2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. LY3526318

LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis.

For research use only. We do not sell to patients.

LY3526318 Chemical Structure

LY3526318 Chemical Structure

CAS No. : 1889218-34-1

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LY3526318 Related Antibodies

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Description

LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM). LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis[1][2].

IC50 & Target

TRPA1

 

In Vitro

LY3526318 blocks transient TRPA1 inward currents activated by Allyl Isothiocyanate (HY-B1515) with IC50 values of 13.5 nM, 55.7 nM, 7.6 nM, and 8.2 nM for TRPA1 channels in humans, rats, dogs, and cynomolgus monkeys, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY3526318 Related Antibodies
Molecular Weight

556.46

Formula

C23H19F3N10O4
CAS No.
SMILES

FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY3526318 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY35263181889218-34-1LY 3526318LY-3526318TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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