Search Result

Results for "

oral carcinoma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (8) Antibiotic (1) Apoptosis (36) Arf Family GTPase (2) ATM/ATR (2) ATP Citrate Lyase (1) Autophagy (19) Bacterial (1) Bcl-2 Family (6) c-Met/HGFR (8) Calcium Channel (2) Caspase (4) CDK (15) COX (6) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (1) Deubiquitinase (1) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (1) Drug Metabolite (2) DYRK (2) EBV (1) EGFR (7) Endogenous Metabolite (1) Epigenetic Reader Domain (1) ERK (4) Estrogen Receptor/ERR (2) Ferroptosis (2) FGFR (3) Fluorescent Dye (1) FXR (2) Glutathione S-transferase (1) HBV (1) HCV (3) HDAC (3) Hedgehog (3) HIF/HIF Prolyl-Hydroxylase (5) Histone Acetyltransferase (3) Histone Methyltransferase (2) HSP (2) IAP (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Interleukin Related (5) Isotope-Labeled Compounds (4) JAK (4) JNK (2) Leukotriene Receptor (2) Lipoxygenase (2) LXR (2) MDM-2/p53 (2) MEK (1) MicroRNA (1) Microtubule/Tubulin (1) MMP (1) Molecular Glues (1) mTOR (2) Na+/H+ Exchanger (NHE) (4) Na+/K+ ATPase (1) Necroptosis (1) NEKs (1) Neuropeptide Y Receptor (1) NF-κB (5) Nuclear Factor of activated T Cells (NFAT) (1) P-glycoprotein (1) p38 MAPK (10) PARP (2) PD-1/PD-L1 (1) PERK (1) PI3K (3) PI5P4K (1) PKA (2) Polo-like Kinase (PLK) (1) Prostaglandin Receptor (4) PROTACs (1) Pyroptosis (1) RAR/RXR (4) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (14) Renin (2) RET (1) ROR (2) SHP2 (1) Sirtuin (3) SphK (2) STAT (4) Syk (2) TNF Receptor (2) Toll-like Receptor (TLR) (1) Topoisomerase (2) Transmembrane Glycoprotein (1) Trk Receptor (1) TRP Channel (4) Tyrosinase (1) Vasopressin Receptor (1) VEGFR (5)
By Research Areas:	Cancer (126) Cardiovascular Disease (13) Endocrinology (2) Infection (4) Inflammation/Immunology (23) Metabolic Disease (4) Neurological Disease (4)

By Targets:

5-HT Receptor (1)

Akt (8)

Antibiotic (1)

Apoptosis (36)

Arf Family GTPase (2)

ATM/ATR (2)

ATP Citrate Lyase (1)

Autophagy (19)

Bacterial (1)

Bcl-2 Family (6)

c-Met/HGFR (8)

Calcium Channel (2)

Caspase (4)

CDK (15)

COX (6)

Cyclin G-associated Kinase (GAK) (1)

Cyclophilin (1)

Deubiquitinase (1)

DNA Alkylator/Crosslinker (4)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

DYRK (2)

EBV (1)

EGFR (7)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

ERK (4)

Estrogen Receptor/ERR (2)

Ferroptosis (2)

FGFR (3)

Fluorescent Dye (1)

FXR (2)

Glutathione S-transferase (1)

HBV (1)

HCV (3)

HDAC (3)

Hedgehog (3)

HIF/HIF Prolyl-Hydroxylase (5)

Histone Acetyltransferase (3)

Histone Methyltransferase (2)

HSP (2)

IAP (3)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (1)

Interleukin Related (5)

Isotope-Labeled Compounds (4)

JAK (4)

JNK (2)

Leukotriene Receptor (2)

Lipoxygenase (2)

LXR (2)

MDM-2/p53 (2)

MEK (1)

MicroRNA (1)

Microtubule/Tubulin (1)

MMP (1)

Molecular Glues (1)

mTOR (2)

Na+/H+ Exchanger (NHE) (4)

Na+/K+ ATPase (1)

Necroptosis (1)

NEKs (1)

Neuropeptide Y Receptor (1)

NF-κB (5)

