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rings

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (109) ADC Payload (2) Adenosine Receptor (1) Adrenergic Receptor (4) Akt (2) Amine N-methyltransferase (1) Amino Acid Derivatives (4) AMPK (12) Amyloid-β (1) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (19) Apoptosis (9) Aurora Kinase (1) Autophagy (2) Bacterial (30) Bcl-2 Family (2) Beta-lactamase (2) Biochemical Assay Reagents (85) Bradykinin Receptor (1) Btk (2) Calcium Channel (1) Caspase (1) Cathepsin (1) CDK (1) Cholinesterase (ChE) (1) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (1) Disulfidptosis (4) DNA/RNA Synthesis (14) Drug Derivative (4) Drug Intermediate (20) Drug Metabolite (6) DYRK (1) E1/E2/E3 Enzyme (7) E3 Ligase Ligand-Linker Conjugates (1) EGFR (1) Endogenous Metabolite (41) Endothelin Receptor (1) Estrogen Receptor/ERR (3) FAAH (1) Ferroptosis (1) FGFR (1) Fluorescent Dye (34) Fungal (10) FXR (1) GABA Receptor (1) Glutathione Peroxidase (1) Glyoxalase (GLO) (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (3) HIV (1) HSP (1) HSV (6) IFNAR (1) Influenza Virus (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (28) Kinesin (1) Ligands for E3 Ligase (4) Liposome (1) mAChR (1) MARCKS (1) MDM-2/p53 (1) Microtubule/Tubulin (2) Monoamine Oxidase (1) mRNA (1) NEDD8-activating Enzyme (3) Neurokinin Receptor (1) NF-κB (4) NO Synthase (1) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (6) Opioid Receptor (2) p38 MAPK (1) Parasite (18) PARP (1) Phosphodiesterase (PDE) (3) Phospholipase (1) PI4K (1) PKC (3) Potassium Channel (2) PPAR (12) Prostaglandin Receptor (3) PROTAC Linkers (9) PROTACs (3) Proteasome (2) RANKL/RANK (1) Reactive Oxygen Species (ROS) (4) Reference Standards (18) Renin (1) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (1) ROCK (2) Sirtuin (1) Small Interfering RNA (siRNA) (3) Sodium Channel (1) Src (1) STING (1) TGF-β Receptor (1) TNF Receptor (1) Topoisomerase (2) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (96) Cardiovascular Disease (28) Endocrinology (4) Infection (59) Inflammation/Immunology (30) Metabolic Disease (35) Neurological Disease (27)
Click Chemistry:	ADC Synthesis (5) Labeling and Fluorescence Imaging (19) DBCO (1) PROTAC Synthesis (11) Azide (153) Tetrazine (1) Alkynes (7)
Oligonucleotides:	Decoy ODNs (1) Nucleoside Phosphoramidites (2) Guanosine (1) Nucleotide Analogs (1) Rat Pre-designed siRNA Sets (1) Adenine (1) Phospholipids (2) mRNA (1) siRNAs (3) Pegylated Lipids (1) Nucleoside Analogs (2) Uridine (1) Mouse Pre-designed siRNA Sets (1) Cytosine (1) Human Pre-designed siRNA Sets (1) Polymers (3)

489

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

154

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17011

Croconazole	Fungal	Metabolic Disease
Croconazole is an antifungal agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile .

HY-W019711

trans-Cinnamaldehyde 5+ Cited Publications	Endogenous Metabolite	Others
trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate . trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits .

HY-124791

MMRi6	MDM-2/p53 PARP	Cancer
MMRi6 is a Mdm2-MdmX RING domain inhibitor that can disrupt Mdm2-MdmX RING-RING interaction in vitro. MMRi6 inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated p53 polyubiquitination in vitro without affecting NEDD4-1 autoubiquitination. MMRi6 induces p53 stabilization and accumulation and induces PARP cleavage in wt-p53 Emu-myc lymphoma cells. MMRi6 inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells with IC₅₀s of approximately 0.5 μM and 3 μM, respectively. MMRi6 can be used for the study of leukemia/lymphoma .

HY-113862

PHOME	Fluorescent Dye	Others
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay .

HY-W012956

2-Acetylpyrrole	Drug Intermediate	Others
2-Acetylpyrrole is an organic compound containing a pyrrole ring. 2-Acetylpyrrole is one of the products of the Maillard browning reaction and can serve as a major flavor component in many foods. As an intermediate, 2-acetylpyrrole can also be used in the synthesis of other active compounds, such as the flavor compound 2-acetyl-1-pyrroline .

HY-W597209

2,6-Diethyl-4-fluoroaniline	Biochemical Assay Reagents	Others
2,6-Diethyl-4-fluoroaniline is a benzene ring compound .

HY-N9005

Dysolenticin J	Others	Cardiovascular Disease
Dysolenticin J has potent vasodilative effects on aortic rings. Dysolenticin J is an alkaloid that can be isolated from Dysoxylum lenticellatum .

HY-W019711R

trans-Cinnamaldehyde (Standard)	Reference Standards Endogenous Metabolite	Others
trans-Cinnamaldehyde (Standard) is the analytical standard of trans-Cinnamaldehyde. This product is intended for research and analytical applications. trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate . trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits .

HY-142467

HIV-1 inhibitor-11	HIV	Infection
HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor. WO2021104413A1 ( compound 1-1b) .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Endogenous Metabolite	Metabolic Disease
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-78315

2',3',4'-Trimethoxyacetophenone	Fluorescent Dye	Infection
2',3',4'-Trimethoxyacetophenone is an organic compound with a benzene ring and an acetyl group. 2',3',4'-Trimethoxyacetophenone can be used as a raw material for synthesizing dyes, fragrances, and certain pesticides .

HY-155536

Antimalarial agent 28	Parasite	Infection
Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent. Antimalarial agent 28 inhibits P. berghei, with IC₅₀s of 0.561 μM, 0.14 μM, 4.34 μM for Liver stage, early gametocytes and ring stages of P. falciparum .

HY-135782

iso-ADP ribose	Fluorescent Dye	Others
iso-ADP ribose (isoADPr) is a ligand used for protein nucleic acid modification. iso-ADP ribose is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain .

HY-144881

(S)-HH2853	Histone Methyltransferase	Inflammation/Immunology Cancer
(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC₅₀ of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases .

HY-90009

Nortadalafil Demethyl Tadalafil	Phosphodiesterase (PDE)	Cardiovascular Disease
Nortadalafil (Demethyl Tadalafil), a tadalafil (HY-90009A) analogue detected in health foods, is a highly selective PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED). Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension .

HY-90009R

Nortadalafil (Standard) Demethyl Tadalafil (Standard)	Reference Standards Phosphodiesterase (PDE)	Cardiovascular Disease
Nortadalafil (Standard) is the analytical standard of Nortadalafil. This product is intended for research and analytical applications. Nortadalafil , a new tadalafil (HY-90009A) analogue detected in health foods, is a PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED). Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension [4] .

HY-142919

μ opioid receptor agonist 2	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 2 （Compound H-3）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .

HY-142918

μ opioid receptor agonist 1	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 1 （Compound H-1a）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .

HY-17466

Sancycline Bonomycin; 6-Demethyl-6-deoxytetracycline	Bacterial Antibiotic	Metabolic Disease Inflammation/Immunology
Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin .

HY-17466A

Sancycline hydrochloride Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride	Antibiotic Bacterial	Metabolic Disease Inflammation/Immunology
Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin .

HY-17466R

Sancycline (Standard) Bonomycin (Standard); 6-Demethyl-6-deoxytetracycline (Standard)	Reference Standards Bacterial Antibiotic	Metabolic Disease Inflammation/Immunology
Sancycline (Standard) is the analytical standard of Sancycline. This product is intended for research and analytical applications. Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].

HY-170823

PRC1-IN-1	E1/E2/E3 Enzyme	Others
PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex PRC1 (IC₅₀=2.3 μM), targeting RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1 with IC₅₀s of 2.8, 2.6, and 1.8 μM, respectively .

HY-W047432

5-Nitro-1H-indazole-3-carbonitrile DL0805	ROCK	Cardiovascular Disease
5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC₅₀ of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research .

HY-U00241

Carburazepam RGH 3331; Uxepam	GABA Receptor	Neurological Disease
Carburazepam is a agent which derives from benzodiazepine. Benzodiazepines (BZD, BZs) are a class of psychoactive agents whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

HY-RS24886

Ring1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ring1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ring1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ring1 Rat Pre-designed siRNA Set A Ring1 Rat Pre-designed siRNA Set A

HY-RS18405

Ring1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ring1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ring1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ring1 Mouse Pre-designed siRNA Set A Ring1 Mouse Pre-designed siRNA Set A

HY-RS11985

RING1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RING1 Human Pre-designed siRNA Set A contains three designed siRNAs for RING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RING1 Human Pre-designed siRNA Set A RING1 Human Pre-designed siRNA Set A

HY-139514

RB-3	E1/E2/E3 Enzyme	Cancer
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to *RING1B-BMI1f, with a K_d* of 2.8 μM .

HY-41587

D-Glucose pentaacetate Penta-O-acetyl-D-glucopyranose	Biochemical Assay Reagents	Others
D-Glucose pentaacetate is a sugar opening ring.

HY-138140

Desertomycin A	Others	Others
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .

HY-W011579

4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone	Biochemical Assay Reagents	Others
4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone, is a heterocyclic compound with a five-membered ring structure, which can be used as a starting material for organic synthesis, a reagent for organic transformation, and a biological probe for studying biological processes. 4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .

HY-Z17187

Feudomycin A 13-Deoxydaunorubicin	Antibiotic Bacterial	Infection Cancer
Feudomycin A is an onion ring antibiotic with anti-tumor cell activity .

HY-W015752

5-Methoxyresorcinol	Drug Intermediate	Others
5-Methoxyresorcinol is a model molecule of the A ring of flavonoids, specifically simulating the chemical behavior of the resorcinol-type A ring found in catechins. 5-Methoxyresorcinol exhibits extremely low reactivity of tocopherol. 5-Methoxyresorcinol hardly inhibits cholesteryl ester transfer protein (CETP) .

HY-156843

Antiproliferative agent-38	Others	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring，but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

HY-W391701

Pomalidomide-COCH2Cl	Ligands for E3 Ligase	Cancer
Pomalidomide-COCH2Cl is a derivative of Pomalidomide with an chloroacetamide group on the benzyl ring.

HY-19555A

Seco Rapamycin sodium salt Secorapamycin A monosodium	Drug Metabolite	Others
Seco Rapamycin sodium salt is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function.

HY-U00379

LM985	Others	Cancer
LM985 is one of a series of compounds based on the flavone ring structure, with anti-tumor activities.

HY-N12172

Kissoone A	Others	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-N1256

Sculponeatic acid	Others	Others
Sculponeatic acid is a new A-ring contracted oleanane triterpene that can be isolated from Isodon sculponeata .

HY-W190974

3-Ethynylperylene Perylene, 3-ethynyl-	Biochemical Assay Reagents	Others
3-Ethynylperylene (Perylene, 3-ethynyl-) is a polyaromatic hydrocarbon with five fused rings and has a terminal propargyl group. 3-Ethynyl perylene possesses intrinsic fluorescence and pyrene derivatives are known for their ability to intercalate dsDNA. The propargyl group can react with azide-bearing compounds to form stable triazole rings.

HY-15350

Trovirdine hydrochloride LY 300046 hydrochloride	Reverse Transcriptase	Others
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .

HY-W265757

4-Ethylcatechol	DNA/RNA Synthesis	Cancer
4-Ethylcatechol is a ring-dihydroxylated metabolite of 4-Ethylphenol that leads to oxidative DNA damage .

HY-19555

Seco Rapamycin Secorapamycin A	Drug Metabolite	Others
Seco Rapamycin (Secorapamycin A) is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function .

HY-W265757R

4-Ethylcatechol (Standard)	DNA/RNA Synthesis	Cancer
4-Ethylcatechol is a ring-dihydroxylated metabolite of 4-Ethylphenol that leads to oxidative DNA damage .

HY-133770

Seco Rapamycin ethyl ester	Drug Metabolite	Others
Seco Rapamycin ethyl ester is an open-ring metabolite of Rapamycin derivative. Seco-rapamycin is reported not to affect the mTOR function .

HY-W460227

Lenalidomide-4-Br-7-fluoro	Ligands for E3 Ligase	Cancer
Lenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide with a flouride and bromide groups on the benzyl ring.

HY-W183178

(Pentyloxy)benzene	Drug Intermediate	Others
(Pentyloxy)benzene is a compound containing a pentyloxy group and a benzene ring, which can be used as an intermediate in the synthesis of other complex molecules .

HY-N11663

Dugesin C	Others	Others
Dugesin C is a diterpenoid isolated from the plant Salvia dugesii with a spiro carbocyclic ring system derived from the normal neocrotane skeleton .

HY-W013205

Bis(4-nitrophenyl) phosphate	Biochemical Assay Reagents	Others
Bis(4-nitrophenyl) phosphate is a catalyst for metal micelles and can catalyze the hydrolysis of (4-nitrophenyl) phosphate. Bis(4-nitrophenyl) phosphate is also an effective catalyst for ring-opening polymerization (ROP), which can achieve controlled polymerization of β-butyrolactone (β-BL) ring-opening and can be used to prepare diembedded polymers without quenching. segment copolymer .

Cat. No.	Product Name

HY-L0116V

Asinex Macrocycles for RNA Library

1,065 compounds

Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.

HY-L068

Flavonoids Library

534 compounds

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 534 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

HY-L0120V

Asinex BioDesign Library

170,269 compounds

“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.

Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

HY-L0122V

Asinex CNS Macrocycles Library

1,122 compounds

Several CNS multi-parameter scoring approaches have been reported: CNS-MPO, CNS-MPO V.2, CNS-TEMPO, which suggesting an algorithm to predict CNS-ike properties of new chemical entities. We have applied these scoring algorithms to select macrocycles satisfying multiple cut-offs and structural desirability criteria. The resulting set consists of 1,122 macrocyclic compounds with CNS-MPO > 4, CNS-MPO.v2 > 4, and CNS-TEMPO < 4 for CNS-related drug discovery and research.

HY-L0094V

Chinese National Compound Library	1,398,968 compounds
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.

