Search Result

Results for "

chronic pain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) AAK1 (6) Adenosine Receptor (1) Adenylate Cyclase (2) Adrenergic Receptor (4) Akt (4) Antibiotic (1) Apoptosis (9) Bacterial (1) Bradykinin Receptor (1) Calcium Channel (16) Cannabinoid Receptor (3) Caspase (4) COX (8) Cyclin G-associated Kinase (GAK) (3) Cytochrome P450 (2) Drug Derivative (1) EAAT (1) Endogenous Metabolite (4) FLT3 (1) Fungal (2) GABA Receptor (2) GlyT (1) Heme Oxygenase (HO) (2) HSP (2) iGluR (16) Influenza Virus (1) Isotope-Labeled Compounds (8) Keap1-Nrf2 (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) mGluR (3) MicroRNA (1) mTOR (2) Myosin (2) nAChR (1) Necroptosis (1) Neurokinin Receptor (1) Neurotensin Receptor (1) Opioid Receptor (8) P2X Receptor (10) P2Y Receptor (2) p38 MAPK (2) Parasite (1) PARP (2) PD-1/PD-L1 (1) PI3K (2) PI4P5K (1) Piezo Channel (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (9) Prostaglandin Receptor (3) Reactive Oxygen Species (ROS) (1) Reference Standards (9) SARS-CoV (3) Serotonin Transporter (4) Sigma Receptor (2) Sodium Channel (22) Somatostatin Receptor (2) Topoisomerase (1) Trk Receptor (4) TRP Channel (8) Virus Protease (2)
By Research Areas:	Cancer (33) Cardiovascular Disease (8) Endocrinology (1) Infection (8) Inflammation/Immunology (49) Metabolic Disease (4) Neurological Disease (95)

By Targets:

5-HT Receptor (1)

AAK1 (6)

Adenosine Receptor (1)

Adenylate Cyclase (2)

Adrenergic Receptor (4)

Akt (4)

Antibiotic (1)

Apoptosis (9)

Bacterial (1)

Bradykinin Receptor (1)

Calcium Channel (16)

Cannabinoid Receptor (3)

Caspase (4)

COX (8)

Cyclin G-associated Kinase (GAK) (3)

Cytochrome P450 (2)

Drug Derivative (1)

EAAT (1)

Endogenous Metabolite (4)

FLT3 (1)

Fungal (2)

GABA Receptor (2)

GlyT (1)

Heme Oxygenase (HO) (2)

HSP (2)

iGluR (16)

Influenza Virus (1)

Isotope-Labeled Compounds (8)

Keap1-Nrf2 (2)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

mGluR (3)

MicroRNA (1)

mTOR (2)

Myosin (2)

nAChR (1)

Necroptosis (1)

Neurokinin Receptor (1)

Neurotensin Receptor (1)

Opioid Receptor (8)

P2X Receptor (10)

P2Y Receptor (2)

p38 MAPK (2)

Parasite (1)

PARP (2)

PD-1/PD-L1 (1)

PI3K (2)

PI4P5K (1)

Piezo Channel (2)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (9)

Prostaglandin Receptor (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (9)

SARS-CoV (3)

Serotonin Transporter (4)

Sigma Receptor (2)

Sodium Channel (22)

Somatostatin Receptor (2)

Topoisomerase (1)

Trk Receptor (4)

TRP Channel (8)

Virus Protease (2)

By Research Areas:

Cancer (33)

Cardiovascular Disease (8)

Endocrinology (1)

Infection (8)

Inflammation/Immunology (49)

Metabolic Disease (4)

Neurological Disease (95)

126

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110292

A-425619	TRP Channel	Inflammation/Immunology
A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain .

HY-152190

JB002	Myosin	Cardiovascular Disease
JB002 is a myosin II inhibitor, with an IC₅₀ of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-103550

A-841720	mGluR	Neurological Disease
A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC₅₀ of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC₅₀ of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research .

HY-169808

BOMA	mGluR	Neurological Disease
BOMA (Compound 7) is a potent and selective metabotropic glutamate receptor 5 (mGluR 5) antagonist with an IC₅₀ value of 3 nM and an K_i value of 3 nM. BOMA is promising for research of various pain states, including acute, persistent and chronic pain, inflammatory pain and neuropathic pain .

