2. Metabolic Enzyme/Protease Apoptosis
  3. NEDD8-activating Enzyme Apoptosis
  4. Pevonedistat (Standard)

Pevonedistat (Standard) is the analytical standard of Pevonedistat. This product is intended for research and analytical applications. Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice.

For research use only. We do not sell to patients.

Pevonedistat (Standard) Chemical Structure

Pevonedistat (Standard) Chemical Structure

CAS No. : 905579-51-3

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Description
Molecular Weight

443.52

Formula

C21H25N5O4S
CAS No.
SMILES

O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Pevonedistat (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pevonedistat (Standard)905579-51-3NEDD8-activating EnzymeApoptosisNAEInhibitorinhibitorinhibit

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