2. Protein Tyrosine Kinase/RTK
  3. VEGFR c-Met/HGFR
  4. Taligantinib

Taligantinib (Compound Example 70) is an orally active and selective dual inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and hepatocyte growth factor receptor (c-Met). Taligantinib suppresses tumor angiogenesis and cell proliferation. Taligantinib is promising for research of solid tumors such as non-small cell lung cancer and hepatocellular carcinoma.

For research use only. We do not sell to patients.

Taligantinib Chemical Structure

Taligantinib Chemical Structure

CAS No. : 2243235-80-3

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Taligantinib Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

Taligantinib (Compound Example 70) is an orally active and selective dual inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2) and hepatocyte growth factor receptor (c-Met). Taligantinib suppresses tumor angiogenesis and cell proliferation. Taligantinib is promising for research of solid tumors such as non-small cell lung cancer and hepatocellular carcinoma[1].

IC50 & Target

VEGFR2

 

c-Met

 

Molecular Weight

660.66

Formula

C35H34F2N4O7
CAS No.
SMILES

O=C(C1(CC1)C(NC2=CC=C(C(F)=C2)OC3=CC=NC4=CC(OCCCN5CCOCC5)=C6OCCOC6=C43)=O)NC7=CC=C(C=C7)F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Taligantinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taligantinib2243235-80-3VEGFRc-Met/HGFRVascular endothelial growth factor receptorVEGFR-2c-Metsolid tumorsInhibitorinhibitorinhibit

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