2. NF-κB
  3. NF-κB
  4. CAY10512

CAY10512 is an inhibitor of NF-κB. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid, and can be used for research on Alzheimer's disease.

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CAY10512

CAY10512 Chemical Structure

CAS No. : 139141-12-1

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Based on 1 publication(s) in Google Scholar

CAY10512 Related Antibodies

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Description

CAY10512 is an inhibitor of NF-κB. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid, and can be used for research on Alzheimer's disease[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
5.4 μM
Compound: 1; LD55
Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay
Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay
[PMID: 28126440]
Molecular Weight

228.26

Formula

C15H13FO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1/C=C/C2=C(C=CC=C2)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References
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CAY10512 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY10512139141-12-1CAY 10512CAY-10512NF-κBNuclear factor-κBNuclear factor-kappaBAlzheimer's diseaseinflammatory signalingmicro RNAInhibitorinhibitorinhibit

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