HY-162244

COX-2-IN-40	COX	Inflammation/Immunology
COX-2-IN-40 (compound 17) is a COX-2 inhibitor with the IC₅₀ of 14.86 μM. COX-2-IN-40 can be used for study of chronic pain .

HY-P991323

MEDI-1912	Trk Receptor Neurokinin Receptor	Inflammation/Immunology
MEDI-1912 is a human monoclonal antibody (mAb) targeting NGF/bNGF. MEDI-1912 inhibits signaling through TrkA and p75 receptors. MEDI-1912 can be used in chronic pain research .

HY-159094

Nav1.8-IN-15	Sodium Channel	Neurological Disease
Nav1.8-IN-15 (compound 6) is a potent Nav1.8 inhibitor. Nav1.8-IN-15 shows analgesic effect. Nav1.8-IN-15 has the potential for the research of chronic pain .

HY-P5907

Helianorphin-19	Opioid Receptor	Neurological Disease
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a K_i of 21 nM and an EC₅₀ of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain .

HY-117683

BCTP	TRP Channel	Neurological Disease
BCTP is a TRPV1 antagonist. BCTP activated at low pH showed functional antagonist activity against human TRPV1 in CHO cells (IC₅₀=18 nM). BCTP can be used in the study of chronic pain .

HY-P5153

ProTx-III μ-TRTX-Tp1a	Sodium Channel	Neurological Disease
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Na_v1.7, with an IC₅₀ of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .

HY-P5857

MmTx2 toxin Micrurotoxin 2	GABA Receptor	Neurological Disease
MmTx2 toxin is a GABA_A receptor modulator that enhances GABA_A receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain .

HY-170804

P2X4 antagonist-3	P2X Receptor	Neurological Disease Inflammation/Immunology Cancer
P2X4 antagonist-3 (Compound 14c) is a P2X4 antagonist with an IC₅₀ value of 1.2 μM. P2X4 antagonist-3 is promising for research of neuroinflammation, chronic pain, and cancer progression .

HY-110358

QAQ dichloride	Sodium Channel	Inflammation/Immunology
QAQ dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-110358A

QAQ	Sodium Channel	Inflammation/Immunology
QAQ dichloride dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-108449

Acoltremon 1 Publications Verification WS-12; AR-15512; AVX-012	TRP Channel	Cancer
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-19589

JTS-653	TRP Channel	Neurological Disease Inflammation/Immunology
JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents .

HY-110237

BX430	P2X Receptor Calcium Channel	Cardiovascular Disease
BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC₅₀ of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

HY-167855

MRS4833	P2Y Receptor	Inflammation/Immunology
MRS4833 (compound 15) is an orally active, potent, competitive P2Y₁₄R antagonist with an of IC₅₀ of 5.92 nM for hP2Y₁₄R and an IC₅₀ of 4.8 nM for mP2Y₁₄R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model .

HY-P99221

Tanezumab RN-624; PF 4383119	Trk Receptor	Neurological Disease Inflammation/Immunology Cancer
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia .

HY-163476

PIP5K1C-IN-1	PI4P5K	Inflammation/Immunology Cancer
PIP5K1C-IN-1 (Compound 30) is a potent PIP5K1C inhibitor, with an IC₅₀ of 0.80 nM. PIP5K1C-IN-1 exhibits low total clearance in mice and high levels of kinase selectivity. PIP5K1C-IN-1 can be used for the research of cancer and chronic pain .

HY-122001

PF-05186462	Sodium Channel	Neurological Disease
PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC₅₀ of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain .

HY-175231

ST171	5-HT Receptor	Neurological Disease
ST171 is a bitopic 5-HT1AR agonist with an K_i of 0.41  nM. ST171 selectively activates G_i/o signaling pathway and inhibits 5-HT1AR-mediated cAMP accumulation without G_s activation and marginal β-arrestin recruitment. T171 reduces hypersensitivity in chronic neuropathic and inflammatory pain mice model. ST171 can be used for pain research .

HY-119097

LY456066	mGluR	Neurological Disease
LY456066 is a selective non-competitive metabotropic glutamate receptors (mGluR1) antagonist with an IC₅₀ value of 52.0 nM. LY456066 is effective in rodent models of anxiolysis and nociception. LY456066 reduces hyperalgesia and the amount of licking and flinching following formalin injection, which is promising for research of analgesics for chronic pain .

