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  4. 3-Picolylamine

3-Picolylamine  (Synonyms: Picolamine; 3-Pyridinemethanamine; Pyridin-3-ylmethanamine)

Cat. No.: HY-Y0047 Purity: 99.36%
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Handling Instructions Technical Support

3-Picolylamine is a primary amine compound containing a pyridine ring structure. 3-Picolylamine inhibits histaminase (diamine oxidase) activity in pig kidneys. 3-Picolylamine significantly enhances the contractile response of isolated guinea pig ileum to Histamine (HY-B1204). 3-Picolylamine can be used to study histamine-related physiological mechanisms or allergic diseases (such as histamine-mediated inflammatory responses).

For research use only. We do not sell to patients.

3-Picolylamine Chemical Structure

3-Picolylamine Chemical Structure

CAS No. : 3731-52-0

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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3-Picolylamine Related Antibodies

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Description

3-Picolylamine is a primary amine compound containing a pyridine ring structure. 3-Picolylamine inhibits histaminase (diamine oxidase) activity in pig kidneys. 3-Picolylamine significantly enhances the contractile response of isolated guinea pig ileum to Histamine (HY-B1204). 3-Picolylamine can be used to study histamine-related physiological mechanisms or allergic diseases (such as histamine-mediated inflammatory responses)[1][2].

In Vitro

3-picolylamine significantly potentiates the ileal contractile response to histamine[2].
3-Picolylamine inhibits the oxidation of cadaverine and histamine by porcine kidney histaminase with an IC50 of approximately 133 µM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Picolylamine Related Antibodies
Molecular Weight

108.14

Formula

C6H8N2
CAS No.
Appearance

Liquid (Density: 1.062  g/cm3)

Color

Colorless to light yellow

SMILES

NCC1=CC=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (924.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.2473 mL 46.2364 mL 92.4727 mL
5 mM 1.8495 mL 9.2473 mL 18.4945 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.36%

SDS (476 KB)

COA (245 KB) HNMR (112 KB) LCMS (94 KB) GC (215 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.2473 mL 46.2364 mL 92.4727 mL 231.1818 mL
5 mM 1.8495 mL 9.2473 mL 18.4945 mL 46.2364 mL
10 mM 0.9247 mL 4.6236 mL 9.2473 mL 23.1182 mL
15 mM 0.6165 mL 3.0824 mL 6.1648 mL 15.4121 mL
20 mM 0.4624 mL 2.3118 mL 4.6236 mL 11.5591 mL
25 mM 0.3699 mL 1.8495 mL 3.6989 mL 9.2473 mL
30 mM 0.3082 mL 1.5412 mL 3.0824 mL 7.7061 mL
40 mM 0.2312 mL 1.1559 mL 2.3118 mL 5.7795 mL
50 mM 0.1849 mL 0.9247 mL 1.8495 mL 4.6236 mL
60 mM 0.1541 mL 0.7706 mL 1.5412 mL 3.8530 mL
80 mM 0.1156 mL 0.5780 mL 1.1559 mL 2.8898 mL
100 mM 0.0925 mL 0.4624 mL 0.9247 mL 2.3118 mL
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3-Picolylamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Picolylamine3731-52-0Picolamine 3-Pyridinemethanamine Pyridin-3-ylmethanamineBiochemical Assay ReagentsInhibitorinhibitorinhibit

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