2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. MNAC13

MNAC13 is a kind of mouse IgG1 chimeric antibody, targeting to human TrkA. MNAC13 inhibits the NGF dependent signaling pathway by specifically binding to TrkA receptors. MNAC13 has good analgesic effect and long-lasting efficacy. MNAC13 can be used for research on inflammatory and chronic pain.

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MNAC13 Chemical Structure

MNAC13 Chemical Structure

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MNAC13 Related Antibodies

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Description

MNAC13 is a kind of mouse IgG1 chimeric antibody, targeting to human TrkA. MNAC13 inhibits the NGF dependent signaling pathway by specifically binding to TrkA receptors. MNAC13 has good analgesic effect and long-lasting efficacy. MNAC13 can be used for research on inflammatory and chronic pain[1][2].

IC50 & Target[1][2]

TrkA

 

In Vitro

MNAC13 (200-300 μg/mL, 1 h) specifically binds TrkA and leads to inhibition of NGF-dependent signaling in 3T3 cells overexpressing TrkA[1].
MNAC13 (4 μg/mL, 4 days) effectively blocks NGF induced survival and axonal growth of PC12 cells[2].
MNAC13 (2 or 20 ng/mL) specifically binds to TrkA immune adhesin, but does not bind to TrkB in TrkA-BALB/C 3T3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MNAC13 Related Antibodies

Western Blot Analysis[1]

Cell Line: 3T3 cells overexpressing TrkA
Concentration: 200-300 μg/mL
Incubation Time: 1 h
Result: Significantly inhibited the phosphorylation of TrkA and the phosphorylation level of downstream signaling molecule PLCγ1.
In Vivo

MNAC13 (0.9-60 μg; i.p. or s.c.; single dose; 18 h before the formalin test) significantly reduce inflammatory pain in the 5 % formalin solution injected CD1 male mice[1].
MNAC13 (30-70 μg; i.p.; once daily; from day 3 to day 10) significantly reduces neuropathic pain and exhibits long-lasting effects in the chronic constriction injury (CCI) CD1 male mice[1].
MNAC13 (1 μg; i.p.; single dose; 15 min before the test) has a significant synergistic analgesic effect combinated with opioid drugs in the 5 % formalin solution injected CD1 male mice[1].
MNAC13 blocks the effect of TrkA on basal forebrain cholinergic neurons (BFCNs) more significantly and persistently than blocking NGF in MNAC13 hybridoma cells injected Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 % formalin solution injected CD1 male mice (30-40 g)[1]
Dosage: 0.9, 1.875, 3.75, 7.5, 15, 30 and 60 μg
Administration: Subcutaneous injection (s.c.) of 0.9, 1.875, 3.75, 7.5, 15, 30 and 60 μg; Intraperitoneal injection (i.p.) of 15μg
Result: Significantly reduced late stage licking behavior and was also effective for early pain at 15 μg.
Animal Model: CCI CD1 male mice (30-40 g)[1]
Dosage: 30, 50 and 70 μg
Administration: Intraperitoneal injection (i.p.); once daily from day 3 to day 10
Result: Significantly reduced mechanical allodynia and has long-lasting effects.
Animal Model: 5 % formalin solution injected CD1 male mice (30-40 g)[1]
Dosage: 1 μg; combinated with morphine (1 mg/kg) or fentanyl (5 μg/kg)
Administration: Intraperitoneal injection (i.p.); 15 min before the test
Result: Generated significant synergistic analgesic effect.
Acted on the central nervous system and naloxone failed to reverse the synergistic effect.
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MNAC13 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNAC13MNAC 13MNAC-13Trk ReceptorTropomyosin related kinase receptorTrkANGFanalgesiainflammationpainInhibitorinhibitorinhibit

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