HY-L0093V

Chemspace Scaffold derived set	10,119 compounds
Diversity-based screening continues to be a vital tool for drug discovery. Efficiency and productivity can be improved by using screening libraries that offer maximum diversity whilst retaining drug-like properties. Chemspace Scaffold derived set composes 10,119 compounds, which including 3,373 scaffolds, 3 compounds per each. This library has exceptional coverage of drug-like chemical space.

HY-L110

Cyclic Peptide Library

92 compounds

Cyclic peptides are polypeptide chains taking cyclic ring structure, which exhibit diverse biological activities, such as antibacterial activity, immunosuppressive activity and anti-tumor activity. Cyclic peptides, with the features of good binding affinity, target selectivity and low toxicity, show great success as therapeutics. Multiple cyclic peptides are currently in clinical use, for examples, gramicidin and tyrocidine with bactericidal activity, cyclosporin A with immunosuppressive activity, and vancomycin with antibacterial activity. Furthermore, cyclic peptides usually have the sufficient size and a balanced conformational flexibility/rigidity for binding to flat protein-protein interaction (PPI) interfaces, which have potential to develop PPI drugs.

MCE offers a unique collection of 92 cyclic peptides, all of which have good bioactivities. MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

HY-L041

Macrocyclic Compound Library

419 compounds

Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity.

MCE offers a unique collection of 419 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

HY-L907

MCE Kinase Hinge Binder Fragment Library

12,513 compounds

The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity.

The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments.

MCE provides over 10,000 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.

Cat. No.	Product Name	Type

HY-113862

PHOME	Dyes
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay .

HY-D1416

HMBR	Fluorescent Dyes/Probes
HMBR is an analogue with an additional methyl group on the aromatic ring and is non-fluorescent. HMBR conjugated with Y-FAST emits yellow fluorescence under blue light excitation (Ex= 419 nm; Em= 525–539 nm). HMBR is non-toxic to zebrafish embryos. HMBR has high cell permeability .

HY-D1314

FAM azide, 6-isomer 6-FAM azide	Dyes
FAM azide, 6-isomer (6-FAM azide), a fluorescent dye, is a click chemistry reagent containing an azide group . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1053

CY7-N3 Sulfo-Cyanine7-N3	Fluorescent Dyes/Probes
CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble NIR dye azide for Click Chemistry. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151708

CalFluor 488 Azide

Fluorescent Dyes/Probes

CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151710

Sulfo-Cy3 Azide

Fluorescent Dyes/Probes

Sulfo-Cy3 Azide is a water-soluble fluorogenic dye containing an azide group, which enables Click Chemistry. Sulfo-Cy3 Azide can be used for the labeling of sensitive molecules such as proteins . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W400925

Sulfo-Cy5-N3	Fluorescent Dyes/Probes
Sulfo-Cy5-N3 is a click chemistry reagent containing an azide group. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1320

Cyanine5 azide chloride

Dyes

Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λ_ex=646 nm, λ_em=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274

Sulfo-cyanine3 azide

Fluorescent Dyes/Probes

Sulfo-cyanine3 azide is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274B

Sulfo-cyanine3 azide TEA

Fluorescent Dyes/Probes

Sulfo-cyanine3 azide TEA is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide TEA can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2138

Cy3-PEG7-Azide	Fluorescent Dyes/Probes
Cy3-PEG7-Azide is a Cyanine 3 (Cy3) (HY-D0822) dye derivative containing 7 PEG units. Cy3-PEG7-Azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-145383

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide

Protein Labeling

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is a clickable, acid-cleavable biotin-picolyl azide. Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is an enrichment handle of cell surface glycoproteins for protein labeling . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2136

Cy3-PEG2-Azide	Fluorescent Dyes/Probes
Cy3-PEG2-Azide is a Cyanine 3 (Cy3) (HY-D0822) dye derivative containing 2 PEG units. Cy3-PEG2-Azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274C

Sulfo-cyanine3 azide potassium

Fluorescent Dyes/Probes

Sulfo-cyanine3 azide potassium is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide potassium can be used for synthesis of fused tricyclic heterocycles, producing immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2137

Cy3-PEG3-Azide	Fluorescent Dyes/Probes
Cy3-PEG3-Azide is a Cyanine 3 (Cy3) (HY-D0822) dye derivative containing 3 PEG units. Cy3-PEG3-Azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1274A

Sulfo-cyanine3 azide sodium

Fluorescent Dyes/Probes

Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2501

Sulfo Cy7 N3	Fluorescent Dyes/Probes
Sulfo Cy7-N3 is a Sulfo Cy7-azide, which is a fluorescent dye. Sulfo Cy7-N3 can be used in cell imagine by Click reaction. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-103609

Pyrene

1 Publications Verification

Benzo[def]phenanthrene

Dyes

Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-D2490

Sulfo Cy5.5-N3	Fluorescent Dyes/Probes
Sulfo Cy5.5-N3 is a Sulfo Cy5.5-azide, which is a fluorescent dye. Sulfo Cy5.5-N3 can be used in cell imagine by Click reaction. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151711

Sulfo-Cy5.5 Azide

Fluorescent Dyes/Probes

Sulfo-Cy5.5 Azide is a click chemistry reagent containing an azide group. Sulfo-Cy5.5 Azide is also a water-soluble dye (Ex=673 nm, Em=707 nm), which designed to label sensitive molecules such as peptides, proteins and oligonucleotides. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2161

AF 594 azide

Fluorescent Dyes/Probes

AF 594 azide is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne). It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-D1308

Sulfo-Cyanine5.5 azide tripotassium

Dyes

Sulfo-Cyanine5.5 azide tripotassium, a near-infrared (NIR) fluorescent dye, is an azide-functionalized Sulfo-Cyanine5.5 (Ex=678 nm, Em=694 nm). Sulfo-Cyanine5.5 azide tripotassium can react with alkynes for Click Chemistry labeling . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-103609R

Pyrene (Standard)

Benzo[def]phenanthrene (Standard)

Dyes

Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-131021

Janelia Fluor® 549, Azide

JF549, Azide

Fluorescent Dyes/Probes

Janelia Fluor? 549, Azide (JF549, Azide) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor? products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2112

TAMRA-PEG7-N3

Fluorescent Dyes/Probes

TAMRA-PEG7-N3 is a TAMRA (HY-135640) dye derivative containing 7 PEG units. TAMRA-PEG7-N3 undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkynyl group (N₃). It also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2111

TAMRA-PEG2-N3

Fluorescent Dyes/Probes

TAMRA-PEG2-N3 is a TAMRA (HY-135640) dye derivative containing 4 PEG units. TAMRA-PEG2-N3 undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkynyl group (N₃). It also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151662

4-Azido-2,3,5,6-tetrafluorobenzoic Acid

N3-TFBA

Fluorescent Dyes/Probes

4-Azido-2,3,5,6-tetrafluorobenzoic Acid (N3-TFBA) is a click chemistry reagent containing an azide group. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid is a complex with FAM-labeled DNA probe. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid can be used as versatile photoaffinity labeling agents to probe biological receptors. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D1850

Sulfo-Cy7.5 azide

Fluorescent Dyes/Probes

Sulfo-Cy7.5 azide is a Cyanine 7.5 (Cy7.5) (HY-D0926) dye derivative with azide and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The azide group of Sulfo-Cy7.5 azide can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Sulfo-Cy7.5 azide can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-41587

D-Glucose pentaacetate Penta-O-acetyl-D-glucopyranose	Carbohydrates
D-Glucose pentaacetate is a sugar opening ring.