HY-152206

JB062	Myosin	Neurological Disease
JB062 is a nonmuscle myosin inhibitor with IC₅₀ values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-176305S

Neurofilament, U-15N	Isotope-Labeled Compounds	Neurological Disease
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-17474A

Parecoxib Sodium 3 Publications Verification SC 69124A	COX	Inflammation/Immunology Cancer
Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474

Parecoxib 3 Publications Verification SC 69124	COX	Inflammation/Immunology Cancer
Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-159931

HW161023	AAK1	Neurological Disease
HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC₅₀ values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model .

HY-118858

UCPH-102	EAAT	Neurological Disease Cancer
UCPH-102 is a highly selective EAAT1 inhibitor with an IC₅₀ of 0.43 µM. UCPH-102 exhibits a specific anti-proliferative effect on T-ALL cells. UCPH-102 also shows good blood-brain permeability, which can be used in studies of amyotrophic lateral sclerosis, Alzheimer’s disease, chronic pain and obsessive compulsive disorder .

HY-17474AR

Parecoxib Sodium (Standard) SC 69124A (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Parecoxib (Sodium) (Standard) is the analytical standard of Parecoxib (Sodium). This product is intended for research and analytical applications. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474R

Parecoxib (Standard) SC 69124 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Parecoxib (Standard) is the analytical standard of Parecoxib. This product is intended for research and analytical applications. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-171846

LY3526318	TRP Channel	Neurological Disease Inflammation/Immunology
LY3526318 is an orally active, selective TRPA1 antagonist (IC₅₀=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis .

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. Acetyl tetrapeptide-15 is used in the cosmetics for sensitive skin .

HY-N0388

Gelsemine	Others	Neurological Disease
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

HY-14777

Radiprodil RGH-896	iGluR	Neurological Disease
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions .

HY-107527A

Org 25543	GlyT	Inflammation/Immunology
Org 25543 is a selective inhibitor of the glycine transporter 2, exhibiting analgesic properties in a rat model of chronic pain.

HY-P10908

H-20	PD-1/PD-L1	Others
H-20 is a PD-1 agonist. H-20 can be used in the research of chronic pain .

HY-174845

Nav1.8-IN-20	Sodium Channel	Neurological Disease
Nav1.8-IN-20 (Compound I) is an orally active and potent voltage-gated sodium channel Nav1.8 inhibitor with an IC₅₀ value of 14 nM. Nav1.8-IN-20 blocks the generation and conduction of action potentials in peripheral nociceptive neurons, exerting analgesic effects. Nav1.8-IN-20 is promising for research of various pain types such as acute pain, chronic pain, inflammatory pain, and neuropathic pain .

HY-14777R

Radiprodil (Standard)	iGluR	Neurological Disease
Radiprodil (Standard) is the analytical standard of Radiprodil. This product is intended for research and analytical applications. Radiprodil (RGH-896) is an orally active and selective NMDA NR2B antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions .

HY-148708

Oleoyl-D-lysine	iGluR	Neurological Disease
Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice，shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression .

HY-123374

(Rac)-AMG 628	TRP Channel	Neurological Disease
(Rac)-AMG 628 is the racemate of AMG 628, a potent TRPV1 antagonist with an IC₅₀ of 3.7nM. AMG 628 can be used in chronic pain research .

HY-P0062

Ziconotide SNX-111	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research .

HY-P0062B

Ziconotide acetate 1 Publications Verification SNX-111 acetate	Calcium Channel	Cardiovascular Disease Inflammation/Immunology Cancer
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research .

HY-N0388R

Gelsemine (Standard)	Reference Standards Others	Neurological Disease
Gelsemine (Standard) is the analytical standard of Gelsemine. This product is intended for research and analytical applications. Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

HY-14466

GW 848687X	Prostaglandin Receptor	Endocrinology
GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain .

HY-111258

GSK345931A	Prostaglandin Receptor	Neurological Disease Inflammation/Immunology
GSK345931A is an EP1 receptor antagonist. GSK345931A shows measurable CNS penetration in the mouse and rat and potent analgesic efficacy in acute and sub-chronic models of inflammatory pain .

