2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Razoxane

Razoxane (ICRF 159), a EDTA (HY-Y0682) derivative, is an orally active antiangiogenic topoisomerase II inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer.

For research use only. We do not sell to patients.

Razoxane Chemical Structure

Razoxane Chemical Structure

CAS No. : 21416-67-1

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Based on 1 publication(s) in Google Scholar

Razoxane Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Razoxane (ICRF 159), a EDTA (HY-Y0682) derivative, is an orally active antiangiogenic topoisomerase II inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer[1][2].

IC50 & Target[1]

Topoisomerase II

 

In Vivo

Razoxane (30 mg/kg; i.p.) exhibits antimetastatic effects in a rat osteosarcoma model[2].
Early treatment with Razoxane (30 mg/kg i.p. from day -2 to +14) shows a greater inhibition of pulmonary metastases than later treatment (30 mg/kg i.p. from day +14 to +28 after transplantation)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[2]
Dosage: 30 mg/kg or 10 mg/kg per day
Administration: Intraperitoneally (i.p.) from 2 days before to 14 days after tumor transplantation
Result: Resulted in a dose-dependent prolongation of median survival time (83 or 48 days respectively, versus 38 days for the control group), but showed no influence on the growth of the primary tumor.
Molecular Weight

268.27

Formula

C11H16N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(CN(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Razoxane Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Razoxane21416-67-1ICRF 159ICRF159ICRF-159TopoisomeraseTopoisomerase II Inhibitorrenal cell carcinomaRCC,Inhibitorinhibitorinhibit

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