HY-W011579

4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone

Biochemical Assay Reagents

4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone, is a heterocyclic compound with a five-membered ring structure, which can be used as a starting material for organic synthesis, a reagent for organic transformation, and a biological probe for studying biological processes. 4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .

HY-15917

DL-dithiothreitol 30+ Cited Publications DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol	Carbohydrates
DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-W134422

(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 4 Publications Verification Polyoxyethylene octylphenol ether	Surfactants
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene?glycol X-114 is a complex of three molecules formed by ortho-, meta-, and para-substitution of the benzene ring.

HY-W017195

Isopropyl benzoate Propan-2-yl benzoate	Biochemical Assay Reagents
Isopropyl benzoate is a class of esters consisting of a benzene ring and an isopropyl group attached to a carboxylic acid group. Isopropyl benzoate can be used as an inducer to biosynthesize phloroglucinol in E. coli .

HY-W016278

Gamma-undecalactone	Biochemical Assay Reagents
Gamma-undecalactone consists of a five-membered dihydrofuran ring with an ester group and a heptyl chain. This compound has a fruity smell and is commonly used as a flavor additive in various food and beverage products such as coffee, tea and baked goods.

HY-157648

18:0-20:4 PI(3)P ammonium	Cell Assay Reagents
18:0-20:4 PI(3)P ammonium can be obtained by phosphorylation of the inositol ring of phosphatidylinositol and can be used in the preparation of liposomes.

HY-172382B

Poly(D,L-lactide-co-glycolide), 65:35 PGCL, 65:35	Drug Delivery
Poly(D,L-lactide-co-glycolide), 65:35 (PGCL, 65:35) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .

HY-172382A

Poly(D,L-lactide-co-glycolide), 75:25 PGCL,75:25	Drug Delivery
Poly(D,L-lactide-co-glycolide), 75:25 (PGCL, 75:25) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .

HY-172382

Poly(D,L-lactide-co-glycolide), 50:50 PGCL, 50:50	Drug Delivery
Poly(D,L-lactide-co-glycolide), 50:50 (PGCL, 50:50) is a copolymer formed by the ring-opening polymerization of lactide and glycolide, which can be used for drug delivery .

HY-20128

Piperazin-2-one	Biochemical Assay Reagents
Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds .

HY-W022036

2-Ethoxyphenol Guaethol; Guethol; NSC 180	Biochemical Assay Reagents
2-Ethoxyphenol, also known as guaiacol ethyl ether, consists of a phenolic ring and an ethoxy group connected to the 2-position. The compound has a sweet, smoky flavor and is commonly used as a flavoring in foods such as baked goods, candy and beverages.

HY-W001851

1-Benzylpyrrole-2,5-dione N-Benzylmaleimide	Biochemical Assay Reagents
1-Benzylpyrrole-2,5-dione (N-Benzylmaleimide) is a heterocyclic compound containing a maleimide ring and a benzyl group. 1-Benzylpyrrole-2,5-dione can be used as a key reactant for the green chemical modification of cellulose nanocrystals (CNC).

HY-W007509

1H-Indol-5-amine 5-Aminoindole	Biochemical Assay Reagents
1H-Indol-5-amine (5-Aminoindole) is an organic compound containing an indole ring structure and belongs to the class of indole derivatives. 1H-Indol-5-amine can serve as a key intermediate for the synthesis of other active compounds .

HY-W127489

3-Pentadecylphenol

Biochemical Assay Reagents

3-PentadecylphenolIt is an organic compound belonging to the phenolic class. It is attached to the phenolic ring by 15Carbon pentadecyl chain composition, with a touch of sweetness.3-Pentadecylphenol has various applications in the chemical and pharmaceutical industries, especially as an intermediate in the synthesis of various chemicals and pharmaceuticals. In addition, it can be used as an antioxidant for plastics and rubber.

HY-W034576

Hexacyclen hexahydrochloride

Hexaaza-18-crown-6 hexahydrochloride; 1,4,7,10,13,16-Hexaazacyclooctadecane hexahydrochloride

Biochemical Assay Reagents

Hexacyclen (Cycloalkene) is an organic compound with a unique macrocyclic structure composed of six nitrogen-containing rings. Hexacyclen is commonly used as a chelating agent in chemistry and biochemistry due to its ability to bind metal ions, and is often used to selectively bind metal ions in proteins or enzymes to study their structure and function. Hexacyclen also acts as an inhibitor of cancer .

HY-155902B

Mal-PEG-OH (MW 1000) Maleimide-PEG-Hydroxy (MW 1000)	Drug Delivery
Mal-PEG-OH (MW 1000) was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902A

Mal-PEG-OH (MW 2000) Maleimide-PEG-Hydroxy (MW 2000)	Drug Delivery
Mal-PEG-OH (MW 2000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-174924A

Cholesterol-PEG8-azide	Drug Delivery
Cholesterol-PEG8-azide is a PEG derivative composed of Cholesterol, 8 PEG units and an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.

HY-174924

Cholesterol-PEG3-azide	Drug Delivery
Cholesterol-PEG3-azide is a PEG derivative composed of Cholesterol, 3 PEG units and an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.

HY-W002458

4-Nitropyrazole	Biochemical Assay Reagents
4-Nitropyrazole is a five-membered nitrogen-containing heterocyclic compound that can be used as a drug intermediate. 4-Nitropyrazole can be synthesized into antibiotics/antifungal/antiviral agents containing pyrazole rings. 4-Nitropyrazole is synthesized through C-H activation reactions to produce LRRK2 inhibitors, which are used in the research of Parkinson's disease .

HY-155902

Mal-PEG-OH (MW 5000) Maleimide-PEG-Hydroxy (MW 5000)	Drug Delivery
Mal-PEG-OH (MW 5000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902D

Mal-PEG-OH (MW 10000)

Maleimide-PEG-Hydroxy (MW 10000)

Drug Delivery

Mal-PEG-OH (MW 10000) (Maleimide-PEG-Hydroxy (MW 10000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 10000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .

HY-155902E

Mal-PEG-OH (MW 20000)

Maleimide-PEG-Hydroxy (MW 20000)

Drug Delivery

Mal-PEG-OH (MW 20000) (Maleimide-PEG-Hydroxy (MW 20000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 20000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .

HY-155902H

Mal-PEG-OH (MW 40000)

Maleimide-PEG-Hydroxy (MW 40000)

Drug Delivery

Mal-PEG-OH (MW 40000) (Maleimide-PEG-Hydroxy (MW 40000)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 40000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .

HY-W090294

Perylene

Peri-dinaphthalene (purified by sublimation); Perylene

Biochemical Assay Reagents

Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.

HY-155902C

Mal-PEG-OH (MW 3400)

Maleimide-PEG-Hydroxy (MW 3400)

Drug Delivery

Mal-PEG-OH (MW 3400) (Maleimide-PEG-Hydroxy (MW 3400)) is a linear heteroterminal bifunctional PEG product with maleimide and hydroxyl groups. Mal-PEG-OH (MW 3400) can be used as a macroinitiator to obtain amphiphilic diblock copolymers through ring-opening polymerization of Lactate (Lactic Acid) (HY-B2227). Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems .

HY-W034566

Hexacyclen

Hexaaza-18-crown-6; 1,4,7,10,13,16-Hexaazacyclooctadecane

Biochemical Assay Reagents

Hexacyclen is an organic compound with a unique macrocyclic structure composed of six nitrogen-containing rings. It is commonly used as a chelating agent in chemistry and biochemistry due to its ability to bind metal ions. Inhibitors of certain diseases such as cancer. In biochemistry, Hexacyclen is often used to selectively bind metal ions in proteins or enzymes to study their structure and function. Due to its large size and complex structure, Hexacyclen is not widely used in daily products or applications .

HY-W096120B

Azide-PEG2-Desthiobiotin

Drug Delivery

Azide-PEG2-Desthiobiotin is a PEG derivative consisting of desthiobiotin, 2 PEG units, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-32959

N-Boc-2-pyrroleboronic acid

Biochemical Assay Reagents

N-Boc-2-pyrroleboronic acid is an organic synthesis intermediate used primarily in the synthesis of chiral pharmaceutical molecules and biologically active molecules. The boronic acid on the pyrrole ring can participate in Suzuki coupling reactions. The boronic acid can be oxidized to a hydroxyl group under the action of nitrogen oxides, and after tautomerization, it can be further transformed into 2-oxo-2,5-dihydro-1-pyrrolecarboxylic acid tert-butyl ester .

HY-174893

Azido-PEG20-NHS ester

Drug Delivery

Azido-PEG20-NHS ester is a PEG derivative that can be used for drug delivery and other research. Azido-PEG20-NHS ester is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-174894

Azido-PEG11-NHS ester

Drug Delivery

Azido-PEG11-NHS ester is a PEG derivative that can be used for drug delivery and other research. Azido-PEG11-NHS ester is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-W034566A

Hexacyclen trisulfate

Hexaaza-18-crown-6 trisulfate; 1,4,7,10,13,16-Hexaazacyclooctadecane trisulfate

Biochemical Assay Reagents

Hexacyclen, also known as cycloalkene, is an organic compound with a unique macrocyclic structure composed of six nitrogen-containing rings. It is commonly used as a chelating agent in chemistry and biochemistry due to its ability to bind metal ions. Inhibitors of certain diseases such as cancer. In biochemistry, Hexacyclen is often used to selectively bind metal ions in proteins or enzymes to study their structure and function. Due to its large size and complex structure, Hexacyclen is not widely used in daily products or applications.

HY-W096120C

Azide-PEG4-Desthiobiotin

Drug Delivery

Azide-PEG4-Desthiobiotin is a PEG derivative consisting of desthiobiotin, 4 PEG unit, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-W096120A

Azide-PEG1-Desthiobiotin

Drug Delivery

Azide-PEG1-Desthiobiotin is a PEG derivative consisting of desthiobiotin, 1 PEG unit, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-174922

Azido-PEG24-Tos

Drug Delivery

Azido-PEG24-Tos is a PEG derivative that can be used for drug delivery and other research. Azido-PEG24-Tos is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W1048861K

4-Arm-PEG-Azide (MW 2000) 4-Arm-PEG-N3 (MW 2000)	Drug Delivery
4-Arm-PEG-Azide (MW 2000) (4-Arm-PEG-N3 (MW 2000)) is a PEG derivative composed of a PEG unit and an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups .

HY-W1048861J

4-Arm-PEG-Azide (MW 1000) 4-Arm-PEG-N3 (MW 1000)	Drug Delivery
4-Arm-PEG-Azide (MW 1000) (4-Arm-PEG-N3 (MW 1000)) is a PEG derivative composed of a PEG unit and an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups .

HY-174946A

DPPE-PEG5-azide DPPE-PEG5-N3	Drug Delivery
DPPE-PEG5-azide (DPPE-PEG5-N3) is a PEG-modified lipid containing an azide group. DPPE-PEG5-azide can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkynyl group. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-174946

DPPE-PEG1-azide DPPE-PEG1-N3	Drug Delivery
DPPE-PEG1-azide (DPPE-PEG1-N3) is a PEG-modified lipid containing an azide group. DPPE-PEG1-azide can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkynyl group. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-W1048861L

4-Arm-PEG-Azide (MW 3400) 4-Arm-PEG-N3 (MW 3400)	Drug Delivery
4-Arm-PEG-Azide (MW .400) (4-Arm-PEG-N3 (MW .400)) is a PEG derivative composed of a PEG unit and an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups .

HY-W1048861H

4-Arm-PEG-Azide (MW 600) 4-Arm-PEG-N3 (MW 600)	Drug Delivery
4-Arm-PEG-Azide (MW 600) (4-Arm-PEG-N3 (MW 600)) is a PEG derivative composed of a PEG unit and an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups .

HY-140807A

Azido-PEG35-alcohol

Azido-PEG35-acid

Drug Delivery

Azido-PEG35-alcohol (Azido-PEG35-acid) is a PEG derivative that can be used for drug delivery and other research. Azido-PEG35-alcohol is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-W190862

Biotin-PEG10-azide

Biotin-PEG10-N3

Drug Delivery

Biotin-PEG10-azide (Biotin-PEG10-N3) is a PEG derivative composed of biotin, 10 PEG units, and an azide group. Biotin can form a stable non-covalent bond with streptavidin. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-174900

Azido-PEG13-amine

Azido-PEG13-NH2

Drug Delivery

Azido-PEG13-amine (Azido-PEG13-NH2) is a PEG derivative that can be used for drug delivery and other research. Azido-PEG13-amine is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-140807C

Azido-PEG22-alcohol

Azido-PEG22-acid

Drug Delivery

Azido-PEG22-alcohol (Azido-PEG22-acid) is a PEG derivative that can be used for drug delivery and other research. Azido-PEG22-alcohol is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-140807B

Azido-PEG39-alcohol

Azido-PEG39-acid

Drug Delivery

Azido-PEG39-alcohol (Azido-PEG39-acid) is a PEG derivative that can be used for drug delivery and other research. Azido-PEG39-alcohol is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group. It can also undergo ring strain driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-W095635

Tetramethylammonium fluoride tetrahydrate

Biochemical Assay Reagents

Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

HY-W017232

6-Methoxyquinoline

p-Quinanisole

Biochemical Assay Reagents

6-Methoxyquinoline consists of a quinoline ring system with a methoxy group attached to the sixth carbon atom. This compound occurs naturally in certain plants, such as tobacco and tea, and has been shown to have biological activities, including antioxidant, anti-inflammatory and antitumor properties. Furthermore, 6-Methoxyquinoline can be used as a building block for the synthesis of other organic compounds, especially those with potential pharmaceutical applications. Due to its ability to bind nucleic acids and proteins, it can also be used as a fluorescent probe in biochemical and biomedical research.

HY-174970C

Silane-PEG-N3 (MW 2000)

Silane-PEG-azide (MW 2000)

Drug Delivery

Silane-PEG-N3 (MW 2000) (Silane-PEG-azide (MW 2000)) is a PEG derivative composed of silane, PEG units, and azide groups, which can be used to modify glass, silicon, or other surfaces by reacting hydroxyl groups with ethoxy (methoxy) silanes. Silane-PEG-N3 (MW 2000) contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

Cat. No.	Product Name	Target	Research Area

HY-P4617

Cyclo(-Leu-Phe)	Peptides	Others
Cyclo(-Leu-Phe) is a cyclic peptide composed of leucine and phenylalanine, forming a ring structure through peptide bonds .

