; Protein kinase PAK5 antibody; Serine/threonine protein kinase PAK 7 antibody; Serine/threonine-protein kinase PAK 7 antibody; CDKN1A activated kinase 6 antibody; EC 2.7.1.37 antibody; P21 activated protein kinase 6 antibody; P21 protein (Cdc42/Rac)-activated kinase 6 antibody; P21(CDKN1A) activated kinase 6 antibody; P21-activated kinase 6 antibody; P21activated kinase 6 antibody; PAK 6 antibody; PAK-6 antibody; Pak6 antibody; PAK6_HUMAN antibody; Serine threonine protein kinase PAK 6 antibody; Serine/threonine protein kinase PAK 6 antibody; Serine/threonine protein kinase PAK6 antibody; Serine/threonine-protein kinase PAK 6 antibody;	WB	Human
	Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Antibody (YA6721) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602).

HY-P87058

	Rac1-2-3 Antibody (YA6751) Cell migration inducing gene 5 protein antibody; EN 7 antibody; OTTMUSP00000004488 antibody; P21 Rac3 antibody; P21-Rac3 antibody; Rac1B antibody; RAC3 antibody; RAC3_HUMAN antibody; RAS related C3 botulinum substrate 3 antibody; Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3) antibody; Cell migration inducing gene 5 protein antibody; EN 7 antibody; OTTMUSP00000004488 antibody; P21 Rac3 antibody; P21-Rac3 antibody; Rac1B antibody	WB, ICC/IF, IF-Tissue, IHC-P	Human, Mouse, Rat
	Rac1-2-3 Antibody (YA6751) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rac1-2-3.

HY-P86345

	HRAS Antibody (YA6037) HRAS,HRAS1,GTPase,H-Ras-1,Ha-Ras,Transforming protein P21, ,c-H-ras, P21ras, Cleaved into: GTPase HRas N-terminally processed,Cleaved into: GTPase Hras,GTPase Hras,HRAS 1,	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HRAS Antibody (YA6037) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HRAS.

HY-P87170

	KRAS Antibody (YA6861) c Ki ras2 antibody; c Kirsten ras protein antibody; c-K-ras antibody; c-Ki-ras antibody; Cellular c Ki ras2 proto oncogene antibody; Cellular transforming proto oncogene antibody; CFC2 antibody; cK Ras antibody; GTPase KRas antibody; K RAS P21 protein antibody; c Ki ras2 antibody; c Kirsten ras protein antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	KRAS Antibody (YA6861) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KRAS.

HY-P86935

	KRAS Antibody (YA6628) c Ki ras2 antibody; c Kirsten ras protein antibody; c-K-ras antibody; c-Ki-ras antibody; Cellular c Ki ras2 proto oncogene antibody; Cellular transforming proto oncogene antibody; CFC2 antibody; cK Ras antibody; GTPase KRas antibody; K RAS P21 protein antibody; c Ki ras2 antibody; c Kirsten ras protein antibody; c-K-ras antibody; c-Ki-ras antibody; Cellular c Ki ras2 proto oncogene antibody; Cellular transforming proto oncogene antibody; CFC2 antibody; cK Ras antibody; GTPase KRas antibody; K RAS P21 protein antibody; K RAS2A antibody; K RAS2B antibody; K RAS4A antibody; K RAS4B antibody; K-Ras 2 antibody; KI RAS antibody; Ki-Ras antibody; KIRSTEN MURINE SARCOMA VIRUS 2 antibody; Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog antibody; Kirsten rat sarcoma viral oncogene homolog antibody; KRAS antibody; KRAS proto oncogene, GTPase antibody; KRAS1 antibody; KRAS2 antibody; N-terminally processed antibody; NS antibody; NS3 antibody; Oncogene KRAS2 antibody; P21ras antibody; PR310 c K ras oncogene antibody; PR310 cK ras oncogene antibody; RALD antibody; RASK_HUMAN antibody; RASK2 antibody; Transforming protein P21 antibody; v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog antibody; v Ki ras2 Kirsten rat sarcoma viral oncogene homolog antibody;	WB, IHC-P	Human, Mouse, Rat
	KRAS Antibody (YA6628) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KRAS.

