Search Result
Results for "
analytical study
" in MedChemExpress (MCE) Product Catalog:
11
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-128480
-
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Melaminsulfone sodium salt
|
Drug Derivative
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Others
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Sulfamidopyrine (Melaminsulfone) sodium salt is an active compound. Sulfamidopyrine (sodium salt) can be used for analytical study .
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-
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- HY-W549985
-
-
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- HY-W010562R
-
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Drug Derivative
|
Others
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2-Methoxypyrazine (Standard) is the analytical standard of 2-Methoxypyrazine. This product is intended for research and analytical applications. 2-Methoxypyrazine is an active compound. 2-Methoxypyrazine can be used for the research of various biochemical studies[1].
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-
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- HY-B1062R
-
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S-(+)-Chlorpheniramine maleate salt (Standard)
|
Histamine Receptor
|
Inflammation/Immunology
Endocrinology
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Dexchlorpheniramine (maleate) (Standard) is the analytical standard of Dexchlorpheniramine (maleate). This product is intended for research and analytical applications. Dexchlorpheniramine maleate is an antihistamine with anticholinergic properties used in the study of allergic diseases.
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- HY-B0465R
-
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|
Bacterial
Antibiotic
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Infection
|
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Oxacillin (sodium monohydrate) (Standard) is the analytical standard of Oxacillin (sodium monohydrate). This product is intended for research and analytical applications. Oxacillin sodium monohydrate is an antibiotic similar to Flucloxacillin used in resistant staphylococci infections study .
|
-
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- HY-18719BR
-
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Cytochrome P450
Estrogen Receptor/ERR
Drug Metabolite
Parasite
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Cancer
|
|
Endoxifen (hydrochloride) (Standard) is the analytical standard of Endoxifen (hydrochloride). This product is intended for research and analytical applications. Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study[1][2].
|
-
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- HY-113365R
-
|
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Endogenous Metabolite
|
Infection
Metabolic Disease
|
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Clebopride (malate) (Standard) is the analytical standard of Clebopride (malate). This product is intended for research and analytical applications. Clebopride malate is a dopamine antagonist used in the study of functional gastrointestinal disorders.
|
-
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- HY-117699R
-
-
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- HY-121527R
-
|
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HIV
|
Infection
Neurological Disease
|
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Amylmetacresol (Standard) is the analytical standard of Amylmetacresol. This product is intended for research and analytical applications. Amylmetacresol possesses antiviral (such HIV) effect. Amylmetacresol has the potential for the study in sore throat .
|
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- HY-12798CR
-
|
AR-13324 M1 metabolite (Standard)
|
PKC
ROCK
|
Cardiovascular Disease
|
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Fluanisone (Standard) is the analytical standard of Fluanisone. This product is intended for research and analytical applications. Fluanisone has potent sedative effect in vivo. Fluanisone can be used to study schizophrenia .
|
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- HY-B1782R
-
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Bacterial
Antibiotic
|
Infection
|
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Sulfamoxole (Standard) is the analytical standard of Sulfamoxole. This product is intended for research and analytical applications. Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .
|
-
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- HY-122365R
-
|
|
Drug Derivative
|
Cardiovascular Disease
|
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Inositol nicotinate (Standard) is the analytical standard of Inositol nicotinate. This product is intended for research and analytical applications. Inositol nicotinate, with vasodilatory effect, is used in the study of Peripheral arterial disease (PAD) .
|
-
-
- HY-107377R
-
|
3,4-Benzopyrene (Standard)
|
Reference Standards
Endogenous Metabolite
|
Cancer
|
|
Benzo[a]pyrene (Standard) is the analytical standard of Benzo[a]pyrene. This product is intended for research and analytical applications. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.
|
-
![Benzo[a]pyrene (Standard)](//file.medchemexpress.eu/product_pic/hy-107377r.gif)
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- HY-W775009R
-
|
|
COX
|
Inflammation/Immunology
|
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Imidazole salicylate (Standard) is the analytical standard of Imidazole salicylate. This product is intended for research and analytical applications. Imidazole salicylate is a nonsteroidal anti-inflammatory drug that can be used to study cirrhosis and ascites .
|
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- HY-119327R
-
|
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Autophagy
AMPK
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Others
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Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.
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- HY-N7697R
-
|
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Others
|
Others
|
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Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.
|
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- HY-108297R
-
|
|
COX
|
Inflammation/Immunology
|
|
Piketoprofen (Standard) is the analytical standard of Piketoprofen. This product is intended for research and analytical applications. Piketoprofen is a non-steroidal anti-inflammatory reagent that can be used as a cream preparation for the study of soft tissue rheumatism .
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- HY-146446R
-
|
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Bacterial
Antibiotic
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Infection
|
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Maltopentaose (Standard) is the analytical standard of Maltopentaose. This product is intended for research and analytical applications. Maltopentaose is the shortest chain oligosaccharide that can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin.
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- HY-N1495R
-
|
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Endogenous Metabolite
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Inflammation/Immunology
|
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Maltopentaose (Standard) is the analytical standard of Maltopentaose. This product is intended for research and analytical applications. Maltopentaose is the shortest chain oligosaccharide that can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin.
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- HY-B1148AR
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Bacterial
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Infection
|
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Furaltadone (Standard) is the analytical standard of Furaltadone. This product is intended for research and analytical applications. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci .
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- HY-B1148R
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Bacterial
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Inflammation/Immunology
|
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Furaltadone (hydrochloride) (Standard) is the analytical standard of Furaltadone (hydrochloride). This product is intended for research and analytical applications. Furaltadone hydrochloride, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci .
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- HY-W097570R
-
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Bacterial
Antibiotic
|
Infection
|
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Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate .
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- HY-G0003R
-
|
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Drug Metabolite
|
Others
|
|
Diamfenetide (Standard) is the analytical standard of Diamfenetide. This product is intended for research and analytical applications. Diamfenetide is used for the study of Fasciola hepatica infections in vitro.?Diamfenetide?leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica .
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- HY-133668R
-
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Drug Metabolite
|
Cancer
|
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Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate .
|
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-
- HY-119893R
-
|
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Parasite
|
Infection
|
|
Diamfenetide (Standard) is the analytical standard of Diamfenetide. This product is intended for research and analytical applications. Diamfenetide is used for the study of Fasciola hepatica infections in vitro.?Diamfenetide?leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica .
|
-
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- HY-B0214R
-
|
Dehydrocortisone (Standard)
|
Glucocorticoid Receptor
Apoptosis
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
Prednisone (Standard) is the analytical standard of Prednisone. This product is intended for research and analytical applications. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus .
|
-
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- HY-106392R
-
|
NB-DGJ (Standard); N-(n-Butyl)deoxygalactonojirimycin (Standard)
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Glucosylceramide Synthase (GCS)
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Metabolic Disease
|
|
Lucerastat (Standard) is the analytical standard of Lucerastat. This product is intended for research and analytical applications. Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study .
|
-
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- HY-N2518R
-
-
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- HY-D0237R
-
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Histamine Receptor
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Inflammation/Immunology
|
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Betahistine (mesylate) (Standard) is the analytical standard of Betahistine (mesylate). This product is intended for research and analytical applications. Betahistine mesylate is an orally active histamine H1 receptor agonist and a H3 receptor antagonist . Betahistine mesylate is used for the study of rheumatoid arthritis (RA) .
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- HY-B0524AR
-
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Histamine Receptor
|
Neurological Disease
Inflammation/Immunology
Endocrinology
|
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Betahistine (dihydrochloride) (Standard) is the analytical standard of Betahistine (dihydrochloride). This product is intended for research and analytical applications. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist . Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA) .
|
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- HY-N7123R
-
|
Sulphacetamide (Standard)
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Antibiotic
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
Sulfacetamide (Standard) (Sulphacetamide (Standard)) is the analytical standard of Sulfacetamide (HY-N7123). This product is intended for research and analytical applications. Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.
|
-
-
- HY-N0658AR
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
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DL-Threonine (Standard) is the analytical standard of DL-Threonine. This product is intended for research and analytical applications. DL-Threonine, an essential amino acid, is a precursor of Glycine (HY-Y0966). DL-Threonine has the potential for the study of hypostatic leg ulceration.
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- HY-B0576R
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Sulphacetamide (sodium) (Standard)
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Antibiotic
Bacterial
Fungal
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Infection
Inflammation/Immunology
|
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Sulfacetamide (Standard) (Sulphacetamide (Standard)) sodium is the analytical standard of Sulfacetamide sodium (HY-B0576). This product is intended for research and analytical applications. Sulfacetamide sodium is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium has antifungal and antibacterial activities .
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- HY-B0888R
-
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Sulphacetamide (sodium monohydrate) (Standard)
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Antibiotic
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
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Sulfacetamide (Standard) (Sulphacetamide (Standard)) sodium monohydrate is the analytical standard of Sulfacetamide sodium monohydrate (HY-B0888). This product is intended for research and analytical applications. Sulfacetamide sodium monohydrate is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium monohydrate has antifungal and antibacterial activities .
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- HY-30151R
-
|
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Cytochrome P450
|
Inflammation/Immunology
Cancer
|
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Methoxsalen (Standard) is the analytical standard of Methoxsalen. This product is intended for research and analytical applications. Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
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- HY-137910R
-
|
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Herbicide
|
Others
|
|
Tembotrione (Standard) is the analytical standard of Tembotrione. This product is intended for research and analytical applications. Tembotrione is a drug that may reduce the
productivity of carrots. Tembotrione has the activity of reducing carrot stem
mass. Tembotrione can be used to study the total productivity of carrot
.
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- HY-A0241R
-
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Bacterial
Antibiotic
|
Infection
|
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Stearic acid (Standard) is the analytical standard of Stearic acid. This product is intended for research and analytical applications. Stearic acid is a long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases .
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- HY-B2060AR
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Bacterial
Antibiotic
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Infection
Cancer
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Tiamulin (fumarate) (Standard) is the analytical standard of Tiamulin (fumarate). This product is intended for research and analytical applications. Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
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- HY-B2060R
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Bacterial
Antibiotic
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Infection
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Tiamulin (Standard) is the analytical standard of Tiamulin. This product is intended for research and analytical applications. Tiamulin (Thiamutilin) is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
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- HY-116857R
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Fungal
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Others
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Ditalimfos (Standard) is the analytical standard of Ditalimfos. This product is intended for research and analytical applications. Ditalimfos is an organophosphate fungicide. Ditalimfos is mainly used in agriculture to control fungal diseases of crops. Ditalimfos can be used for fungal resistance studies and risk assessment of residues in the environment .