HY-146127A

Grb2 SH2 domain inhibitor 1 TFA	Src	Others
Grb2 SH2 domain inhibitor 1 TFA is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-P6351

c(avb6)-DOTA TFA	Integrin	Cancer
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has a comparable affinity for αvβ6 integrin (IC₅₀=0.8 nM) and can be used as a tumor diagnostic .

HY-103291

Sar-[D-Phe8]-des-Arg9-Bradykinin	Bradykinin Receptor	Inflammation/Immunology Endocrinology
Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

HY-P10814

MciZ (B. subtilis)	Bacterial	Infection
MciZ (B. subtilis), a 40-amino-acid peptide, inhibits the GTPase activity of FtsZ that prevents inappropriate Z-ring formation during sporulation .

HY-P3228

JKC 302	Endothelin Receptor	Cardiovascular Disease
JKC 302 is an ET-A receptor antagonist. JKC 302 partly blocks ET-1-induced contraction in asthmatic rat trachea ring .

HY-P2331

Actagardin Antibiotic A 3802-IV-3; Gardimycin	Antibiotic	Infection
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.

HY-P2788

Hyp-Phe-Phe	Peptides	Others
Hyp-Phe-Phe is a tripeptide that forms helical-like sheets via aromatic interactions of the Phe rings to comprise a cross helical architecture. Hyp-Phe-Phe possesses a high shear piezoelectricity and acts as piezoelectric material .

HY-146127

Grb2 SH2 domain inhibitor 1	EGFR	Others
Grb2 SH2 domain inhibitor 1 is a conformationally restricted cyclic cell penetrating peptide (CPP) containing d-pro-l-pro motif ring (AF Φ Rpprrfq) (where Φ It is L-naphthylalanine, R is D-arginine, P is D-proline), which is mainly used as a cyclic peptide inhibitor.

HY-W012908

DL-Proline	Biochemical Assay Reagents	Infection Cancer
DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection .

HY-P5479

EE epitope	Peptides	Others
EE epitope is a biological active peptide. (This peptide is a 314 to 319 amino acids fragment of the middle T antigen of mouse polymavirus. Glu-Glu epitope peptide is widely used as an epitope tag.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P5429

DNA-PK Substrate	Peptides	Others
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P5471

Melan-A/MART-1 analog [Leu27]-Melan-A, MART-1 (26-35)	Peptides	Others
Melan-A/MART-1 analog ([Leu27]-Melan-A, MART-1 (26-35)) is a biological active peptide. (This Melan-A (26-35) analog, Leu substituted for Ala at position 27, shows better HLA-A0201 binding properties as well as better immunogenicity and antigenicity than the natural Melan-A (26-35).Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring* of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC MARCKS	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-W111226

Fmoc-His(3-Me)-OH	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca ²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel .

HY-P5325

Bid BH3 (80-99)	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W019711

trans-Cinnamaldehyde 5+ Cited Publications	Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Phenylpropanoids Plants Lauraceae Endogenous metabolite Disease Research Fields	Endogenous Metabolite
trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate . trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits .

HY-W012956

2-Acetylpyrrole	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Disease Research Fields	Drug Intermediate
2-Acetylpyrrole is an organic compound containing a pyrrole ring. 2-Acetylpyrrole is one of the products of the Maillard browning reaction and can serve as a major flavor component in many foods. As an intermediate, 2-acetylpyrrole can also be used in the synthesis of other active compounds, such as the flavor compound 2-acetyl-1-pyrroline .

HY-W015752

5-Methoxyresorcinol	Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Drug Intermediate
5-Methoxyresorcinol is a model molecule of the A ring of flavonoids, specifically simulating the chemical behavior of the resorcinol-type A ring found in catechins. 5-Methoxyresorcinol exhibits extremely low reactivity of tocopherol. 5-Methoxyresorcinol hardly inhibits cholesteryl ester transfer protein (CETP) .

HY-N9005

Dysolenticin J	Triterpenes Dysoxylum lenticellatum C. Y. Wu ex H. Li Terpenoids Source classification Plants Meliaceae	Others
Dysolenticin J has potent vasodilative effects on aortic rings. Dysolenticin J is an alkaloid that can be isolated from Dysoxylum lenticellatum .

HY-W019711R

trans-Cinnamaldehyde (Standard)	Cinnamomum cassia (L.) D. Don Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae Endogenous metabolite	Reference Standards Endogenous Metabolite
trans-Cinnamaldehyde (Standard) is the analytical standard of trans-Cinnamaldehyde. This product is intended for research and analytical applications. trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate . trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Alkaloids Source classification Cocculus laurifolius DC. Plants Isoquinoline Alkaloids Menispermaceae	Endogenous Metabolite
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-138140

Desertomycin A	Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Others
Desertomycin A is an aminopolyol polyketide containing a macrolactone ring .

HY-Z17187

Feudomycin A 13-Deoxydaunorubicin	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Feudomycin A is an onion ring antibiotic with anti-tumor cell activity .

HY-N12172

Kissoone A	Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-N1256

Sculponeatic acid	Triterpenes Senna Mill. Terpenoids Labiatae Source classification Plants	Others
Sculponeatic acid is a new A-ring contracted oleanane triterpene that can be isolated from Isodon sculponeata .

HY-N11663

Dugesin C	Gynoxys verrucosa Sch.Bip. ex Wedd. Terpenoids Labiatae Source classification Diterpenoids Plants	Others
Dugesin C is a diterpenoid isolated from the plant Salvia dugesii with a spiro carbocyclic ring system derived from the normal neocrotane skeleton .

HY-W015752R

5-Methoxyresorcinol (Standard)	Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Drug Intermediate
5-Methoxyresorcinol (Standard) is an analytical standard for 5-Methoxyresorcinol (HY-W015752). This product is intended for research and analytical applications. 5-Methoxyresorcinol is a model molecule for the A ring of flavonoids, specifically mimicking the chemical behavior of the resorcinol-type A ring in catechins. 5-Methoxyresorcinol exhibits very low tocopherol regeneration activity. 5-Methoxyresorcinol shows little inhibition of cholesteryl ester transfer protein (CETP).

HY-B1449

Uridine 10+ Cited Publications β-Uridine	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Other Diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Nucleoside Antimetabolite/Analog NF-κB
Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond .

HY-N0762

Isobavachin 4 Publications Verification	Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	Autophagy Cytochrome P450 p38 MAPK NF-κB
Isobavachin, an antioxidant isaolated from Psoralea corylifolia with a prenyl group at position 8 of ring A, promotes neuronal differentiation and the potential role of its protein prenylation .

HY-W021267

3-Demethylcolchicine	Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species (ROS)
3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema .

HY-124003

Phytomonic acid	Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Phytomonic acid is a long-chain fatty acid containing a cyclopropane ring produced by Lactobacillus reuteri. Lactobacilli that normally produce Lactobacillic acid also have the ability to resist TNF-α .

HY-N11925

(+)-Osbeckic acid	Polygonaceae Source classification Fagopyrum tataricum (L.) Gaertn. Plants	Others
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM .

HY-N3558

Ceanothic acid Emmolic acid	Other Terpenoids other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Ceanothic acid (Emmolic acid) is a ring-A homologue of betulinic acid. Ceanothic acid inhibits OVCAR-3, HeLa, and FS-5 cells with the cell survival of 68%, 65%, and 81%, respectively .