Nuclear Factor of activated T Cells (NFAT) (1)

P-glycoprotein (1)

p38 MAPK (10)

PARP (2)

PD-1/PD-L1 (1)

PERK (1)

PI3K (3)

PI5P4K (1)

PKA (2)

Polo-like Kinase (PLK) (1)

Prostaglandin Receptor (4)

PROTACs (1)

Pyroptosis (1)

RAR/RXR (4)

Ras (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (14)

Renin (2)

RET (1)

ROR (2)

SHP2 (1)

Sirtuin (3)

SphK (2)

STAT (4)

Syk (2)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

Topoisomerase (2)

Transmembrane Glycoprotein (1)

Trk Receptor (1)

TRP Channel (4)

Tyrosinase (1)

Vasopressin Receptor (1)

VEGFR (5)

By Research Areas:

Cancer (126)

Cardiovascular Disease (13)

Endocrinology (2)

Infection (4)

Inflammation/Immunology (23)

Metabolic Disease (4)

Neurological Disease (4)

129

Inhibitors & Agonists

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106735

Arotinoid Ro 13-6298; Arotinoid ethyl ester	RAR/RXR	Inflammation/Immunology Cancer
Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED₅₀ of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas .

HY-N0746

Oxysophocarpine 4 Publications Verification	Others	Cancer
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .

HY-101246

RPI-1	RET	Cancer
RPI-1 is a specific, orally available 2-indolinone Ret tyrosine kinase inhibitor. RPI-1 inhibits proliferation, Ret tyrosine phosphorylation, Ret protein expression, and the activation of PLCgamma, ERKs and AKT in human medullary thyroid carcinoma TT cells. Antitumor activity .

HY-103317A

NAADP tetrasodium	Calcium Channel	Cardiovascular Disease Cancer
NAADP tetrasodium is a second messenger. NAADP tetrasodium releases Ca ²⁺ from acidic endosomes and lysosomes. NAADP tetrasodium can be used to study cancer (such as oral squamous cell carcinoma, malignant melanoma) and angiogenesis-related diseases .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-170647

SEPT9-IN-1	Ras	Cancer
SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC₅₀ value of 94.83 μM. SEPT9-IN-1 shows cytotoxicity to human oral squamous carcinomas with an IC₅₀ value of 21 µM .

HY-10320G

Doramapimod (GMP) BIRB 796 (GMP)	p38 MAPK	Cancer
Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC₅₀s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity .

HY-155785

MTP	Apoptosis Autophagy Reactive Oxygen Species (ROS) JAK	Cancer
MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases ROS generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma .

HY-144254

PI3Kδ-IN-10	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC₅₀ of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models .

HY-W599279

ABS-752	Molecular Glues NEKs	Cancer
ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 shows anticancer activity. ABS-752 has the potential for the research of hepatocellular carcinoma .

HY-N12960

Artobiloxanthone	Apoptosis Bcl-2 Family Caspase COX MMP STAT	Cancer
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC₅₀ of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9 .

HY-106364

Peplomycin Bleomycin PEP; Pepleomycin	Antibiotic	Cancer
Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats .

HY-111458

GSK2643943A 5 Publications Verification	Deubiquitinase	Cancer
GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC₅₀ of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) .

HY-101266A

Milademetan tosylate DS-3032 tosylate	MDM-2/p53	Cancer
Milademetan tosylate is the tosylate salt form of Milademetan (HY-101266). Milademetan tosylate is an orally active inhibitor for MDM2. Milademetan tosylate arrests the cell cycle at G1 pahse, induces the apoptosis Milademetan tosylate restores the p53 activity by targeting the p53-MDM2 interaction, and exhibits anticancer activity against Merkel cell carcinoma (MCC) .

HY-114594

Khusimol	Vasopressin Receptor	Others
Khusimol is a compound used in chemotherapy for oral squamous cell carcinoma.

HY-151461

CHNQD-01255	Arf Family GTPase	Cancer
CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy .

HY-N1261

Scutebarbatine B	Others	Cancer
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

HY-171450

VMD-928	Trk Receptor	Cancer
VMD-928 is an orally active, allosteric, irreversible and selective tropomyosin receptor kinase A (TrkA) inhibitor. VMD-928 blocks the downstream signaling pathways triggered by the binding of nerve growth factor (NGF) to TrkA, thereby inhibiting cell proliferation, invasion, and promoting cancer cell death. VMD-928 is promising for research of various cancers, including prostate cancer, thymic carcinoma, mesothelioma, squamous cell carcinoma of the head and neck, squamous cell carcinoma of the lung, ovarian cancer, hepatocellular carcinoma .

HY-101840A

EIPA hydrochloride 70+ Cited Publications L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride	TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-19909A

NRC-2694-A	EGFR	Cancer
NRC-2694-A is an orally effective EGFR tyrosine kinase inhibitor. NRC-2694-A can be used in the study of malignant squamous cell carcinoma (HNSCC) .

HY-W725179

VK-2019	EBV	Cancer
VK-2019 is an oral active, selective EBNA1((Epstein-Barr Nuclear Antigen 1) inhibitor and can be used for study of EBV-associated carcinomas .

HY-14653

Amsilarotene TAC-101; Am 555S	RAR/RXR Apoptosis	Cancer
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with K_i of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .

HY-101840

EIPA 70+ Cited Publications L593754; MH 12-43; Ethylisopropylamiloride	TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-N8380

(-)-Latifolin	Apoptosis Autophagy PI3K Necroptosis	Cardiovascular Disease Inflammation/Immunology Cancer
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

HY-N12760

Lobophorin CR-2	Others	Cancer
Lobophorin CR-2 is a lobophorin congener which induces UPR-associated gene expression, inhibits oral squamous cell carcinoma cell growth, and causes UPR-dependent cell death in MEF cells .

HY-101840AR

EIPA hydrochloride (Standard) L593754 hydrochloride (Standard); MH 12-43 hydrochloride (Standard); Ethylisopropylamiloride hydrochloride (Standard)	Reference Standards TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-101840R

EIPA (Standard) L593754 (Standard); MH 12-43 (Standard); Ethylisopropylamiloride (Standard)	Reference Standards TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-153967

BLU0588 1 Publications Verification	PKA	Cancer
BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC₅₀ of 1 nM and dissociation constant (K_d) of 4 nM. BLU0588 can be used for fibrolamellar carcinoma (FLC) research .

HY-159644

Casdatifan AB521	HIF/HIF Prolyl-Hydroxylase	Cancer
Casdatifan (AB521) is an orally active HIF-2α (hypoxia-inducible factor 2α) inhibitor. Casdatifan exhibited significant antitumor activity and favorable pharmacokinetics in ccRCC (clear cell renal cell carcinoma) models .

HY-13593

Chlorambucil 4 Publications Verification CB-1348; WR-139013	DNA Alkylator/Crosslinker	Cancer
Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

HY-103706

ROC-325 1 Publications Verification	Autophagy Apoptosis	Cancer
ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis .

HY-168920

NSD-IN-4	Histone Methyltransferase Apoptosis	Cancer
NSD-IN-4 (Compound A8) is a potent and an orally active NSD3 inhibitor. NSD-IN-4 induces Apoptosis in a dose-dependent manner. NSD-IN-4 exhibits significant antitumor effects against lung squamous carcinoma .

HY-N0530

Dryocrassin ABBA 2 Publications Verification Dryocrassin	Apoptosis Influenza Virus	Cancer
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase .

HY-119425

Razoxane ICRF 159	Topoisomerase	Cancer
Razoxane (ICRF 159), a EDTA (HY-Y0682) derivative, is an orally active antiangiogenic topoisomerase II inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer .

HY-100492

Fisogatinib 3 Publications Verification BLU-554	FGFR	Cancer
Fisogatinib (BLU-554) is a potent, highly selective and orally active fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC₅₀ of 5 nM. Fisogatinib has significant anti-tumor activity in models of hepatocellular carcinoma (HCC) that are dependent on FGFR4 signalling .

HY-W010593

Ethylenethiourea	Drug Metabolite	Cancer
Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .

HY-W010593R

Ethylenethiourea (Standard)	Drug Metabolite Reference Standards	Cancer
Ethylenethiourea (Standard) is the analytical standard of Ethylenethiourea. This product is intended for research and analytical applications. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .

HY-114338A

Dalpiciclib hydrochloride SHR-6390 hydrochloride	CDK	Cancer
Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC₅₀ values of 12.4 nM and 9.9 nM, respectively . Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal squamous cell carcinoma .

HY-163569

FGFR4-IN-20	FGFR	Cancer
FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor with IC₅₀s of 19 and 36 nM against Huh7 cells and FGFR4 enzyme. FGFR4-IN-20 can be used for hepatocellular carcinoma research .

HY-114338

Dalpiciclib SHR-6390	CDK	Cancer
Dalpiciclib (SHR-6390) is an orally active and highly selective inhibitor of CDK4 and 6 with IC₅₀ values of 12.4 nM and 9.9 nM, respectively . Dalpiciclib shows antitumor activity against breast cancer and esophageal squamous cell carcinoma .

HY-N3665

Cyclocommunol	Tyrosinase	Cancer
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

HY-N0746R

Oxysophocarpine (Standard)	Reference Standards Others	Cancer
Oxysophocarpine (Standard) is the analytical standard of Oxysophocarpine. This product is intended for research and analytical applications. Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) .

HY-112532A

REV 5901 hydrochloride	Leukotriene Receptor Lipoxygenase	Inflammation/Immunology Cancer
REV 5901 hydrochloride is a competitive and orally active antagonist of leukotriene receptor, with a K_i of 0.7 μM. REV 5901 hydrochloride is also a 5-lipoxygenase inhibitor. REV 5901 hydrochloride can be used for the research of asthma in which leukotriene release be involved. REV 5901 hydrochloride can be used for the study of colon carcinoma .

HY-13593S

Chlorambucil-d8 CB-1348-d₈; WR-139013-d₈	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

HY-125840

Belzutifan 5+ Cited Publications PT2977; MK-6482	HIF/HIF Prolyl-Hydroxylase	Cancer
Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC₅₀ of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC) .

HY-112532

REV 5901	Leukotriene Receptor Lipoxygenase	Inflammation/Immunology Cancer
REV 5901 is a competitive and orally active antagonist of leukotriene receptor, with a K_i of 0.7 μM. REV 5901 is also a 5-lipoxygenase inhibitor. REV 5901 can be used for the research of asthma in which leukotriene release be involved. REV 5901 can be used for the study of colon carcinoma .

HY-13593S1

Chlorambucil-d8-1 CB-1348-d₈-1; WR-139013-d₈-1	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

HY-144614

JH-XVII-10	DYRK Apoptosis	Neurological Disease Cancer
JH-XVII-10 is a potent, selective and orally active DYRK1A and DYRK1B inhibitor with IC₅₀s of 3 nM and 5 nM for DYRK1A and DYRK1B, respectively. JH-XVII-10 shows antitumor efficacy in neck squamous cell carcinoma (HNSCC) cell lines .

HY-145835

PERK-IN-5	PERK	Cancer
PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC₅₀s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model .

HY-13593R

Chlorambucil (Standard) CB-1348 (Standard); WR-139013 (Standard)	Reference Standards DNA Alkylator/Crosslinker	Cancer
Chlorambucil (Standard) is the analytical standard of Chlorambucil. This product is intended for research and analytical applications. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

Cat. No.	Product Name	Target	Research Area

HY-P1130

M871 Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain) .

Cat. No.	Product Name	Target	Research Area

HY-P990173

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1)	PD-1/PD-L1	Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) is a mouse-derived PD-L1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) increases IFN-γ levels in organoid-primed T cells. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) can be used for the researches of cancer, such as oral squamous cell carcinoma and mammary cancer .

HY-P99139

Anti-Mouse IL-1b Antibody (B122)	Interleukin Related Reactive Oxygen Species (ROS) Ferroptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combined with Sulfasalazine (SAS) (HY-14655). Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for researches on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0746

Oxysophocarpine 4 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Sophora alopecuroides L Plants Disease Research Fields Cancer	Others
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .

HY-N0530

Dryocrassin ABBA 2 Publications Verification Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by Caspase .