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- HY-B2219R
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Endogenous Metabolite
Apoptosis
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Cardiovascular Disease
Metabolic Disease
Cancer
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Stearic acid (Standard) is the analytical standard of Stearic acid. This product is intended for research and analytical applications. Stearic acid is a long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases .
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- HY-76316R
-
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Cytochrome P450
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Neurological Disease
Inflammation/Immunology
Cancer
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|
Bergaptol (Standard) is the analytical standard of Bergaptol. This product is intended for research and analytical applications. Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties .
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- HY-N2406R
-
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p38 MAPK
Endogenous Metabolite
Reactive Oxygen Species
NO Synthase
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Inflammation/Immunology
|
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Ditalimfos (Standard) is the analytical standard of Ditalimfos. This product is intended for research and analytical applications. Ditalimfos is an organophosphate fungicide. Ditalimfos is mainly used in agriculture to control fungal diseases of crops. Ditalimfos can be used for fungal resistance studies and risk assessment of residues in the environment .
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- HY-A0168R
-
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|
Adenosine Receptor
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Cardiovascular Disease
|
|
Regadenoson (Standard) is the analytical standard of Regadenoson. This product is intended for research and analytical applications. Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .
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- HY-148053R
-
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Drug Metabolite
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Cancer
|
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Rezivertinib analogue 1 (Standard) is the analytical standard of Rezivertinib analogue 1. This product is intended for research and analytical applications. Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer[1].
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-
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- HY-W011303R
-
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4-Hydroxysphinganine (Standard)
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Apoptosis
Endogenous Metabolite
Fungal
Free Fatty Acid Receptor
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Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].
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- HY-B1051R
-
|
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Fungal
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Inflammation/Immunology
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Flumethasone (Standard) is the analytical standard of Flumethasone. This product is intended for research and analytical applications. Flumethasone is a corticosteroid, a topical agent used in combination with Clioquinol for the study of otitis externa and otomycosis. When used in animal models, Flumethasone's anti-inflammatory activity is 420 times higher than that of Cortisone.
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- HY-B0739AR
-
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Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
Caspase
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Neurological Disease
Cancer
|
|
Citicoline sodium (Standard) is the analytical standard of Citicoline sodium. This product is intended for research and analytical applications. Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study.
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-
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- HY-N2526R
-
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Selacholeic acid (Standard); cis-15-Tetracosenoic acid (Standard)
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Endogenous Metabolite
NF-κB
|
Neurological Disease
Inflammation/Immunology
|
|
Nervonic acid (Standard) is the analytical standard of Nervonic acid. This product is intended for research and analytical applications. Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases[1][2][3].
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- HY-14805R
-
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Arenavirus
Orthopoxvirus
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Infection
|
|
Tecovirimat (Standard) is the analytical standard of Tecovirimat. This product is intended for research and analytical applications. Tecovirimat(ST-246) is an orally bioavailable antipoxvirus compound; potent and selective active against multiple orthopoxviruses with EC50 about 10 nM. Tecovirimat could be used in the study for orthopoxvirus-induced diseases.
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- HY-W017401R
-
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Bacterial
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Infection
Cancer
|
|
Benzisothiazolone (Standard) is the analytical standard of Benzisothiazolone. This product is intended for research and analytical applications. Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model .
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- HY-B1131R
-
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Endogenous Metabolite
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Inflammation/Immunology
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Zuclopenthixol (dihydrochloride) (Standard) is the analytical standard of Zuclopenthixol (dihydrochloride). This product is intended for research and analytical applications. Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia .
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- HY-A0163BR
-
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Dopamine Receptor
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Neurological Disease
|
|
Zuclopenthixol (dihydrochloride) (Standard) is the analytical standard of Zuclopenthixol (dihydrochloride). This product is intended for research and analytical applications. Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia .
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- HY-17455R
-
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Prolyl Endopeptidase (PREP)
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Neurological Disease
|
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Pramiracetam (Standard) is the analytical standard of Pramiracetam. This product is intended for research and analytical applications. Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .
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- HY-B1730R
-
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Cyclic GMP-AMP Synthase
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Neurological Disease
Metabolic Disease
|
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Phensuximide (Standard) is the analytical standard of Phensuximide. This product is intended for research and analytical applications. Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal .
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- HY-A0090R
-
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Bacterial
Antibiotic
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Infection
|
|
Nitrofurantoin (Standard) is the analytical standard of Nitrofurantoin. This product is intended for research and analytical applications. Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
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- HY-W017194R
-
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Endogenous Metabolite
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Metabolic Disease
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2-Phenylbutanoic acid (Standard) is the analytical standard of 2-Phenylbutanoic acid. This product is intended for research and analytical applications. 2-Phenylbutanoic acid is a monocarboxylic acid. 2-Phenylbutanoic acid interacts with proteins. 2-Phenylbutanoic acid is used in the study of malignant lymphoma and HIV virus-related diseases 。
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- HY-131276R
-
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Angiotensin Receptor
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Cardiovascular Disease
|
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Olmesartan lactone impurity (Standard) is the analytical standard of Olmesartan lactone impurity. This product is intended for research and analytical applications. Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study .
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- HY-W016352R
-
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Biochemical Assay Reagents
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Others
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2-Hydroxy-5-nitrobenzoic acid, 99% (Standard) is the analytical standard of 2-Hydroxy-5-nitrobenzoic acid, 99%. This product is intended for research and analytical applications. 2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
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- HY-B0739R
-
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Cytidine diphosphate-choline (Standard); CDP-Choline (Standard); Cytidine 5'-diphosphocholine (Standard)
|
Apoptosis
Endogenous Metabolite
Caspase
Reactive Oxygen Species
|
Neurological Disease
Cancer
|
|
Citicoline (Cytidine diphosphate-choline) (Standard) is the analytical standard of Citicoline. This product is intended for research and analytical applications. Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study.
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- HY-135326R
-
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Drug Derivative
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Inflammation/Immunology
|
|
4-Propionamidophenol (Standard) is the analytical standard of 4-Propionamidophenol. This product is intended for research and analytical applications. 4-Propionamidophenol is an important intermediate of alkanolamine derivatives with β-adrenergic blocking activity. 4-Propionamidophenol can be used in the study of diseases such as heart disease and hypertension .
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- HY-W009247R
-
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Endogenous Metabolite
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Neurological Disease
|
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N-Desmethylolanzapine (Standard) is the analytical standard of N-Desmethylolanzapine. This product is intended for research and analytical applications. N-Desmethylolanzapine is an antipsychotic drug.
The formation of N-Desmethylolanzapine correlates with the level and activity
of human liver flavin-containing monooxygenase (FMO3). N-Desmethylolanzapine
can be used in the study of antipsychotic drugs .
|
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- HY-B0572R
-
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Reference Standards
Cuproptosis
Proton Pump
Bacterial
Fungal
|
Infection
Metabolic Disease
|
|
Zinc Pyrithione (Standard) is the analytical standard of Zinc Pyrithione. This product is intended for research and analytical applications. Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump . Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis .
|
-
- HY-N7028R
-
|
|
Notch
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Withanolide A (Standard) is the analytical standard of Withanolide A. This product is intended for research and analytical applications. Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases .
|
-
- HY-B0337AR
-
|
Sulphadimethoxine sodium (Standard)
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfadimethoxine (sodium) (Standard) is the analytical standard of Sulfadimethoxine sodium (HY-B0337A). This product is intended for research and analytical applications. Sulfadimethoxine sodium (Sulphadimethoxine sodium) is a sulfonamide antibiotic. Sulfadimethoxine sodium causes a displacement of Thiopental in plasma protein binding in rats. Sulfadimethoxine sodium is used in a variety of infection studies including urinary tract infections .
|
-
- HY-N0034R
-
|
|
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Arctiin (Standard) is the analytical standard of Arctiin. This product is intended for research and analytical applications. Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in?ammatory cytokines levels. Arctiin can used in study glomerulonephritis .
|
-
- HY-B0078R
-
|
Imidazole Carboxamide (Standard)
|
Apoptosis
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
Dacarbazine (Standard) is the analytical standard of Dacarbazine. This product is intended for research and analytical applications. Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .
|
-
- HY-109171R
-
|
|
Neurokinin Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Elinzanetant (Standard) is the analytical standard of Elinzanetant. This product is intended for research and analytical applications. Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .
|
-
- HY-77995R
-
|
|
Bacterial
Fungal
|
Infection
|
|
2-Methoxybenzaldehyde (Standard) is the analytical standard of 2-Methoxybenzaldehyde. This product is intended for research and analytical applications. 2-Methoxybenzaldehyde (o-Anisaldehyde) is a bacterial/fungal inhibitor with a BA50 value of 0.19 for Salmonella. 2-Methoxybenzaldehyde can be used for the study of bacterial and fungal infectious diseases .
|
-
- HY-A0124AR
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
Sapropterin (dihydrochloride) (Standard) is the analytical standard of Sapropterin (dihydrochloride). This product is intended for research and analytical applications. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) .
|
-
- HY-B1487R
-
|
|
iGluR
mAChR
|
Neurological Disease
|
|
Procyclidine (hydrochloride) (Standard) is the analytical standard of Procyclidine (hydrochloride). This product is intended for research and analytical applications. Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy .
|
-
- HY-B0458R
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cefprozil monohydrate (Standard) is the analytical standard of Cefprozil monohydrate (HY-B0458). This product is intended for research and analytical applications. Cefprozil monohydrate is a second-generation cephalosporin type antibiotic. Cefprozil monohydrate exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil monohydrate can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
|
-
- HY-A0042R
-
|
CGP 33101 (Standard); E 2080 (Standard); RUF 331 (Standard)
|
Sodium Channel
|
Neurological Disease
|
|
Rufinamide (Standard) is the analytical standard of Rufinamide (HY-A0042). This product is intended for research and analytical applications. Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na + current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .
|
-
- HY-N0380R
-
|
|
Others
|
Neurological Disease
|
|
Nardosinone (Standard) is the analytical standard of Nardosinone. This product is intended for research and analytical applications. Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances .
|
-
- HY-W016352
-
|
Anilotic acid, 99%
|
Biochemical Assay Reagents
|
Others
|
|
2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
|
-
- HY-B1843R
-
|
|
Fungal
|
Infection
|
|
Fuberidazole (Standard) is the analytical standard of Fuberidazole. This product is intended for research and analytical applications. Fuberidazole (BAY 33172; Furidazole) is a fungicide. Fuberidazole shows a synergistic effect with cucurbituril (CB) macromolecules, such as CB7 and CB8. Studies have shown that, CB8 induces pKa shifts on Fuberidazole. Fuberidazole significantly inhibits the growth of B. cinerea .