HY-P83545

	RAC1/2/3 Antibody (YA3290) Cell migration-inducing gene 5 protein; EN-7; GX; P21-Rac1; P21-Rac2; P21-Rac3; RAC1; RAC2; RAC3; TC25	WB	Human, Mouse, Rat
	RAC1/2/3 Antibody (YA3290) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAC1/2/3.

HY-P81618

	PAK1 Antibody (YA1363) 1 Publications Verification PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; P21-activated kinase 1; PAK-1; p65-PAK	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PAK1 Antibody (YA1363) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAK1.

HY-P86446

	PAK1 Antibody (YA6138) PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; P21-activated kinase 1; PAK-1; p65-PAK	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PAK1 Antibody (YA6138) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAK1.

HY-P81622

	PAK3 Antibody (YA1367) PAK3; OPHN3; Serine/threonine-protein kinase PAK 3; Beta-PAK; Oligophrenin-3; P21-activated kinase 3; PAK-3	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	PAK3 Antibody (YA1367) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAK3.

HY-P80778

	PAK2 Antibody (YA695) PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; P21-activated kinase 2; PAK-2; p58	WB, IHC-F, IHC-P, ICC/IF	Human, Monkey
	PAK2 Antibody (YA695) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PAK2.

HY-P85312

	PAK2 Antibody (YA5004) PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; P21-activated kinase 2; PAK-2; p58	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
	PAK2 Antibody (YA5004) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PAK2.

HY-P87048

	RAP1A + RAP1B Antibody (YA6741) C21KG antibody; G 22K antibody; G-22K antibody; GTP binding protein smg P21A antibody; GTP-binding protein smg P21A antibody; KREV 1 antibody; KREV1 antibody; OTTHUMP00000013741 antibody; RAP 1A antibody; RAP1 antibody; C21KG antibody; G 22K antibody; G-22K antibody; GTP binding protein smg P21A antibody; GTP-binding protein smg P21A antibody; KREV 1 antibody; KREV1 antibody; OTTHUMP00000013741 antibody; RAP 1A antibody; RAP1 antibody; RAP1A antibody; RAP1A member of RAS oncogene family antibody; RAP1A_HUMAN antibody; Ras related protein Krev 1 antibody; Ras related protein Rap 1A antibody; RAS related protein RAP1A antibody; Ras-related protein Krev-1 antibody; Ras-related protein Rap-1A antibody; SMGP21 antibody; GTP-binding protein smg P21B antibody; K-REV antibody; OK/SW-cl.11 antibody; RAL1B antibody; rap1b antibody; RAP1B member of RAS oncogene family antibody; RAP1B_HUMAN antibody; Ras family small GTP binding protein RAP1B antibody; RAS related protein RAP1B antibody; Ras-related protein Rap-1b antibody; Small GTP binding protein antibody;	WB, FC	Human, Mouse
	RAP1A + RAP1B Antibody (YA6741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAP1A + RAP1B.

HY-P81785

	Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530) PAK3; OPHN3; Serine/threonine-protein kinase PAK 3; Beta-PAK; Oligophrenin-3; P21-activated kinase 3; PAK-3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-PAK1/2/3 (Ser144/Ser141/Ser154) Antibody (YA1530) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PAK1/2/3 (Ser144/Ser141/Ser154).

HY-P87378

	RBM15B Antibody (YA7061) 1810017N16Rik antibody; Chromosome 3P21.1 gene sequence antibody; HUMAGCGB antibody; huOTT3 antibody; One twenty two protein 3 antibody; One-twenty two protein 3 antibody; OTT3 antibody; Putative RNA binding protein 15B antibody; Putative RNA-binding protein 15B antibody; RB15B_HUMAN antibody	WB	Human, Mouse, Rat
	RBM15B Antibody (YA7061) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RBM15B.