HY-N15186

Gymnoascolide A	Natural Products Microorganisms Source classification	Fungal
Gymnoascolide A, identified as a fungal metabolite in M. filamentosa, demonstrates vasodilatory effects. At a concentration of 1 µM, it effectively inhibits contractions induced by calcium in isolated rat aortic rings .

HY-N10117

2,3-Bis(3-indolylmethyl)indole	Alkaloids Hordeum vulgare var. coeleste Linnaeus Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	RANKL/RANK
2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.

HY-W005255R

3-(3-Hydroxyphenyl)propionic acid (Standard)	Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Reference Standards Endogenous Metabolite
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Cardiovascular Disease Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and endothelial nitric oxide synthase (eNOS) activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-N14729

De-N-methylpamamycin-593A	Natural Products Microorganisms Source classification	Fungal
De-N-methylpamamycin-593A is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593A has Aerial Mycelium-inducing activity .

HY-N0097

Guanosine 5+ Cited Publications DL-Guanosine; Vernine	Infection Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Anti-aging Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields	HSV Endogenous Metabolite
Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

HY-N14730

De-N-methylpamamycin-593B	Natural Products Microorganisms Source classification	Fungal
De-N-methylpamamycin-593B is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593B has Aerial Mycelium-inducing activity .

HY-W016278

Gamma-undecalactone	Microorganisms Source classification	Biochemical Assay Reagents
Gamma-undecalactone consists of a five-membered dihydrofuran ring with an ester group and a heptyl chain. This compound has a fruity smell and is commonly used as a flavor additive in various food and beverage products such as coffee, tea and baked goods.

HY-W017189R

3-Phenylbutyric acid (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid can be used to isolate Rhodococcus rhodochrous PB1 from compost soil .

HY-W017189

3-Phenylbutyric acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid can be used to isolate Rhodococcus rhodochrous PB1 from compost soil .

HY-119465

Restricticin	Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Restricticin is a compound obtained from marine fungi, whose structure contains alkene, tetrahydropyran ring and glycine ester functional groups, and has anti-neuroinflammatory effects in lipopolysaccharide-induced BV-2 microglia by inhibiting the production of proinflammatory mediators.

HY-N12170

Kissoone C	Terpenoids Sesquiterpenes Source classification Valeriana officinalis Linn. Plants Valerianaceae	Others
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-N6718

Filipin III Maximum Cited Publications 13 Publications Verification	Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics	Antibiotic Fungal
Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure .

HY-100593

Spiramycin 1 Publications Verification Rovamycin	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Disease Research Fields	Bacterial Parasite Antibiotic
Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached .

HY-107486

Nosiheptide Multhiomycin; RP 9671	Infection Microorganisms Antibiotics Source classification Animal Husbandry Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .

HY-N3426

Kazinol B	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	NO Synthase Akt AMPK
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research .

HY-W021267R

3-Demethylcolchicine (Standard)	Alkaloids Monophenols other families Other Alkaloids Source classification Phenols Plants	Reference Standards Reactive Oxygen Species (ROS)
3-Demethylcolchicine (Standard) is the analytical standard of 3-Demethylcolchicine. This product is intended for research and analytical applications. 3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema .

HY-Y1055

Guanine 3 Publications Verification	Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y1055R

Guanine (Standard)	Natural Products Microorganisms Source classification Endogenous metabolite	Reference Standards DNA/RNA Synthesis Endogenous Metabolite
Guanine (Standard) is the analytical standard of Guanine. This product is intended for research and analytical applications. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool .

HY-134650

(4E)-7-(4-Hydroxyphenyl)-1-phenylhept-4-en-3-one	Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Biochemical Assay Reagents
(4E)-7-(4-Hydroxyphenyl)-1-phenylhept-4-en-3-one (Compound 8) is a diarylheptanoid containing two benzene rings. Diarylheptanoid is widely distributed in Alpinia, and exhibits cytotoxic, anti-inflammatory, antiplatelet, antioxidant, and antiproliferative activities .

HY-N7082

D-Arabinopyranose	Infection Microorganisms Classification of Application Fields Source classification Disease Research Fields Saccharides Monosaccharides	Parasite Bacterial AMPK PPAR
D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N16025

DOPE-PEG(2000) Amine ammonium	Lipid	Biochemical Assay Reagents
DOPE-PEG(2000) Amine ammonium is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring .

HY-107486R

Nosiheptide (Standard) Multhiomycin (Standard); RP 9671 (Standard)	Microorganisms Antibiotics Source classification Animal Husbandry Antibacterial Disease Research Other Antibiotics	Reference Standards Bacterial Antibiotic
Nosiheptide (Standard) is the analytical standard of Nosiheptide. This product is intended for research and analytical applications. Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .

HY-N13614

Centaurein	Flavonoids Flavones Source classification Amburana cearensis (Allemão) A.C.Sm. Plants Compositae	Bacterial IFNAR Nuclear Factor of activated T Cells (NFAT) NF-κB
Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection ^[1][2][3][4].

HY-76228

1H-pyrazole Pyrazole	Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Intermediate Biochemical Assay Reagents
1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-121125

Aucubigenin	Plantaginaceae Iridoids Terpenoids Source classification Plants Pseudolysimachion linariifolium subsp. dilatatum (Nakai & Kitag.) D. Y. Hong	Others
Aucubigenin, the aglycone of the iridoid glycoside aucubin, has been characterized through X-ray diffraction analysis. Its crystal structure reveals monoclinic symmetry with specific conformations adopted by its cyclopentane and pyran rings. The study also determined the absolute configurations of both aucubin and aucubigenin. Significant O-H O hydrogen bonding interactions were observed in the crystal lattices of both compounds, highlighting their structural stability and potential for intermolecular interactions .

HY-N1773

5,7,3'-Tri-O-methyl (-)-epicatechin	Machilus thunbergii Sieb. et Zucc. Flavonoids Flavanols Source classification Plants Lauraceae	Others
5,7,3' -tri-O-Methyl (-)-epicatechin (Compound 13) is a phospholipase Cγ1 (PLCγ1) inhibitor. 5,7,3' -tri-o-methyl (-)-epicatechin has a methylene dioxy benzene ring and can express inhibitory activity against PLCγ1. 5,7,3' -tri-O-Methyl (-)-epicatechin can be used in the study of chemotherapy and chemopexic agents for cancer .

HY-W016103

1-Hydroxy-2-naphthoic acid	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Bacterial
1-Hydroxy-2-naphthoic acid is a polycyclic aromatic hydrocarbon (PAHs) degradation intermediate, mainly formed during the microbial degradation of aromatic hydrocarbons such as phenanthrene and naphthalene. 1-Hydroxy-2-naphthoic acid can undergo further hydroxylation, resulting in the naphthalene degradation pathway, or direct ring opening, leading to the phthalic acid pathway. 1-Hydroxy-2-naphthoic acid can be eliminated by introducing a heterologous salicylate hydroxylase gene (nahG) into the degrading bacterium .

HY-Y0337A

L-Cysteine hydrochloride 5+ Cited Publications	Classification of Application Fields Anti-aging Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

HY-76228R

1H-pyrazole (Standard)	Alkaloids Other Alkaloids Source classification Endogenous metabolite	Drug Intermediate Biochemical Assay Reagents
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-N0097R

Guanosine (Standard) DL-Guanosine (Standard); Vernine (Standard)	Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite	Reference Standards HSV Endogenous Metabolite
Guanosine (Standard) is the analytical standard of Guanosine. This product is intended for research and analytical applications. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. In Vitro: Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP).