|
-
- HY-124408R
-
|
|
Fungal
|
Infection
|
|
Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection .
|
-
- HY-N6257R
-
-
- HY-B1613AR
-
|
|
Reference Standards
Dopamine Receptor
Adrenergic Receptor
|
Metabolic Disease
|
|
Clebopride malate (Standard) is the analytical standard of Clebopride malate (HY-B1613A). This product is intended for research and analytical applications. Clebopride malate is an orally active dopamine Receptor antagonist. Clebopride malate acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride malate can be used in the study of functional gastrointestinal disorders.
|
-
- HY-B1285R
-
|
|
HIV
|
Infection
|
|
Dimercaprol (Standard) is the analytical standard of Dimercaprol. This product is intended for research and analytical applications. Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .
|
-
- HY-B1703R
-
|
|
Bacterial
Antibiotic
Parasite
|
Infection
|
|
Nifursol (Standard) is the analytical standard of Nifursol (HY-B1703). This product is used for research and analytical applications. Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals .
|
-
- HY-123294R
-
|
|
Herbicide
|
Neurological Disease
Metabolic Disease
|
|
Fentrazamide (Standard) is the analytical standard of Fentrazamide. This product is intended for research and analytical applications. Fentrazamide (YRC 2388) is a herbicide. Fentrazamide has specific toxic effects on the nervous system and erythrocytes in rats, affecting the energy supply of cells mainly by interfering with the glycolysis process. Fentrazamide can be used as a useful tool to study the mechanisms of neurodegenerative diseases and erythrocyte dysfunction .
|
-
- HY-135910R
-
|
|
Drug Metabolite
|
Cardiovascular Disease
Cancer
|
|
3,4-Dehydro Cilostazol (Standard) is the analytical standard of 3,4-Dehydro Cilostazol. This product is intended for research and analytical applications. 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study .
|
-
- HY-N0528R
-
-
- HY-W127641R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
β-Methylcholine (chloride) (Standard) is the analytical standard of β-Methylcholine (chloride). This product is intended for research and analytical applications. β-Methylcholine chloride is an organic compound containing choline and chloride ions. It is commonly used as a pharmacological research tool, especially in the study of acetylcholine receptors and signaling pathways. β-Methylcholine chloride has various applications in the pharmaceutical industry, especially as a standard reference material for the calibration of analytical instruments. In addition, it can be used in the production of other choline derivatives and as a precursor of neurotransmitters.
|
-
- HY-W004049R
-
-
- HY-Y1004R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Decanol (Standard) is the analytical standard of 1-Decanol. This product is intended for research and analytical applications. 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
|
-
- HY-15408AR
-
|
|
Dipeptidyl Peptidase
|
Metabolic Disease
|
|
Trelagliptin (succinate) (Standard) is the analytical standard of Trelagliptin (succinate). This product is intended for research and analytical applications. Trelagliptin (SYR-472) succinate is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM) .
|
-
- HY-16102R
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Bismuth subcitrate potassium (Standard) is the analytical standard of Bismuth subcitrate potassium (HY-16102). This product is intended for research and analytical applications. Bismuth subcitrate potassium is a compound bismuth salt with oral activity. Bismuth subcitrate potassium has antibacterial activity and can inhibit the growth of Campylobacter pyloridis with a MIC50 of 8 μg/mL. Bismuth subcitrate potassium can be used in the study of gastrointestinal diseases infected by Campylobacter pyloridis.
|
-
- HY-D0858AR
-
|
2-Morpholinoethanesulphonic acid (monohydrate) (Standard)
|
Biochemical Assay Reagents
|
Others
|
|
MES (monohydrate) (Standard) is the analytical standard of MES (monohydrate). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies .
|
-
- HY-B0878R
-
|
BMY-30056 (Standard); CGP-14458 (Standard); Ulobetasol propionate (Standard)
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Halobetasol propionate (Standard) (BMY-30056 (Standard)) is the analytical standard of Halobetasol propionate (HY-B0878). This product is intended for research and analytical applications. Halobetasol propionate (BMY-30056) is a synthetic glucocorticoid corticosteroid. Halobetasol propionate exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties. Halobetasol propionate can be used for the study of psoriasis .
|
-
- HY-B1172R
-
|
|
Endogenous Metabolite
Bacterial
|
Others
Cancer
|
|
Lactulose (Standard) is the analytical standard of Lactulose. This product is intended for research and analytical applications. Lactulose (4-O-β-D-Galactopyranosyl-D-fructose) is a poorly absorbed sugar that can be used to study constipation and hepatic encephalopathy. The drug generally begins to take effect 8 to 12 hours after administration, but it may take two days to improve constipation.
|
-
- HY-122141R
-
|
GHCA (Standard)
|
Reference Standards
Endogenous Metabolite
|
Infection
Metabolic Disease
|
|
Glycohyocholic acid (Standard) is the analytical standard of Glycohyocholic acid (HY-122141). This product is intended for use in research and analytical applications. Glycohyocholic acid (GHCA) is a primary conjugated bile acid formed by the conjugation of Cholic acid (HY-N0324) and Glycine (HY-Y0966). Glycohyocholic acid can be used in the study of hepatitis C-related cirrhosis and diabetes mellitus .
|
-
- HY-B0192AR
-
|
|
Adrenergic Receptor
|
Endocrinology
|
|
Alfuzosin (hydrochloride) (Standard) is the analytical standard of Alfuzosin (hydrochloride). This product is intended for research and analytical applications. Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .
|
-
- HY-N0842R
-
|
PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)
|
Virus Protease
|
Infection
|
|
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].
|
-
- HY-13676R
-
|
|
Progesterone Receptor
Autophagy
HIV
|
Endocrinology
Cancer
|
Megestrol acetate (Standard) is the analytical standard of Megestrol acetate. This product is intended for research and analytical applications. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
|
-
- HY-W015883R
-
|
|
Endogenous Metabolite
NF-κB
p38 MAPK
|
Metabolic Disease
Inflammation/Immunology
|
|
Fumaric acid (Standard) is the analytical standard of Fumaric acid. This product is intended for research and analytical applications. Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension .
|
-
- HY-W103960R
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
Mirabegron impurity-1 (Standard) is the analytical standard of Mirabegron impurity-1. This product is intended for research and analytical applications. Mirabegron impurity-1 is a potent and selective
β3- adrenergic receptor agonist. Mirabegron impurity-1
has the activity of inhibiting metabolism. Mirabegron impurity-1 can be used in
the study of the treatment of bladder impurity .
|
-
- HY-106542AR
-
|
|
Fungal
|
Infection
|
|
Eberconazole nitrate (Standard) is the analytical standard of Eberconazole nitrate. This product is intended for research and analytical applications. Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate is more effective than Clotrimazole (HY-10882), Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole nitrate has potential for the study of dermatophytosis .
|
-
- HY-105129R
-
|
|
Others
|
Cancer
|
|
Pimonidazole (hydrochloride) (Standard) is the analytical standard of Pimonidazole (hydrochloride). This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
|
-
- HY-B0191R
-
|
|
Prostaglandin Receptor
MMP
|
Cardiovascular Disease
Endocrinology
|
|
Bimatoprost (Standard) is the analytical standard of Bimatoprost. This product is intended for research and analytical applications. Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus [4] .
|
-
- HY-105129AR
-
|
|
Others
|
Cancer
|
|
Pimonidazole (Standard) is the analytical standard of Pimonidazole. This product is intended for research and analytical applications. Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor . Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia .
|
-
- HY-Y0946R
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Inflammation/Immunology
Cancer
|
|
Acetamide (Standard) is the analytical standard of Acetamide. This product is intended for research and analytical applications. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .
|
-
- HY-B0395CR
-
|
DU6859a hydrate (Standard)
|
Bacterial
Antibiotic
|
Infection
|
|
Sitafloxacin (hydrate) (Standard) is the analytical standard of Sitafloxacin (hydrate). This product is intended for research and analytical applications. Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections .
|
-
- HY-D0143AR
-
|
|
Flavivirus
Dengue Virus
Parasite
Potassium Channel
|
Infection
|
|
Quinine (dihydrochloride) (Standard) is the analytical standard of Quinine (dihydrochloride). This product is intended for research and analytical applications. Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
|
-
- HY-W010040R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
4-Hydroxyphenylpyruvic acid (Standard) is the analytical standard of 4-Hydroxyphenylpyruvic acid (HY-W010040). This product is intended for research and analytical applications. 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-Hydroxyphenylpyruvic acid is a substrate of 4-hydroxyphenylpyruvic acid dioxygenase. 4-Hydroxyphenylpyruvic acid can be used in the study of HPD-related diseases, such as type III tyrosinemia and hawkinsinuria .
|
-
- HY-B0002AR
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
Ondansetron (hydrochloride dihydrate) (Standard) is the analytical standard of Ondansetron (hydrochloride dihydrate). This product is intended for research and analytical applications. Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery .
|
-
- HY-N6996R
-
|
|
Reference Standards
Autophagy
PI3K
mTOR
Akt
|
Inflammation/Immunology
Cancer
|
|
Methyl Eugenol (Standard) is the analytical standard of Methyl Eugenol. This product is intended for research and analytical applications. Methyl Eugenol is a bait that has oral activity against oriental fruit fly (Hendel).Methyl Eugenol has anti-cancer and anti-inflammatory activities. Methyl Eugenol can induce Autophagy in cells. Methyl Eugenol can be used in the study of intestinal ischemia/reperfusion injury .
|
-
- HY-12641R
-
|
|
Parasite
nAChR
Antibiotic
|
Infection
|
|
Pyrantel (tartrate) (Standard) is the analytical standard of Pyrantel (tartrate). This product is intended for research and analytical applications. Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
|
-
- HY-12366R
-
|
MK-1602 (Standard)
|
CGRP Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Ubrogepant (Standard) is the analytical standard of Ubrogepant. This product is intended for research and analytical applications. Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor (CGRP). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine .
|
-
- HY-B0433AR
-
|
|
Dengue Virus
Flavivirus
Parasite
Potassium Channel
|
Infection
|
|
Quinine (hydrochloride dihydrate) (Standard) is the analytical standard of Quinine (hydrochloride dihydrate). This product is intended for research and analytical applications. Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
|
-
- HY-W007828R
-
|
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Methyl 3-phenylpropanoate (Standard) is the analytical standard of Methyl 3-phenylpropanoate (HY-W007828). This product is intended for research and analytical applications. Methyl 3-phenylpropanoate is a phenylpropionate compound. Methyl 3-phenylpropanoate derivatives interfere with insect feeding behavior. Methyl 3-phenylpropanoate can be used to study insect feeding behavior .