HY-D2868

DAPI 4',6-Diamidino-2-phenylindole	Sodium Channel	Neurological Disease
DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment .

HY-120751

TROX-1	Calcium Channel	Neurological Disease
TROX-1 is an N-type calcium channel (CaV2.2) inhibitor with an IC₅₀ value of 0.11 μM. TROX-1 can be used in chronic pain research .

HY-P0062A

Ziconotide TFA SNX-111 TFA	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research .

HY-150270A

NP-1815-PX sodium	P2X Receptor	Neurological Disease Inflammation/Immunology
NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions .

Cat. No.	Product Name

HY-L139

Pain-Related Compound Library

2,658 compounds

Pain is a kind of distressing feeling caused by the stimulation of tissue damage. According to the International Association for the Study of Pain (IASP), pain is defined as ”An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”.

Pain is usually classified according to its location, duration, underlying causes, and intensity. For example, acute and chronic pain, muscle pain, and nerve pain. Pain is the main symptom of most diseases, which seriously affects the quality of life and body function of patients. In the medical treatment of pain, anti-inflammatory drugs and opioid analgesic agents have traditionally been used, but the side effects are serious. In recent years, targeted drugs targeting the ERK/MAPK pathway or other targets have gradually become a research hotspot.

MCE supplies a unique collection of 2,658 compounds targeting key proteins in the pain system. MCE Pain-Related Compound Library is a useful tool for pain related research and anti-pain drug development.

HY-L105

Peptide Library

2,007 compounds

Peptides are a group of biologically active substances that are involved in various cellular functions of organisms. Peptides are often used in functional analysis, vaccine research and especially in the field of drug research and development. At present, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain.

MedChemExpress (MCE) offers a comprehensive collection of 2,007 peptides, including bioactive peptides, amino acid derivatives, and blocking peptides. MCE Peptide Library can be used for peptide library screening, peptide drug discovery, vaccine development, target verification, structural activity research, etc.

Cat. No.	Product Name	Type

HY-D2868

DAPI 4',6-Diamidino-2-phenylindole	Fluorescent Dyes/Probes
DAPI (Compound 3) is an acid-sensing ion channel 3 (ASIC3) inhibitor. DAPI binds to ASIC3 and blocks the channel function. DAPI can be used in the study of chronic pain treatment .

Cat. No.	Product Name	Target	Research Area

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. Acetyl tetrapeptide-15 is used in the cosmetics for sensitive skin .

HY-P0062B

Ziconotide acetate 1 Publications Verification SNX-111 acetate	Calcium Channel	Cardiovascular Disease Inflammation/Immunology Cancer
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research .

HY-P5907

Helianorphin-19	Opioid Receptor	Neurological Disease
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a K_i of 21 nM and an EC₅₀ of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain .

HY-P5153

ProTx-III μ-TRTX-Tp1a	Sodium Channel	Neurological Disease
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Na_v1.7, with an IC₅₀ of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .

HY-P5857

MmTx2 toxin Micrurotoxin 2	GABA Receptor	Neurological Disease
MmTx2 toxin is a GABA_A receptor modulator that enhances GABA_A receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain .

HY-P10908

H-20	PD-1/PD-L1	Others
H-20 is a PD-1 agonist. H-20 can be used in the research of chronic pain .

HY-P0062

Ziconotide SNX-111	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research .

HY-P0062A

Ziconotide TFA SNX-111 TFA	Calcium Channel	Neurological Disease Inflammation/Immunology Cancer
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-P10898

GeX-2	nAChR Calcium Channel GABA Receptor	Neurological Disease
GeX-2 is a truncated analogue of αO-conotoxin. GeX-2 activates GABA_B receptor. GeX-2 inhibits α9α10 nAChR and Ca_V2.2 channels. GeX-2 alleviates pain in the rat model of chronic constriction injury .

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P1410B

D-GsMTx4	Piezo Channel Calcium Channel mTOR PI3K Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology
D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 inhibits [Ca ²⁺]_i elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .

HY-P1410C

D-GsMTx4 TFA	Piezo Channel Calcium Channel mTOR PI3K Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca ²⁺]_i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis .

HY-P5865

Tap1a Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a	Sodium Channel	Neurological Disease
Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC₅₀s of 80 nM and 301 nM against Na_v1.7 and Na_v1.1, respectively. Tap1a shows analgesic effects .

