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Results for "

MCP-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (4) AMPK (1) Antibiotic (2) Apoptosis (5) Arginase (1) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (1) CCR (5) COX (2) DNA/RNA Synthesis (2) Drug Intermediate (2) EBI2/GPR183 (1) Endogenous Metabolite (1) Epigenetic Reader Domain (3) FABP (1) Fungal (2) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) IFNAR (1) Integrin (1) Interleukin Related (10) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) MDM-2/p53 (1) MMP (1) mRNA (1) NF-κB (13) NO Synthase (8) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (3) Phospholipase (1) PI3K (3) PPAR (2) Protease Activated Receptor (PAR) (3) Pyruvate Kinase (2) Reference Standards (5) SARS-CoV (1) Sirtuin (1) Small Interfering RNA (siRNA) (3) Src (1) STAT (3) Survivin (1) TGF-beta/Smad (2) TNF Receptor (6) Toll-like Receptor (TLR) (1) Topoisomerase (2) Transmembrane Glycoprotein (1) Virus Protease (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (6) Endocrinology (1) Infection (8) Inflammation/Immunology (44) Metabolic Disease (9) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162011

GPR183 antagonist-2	EBI2/GPR183	Inflammation/Immunology
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases ^[1].

HY-125864

Fibrinogen (Bovine) 1 Publications Verification	Interleukin Related NF-κB	Inflammation/Immunology
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* and *MCP-1*. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases ^[1] .

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1* Antibody (2H5)** 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[1] .

HY-162622

BET-IN-26	Epigenetic Reader Domain	Inflammation/Immunology
BET-IN-26 (compound 13a) is a potent, selective and orally active *BD1* inhibitor with IC₅₀ values of 0.0055, 9.0 µM for BD1, BD2, respectively. BET-IN-26 decreases LPS (HY-D1056) induced serum levels of IL-6 and MCP-1 ^[1].

HY-P991426

MB-314	Transmembrane Glycoprotein IFNAR TNF Receptor	Cancer
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research ^[1].

HY-10109A

AS-605240 potassium	PI3K Akt	Inflammation/Immunology
AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC₅₀: 8 nM; K_i: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC₅₀ values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC₅₀ values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice ^[1].

HY-120544

BAY-386	Protease Activated Receptor (PAR)	Inflammation/Immunology
BAY-386, a chemical probe, is a *PAR-1* antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC ^[1].

HY-NP018

Bovine fibrinogen (from plasma) FGA; FGA protein	NF-κB	Inflammation/Immunology
Bovine fibrinogen (from fibrinogen) is a native fibrinogen from bovine plasma. Bovine fibrinogen (from fibrinogen) can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* ^[1].

HY-118312

CAY10657	NF-κB	Inflammation/Immunology
CAY10657 is an inhibitor for NF-κB pathway. CAY10657 downregulates expressions of proinflammatory cytokine (IL-6) and chemokine (MCP-1), and thus exhibits anti-inflammatory efficacy against meningitis induced by Streptococcus suis ^[1].

HY-149429

PPARδ agonist 9	PPAR	Metabolic Disease
PPARδ agonist 9 (compound 21) is a PPARδ agonist (EC₅₀: 3.6 nM). PPARδ agonist 9 has in vivo efficacy, reducing serum levels of MCP-1 in mice and significantly inhibiting atherosclerosis progression in the LDLr-KO model (inhibition rate: 50-60%) ^[1].

HY-N3007

Naringenin chalcone 5 Publications Verification	Drug Intermediate Apoptosis NO Synthase	Inflammation/Immunology Cancer
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of *MCP-1* and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties ^[1] .

HY-110151

Bengamide B	NF-κB Interleukin Related	Cancer
Bengamide B is an inhibitor for NF-κB with an IC₅₀ of 85 nM. Bengamide B inhibits LPS (HY-D1056)-induced expression of TNF-α, IL-6 and MCP-1, exhibits anti-inflammatory activity. Bengamide B exhibits antitumor efficacy (IC₅₀ for HCT-116 is 2 nM) ^[1].