HY-119906

Conglobatin FW-04-806	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N12960

Artobiloxanthone	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Artocarpus altilis (Parkinson) Fosberg	Apoptosis Bcl-2 Family Caspase COX MMP STAT
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC₅₀ of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9 .

HY-114594

Khusimol	Structural Classification Terpenoids Gramineae Sesquiterpenes Source classification Plants Chrysopogon zizanioides (L.) Roberty	Vasopressin Receptor
Khusimol is a compound used in chemotherapy for oral squamous cell carcinoma.

HY-N1261

Scutebarbatine B	Alkaloids Classification of Application Fields Labiatae Source classification Derris robusta Pyridine Alkaloids Plants Disease Research Fields Cancer	Others
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

HY-N8380

(-)-Latifolin	Structural Classification Dalbergia hupeana Hance Source classification Phenols Polyphenols Plants Fabaceae	Apoptosis Autophagy PI3K Necroptosis
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

HY-N12760

Lobophorin CR-2	Structural Classification Natural Products Microorganisms Source classification	Others
Lobophorin CR-2 is a lobophorin congener which induces UPR-associated gene expression, inhibits oral squamous cell carcinoma cell growth, and causes UPR-dependent cell death in MEF cells .

HY-N3665

Cyclocommunol	Flavonoids Source classification Distemonanthus benthamianus Baill. Plants Compositae Other Flavonoids	Tyrosinase
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

HY-N0746R

Oxysophocarpine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Source classification Sophora alopecuroides L Plants	Reference Standards Others
Oxysophocarpine (Standard) is the analytical standard of Oxysophocarpine. This product is intended for research and analytical applications. Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) .

HY-17473

Embelin 5 Publications Verification Embelic acid; Emberine; NSC 91874	Quinones Structural Classification Classification of Application Fields Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae Disease Research Fields Cancer	IAP NF-κB Apoptosis Autophagy
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N2115

Araloside A 1 Publications Verification Chikusetsusaponin IV	Cardiovascular Disease Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Renin Apoptosis Bcl-2 Family Interleukin Related
Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

HY-N0885

Telocinobufagin 1 Publications Verification Telobufotoxin; Telocinobufogenin	Structural Classification Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields Steroids	JAK STAT mTOR PI3K Akt Polo-like Kinase (PLK) Na+/K+ ATPase Apoptosis Bacterial
Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na ⁺/K ⁺-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models .

HY-N2115R

Araloside A (Standard) Chikusetsusaponin IV (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants Araliaceae	Reference Standards Renin Apoptosis Bcl-2 Family Interleukin Related
Araloside A (Standard) (Chikusetsusaponin IV (Standard)), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A (Standard) shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A (Standard) can inhibit cell proliferation and induce apoptosis. Araloside A (Standard) suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A (Standard) can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

HY-17473R

Embelin (Standard) Embelic acid (Standard); Emberine (Standard); NSC 91874 (Standard)	Quinones Structural Classification Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae	Reference Standards IAP NF-κB Apoptosis Autophagy
Embelin (Standard) is the analytical standard of Embelin. This product is intended for research and analytical applications. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-W403933R

12-Ketochenodeoxycholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Autophagy Reference Standards
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .

HY-N6954

Garcinone C 2 Publications Verification	Structural Classification other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	ATM/ATR STAT CDK Hedgehog
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .

HY-N10009

Cudraflavone B	Structural Classification Brosimopsis oblongifolia Source classification Phenols Polyphenols Plants Moraceae	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-N6576

Hellebrigenin	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	p38 MAPK ERK JNK IAP PARP Apoptosis Caspase
Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway (ERK, p38, JNK) and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins (Bcl-2, Bcl-xL) and upregulate pro-apoptotic proteins (Bax, Bak). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers .

HY-N6954R

Garcinone C (Standard)	Structural Classification other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Source classification Phenols Polyphenols Plants	Reference Standards ATM/ATR STAT CDK Hedgehog
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .

Cat. No.	Product Name	Chemical Structure

HY-W654305

Palbociclib-d4

Palbociclib-d₄ is deuterium labeled Palbociclib. Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC₅₀ values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma .