2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling
  3. HSP Apoptosis Bcr-Abl p38 MAPK CDK STAT
  4. KW-2478 hydrochloride

KW-2478 (hydrochloride) is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 downregulates STAT3 expression. KW-2478 may be used in research on cancers such as CML and liver cancer.

For research use only. We do not sell to patients.

KW-2478 hydrochloride

KW-2478 hydrochloride Chemical Structure

CAS No. : 819812-18-5

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KW-2478 hydrochloride Related Antibodies

Top Publications Citing Use of Products

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Abl Bcr-Abl

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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STAT3 STAT5 STAT6 STAT1

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Description

KW-2478 (hydrochloride) is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 downregulates STAT3 expression. KW-2478 may be used in research on cancers such as CML and liver cancer[1][2].

Molecular Weight

611.12

Formula

C30H43ClN2O9
CAS No.
SMILES

O=C(N(CCOC)CCOC)CC1=C(C(C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=O)C(O)=CC(O)=C1CC.Cl
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KW-2478 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KW-2478819812-18-5KW2478KW 2478HSPApoptosisBcr-Ablp38 MAPKCDKSTATHeat shock proteinsCyclin dependent kinaseInhibitorinhibitorinhibit

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