HY-N2572

Nepetin 6-Methoxyluteolin	Interleukin Related	Inflammation/Immunology
Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and *MCP-1* secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells ^[1] .

HY-N3007R

Naringenin chalcone (Standard)	Reference Standards Drug Intermediate Apoptosis NO Synthase	Inflammation/Immunology
Naringenin chalcone (Standard) is an analytical standard of Naringenin chalcone. This product is intended for research and analytical applications. Naringenin chalcone is an orally active intermediate in the biosynthesis of flavonols. Naringenin chalcone induces apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties.

HY-120245

GSK-340	Epigenetic Reader Domain	Inflammation/Immunology
GSK-340 is a BET inhibitor with high affinity and significant selectivity for BD2 from BRD4 with a pIC50 of 7.2. GSK-340 inhibits *MCP-1* release in Lipopolysaccharide (HY-D1056) treated PBMCs and whole blood with the pIC50 of 7.4 and 6.0, respectively. GSK-340 has immunomodulatory activity ^[1].

HY-N9914

D-Psicose	p38 MAPK NF-κB	Metabolic Disease
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] .

HY-173463

Sirtuin modulator 8	Sirtuin	Metabolic Disease Inflammation/Immunology
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases ^[1].

HY-112868B

ABH hydrochloride	Arginase NO Synthase Integrin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
ABH (hydrochloride) is an orally active arginase inhibitor (K_i = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, *VCAM-1, MCP-1*). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis ^[1] .

HY-159069

Zymosan (ZM), 95%	Biochemical Assay Reagents	Inflammation/Immunology
Zymosan (ZM), 95% is a β-1,3-glucan polysaccharide that can be used as a functional food (as dietary fiber), phagocytic stimulus, and immune potentiator. Zymosan (ZM), 95% increases the levels of lysosomal enzyme secretion, upregulates the leukotriene production of monocytes, and enhances the release of proinflammatory cytokines, IL6 and TNFα, MCP-1, CXCL1, IL8, and MMP9 ^[1].

HY-N2572R

Nepetin (Standard) 6-Methoxyluteolin (Standard)	Reference Standards Interleukin Related	Inflammation/Immunology
Nepetin (Standard) is the analytical standard of Nepetin. This product is intended for research and analytical applications. Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells ^[1] .

HY-N0847

Micheliolide 5+ Cited Publications	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis ^[1] .

HY-N0847R

Micheliolide (Standard)	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis ^[1] .

HY-N9914S

D-Psicose-d	Isotope-Labeled Compounds p38 MAPK NF-κB	Metabolic Disease
D-Psicose-d is the deuterium labeled D-Psicose (HY-N9914). D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] .

HY-162122

PPARα/γ agonist 3	PPAR	Inflammation/Immunology
PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD) ^[1].

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, *VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis ^[1] .

HY-108323

CCR2 antagonist 4 5 Publications Verification Teijin compound 1	CCR	Inflammation/Immunology
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM ^[1].

HY-103362

CCR2 antagonist 4 hydrochloride 5 Publications Verification Teijin compound 1 hydrochloride	CCR	Inflammation/Immunology
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM ^[1].

HY-156025

HCAR2 agonist 1	Hydroxycarboxylic Acid Receptor (HCAR)	Inflammation/Immunology
HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis ^[1].

HY-N9914R

D-Psicose (Standard)	Reference Standards p38 MAPK NF-κB	Metabolic Disease
D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] .

HY-33037

Phenazine-1-carboxylic acid	Fungal	Infection Inflammation/Immunology Cancer
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation ^[1] .

HY-N1940

β-Anhydroicaritin 2 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties ^[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-174744

Human CCR4 mRNA	mRNA	Inflammation/Immunology
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

HY-159580

STAT3-IN-31	STAT	Cancer
STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide (HY-17364)-resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1 ^[1].

