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  4. Tetramethylammonium fluoride tetrahydrate

Tetramethylammonium fluoride tetrahydrate 

Cat. No.: HY-W095635 Purity: ≥98.0%
COA
SDS
Handling Instructions Technical Support

Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

For research use only. We do not sell to patients.

Tetramethylammonium fluoride tetrahydrate Chemical Structure

Tetramethylammonium fluoride tetrahydrate Chemical Structure

CAS No. : 17787-40-5

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25 g In-stock
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Tetramethylammonium fluoride tetrahydrate Related Antibodies

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Description

Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.

In Vitro

Tetramethylammonium fluoride tetrahydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetramethylammonium fluoride tetrahydrate Related Antibodies
Molecular Weight

165.20

Formula

C4H20FNO4
CAS No.
Appearance

<39°C Solid,>42°C Liquid

Color

Colorless to off-white

SMILES

C[N+](C)(C)C.[F-].O.O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (302.66 mM; Need ultrasonic)

DMSO : 2 mg/mL (12.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0533 mL 30.2663 mL 60.5327 mL
5 mM 1.2107 mL 6.0533 mL 12.1065 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.0533 mL 30.2663 mL 60.5327 mL 151.3317 mL
5 mM 1.2107 mL 6.0533 mL 12.1065 mL 30.2663 mL
10 mM 0.6053 mL 3.0266 mL 6.0533 mL 15.1332 mL
H2O 15 mM 0.4036 mL 2.0178 mL 4.0355 mL 10.0888 mL
20 mM 0.3027 mL 1.5133 mL 3.0266 mL 7.5666 mL
25 mM 0.2421 mL 1.2107 mL 2.4213 mL 6.0533 mL
30 mM 0.2018 mL 1.0089 mL 2.0178 mL 5.0444 mL
40 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
50 mM 0.1211 mL 0.6053 mL 1.2107 mL 3.0266 mL
60 mM 0.1009 mL 0.5044 mL 1.0089 mL 2.5222 mL
80 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8916 mL
100 mM 0.0605 mL 0.3027 mL 0.6053 mL 1.5133 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tetramethylammonium fluoride tetrahydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetramethylammonium fluoride tetrahydrate17787-40-5Biochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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