HY-12545

Brevetoxin-3 PbTx-3	Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺ channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

Cat. No.	Product Name	Chemical Structure

HY-15917S2

DL-dithiothreitol-d6
DL-dithiothreitol-d₆ is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-Y1055S

Guanine-13C
Guanine- ¹³C is the ¹³C labeled Guanine . Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-15917S

DL-dithiothreitol-d10
DL-dithiothreitol-d₁₀ is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .

HY-N7106S

*Dimethyl phthalate (Ring-d4)*
Dimethyl phthalate (Ring-d₄) is the deuterium labeled Dimethyl phthalate. Dimethyl phthalate, a known endocrine disruptor and one of the phthalate esters (PAEs), is a ubiquitous pollutant. Dimethyl phthalate is commonly used as a plasticizer to impart flexibility to rigid polyvinylchloride (PVC) resins .

HY-N0097S3

Guanosine-15N5
Guanosine- ¹⁵N₅ is the ¹⁵N labeled Guanosine . Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-Y1055S3

Guanine-15N5
Guanine- ¹⁵N₅ is ¹⁵N labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-Y1055S1

Guanine-13C,15N2
Guanine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Guanine . Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-Y1055S4

Guanine-13C5
Guanine- ¹³C₅ is ¹³C-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-N0097S4

Guanosine-13C10
Guanosine- ¹³C₁₀ is the ¹³C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-15917S1

DL-dithiothreitol-d10-1
DL-dithiothreitol-d₁₀-1 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond .

HY-N0097S1

Guanosine-8-d-1
Guanosine-8-d-1 is the deuterium labeled Guanosine. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activ .

HY-B1449S10

Uridine-13C5 1 Publications Verification
Uridine- ¹³C₅ (β-Uridine- ¹³C₅) is a ¹³C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.

HY-B1449S12

Uridine-d12
Uridine-d12 (β-Uridine-d12) is the deuterium labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .

HY-Y1055S2

Guanine-13C5,15N5
Guanine- ¹³C₅, ¹⁵N₅ is ¹³C and ¹⁵N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

HY-177079S

Dazodeunetant
Dazodeunetant (Example 56) is a nitrogen-containing fused ring derivative. Dazodeunetant is an inhibitor of neurokinin (NK). Dazodeunetant has an IC₅₀ 0f 75.99 nM against NK3R in HEK293-NK3 (IP1). Dazodeunetant can be studied in research for menopausal hot flashes .

HY-N0097S5

Guanosine-d13
Guanosine-d13 (DL-Guanosine-d13) is a deuterium of Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-N0097S6

Guanosine-13C10,15N5
Guanosine- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-20128S

Piperazin-2-one-d6
Piperazin-2-one-d₆ is the deuterium labeled Piperazin-2-one (HY-20128). Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds .

HY-B1449S11

Uridine-13C9
Uridine- ¹³C₉ (β-Uridine- ¹³C₉) is a ¹³C9-labeled form of Uridine (HY-B1449). Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .

HY-116852S

Thiocolchicine-d3

Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC₅₀=2.5 μM) and competitively binds to tubulin with a K_i of 0.7 μM. Thiocolchicine induces cell apoptosis . Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-N7082S

D-Arabinopyranose-13C5

D-Arabinopyranos- ¹³C₅ is ¹³C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-W778114

Guanine-13C2,7-15N

Guanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-W777809

Guanine-13C2,15N

HY-W751165

Uridine-13C9,15N2
Uridine-13C9,15N2 (β-Uridine-13C9,15N2) is ¹³C and ¹⁵N labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond .

HY-135334S

ACP-5862-d4

ACP-5862-d₄ is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC₅₀ of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC₅₀ of 3 nM and EC₅₀ of 8 nM .

HY-B0573S1

Propranolol-d7 (ring-d7)

Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-W779244

1H-Pyrazole-3,4,5-d3
1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-N0059S4

D-Arabinose-d2

D-Arabinose-d₂ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S

D-Arabinose-13C

D-Arabinose- ¹³C is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S6

D-Arabinose-d6

D-Arabinose-d₆ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S5

D-Arabinose-d5

D-Arabinose-d₅ is the deuterium labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S1

D-Arabinose-13C-1

D-Arabinose- ¹³C-1 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S2

D-arabinose-13C-2

D-Arabinose- ¹³C-2 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

HY-N0059S3

D-Arabinose-13C-3

D-Arabinose- ¹³C-3 is the ¹³C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .

Cat. No.	Product Name		Classification

HY-B1449

Uridine 10+ Cited Publications β-Uridine		Nucleoside Analogs Uridine
Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond .

HY-N0097

Guanosine 5+ Cited Publications DL-Guanosine; Vernine		Nucleoside Analogs Guanosine
Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

HY-148230

TFEB Decoy ODN sodium		Decoy ODNs
TFEB Decoy ODN sodium is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB). TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects.

HY-RS24886

Ring1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ring1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ring1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18405

Ring1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ring1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ring1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11985

RING1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RING1 Human Pre-designed siRNA Set A contains three designed siRNAs for RING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-157648

18:0-20:4 PI(3)P ammonium		Phospholipids
18:0-20:4 PI(3)P ammonium can be obtained by phosphorylation of the inositol ring of phosphatidylinositol and can be used in the preparation of liposomes.

HY-W440991

DOPE-PEG-Amine (MW 2000)		Pegylated Lipids
DOPE-PEG-Amine (MW 2000) is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring.

HY-174563

Human OLA1 mRNA		mRNA
Human OLA1 mRNA encodes the human Obg like ATPase 1 (OLA1) protein, a member of the GTPase protein family. OLA1 interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation.

HY-155902B

Mal-PEG-OH (MW 1000) Maleimide-PEG-Hydroxy (MW 1000)		Polymers
Mal-PEG-OH (MW 1000) was used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902A

Mal-PEG-OH (MW 2000) Maleimide-PEG-Hydroxy (MW 2000)		Polymers
Mal-PEG-OH (MW 2000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-155902

Mal-PEG-OH (MW 5000) Maleimide-PEG-Hydroxy (MW 5000)		Polymers
Mal-PEG-OH (MW 5000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.

HY-157693

C18:1 Cyclic LPA		Phospholipids
C18:1 Cyclic LPA is a naturally occurring analog of the growth factor-like phospholipid mediator, lysophosphatidic acid (LPA), characterized by the formation of a 5-membered ring between its sn-2 hydroxy group and the sn-3 phosphate. This unique structure allows C18:1 Cyclic LPA to influence a variety of cellular functions, such as inhibiting cell cycle progression, promoting the formation of stress fibers, curtailing tumor cell invasiveness and metastasis, and modulating the differentiation and survival of neuronal cells. Notably, many of these cellular effects elicited by C18:1 Cyclic LPA appear to counter those induced by LPA, despite the activation of seemingly similar receptor populations.

HY-148505

5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)		Nucleoside Phosphoramidites Cytosine
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds .

HY-132137

5-Propargylamino-3'-azidomethyl-dUTP		Nucleotide Analogs
5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)		Nucleoside Phosphoramidites Adenine
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .

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