HY-125726

Sulfo galactosylceramide (3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

HY-163748

GSK-3β inhibitor 17	GSK-3	Inflammation/Immunology
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury ^[1].

HY-13324

Bardoxolone methyl Maximum Cited Publications 32 Publications Verification RTA 402; NSC 713200; CDDO Methyl ester	Keap1-Nrf2 SARS-CoV Virus Protease	Infection Cardiovascular Disease Inflammation/Immunology
Bardoxolone (CDDO; RTA 401) methyl is an orally active and brain-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC₅₀ value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) ^[1] .

HY-33037R

Phenazine-1-carboxylic acid (Standard)	Reference Standards Fungal	Infection Inflammation/Immunology Cancer
Phenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].

HY-N7064

Iminostilbene	Pyruvate Kinase COX STAT TNF Receptor NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Inflammation/Immunology
Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with *HIF-1α* and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of *IL-1β, IL-6, TNF-α, and MCP-1*, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases ^[1] .

HY-W753956

Iminostilbene-d10	Isotope-Labeled Compounds Interleukin Related Pyruvate Kinase COX STAT TNF Receptor HIF/HIF Prolyl-Hydroxylase NO Synthase	Inflammation/Immunology
Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases ^[1] .

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	NF-κB TNF Receptor NO Synthase Interleukin Related	Inflammation/Immunology
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health ^[1] .

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as *IL1α, IL6* and *MCP1. Astegolimab mitigates IL33-increased p-p65/p65* ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research ^[1] .

HY-125740R

Malvidin-3-glucoside chloride (Standard) Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)	Reference Standards Interleukin Related NO Synthase NF-κB TNF Receptor	Metabolic Disease Inflammation/Immunology
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health ^[1] .

HY-B0498

Bindarit 15+ Cited Publications AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1*β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity ^[1].

HY-RS22945

Ccl2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl2 Rat Pre-designed siRNA Set A Ccl2 Rat Pre-designed siRNA Set A

HY-RS16514

Ccl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl2 Mouse Pre-designed siRNA Set A Ccl2 Mouse Pre-designed siRNA Set A

HY-RS02089

CCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL2 Human Pre-designed siRNA Set A CCL2 Human Pre-designed siRNA Set A

HY-117562

a-FABP-IN-1	FABP	Metabolic Disease
a-FABP-IN-1 (Compound 5g) is a potent and selective human adipocyte fatty acid-binding protein (a-FABP) inhibitor with a K_i below 1.0 nM. a-FABP-IN-1 inhibits the pro-inflammatory cytokine production ^[1].

HY-149120

ASM-IN-1	Phospholipase	Cardiovascular Disease Inflammation/Immunology
ASM-IN-1 is a potent and orally active acid sphingomyelinase (ASM) inhibitor with an IC₅₀ value of 1.5 µM. ASM-IN-1 reduces lipid plaques in the aortic arch and aorta and reduces plasma ceramide concentration and Ox-LDL levels. ASM-IN-1 shows antiatherosclerotic and anti-inflammatory activity ^[1].

HY-124748

ENMD-1068	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting *TGF-β1/Smad* signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis ^[1] .

HY-124748A

ENMD-1068 hydrochloride 2 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Inflammation/Immunology
ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting *TGF-β1/Smad* signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis ^[1] .

Cat. No.	Product Name	Type

HY-125864

Fibrinogen (Bovine)

1 Publications Verification

Native Proteins

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases ^[1] .

HY-N9914

D-Psicose	Biochemical Assay Reagents
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] .

HY-N9914R

D-Psicose (Standard)

Biochemical Assay Reagents

D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] .

HY-NP018

Bovine fibrinogen (from plasma) FGA; FGA protein	Native Proteins
Bovine fibrinogen (from fibrinogen) is a native fibrinogen from bovine plasma. Bovine fibrinogen (from fibrinogen) can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* ^[1].

HY-159069

Zymosan (ZM), 95%	Carbohydrates
Zymosan (ZM), 95% is a β-1,3-glucan polysaccharide that can be used as a functional food (as dietary fiber), phagocytic stimulus, and immune potentiator. Zymosan (ZM), 95% increases the levels of lysosomal enzyme secretion, upregulates the leukotriene production of monocytes, and enhances the release of proinflammatory cytokines, IL6 and TNFα, MCP-1, CXCL1, IL8, and MMP9 ^[1].

Cat. No.	Product Name	Target	Research Area

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, *VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1* Antibody (2H5)** 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[1] .

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as *IL1α, IL6* and *MCP1. Astegolimab mitigates IL33-increased p-p65/p65* ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research ^[1] .

HY-P991426

MB-314	Transmembrane Glycoprotein IFNAR TNF Receptor	Cancer
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research ^[1].

Species:	Human (7) Mouse (8) Rat (1) Cynomolgus (1) Pig (1)
Tag:	His (12) Tag Free (5) Avi (2) Myc (1) Fc (1)
Source:	HEK293 (10) Sf9 insect cells (2) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P7237

	MCP-1/CCL2 Protein, Human 5 Publications Verification rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Human	E. coli
	MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.

HY-P7235

	MCP-1/CCL2 Protein, Mouse (HEK293) rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.

HY-P7236

	MCP-1/CCL2 Protein, Rat (HEK293, C-His) rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Rat	HEK293
	MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.

HY-P7764

	MCP-1/CCL2 Protein, Mouse Maximum Cited Publications 6 Publications Verification rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Ccl2; Scya2	Mouse	E. coli
	MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.

HY-P78488

	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P78173

	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P74758

	MCP-1/CCL2 Protein, Mouse (sf9, His) C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (sf9, His) is a mouse MCP-1/CCL2 expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P76489

	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a biotinylated mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P700787

	MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Cynomolgus	HEK293
	MCP-1/CCL2 protein activates CCR2 and induces chemotaxis and calcium ion mobilization. It attracts monocytes and basophils, not neutrophils or eosinophils. It also contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. MCP-1/CCL2 exists as a monomer or homodimer and binds to endothelial cells through proteoglycans. It interacts with TNFAIP6 via its Link domain. MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MCP-1/CCL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704401

	MCP-1/CCL2 Protein, Human (HEK293, hFc) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. MCP-1/CCL2 Protein, Human (HEK293, hFc) is the recombinant human-derived MCP-1/CCL2 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P72757

	MCP-1/CCL2 Protein, Mouse (HEK293, His) C-C motif chemokine ligand 2; GDCF-2; HC11; HSMCR30; MCAF; SCYA2; SMC-CF	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293, His) is a mouse MCP-1/CCL2 expressed by HEK293 with a His tag at the C-terminus.

HY-P700164AF

	*Animal-Free MCP-1/CCL2 Protein, Mouse (His)* Monocyte Chemotactic Protein-1; MCP-1; JE	Mouse	E. coli
	The MCP-1/CCL2 protein, as a CCR2 ligand, induces potent chemotactic responses and intracellular calcium mobilization in monocytes and basophils, without affecting neutrophils or eosinophils.It is critical for neuropathic pain and enhances NMDA-mediated synaptic transmission in neurons containing dopamine D1 and D2 receptors, possibly involving MAPK/ERK-dependent GRIN2B/NMDAR2B phosphorylation.Animal-Free MCP-1/CCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMCP-1/CCL2 protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.

HY-P700034AF

	*Animal-Free MCP-1/CCL2 Protein, Human (His)* 1 Publications Verification C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	E. coli
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. Animal-Free MCP-1/CCL2 Protein, Human (His) is the recombinant human-derived animal-FreeMCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700231AF

	*Animal-Free MCP-1/CCL2 Protein, Pig (His)* C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Pig	E. coli
	MCP-1/CCL2 protein acts as a ligand for CCR2, inducing chemotactic responses and calcium mobilization. It attracts monocytes and basophils but not neutrophils or eosinophils. Animal-Free MCP-1/CCL2 Protein, Pig (His) is the recombinant pig-derived animal-Free MCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag.This product is for cell culture use only.

