Azido-PEG(4)-Val-Cit-PAB-PNP

Cat. No.: HY-151726: Data Sheet Handling Instructions
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Azido-PEG(4)-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. Azido-PEG(4)-Val-Cit-PAB-PNP is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azido-PEG(4)-Val-Cit-PAB-PNP Chemical Structure

CAS No. : 1869126-60-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
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Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

817.84

Formula

C₃₆H₅₁N₉O₁₃

CAS No.

1869126-60-2

Appearance

Solid

Color

white

SMILES

[N-]=[N+]=NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (122.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2227 mL	6.1137 mL	12.2273 mL
5 mM	0.2445 mL	1.2227 mL	2.4455 mL
10 mM	0.1223 mL	0.6114 mL	1.2227 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2227 mL	6.1137 mL	12.2273 mL	30.5683 mL
	5 mM	0.2445 mL	1.2227 mL	2.4455 mL	6.1137 mL
	10 mM	0.1223 mL	0.6114 mL	1.2227 mL	3.0568 mL
	15 mM	0.0815 mL	0.4076 mL	0.8152 mL	2.0379 mL
	20 mM	0.0611 mL	0.3057 mL	0.6114 mL	1.5284 mL
	25 mM	0.0489 mL	0.2445 mL	0.4891 mL	1.2227 mL
	30 mM	0.0408 mL	0.2038 mL	0.4076 mL	1.0189 mL
	40 mM	0.0306 mL	0.1528 mL	0.3057 mL	0.7642 mL
	50 mM	0.0245 mL	0.1223 mL	0.2445 mL	0.6114 mL
	60 mM	0.0204 mL	0.1019 mL	0.2038 mL	0.5095 mL
	80 mM	0.0153 mL	0.0764 mL	0.1528 mL	0.3821 mL
	100 mM	0.0122 mL	0.0611 mL	0.1223 mL	0.3057 mL