Cat. No.	Product Name	Target	Research Area

HY-P99221

Tanezumab RN-624; PF 4383119	Trk Receptor	Neurological Disease Inflammation/Immunology Cancer
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia .

HY-P991323

MEDI-1912	Trk Receptor Neurokinin Receptor	Inflammation/Immunology
MEDI-1912 is a human monoclonal antibody (mAb) targeting NGF/bNGF. MEDI-1912 inhibits signaling through TrkA and p75 receptors. MEDI-1912 can be used in chronic pain research .

HY-P991321

ABT-110	Trk Receptor	Inflammation/Immunology
ABT-110 is a human monoclonal antibody (mAb) targeting NGF/bNGF. ABT-110 reduces established thermal and mechanical hypersensitivity in the CFA rat model. ABT-110 can be used in persistent/chronic inflammatory pain research .

HY-P991622

MNAC13	Trk Receptor	Neurological Disease Inflammation/Immunology
MNAC13 is a kind of mouse IgG1 chimeric antibody, targeting to human TrkA. MNAC13 inhibits the NGF dependent signaling pathway by specifically binding to TrkA receptors. MNAC13 has good analgesic effect and long-lasting efficacy. MNAC13 can be used for research on inflammatory and chronic pain .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0388

Gelsemine	Alkaloids Pyrrole Alkaloids Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth.	Others
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

HY-N1478

Gardenoside 1 Publications Verification	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis	P2X Receptor Reactive Oxygen Species (ROS)
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-N2071

Cedrol 1 Publications Verification (+)-Cedrol; α-Cedrol	Structural Classification Cedrus deodara (Roxburgh) G. Don Classification of Application Fields Pinaceae Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields Cancer	Cytochrome P450 Fungal Apoptosis Caspase Platelet-activating Factor Receptor (PAFR)
Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties .

HY-N3990

Hardwickiic acid 1 Publications Verification (-)-Hardwickiic acid; (-)-Hardwikiic acid	Pueraria tuberosa (Roxb. ex Willd.) DC. Neurological Disease Classification of Application Fields Source classification Plants Compositae Infection other families Terpenoids Croton tiglium Linn. Diterpenoids Euphorbiaceae Disease Research Fields	Sodium Channel Parasite
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases .

HY-N0576

Solanesol 1 Publications Verification	Structural Classification Natural Products other families Neurological Disease Classification of Application Fields Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP
Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder .

HY-N0388R

Gelsemine (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth.	Reference Standards Others
Gelsemine (Standard) is the analytical standard of Gelsemine. This product is intended for research and analytical applications. Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

HY-N2071R

Cedrol (Standard) (+)-Cedrol (Standard); α-Cedrol (Standard)	Structural Classification Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Source classification Plants	Reference Standards Cytochrome P450 Fungal Apoptosis Caspase
Cedrol (Standard) is the analytical standard of Cedrol. This product is intended for research and analytical applications. Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.

HY-N0576R

Solanesol (Standard)	Structural Classification Natural Products other families Source classification Plants Endogenous metabolite	Reference Standards Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP
Solanesol (Standard) is the analytical standard of Solanesol (HY-N0576). This product is intended for research and analytical applications. Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder .

Cat. No.	Product Name	Chemical Structure

HY-B0405S

Bupivacaine-d9
Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine can be used for the research of chronic pain .

HY-176305S

Neurofilament, U-15N
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-W702016

Bupivacaine-d9 hydrochloride
Bupivacaine-d₉ hydrochloride is the deuterium labeled Bupivacaine hydrochloride (HY-B0405A). Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain .

HY-17474S

Parecoxib-d3

Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17474AS

Parecoxib-d5 sodium

Parecoxib-d₅ sodium is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo .

HY-17474S1

Parecoxib-d5

Parecoxib-d₅ (SC 69124-d₅) is deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-167855S

1’-Epi Gemcitabine hydrochloride-13C,15N2

1’-Epi Gemcitabine hydrochloride- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled MRS4833 (HY-167855). MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC₅₀ of 5.92 nM for hP2Y14R and an IC₅₀ of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model .

HY-111124

Paroxetine-d2

Paroxetine-d₂ (CTP 347) is a deuterium labeled Paroxetine (HY-122272). Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

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