HY-P700541

	CCR2 Protein, Mouse (N-His, C-Myc) 1 Publications Verification CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2	Mouse	E. coli
	CCR2 protein is an important chemokine receptor that coordinates chemotaxis and migration by binding to CCL2, CCL7, and CCL12 and activating the PI3K cascade. In addition to chemokine signaling, CCR2 regulates T cell inflammatory cytokines, promotes Th17 cell generation, and promotes mature thymocyte output. CCR2 Protein, Mouse (N-His, C-Myc) is the recombinant mouse-derived CCR2 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P77078

	Mast Cell Protease-1/MCPT-1 Protein, Mouse (HEK293, His) Mast cell protease 1; mMCP-1; MCPt1	Mouse	HEK293
	Mast Cell Protease-1 (MCPT-1) displays chymotrypsin-like enzymatic activity.Mast Cell Protease-1/MCPT-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Mast Cell Protease-1/MCPT-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77589

	CCR2b Protein-VLP, Human (HEK293) C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2	Human	HEK293
	CCR2b Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P77590

	CCR2b Protein-VLP, Human (Biotinylated, HEK293) C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2	Human	HEK293
	CCR2b Protein-VLP, Human (Biotinylated, HEK293) is available in solution form, no concentration information, recommended only for SPR analysis. HY-P77589 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

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Cat. No.	Product Name	Chemical Structure

HY-N9914S

D-Psicose-d
D-Psicose-d is the deuterium labeled D-Psicose (HY-N9914). D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease ^[1] .

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84082

	MCP1 Antibody (YA3779) HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

HY-P81171

	MCP1 Antibody MCP-1/CCL2; C-C motif chemokine 2; CCL 2; CCL2; CCL2_HUMAN; Chemokine (C C motif) ligand 2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF-2; GDCF2; HC11; HSMCR30; HSMCR30; JE; MCAF; MCP 1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); Small inducible cytokine A2; Small inducible cytokine subfamily A (Cys Cys), member 2; Small inducible cytokine subfamily A Cys Cys member 2; Small-inducible cytokine A2; SMC CF; SMC-CF; SMCCF.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat
	MCP1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MCP1.

HY-P80385

	CCR2 Antibody (YA548) 1 Publications Verification C C chemokine receptor type 2 antibody; C C CKR 2 antibody; C-C chemokine receptor type 2 antibody; C-C CKR-2 antibody; CC chemokine receptor type 2 antibody; CC CKR 2 antibody; CC-CKR-2 antibody; CCCKR2 antibody; CCR 2 antibody; CCR-2 antibody; CCR1L antibody; CCR2 antibody; CCR2_HUMAN antibody; CCR2A antibody; CCR2B antibody; CCR5L antibody; CD192 antibody; CD192 antigen antibody; Chemokine C C motif receptor 2 antibody; Chemokine CC Motif Receptor 2 antibody; CKR 2 antibody; CKR2 antibody; CKR2A antibody; CKR2B antibody; CMKBR2 antibody; MCP 1 R antibody; MCP-1-R antibody; MCP1 RECEPTOR antibody; MCP1R antibody; Monocyte chemoattractant protein 1 receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody	WB, IHC-P, IP, FC	Human
	CCR2 Antibody (YA548) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR2.

HY-P85270

	MCP1 Antibody (YA4962) CCL2; MCP1; SCYA2; C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2	WB, ELISA	Human
	MCP1 Antibody (YA4962) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MCP1.

HY-P84311

	CCR2 Antibody (YA4008) CCR2; CKR2; CCR-2; CCR2A; CCR2B; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2	WB, FC, ELISA	Human
	CCR2 Antibody (YA4008) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR2.

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Cat. No.	Product Name		Classification

HY-174744

Human CCR4 mRNA		mRNA
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

HY-RS22945

Ccl2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccl2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16514

Ccl2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02089

CCL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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MCP-1

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