|
-
- HY-B0164R
-
|
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Mizolastine (Standard) is the analytical standard of Mizolastine. This product is intended for research and analytical applications. Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial .
|
-
- HY-Y0966R
-
|
|
Endogenous Metabolite
iGluR
VEGFR
|
Neurological Disease
|
|
Glycine (Standard) is the analytical standard of Glycine. This product is intended for research and analytical applications. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .
|
-
- HY-A0152R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Thyroxine (Standard) is the analytical standard of D-Thyroxine (HY-A0152). This product is intended for research and analytical applications. D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. D-Thyroxine can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia .
|
-
- HY-10521R
-
|
SB-480848 (Standard)
|
Phospholipase
Apoptosis
|
Cardiovascular Disease
Cancer
|
|
Darapladib (Standard) is the analytical standard of Darapladib. This product is intended for research and analytical applications. Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor (IC50=0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer .
|
-
- HY-108913R
-
|
|
Beta-lactamase
Antibiotic
|
Infection
|
|
Nitrocefin (Standard) is the analytical standard of Nitrocefin. This product is intended for research and analytical applications. Nitrocefin is a chromogenic β-lactamase substrate that undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .
|
-
- HY-17443BR
-
|
|
Elastase
SARS-CoV
|
Cancer
|
|
Sivelestat (sodium tetrahydrate) (Standard) is the analytical standard of Sivelestat (sodium tetrahydrate). This product is intended for research and analytical applications. Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19 .
|
-
- HY-B1069R
-
|
SIN-10 (Standard); Morsydomine (Standard)
|
Drug Metabolite
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
|
|
Molsidomine (Standard) (SIN-10 (Standard)) is the analytical standard of Molsidomine (HY-B1069). This product is intended for research and analytical applications. Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications.
|
-
- HY-103609R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
|
-
- HY-B0607R
-
|
NTBC (Standard); Nitisone (Standard); SC56735 (Standard)
|
HPPD
|
Metabolic Disease
|
|
Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
|
-
- HY-B1715R
-
|
ISF2522 (Standard)
|
Reference Standards
GABA Receptor
NO Synthase
|
Neurological Disease
Inflammation/Immunology
|
|
Oxiracetam (Standard) is the analytical standard of Oxiracetam. This product is intended for research and analytical applications. Oxiracetam (ISF2522) is an orally active and a BBB-penetrable cyclic derivative of γ-aminobutyric acid (GABA). Oxiracetam reaches the hippocampus and cerebral cortex in high concentrations. Oxiracetam can promote cognitive function and regulate inflammatory response, with powerful neuroprotective effects. Oxiracetam can be used in the study of central nervous system diseases .
|
-
- HY-B1695R
-
|
|
Others
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .
|
-
- HY-N1458R
-
|
|
Parasite
Autophagy
p62
Reactive Oxygen Species
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Isoschaftoside (Standard) is the analytical standard of Isoschaftoside. This product is intended for research and analytical applications. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.
|
-
- HY-12640R
-
|
Pyrantel embonate (Standard)
|
Parasite
nAChR
Antibiotic
|
Infection
|
|
Pyrantel (pamoate) (Standard) is the analytical standard of Pyrantel (pamoate). This product is intended for research and analytical applications. Pyrantel pamoate (Pyrantel embonate) is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel pamoate can cause spasmodic muscle paralysis in parasites. Pyrantel pamoate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis .
|
-
- HY-A0061R
-
|
|
Thymidylate Synthase
HSV
Nucleoside Antimetabolite/Analog
Orthopoxvirus
DNA/RNA Synthesis
Apoptosis
Autophagy
|
Cancer
|
|
Trifluridine (Standard) is the analytical standard of Trifluridine. This product is intended for research and analytical applications. Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors .
|
-
- HY-B0966R
-
|
Benzophenone-8 (Standard); UV-24 (Standard)
|
Biochemical Assay Reagents
|
Inflammation/Immunology
Cancer
|
|
Dioxybenzone (Standard) is the analytical standard of Dioxybenzone. This product is intended for research and analytical applications. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study.
|
-
- HY-75087R
-
|
(+)-(R)-Proline (Standard); (R)-(+)-Proline (Standard); (R)-2-Carboxypyrrolidine (Standard); (R)-Proline (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-pyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-pyrrolidine-2-carboxylic acid. This product is intended for research and analytical applications. (R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms[1].
|
-
- HY-105634AR
-
|
|
Progesterone Receptor
|
Endocrinology
Cancer
|
|
Nomegestrol acetate (Standard) is the analytical standard of Nomegestrol acetate. This product is intended for research and analytical applications. Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies .
|
-
- HY-B0757AR
-
|
rel-Vitamin E Nicotinate (Standard)
|
Reactive Oxygen Species
Endogenous Metabolite
|
Cardiovascular Disease
|
|
(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
|
-
- HY-B0143R
-
|
Nicotinic acid (standard); Vitamin B3 (standard)
|
Autophagy
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Niacin (Standard) is the analytical standard of Niacin. This product is intended for research and analytical applications. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases .
|
-
- HY-16742BR
-
|
|
Antibiotic
Bacterial
Topoisomerase
|
Infection
|
|
Niacin (Standard) is the analytical standard of Niacin. This product is intended for research and analytical applications. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases .
|
-
- HY-113071AR
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
|
|
Mevalonic acid (lithium salt) (Standard) is the analytical standard of Mevalonic acid (lithium salt). This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .
|
-
- HY-17438R
-
|
|
CMV
Apoptosis
DNA/RNA Synthesis
Orthopoxvirus
Endogenous Metabolite
|
Infection
Cancer
|
|
Cidofovir (Standard) is the analytical standard of Cidofovir. This product is intended for research and analytical applications. Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .
|
-
- HY-16566R
-
|
Kanamycin A (Standard)
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
|
Kanamycin (Standard) is the analytical standard of Kanamycin. This product is intended for research and analytical applications. Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].
|
-
- HY-N0567R
-
|
|
Apoptosis
Autophagy
|
Cardiovascular Disease
Cancer
|
|
Hydroxysafflor yellow A (Standard) is the analytical standard of Hydroxysafflor yellow A. This product is intended for research and analytical applications. Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease .
|
-
- HY-B1363R
-
|
Bendrofluazide (Standard)
|
NKCC
Reference Standards
|
Cardiovascular Disease
|
|
Bendroflumethiazide (Standard) (Bendrofluazide (Standard)) is the analytical standard of Bendroflumethiazide (HY-B1363). This product is intended for research and analytical applications. Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .
|
-
- HY-113315R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3b-Hydroxy-5-cholenoic acid (Standard) is an analytical standard for 3b-Hydroxy-5-cholenoic acid. This product is intended for research and analytical applications. 3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin. 3b-Hydroxy-5-cholenoic acid can be used in the study of hepatic ductular hypoplasia syndrome .
|
-
- HY-W016009R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2'-Deoxyadenosine-5'-monophosphate (Standard) is the analytical standard of 2'-Deoxyadenosine-5'-monophosphate. This product is intended for research and analytical applications. 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage .
|
-
- HY-125911R
-
-
- HY-B0084R
-
|
|
Progesterone Receptor
|
Endocrinology
|
|
Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
|
-
- HY-B1028R
-
|
|
Endogenous Metabolite
SARS-CoV
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Pantethine (Standard) is the analytical standard of Pantethine. This product is intended for research and analytical applications. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .
|
-
- HY-N2393R
-
-
- HY-W012653R
-
|
|
Reference Standards
Biochemical Assay Reagents
|
Others
|
|
4'-Methylacetophenone (Standard) is the analytical standard of 4'-Methylacetophenone (HY-W012653). This product is intended for research and analytical applications. 4′-Methylacetophenone is a phenolic compound that can be used as a fragrance material. 4′-Methylacetophenone is wildly occurs in volatile compounds in food and in some natural complex substances (NCS). 4′-Methylacetophenone can be used to study the Bayer-Villiger reaction and to synthesize functionalized terpolymers.
|
-
- HY-107469R
-
|
Pyridoxaldehyde (Standard)
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
Pyridoxal (Standard) is the analytical standard of Pyridoxal. This product is intended for research and analytical applications. Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].
|
-
- HY-117235R
-
|
|
Reactive Oxygen Species
Fungal
Apoptosis
SOD
Bcl-2 Family
Influenza Virus
Interleukin Related
|
Infection
Inflammation/Immunology
Cancer
|
|
Diallyl Trisulfide (Standard) is the analytical standard of Diallyl Trisulfide. This product is intended for research and analytical applications. Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer[1][2][3][4].
|
-
- HY-10232R
-
|
Gaboxadol (Standard)
|
GABA Receptor
|
Neurological Disease
|
|
THIP (Standard) is the analytical standard of THIP. This product is intended for research and analytical applications. THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders .
|
-
- HY-14608AR
-
|
|
iGluR
Apoptosis
Ferroptosis
Endogenous Metabolite
|
Neurological Disease
|
|
L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases .
|
-
- HY-118545AR
-
|
|
Reference Standards
STAT
|
Inflammation/Immunology
Cancer
|
|
Butamirate citrate (Standard) is the analytical standard of Butamirate citrate (HY-118545A). This product is intended for research and analytical applications. Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .
|
-
- HY-136633R
-
|
|
Herbicide
|
Others
|
|
Pyroxasulfone (Standard) is the analytical standard of Pyroxasulfone. This product is intended for research and analytical applications. Pyroxasulfone is a broad-spectrum pyrazole herbicide used primarily for all-season residual weed control in corn and soybeans. Pyroxasulfone is active against a variety of annual grasses and some broad-leaved weeds, and can be absorbed through roots and stems to inhibit early seedling growth of sensitive plants. Pyroxasulfone can be used to study herbicide effects and weed resistance .
|
-
- HY-13858AR
-
|
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
Sarecycline (hydrochloride) (Standard) is the analytical standard of Sarecycline (hydrochloride). This product is intended for research and analytical applications. Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .
|
-
- HY-B1703S
-
|
|
Antibiotic
Bacterial
Parasite
|
Infection
|
|
Nifursol- 13C6 is the 13C6 labeled Nifursol (HY-B1703). Nifursol (Standard) is the analytical standard of Nifursol (HY-B1703). This product is used for research and analytical applications. Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals .
|
-
- HY-B0322R
-
|
Ro 4-2130 (Standard)
|
Antibiotic
Bacterial
|
Infection
|
|
Sulfamethoxazole (Standard) (Ro 4-2130 (Standard)) is the analytical standard of Sulfamethoxazole (HY-B0322). This product is intended for research and analytical applications. Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.
|
-
- HY-B0004R
-
|
|
Adenosine Receptor
Phosphodiesterase (PDE)
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Doxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm .
|
-
- HY-A0082R
-
|
|
mAChR
Sodium Channel
|
Neurological Disease
|
|
Diphenidol (hydrochloride) (Standard) is the analytical standard of Diphenidol (hydrochloride). This product is intended for research and analytical applications. Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea [4] .
|
-
- HY-Y1362R
-
|
|
Autophagy
Apoptosis
Pyroptosis
NF-κB
|
Inflammation/Immunology
Cancer
|
|
Ethyl pyruvate (Standard) is the analytical standard of Ethyl pyruvate. This product is intended for research and analytical applications. Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease .
|
-
- HY-N8423R
-
|
|
ERK
GSK-3
|
Neurological Disease
Metabolic Disease
|
|
α-Amyrin (Standard) is the analytical standard of α-Amyrin. This product is intended for research and analytical applications. α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission .
|
-
- HY-B1037R
-
|
Albuterol (Standard); AH-3365 (Standard)
|
Adrenergic Receptor
ERK
|
Inflammation/Immunology
Cancer
|
|
Salbutamol (Standard) is the analytical standard of Salbutamol. This product is intended for research and analytical applications. Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD) .
|
-
- HY-B0322AR
-
|
Ro 4-2130 sodium (Standard)
|
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Sulfamethoxazole (Standard) (Ro 4-2130 (Standard)) sodium is the analytical standard of Sulfamethoxazole sodium (HY-B0322A). This product is intended for research and analytical applications. Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.
|
-
- HY-B0415R
-
|
|
Glucocorticoid Receptor
Wnt
|
Inflammation/Immunology
Endocrinology
|
|
Fluocinolone (Acetonide) (Standard) is the analytical standard of Fluocinolone (Acetonide). This product is intended for research and analytical applications. Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .
|
-
- HY-113958R
-
|
|
TrxR
|
Others
|
|
Difethialone (Standard) is the analytical standard of Difethialone. This product is intended for research and analytical applications. Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts .
|
-
- HY-N0246R
-
|
|
LXR
Bacterial
|
Metabolic Disease
Inflammation/Immunology
|
|
Saikosaponin A (Standard) is the analytical standard of Saikosaponin A. This product is intended for research and analytical applications. Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also act as a potential peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis .
|
-
- HY-128423R
-
|
|
Antibiotic
Bacterial
NF-κB
Apoptosis
|
Infection
Inflammation/Immunology
|
|
Tylvalosin (tartrate) (Standard) is the analytical standard of Tylvalosin (tartrate). This product is intended for research and analytical applications. Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation [4].
|
-
- HY-117651R
-
|
|
Acyltransferase
|
Cancer
|
|
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
|
-
- HY-119358R
-
|
|
Reactive Oxygen Species
Apoptosis
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Traumatic Acid (Standard) is the analytical standard of Traumatic Acid. This product is intended for research and analytical applications. Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].
|
-
- HY-P0263R
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
|
-
- HY-105064R
-
|
CP-597396 (Standard)
|
Na+/H+ Exchanger (NHE)
|
Cardiovascular Disease
|
|
Zoniporide (Standard) is the analytical standard of Zoniporide. This product is intended for research and analytical applications. Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .
|
-
- HY-N6703R
-
|
(+)-ar-Turmerone (Standard)
|
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
ar-Turmerone (Standard) is the analytical standard of ar-Turmerone. This product is intended for research and analytical applications. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study.
|
-
- HY-B0843AR
-
|
(R)-Metalaxyl (Standard)
|
DNA/RNA Synthesis
Fungal
|
Infection
Inflammation/Immunology
|
|
Metalaxyl-M ((R)-Metalaxyl) (Standard) is the analytical standard of Metalaxyl-M (HY-B0843A). This product is intended for research and analytical applications. Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .
|
-
- HY-B0093AR
-
|
CGS14824A (Standard)
|
Angiotensin-converting Enzyme (ACE)
Apoptosis
Reactive Oxygen Species
Akt
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Benazepril hydrochloride (Standard) is the analytical standard of Benazepril hydrochloride. This product is intended for research and analytical applications. Benazepril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor to reduce angiotensin-II production. Benazepril hydrochloride inhibits oxidative stress and inhibits apoptosis by the PI3K/Akt signaling pathway. In addition, Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria. Benazepril hydrochloride can be used in the study of hypertension, heart failure and diabetic nephropathy .
|
-
- HY-W010668R
-
|
|
Flavivirus
Dengue Virus
Parasite
Potassium Channel
|
Others
|
|
Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
|
-
- HY-16566AR
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
|
-
- HY-B1126R
-
|
|
iGluR
|
Neurological Disease
Cancer
|
|
Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .
|
-
- HY-N7513R
-
|
|
TNF Receptor
Drug Metabolite
|
Cardiovascular Disease
|
|
Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .
|
-
- HY-W042416R
-
|
DMAc (Standard)
|
Reference Standards
NF-κB
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
|
-
- HY-A0016R
-
|
|
mAChR
Sodium Channel
Calcium Channel
Adrenergic Receptor
Cytochrome P450
Autophagy
|
Cardiovascular Disease
|
|
Dronedarone (Standard) is the analytical standard of Dronedarone. This product is intended for research and analytical applications. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4 .
|
-
- HY-B1456AR
-
|
LILLY-53858 (Standard)
|
COX
Melanocortin Receptor
ERK
|
Inflammation/Immunology
|
|
Fenoprofen (Standard) (LILLY-53858 (Standard)) is the analytical standard of Fenoprofen (HY-B1456A). This product is intended for research and analytical applications. Fenoprofenc is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.
|
-
- HY-B0882R
-
|
|
Reference Standards
Cholinesterase (ChE)
|
Neurological Disease
Inflammation/Immunology
|
|
Edrophonium chloride (Standard) is the analytical standard of Edrophonium chloride (HY-B0882). This product is intended for research and analytical applications. Edrophonium chloride is a short-acting acetylcholinesterase (AChE) inhibitor. Edrophonium chloride has Ki values of 0.2, 0.2, and 0.4 μM and IC50 values of 0.2, 0.05, and 0.5 μM for AChE in human erythrocytes, purified calf forebrain, and purified octopus brain, respectively. Edrophonium chloride can be used to detect early digitalis toxicity and in the study of myasthenia gravis.
|
-
- HY-B0182R
-
|
|
Nucleoside Antimetabolite/Analog
SARS-CoV
Virus Protease
FAAH
Ceramidase
Glutathione Peroxidase
|
Infection
Inflammation/Immunology
Cancer
|
|
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .
|
-
- HY-121383R
-
|
AH5158 (Standard); Sch-15719W free base (Standard)
|
Adrenergic Receptor
|
Cardiovascular Disease
Inflammation/Immunology
Endocrinology
|
|
Labetalol (Standard) is the analytical standard of Labetalol. This product is intended for research and analytical applications. Labetalol (AH5158) is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
|
-
- HY-B0484R
-
|
|
Adrenergic Receptor
|
Cardiovascular Disease
|
|
Buflomedil hydrochloride (Standard) is the analytical standard of Buflomedil hydrochloride (HY-B0484). This product is intended for research and analytical applications. Buflomedil hydrochloride (Standard), a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders .
|
-
- HY-B0369AR
-
|
|
iGluR
|
Neurological Disease
|
|
Orphenadrine (citrate) (Standard) is the analytical standard of Orphenadrine (citrate). This product is intended for research and analytical applications. Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .
|
-
- HY-W039454R
-
|
|
Reference Standards
Bacterial
SARS-CoV
|
Infection
|
|
2,4-Dichlorobenzyl alcohol (Standard) is the analytical standard of 2,4-Dichlorobenzyl alcohol (HY-W039454). This product is intended for research and analytical applications. 2,4-Dichlorobenzyl alcohol is an orally active mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections. 2,4-Dichlorobenzyl alcohol exhibits prenatal developmental toxicity.2,4-Dichlorobenzyl alcohol can be used in the study of SARS-CoV .
|
-
- HY-B0543R
-
|
|
Reactive Oxygen Species
|
Cancer
|
|
Allylthiourea (Standard) is the analytical standard of Allylthiourea. This product is intended for research and analytical applications. Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC50 of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies [4].
|
-
- HY-106577R
-
|
|
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
Cibenzoline (Standard) is the analytical standard of Cibenzoline. This product is intended for research and analytical applications. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .
|
-
- HY-B0288BR
-
|
LILLY-53858 Calcium hydrate (Standard)
|
COX
Melanocortin Receptor
ERK
|
Inflammation/Immunology
|
|
Fenoprofen (LILLY-53858 (Standard)) (Standard) Calcium hydrate is the analytical standard of Fenoprofen Calcium hydrate (HY-B0288B). This product is intended for research and analytical applications. Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.
|
-
- HY-B1108R
-
|
AH-5158 hydrochloride(Standard); Sch-15719W (Standard)
|
Adrenergic Receptor
|
Cardiovascular Disease
Inflammation/Immunology
Endocrinology
|
|
Labetalol hydrochloride (Standard) is the analytical standard of Labetalol hydrochloride (HY-B1108). This product is intended for research and analytical applications. Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
|
-
- HY-B0600R
-
|
|
Prostaglandin Receptor
|
Cardiovascular Disease
Others
|
|
Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [4] .
|
-
- HY-B0568R
-
|
|
Ferroptosis
HCV
Apoptosis
COX
|
Infection
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Deferiprone (Standard) is the analytical standard of Deferiprone. This product is intended for research and analytical applications. Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study .
|
-
- HY-B0985R
-
|
|
TRP Channel
|
Neurological Disease
|
|
Phenazopyridine (hydrochloride) (Standard) is the analytical standard of Phenazopyridine (hydrochloride). This product is intended for research and analytical applications. Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases .
|
-
- HY-B1050R
-
|
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
|
Gemifloxacin (mesylate) (Standard) is the analytical standard of Gemifloxacin (mesylate). This product is intended for research and analytical applications. Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-B0973R
-
|
DBT (Standard); Diphenylene sulfide (Standard)
|
Cytochrome P450
Aryl Hydrocarbon Receptor
|
Metabolic Disease
|
|
Dibenzothiophene (Standard) is the analytical standard of Dibenzothiophene (HY-B0973). This product is intended for research and analytical applications. Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .
|
-
- HY-N1501R
-
|
|
α-synuclein
Reference Standards
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
Beta-asarone (Standard) is the analytical standard of Beta-asarone. This product is intended for research and analytical applications. Beta-asarone is an orally active and BBB-penetrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases .
|
-
- HY-N0405R
-
|
|
TNF Receptor
Interleukin Related
|
Neurological Disease
Cancer
|
|
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .
|
-
- HY-W004563
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Neocuproine is an organic compound commonly used as a complexing reagent and copper ion detector. It can form stable complexes with copper ions, and can play a catalytic role in certain chemical reactions and analytical methods. In addition, this compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases
|
-
- HY-10224R
-
|
LBH589 (Standard); NVP-LBH589 (Standard)
|
HDAC
Autophagy
HIV
Apoptosis
|
Infection
Cancer
|
|
Panobinostat (Standard) (LBH589 (Standard)) is the analytical standard of Panobinostat (HY-10224). This product is intended for research and analytical applications. Panobinostat is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities . Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells . Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma .
|
-
- HY-10585R
-
|
Dipropylacetic Acid (Standard)
|
Organoid
HDAC
Autophagy
Mitophagy
HIV
Notch
Apoptosis
Endogenous Metabolite
|
Infection
Neurological Disease
Metabolic Disease
Cancer
|
|
Valproic acid (Dipropylacetic Acid) (Standard) is an analytical standard for valproic acid. This product is intended for research and analytical applications. Valproic acid is an orally active HDAC inhibitor (IC50=0.5-2 mM), inhibits the activity of HDAC1 (IC50=400 μM), and induces the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits the proliferation of small cell lung cancer (SCLC) cells. Valproic acid is used in the study of epilepsy, bipolar disorder, metabolic diseases, HIV infection, and migraine .
|
-
- HY-D0803R
-
|
|
Apoptosis
VEGFR
PI3K
Akt
|
Infection
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Thymoquinone (Standard) is the analytical standard of Thymoquinone. This product is intended for research and analytical applications. Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .
|
-
- HY-B0135R
-
|
|
NKCC
GABA Receptor
|
Metabolic Disease
Cancer
|
|
Furosemide (Standard) is the analytical standard of Furosemide. This product is intended for research and analytical applications. Furosemide is a potent and orally active inhibitor of Na +/K +/2Cl - (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .
|
-
- HY-135470R
-
|
P-7138 (Standard)
|
Reference Standards
Bacterial
|
Infection
|
|
Nifurpirinol (P-7138) (Standard) is the analytical standard of Nifurpirinol (HY-135470). This product is intended for research and analytical applications. Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) .
|
-
- HY-B0573R
-
|
|
Adrenergic Receptor
Bacterial
|
Neurological Disease
Endocrinology
Cancer
|
|
Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
|
-
- HY-B0347R
-
|
|
Calcium Channel
Reactive Oxygen Species
Caspase
Apoptosis
|
Cardiovascular Disease
|
|
Lacidipine (Standard) is the analytical standard of Lacidipine. This product is intended for research and analytical applications. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
|
-
- HY-B0124R
-
|
|
Carbonic Anhydrase
Apoptosis
|
Neurological Disease
|
|
Zonisamide (Standard) is the analytical standard of Zonisamide. This product is intended for research and analytical applications. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
|
-
- HY-A0012R
-
|
UK-88525 (hydrobromide) (Standard)
|
mAChR
p38 MAPK
Akt
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Darifenacin (hydrobromide) (Standard) is the analytical standard of Darifenacin (hydrobromide). This product is intended for research and analytical applications. Darifenacin (hydrobromide) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin (hydrobromide) binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin (hydrobromide) can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin (hydrobromide) inhibits tumor growth in colorectal cancer cells and has anti-tumor effects .
|
-
- HY-B0988R
-
|
|
Autophagy
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Apoptosis
Akt
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Deferoxamine (mesylate) (Standard) is the analytical standard of Deferoxamine (mesylate). This product is intended for research and analytical applications. Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
|
-
- HY-10571R
-
|
U 90152 (Standard); BHAP-U 90152 (Standard)
|
HIV
Reverse Transcriptase
|
Infection
|
|
Delavirdine (Standard) is the analytical standard of Delavirdine. This product is intended for research and analytical applications. Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .
|
-
- HY-136587R
-
|
|
Reference Standards
Histamine Receptor
mGluR
|
Inflammation/Immunology
|
|
Oxomemazine (Standard) is the analytical standard of Oxomemazine (HY-136587). This product is intended for research and analytical applications. Oxomemazine is a phenothiazine-based histamine H1-receptor blocker. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine is an antihistamine and anticholinergic agent used for the study of cough treatment. Oxomemazine is protective against anaphylactic microshock in guinea pigs .
|
-
- HY-N4095R
-
|
|
Aryl Hydrocarbon Receptor
Glycosidase
Reactive Oxygen Species
GLUT
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Brevifolincarboxylic acid (Standard) is the analytical standard of Brevifolincarboxylic acid (HY-N4095). This product is intended for research and analytical applications. Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC50 value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases .
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- HY-B1231R
-
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Adrenergic Receptor
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Heptaminol (hydrochloride) (Standard) is the analytical standard of Heptaminol (hydrochloride). This product is intended for research and analytical applications. Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels .
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- HY-B0712AR
-
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Bacterial
Antibiotic
GSK-3
Aurora Kinase
|
Infection
Cancer
|
|
Ceftriaxone (sodium hydrate) (Standard) is the analytical standard of Ceftriaxone (sodium hydrate). This product is intended for research and analytical applications. Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis .
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- HY-16474R
-
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GnRH Receptor
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Endocrinology
Cancer
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Relugolix (Standard) is the analytical standard of Relugolix. This product is intended for research and analytical applications. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209) . Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al .
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- HY-A0066AR
-
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Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)
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Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
|
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Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research .
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- HY-W015236R
-
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Biochemical Assay Reagents
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Others
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H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
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- HY-118700AR
-
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NO Synthase
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Neurological Disease
|
|
H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
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- HY-W013549R
-
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Drug Metabolite
Bacterial
|
Infection
|
|
6-Aminopenicillanic acid (Standard) is the analytical standard of 6-Aminopenicillanic acid. This product is intended for research and analytical applications. 6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses .
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- HY-B0215R
-
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Reactive Oxygen Species
Endogenous Metabolite
Apoptosis
Ferroptosis
Influenza Virus
Disulfidptosis
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Infection
Neurological Disease
Cancer
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Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .
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- HY-B1625R
-
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HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Apoptosis
Akt
Autophagy
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Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
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Deferoxamine (Standard) is the analytical standard of Deferoxamine. This product is intended for research and analytical applications. Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
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- HY-139554AR
-
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KBP-7072 TFA (Standard)
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Bacterial
Antibiotic
|
Infection
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|
Zifanocycline (TFA) (Standard) is the analytical standard of Zifanocycline (TFA). This product is intended for research and analytical applications. Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections[1][2].
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- HY-N2013R
-
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Aristololactam (Standard); Aristolactam (Standard)
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Caspase
Apoptosis
|
Inflammation/Immunology
|
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Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .
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- HY-10571AR
-
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U 90152 mesylate (Standard); BHAP-U 90152 mesylate (Standard)
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HIV
Reverse Transcriptase
|
Infection
|
|
Delavirdine (mesylate) (Standard) is the analytical standard of Delavirdine (mesylate). This product is intended for research and analytical applications. Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .
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- HY-N1516R
-
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Apoptosis
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Cancer
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3-Aminobenzoic acid (Standard) is the analytical standard of 3-Aminobenzoic acid. This product is intended for research and analytical applications. 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects .
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- HY-W015786R
-
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Bacterial
|
Infection
Metabolic Disease
|
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L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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- HY-15790R
-
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A 3309 (Standard); AZD 7806 (Standard)
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Apical Sodium-Dependent Bile Acid Transporter
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Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Elobixibat (Standard) is the analytical standard of Elobixibat (HY-15790). This product is intended for research and analytical applications. Elobixibat (A 3309; AZD 7806) is orally active, bile acid transporter (IBAT) inhibitor with IC50 values ??of 0.53 nM (human IBAT), 0.13 nM (mouse IBAT), and 5.8 nM (canine IBAT). Elobixibat can lower LDL cholesterol, increase serum GLP-1, promote colonic motility, and has the potential to treat metabolic syndrome. Elobixibat can be used in the study of chronic functional constipation (CIC), dyslipidemia, non-alcoholic hepatitis, and liver tumors in the elderly .
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- HY-A0245R
-
|
|
VD/VDR
|
Metabolic Disease
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers .
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- HY-N0546R
-
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Nuezhenoside (Standard)
|
Reference Standards
CaSR
RIP kinase
Mixed Lineage Kinase
TGF-beta/Smad
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
Endocrinology
|
|
Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546). This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .
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- HY-113224R
-
|
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Endogenous Metabolite
LXR
Fatty Acid Synthase (FASN)
Interleukin Related
Reactive Oxygen Species
NOD-like Receptor (NLR)
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].
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- HY-B1693R
-
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Methotrimeprazine (Standard)
|
5-HT Receptor
Dopamine Receptor
Autophagy
Histamine Receptor
Enterovirus
Calcium Channel
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Levomepromazine (Standard) is the analytical standard of Levomepromazine. This product is intended for research and analytical applications. Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca 2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca 2+ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting .
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- HY-130462R
-
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Liposome
|
Others
|
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers .
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- HY-B1275AR
-
|
Cephalotin (Standard)
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cardiovascular Disease
|
|
Cephalothin (Standard) is the analytical standard of Cephalothin (HY-B1275A). This product is intended for research and analytical applications. Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies .
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- HY-I0746R
-
|
|
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
|
|
3-Aminobenzoic acid (Standard) is the analytical standard of 3-Aminobenzoic acid. This product is intended for research and analytical applications. 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects .
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- HY-129836R
-
|
|
Antibiotic
|
Infection
|
|
L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
|
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- HY-B1907R
-
|
Rifamycin SV (sodium) (Standard)
|
Bacterial
Antibiotic
|
Infection
|
|
Rifamycin (sodium) (Standard) is the analytical standard of Rifamycin (sodium). This product is intended for research and analytical applications. Rifamycin sodium (Rifamycin SV sodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
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-
- HY-B0455R
-
|
SC47111A hydrochloride (Standard); NY-198 hydrochloride (Standard)
|
Reference Standards
Bacterial
Antibiotic
Topoisomerase
Reactive Oxygen Species
Apoptosis
|
Infection
Endocrinology
Cancer
|
|
Lomefloxacin (hydrochloride) (Standard) is the analytical standard of Lomefloxacin hydrochloride (HY-B0455). This product is intended for research and analytical applications. Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma .
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- HY-B0712R
-
|
Ro 13-9904 free acid (Standard)
|
Bacterial
Antibiotic
GSK-3
Aurora Kinase
|
Infection
Inflammation/Immunology
Cancer
|
|
Ceftriaxone (Standard) is the analytical standard of Ceftriaxone. This product is intended for research and analytical applications. Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis[1][2][3][4][5][6][7].
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-
- HY-N1181R
-
|
|
Endogenous Metabolite
ClpP
Bacterial
Apoptosis
Akt
Interleukin Related
COX
JNK
p38 MAPK
Reactive Oxygen Species
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
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-
- HY-A0165R
-
|
|
Phosphodiesterase (PDE)
Reference Standards
|
Neurological Disease
|
|
Tofisopam (Standard) is the analytical standard of Tofisopam (HY-A0165). This product is intended for research and analytical applications. Tofisopam, a 2,3-benzodiazepine compound, is an orally active anxiolytic agent. Tofisopam can inhibit phosphodiesterase PDE isoenzyme activity, withIC50 values of 2.11 μM, 1.98 μM, 0.42 μM, and 0.92 μM for PDE-2A3, PDE-3A, PDE-4A1, and PDE-10A1, respectively. Tofisopam can be used for the study of anxiety .
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-
- HY-17471AR
-
|
1,1-Dimethylbiguanide (hydrochloride) (Standard)
|
AMPK
Autophagy
Mitophagy
Apoptosis
mTOR
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Metformin hydrochloride (Standard) is the analytical standard of Metformin (hydrochloride). This product is intended for research and analytical applications. Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
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-
- HY-70057R
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
Safinamide (Standard) is the analytical standard of Safinamide. This product is intended for research and analytical applications. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM) . Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al .
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-
- HY-N0671R
-
|
Rhaponiticin (Standard)
|
Reference Standards
Apoptosis
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .
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-
- HY-G0004R
-
|
3-Hydroxyacetaminophen (Standard)
|
Drug Metabolite
|
Inflammation/Immunology
|
|
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) (Standard) is the analytical standard of Acetaminophen metabolite 3-hydroxy-acetaminophen (HY-G0004). This product is intended for research and analytical applications. Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .
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- HY-W003607R
-
|
|
Tyrosinase
|
Inflammation/Immunology
|
|
3-O-Ethyl-L-ascorbic acid (Standard) is the analytical reference standard for 3-O-Ethyl-L-ascorbic acid. 3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic .
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-
- HY-W012814R
-
|
|
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
4-Methylcatechol (Standard) is the analytical standard of 4-Methylcatechol. This product is intended for research and analytical applications. 4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation[1][2][3][4][5][6].
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-
- HY-14151R
-
|
|
5-HT Receptor
Apoptosis
Autophagy
|
Neurological Disease
Cancer
|
|
Prucalopride (Standard) is the analytical standard of Prucalopride. This product is intended for research and analytical applications. Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer .
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-
- HY-B0267AR
-
|
|
mAChR
Potassium Channel
|
Neurological Disease
|
|
Oxybutynin (chloride) (Standard) is the analytical standard of Oxybutynin (chloride). This product is intended for research and analytical applications. Oxybutynin chloride is an oral active and competitive mAChR antagonist with Kis of 14.3 and 5.55 nM for specific [ 3H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC50 value of 11.51 μM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB) . Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-113410R
-
|
|
Na+/K+ ATPase
Mitochondrial Metabolism
Reactive Oxygen Species
|
Neurological Disease
Metabolic Disease
|
|
3-Methylglutaric acid (Standard) is the analytical standard of 3-Methylglutaric acid (HY-113410). This product is intended for research and analytical applications. 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na +, K +-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na +, K +-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration .
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- HY-B0168AR
-
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Reference Standards
Serotonin Transporter
PERK
|
Neurological Disease
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Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran hydrochloride (HY-B0168A). This product is intended for research and analytical applications. Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
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- HY-W014901R
-
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BPF (Standard); 4,4'-Dihydroxydiphenylmethane (Standard)
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Reference Standards
Reactive Oxygen Species
Akt
GSK-3
Apoptosis
|
Neurological Disease
Metabolic Disease
Endocrinology
|
|
Bisphenol F (Standard) is the analytical standard of Bisphenol F (HY-W014901). This product is intended for research and analytical applications. Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) .
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- HY-D0889R
-
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Endogenous Metabolite
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Metabolic Disease
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Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
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- HY-B1885R
-
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Insecticide
Parasite
Cholinesterase (ChE)
AMPK
PI3K
Akt
Apoptosis
SOD
|
Infection
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|
Fenitrothion (Standard) is the analytical standard of Fenitrothion (HY-B1885). This product is intended for research and analytical applications. Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies .
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- HY-W001160R
-
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Endogenous Metabolite
nAChR
Calcium Channel
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Neurological Disease
Endocrinology
Cancer
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5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160). This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT3 receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders .
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- HY-W010516R
-
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2-Methylpentanoic acid (Standard)
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Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
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- HY-W090065
-
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1-Pyrenemethylamine hydrochloride
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Biochemical Assay Reagents
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Others
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|
Pyren-1-ylmethanamine hydrochloride, Pyren-1-ylmethanamine hydrochloride is commonly used as a fluorescent probe in biochemistry and molecular biology to detect and study nucleic acids, proteins and other biomolecules, moreover, it has been used in analytical chemistry Among them, for the detection of heavy metals and other pollutants in environmental samples, the pyrene group in the molecule exhibits strong fluorescence properties, which makes it useful as a sensitive and selective detector in various applications.
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- HY-D0932R
-
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Solvent Red 24 (Standard); C.I. 26105 (Standard)
|
Biochemical Assay Reagents
Aryl Hydrocarbon Receptor
Cytochrome P450
|
Metabolic Disease
|
|
Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
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- HY-N0667R
-
|
(-)-Asparagine (Standard); Asn (Standard); Asparamide (Standard)
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Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Inflammation/Immunology
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|
L-Asparagine (Standard) is the analytical standard of L-Asparagine (HY-N0667). This product is intended for research and analytical applications. L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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- HY-N2037AR
-
|
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MAP3K
MDM-2/p53
ROS Kinase
Apoptosis
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Infection
Cardiovascular Disease
Endocrinology
Cancer
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|
Higenamine (hydrochloride) (Standard) is the analytical standard of Higenamine (hydrochloride). This product is intended for research and analytical applications. Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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- HY-W017443R
-
|
|
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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- HY-N4314R
-
|
|
Bacterial
COX
NO Synthase
NF-κB
|
Infection
Inflammation/Immunology
Cancer
|
|
Scutellarein tetramethyl ether (Standard) is the analytical standard of Scutellarein tetramethyl ether. This product is intended for research and analytical applications. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL) .
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- HY-B0927R
-
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(-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)
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Reference Standards
Tyrosine Hydroxylase
Dopamine Receptor
OAT
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Others
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|
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
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- HY-N1442R
-
|
Orange II (Standard); D&C Orange NO. 4 (Standard)
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Biochemical Assay Reagents
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Others
|
|
Acid orange 7 (Standard) is the analytical standard of Acid orange 7 (HY-1442). This product is intended for research and analytical applications. Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. Acid Orange 7 is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .
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- HY-113469R
-
|
|
STING
Endogenous Metabolite
|
Infection
Cardiovascular Disease
Inflammation/Immunology
|
|
Cyclic GMP (Standard) is the analytical standard of Cyclic GMP. This product is intended for research and analytical applications. Cyclic GMP is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases.
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- HY-130207
-
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NSC-743380
|
Endogenous Metabolite
|
Cancer
|
|
Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor with activity in inhibiting growth and inducing cell death in human cancer cells. Oncrasin-72 exhibits antitumor activity through JNK activation and STAT3 inhibition. Analytical method development and validation for Oncrasin-72 is essential for quantifying its concentration in biological fluids for pharmacokinetic studies. This method was able to successfully quantify Oncrasin-72 in different dose groups when applied in rat plasma .
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- HY-40136R
-
|
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Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Endocrinology
Cancer
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cis-4-Hydroxy-L-proline (Standard) is the analytical standard of cis-4-Hydroxy-L-proline (HY-40136). This product is intended for research and analytical applications. cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension .
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- HY-100607AR
-
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ONO1101 hydrochloride (Standard)
|
Reference Standards
Adrenergic Receptor
Calcium Channel
Potassium Channel
Reactive Oxygen Species
|
Cardiovascular Disease
Inflammation/Immunology
Endocrinology
|
|
Landiolol (ONO1101) hydrochloride (Standard) is the analytical standard of Landiolol hydrochloride (HY-100607A). This product is intended for research and analytical applications. Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury .
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- HY-B2169R
-
|
|
5-HT Receptor
Reference Standards
Dopamine Receptor
Adrenergic Receptor
Cytochrome P450
|
Neurological Disease
|
|
Melperone (Standard) is the analytical standard of Melperone (HY-B2169). This product is intended for research and analytical applications. Melperone is a butyrophenone with atypical antipsychotic properties. Melperone is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone is also a CYP2D6 inhibitor. Melperone can be used for the study of schizophrenia, and agitation in the elderly.
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- HY-N10319R
-
|
|
Reference Standards
TRP Channel
Necroptosis
Epigenetic Reader Domain
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Artepillin C (Standard) is the analytical standard of Artepillin C (HY-N10319). This product is intended for research and analytical applications. Artepillin C is an orally active CREB/CRTC2 inhibitor and TRPA1 covalent agonist (EC50=1.8 μM). Artepillin C inhibits CREB/CRTC2-mediated gene transcription and downregulates BMAL1 expression to regulate glucose and lipid metabolism. Artepillin C can also activate TRPA1 channels to induce spicy taste signals. Artepillin C can inhibit tumor cell proliferation, induce apoptosis, improve insulin resistance and inhibit liver lipid synthesis. Artepillin C can be used in the study of metabolic syndrome, tumor prevention and treatment, and inflammation .
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- HY-B0515R
-
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BM-210955 (Standard); RPR-102289A (Standard)
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Apoptosis
|
Cancer
|
|
Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) (Standard) is the analytical standard of Ibandronate Sodium Monohydrate (HY-B0515). This product is intended for research and analytical applications. Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium Monohydrate can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium Monohydrate inhibits tumor cell proliferation (such as ER + breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium Monohydrate is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .
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- HY-W015924R
-
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Endogenous Metabolite
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Metabolic Disease
|
|
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].
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- HY-N7046R
-
|
Silibinin B (Standard)
|
Reference Standards
JNK
Amyloid-β
p38 MAPK
Apoptosis
|
Neurological Disease
Cancer
|
|
Silybin (Silibinin B) (Standard) is the analytical standard of Silybin B (HY-N7046). This product is intended for research and analytical applications. Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity .
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- HY-N1420AR
-
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L-Rhamnose monohydrate (Standard)
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Endogenous Metabolite
MMP
Interleukin Related
PKA
|
Infection
Metabolic Disease
Cancer
|
|
Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
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- HY-N0440R
-
|
|
Influenza Virus
NF-κB
5 alpha Reductase
Keap1-Nrf2
Lactate Dehydrogenase
Apoptosis
|
Infection
Neurological Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 influenza A viruses and the influenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .
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- HY-B1173R
-
|
D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)
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Bacterial
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .
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- HY-113416R
-
|
DHEA sulfate (Standard); Prasterone sulfate (Standard)
|
GABA Receptor
Sigma Receptor
iGluR
PPAR
NF-κB
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) (Standard) is the analytical standard of Dehydroepiandrosterone sulfate (HY-113416). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
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- HY-B0380AR
-
|
|
Reference Standards
Opioid Receptor
Apoptosis
Potassium Channel
NF-κB
Akt
IRAK
JNK
Toll-like Receptor (TLR)
ERK
Calcium Channel
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Trimebutine maleate (Standard) is the analytical standard of Trimebutine maleate (HY-B0380A). This product is intended for research and analytical applications. Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine maleate inhibits L-type Ca 2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine maleate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine maleate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine maleate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .
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- HY-B0407AR
-
|
|
Reference Standards
Dopamine Receptor
Autophagy
Cytochrome P450
5-HT Receptor
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
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- HY-N0837R
-
|
NSC17821 (Standard); NSC23880 (Standard)
|
PI3K
Akt
mTOR
Autophagy
Apoptosis
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .
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-
- HY-14608R
-
|
|
Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
|
Neurological Disease
|
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases .
IC50 & Target:DA .
In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus .
L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma .
In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice .
L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .
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- HY-B0380R
-
|
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Opioid Receptor
Toll-like Receptor (TLR)
Calcium Channel
Potassium Channel
IRAK
ERK
JNK
NF-κB
Akt
Apoptosis
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Trimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca 2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .
|
-
- HY-W041470R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
|
-
- HY-128483R
-
|
|
TGF-beta/Smad
PI3K
NF-κB
Akt
Apoptosis
Dopamine β-hydroxylase
mTOR
Adrenergic Receptor
|
Cardiovascular Disease
Endocrinology
Cancer
|
|
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .
|
-
- HY-N1957R
-
|
γ-Mangostin (Standard)
|
Reference Standards
5-HT Receptor
COX
Transthyretin (TTR)
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .
|
-
- HY-N0805R
-
|
23-Acetylalismol B (Standard); 23-O-Acetylalisol B (Standard); Alisol B monoacetate (Standard)
|
Reference Standards
Apoptosis
Reactive Oxygen Species
CDK
MMP
PARP
FXR
Syk
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Alisol B 23-acetate (Standard) is the analytical standard of Alisol B 23-acetate (HY-N0805). This product is intended for research and analytical applications. Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .
|
-
- HY-B0765R
-
|
DHEA sulfate sodium (Standard); Prasterone sulfate sodium (Standard)
|
GABA Receptor
Sigma Receptor
iGluR
PPAR
NF-κB
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt (Standard) is the analytical standard of Dehydroepiandrosterone sulfate sodium salt (HY-B0765). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
|
-
- HY-N1353R
-
|
|
Others
p38 MAPK
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
|
-
- HY-125740R
-
|
Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)
|
Reference Standards
Interleukin Related
NO Synthase
NF-κB
TNF Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .
|
-
- HY-N0534R
-
|
|
DNA/RNA Synthesis
Apoptosis
PI3K
Akt
Caspase
SOD
Interleukin Related
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Vitexin-2"-O-rhamnoside (Standard) is the analytical standard of Vitexin-2"-O-rhamnoside (HY-N0534). This product is intended for research and analytical applications. Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases .
|
-
- HY-W015954R
-
|
|
Endogenous Metabolite
Calcium Channel
Bacterial
|
Infection
Metabolic Disease
|
|
(2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La 3+)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC50 of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .
|
-
- HY-W034953
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bathocuproine disulfonate disodium (BCS) is an organic compound used as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. It has a bright yellow color and absorbs light at specific wavelengths, so it can be used to detect and quantify trace copper. In biochemical applications, BCS is commonly used to study the role of copper ions in various biological processes. Copper is an essential nutrient for many organisms, but it can also be toxic in high concentrations, so accurate measurement of copper levels is important to understand its impact on living systems. In terms of analysis, BCS is often used in environmental monitoring and water quality testing to detect copper pollution. It can detect copper even at very low concentrations, making it an invaluable tool for identifying potential sources of pollution and assessing the impact of industrial activities on aquatic ecosystems.
|
-
- HY-N0696R
-
|
Imperialine (Standard)
|
PI3K
NF-κB
Akt
NOD-like Receptor (NLR)
Pyroptosis
Ferroptosis
|
Inflammation/Immunology
|
|
Sipeimine (Standard) is the analytical standard of Sipeimine (HY-N0696R). Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .
|
-
- HY-N0322BR
-
|
|
Reference Standards
Liposome
Endogenous Metabolite
|
Others
|
Cholesterol (Excipient) (Standard) is the analytical standard of Cholesterol (Excipient) (HY-N0322B). This product is intended for research and analytical applications. Cholesterol Excipient is a component of the cell membrane and a precursor of some hormones, vitamin D and bile acid, with oral activity. Cholesterol Excipient is a drug delivery carrier based on the lipid environment of the cell membrane. Due to its amphiphilicity, good biocompatibility and biodegradability, it can be used as an excipient in drug preparations. Cholesterol Excipient can self-assemble into delivery systems such as micelles, nanoparticles, and liposomes, and achieve controlled drug release by regulating membrane fluidity or responding to the microenvironment. It has the characteristics of high drug loading efficiency and good biocompatibility. Cholesterol Excipient is mainly used for research in the fields of targeted delivery of anticancer, antibacterial, antiviral drugs and treatment of skin diseases.
Cholesterol itself is also an endogenous regulator involved in the cleavage of amyloid precursor protein (APP) mediated by β-secretase and intestinal absorption, as well as an endogenous estrogen-related receptor α (ERRα) agonist. Cholesterol affects the subcellular localization of APP processing enzymes by regulating the cell membrane lipid environment, which can promote the production of β-amyloid protein and its adsorption and removal by probiotics. It is used to study the pathogenesis of Alzheimer's disease (AD) and the cholesterol-lowering function of probiotics[1][2][3][4][5].
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-103609R
-
|
|
Dyes
|
|
Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.
|
-
- HY-D0932R
-
|
Solvent Red 24 (Standard); C.I. 26105 (Standard)
|
Dyes
|
|
Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.
|
-
- HY-N1442R
-
|
Orange II (Standard); D&C Orange NO. 4 (Standard)
|
Dyes
|
|
Acid orange 7 (Standard) is the analytical standard of Acid orange 7 (HY-1442). This product is intended for research and analytical applications. Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. Acid Orange 7 is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W016352
-
|
Anilotic acid, 99%
|
Indicators
|
|
2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
|
-
- HY-D0858AR
-
|
2-Morpholinoethanesulphonic acid (monohydrate) (Standard)
|
Buffer Reagents
|
|
MES (monohydrate) (Standard) is the analytical standard of MES (monohydrate). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies .
|
-
- HY-W004563
-
|
|
Chelators
|
|
Neocuproine is an organic compound commonly used as a complexing reagent and copper ion detector. It can form stable complexes with copper ions, and can play a catalytic role in certain chemical reactions and analytical methods. In addition, this compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases
|
-
- HY-W090065
-
|
1-Pyrenemethylamine hydrochloride
|
Biochemical Assay Reagents
|
|
Pyren-1-ylmethanamine hydrochloride, Pyren-1-ylmethanamine hydrochloride is commonly used as a fluorescent probe in biochemistry and molecular biology to detect and study nucleic acids, proteins and other biomolecules, moreover, it has been used in analytical chemistry Among them, for the detection of heavy metals and other pollutants in environmental samples, the pyrene group in the molecule exhibits strong fluorescence properties, which makes it useful as a sensitive and selective detector in various applications.
|
-
- HY-W016352R
-
|
|
Indicators
|
|
2-Hydroxy-5-nitrobenzoic acid, 99% (Standard) is the analytical standard of 2-Hydroxy-5-nitrobenzoic acid, 99%. This product is intended for research and analytical applications. 2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
|
-
- HY-W127641R
-
|
|
Biochemical Assay Reagents
|
|
β-Methylcholine (chloride) (Standard) is the analytical standard of β-Methylcholine (chloride). This product is intended for research and analytical applications. β-Methylcholine chloride is an organic compound containing choline and chloride ions. It is commonly used as a pharmacological research tool, especially in the study of acetylcholine receptors and signaling pathways. β-Methylcholine chloride has various applications in the pharmaceutical industry, especially as a standard reference material for the calibration of analytical instruments. In addition, it can be used in the production of other choline derivatives and as a precursor of neurotransmitters.
|
-
- HY-B0757AR
-
|
rel-Vitamin E Nicotinate (Standard)
|
Biochemical Assay Reagents
|
|
(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
|
-
- HY-W042416R
-
|
DMAc (Standard)
|
Co-solvents
|
|
N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
|
-
- HY-W015236R
-
|
|
Chelators
|
|
H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
|
-
- HY-130462R
-
|
|
Drug Delivery
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers .
|
-
- HY-W034953
-
|
|
Biochemical Assay Reagents
|
|
Bathocuproine disulfonate disodium (BCS) is an organic compound used as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. It has a bright yellow color and absorbs light at specific wavelengths, so it can be used to detect and quantify trace copper. In biochemical applications, BCS is commonly used to study the role of copper ions in various biological processes. Copper is an essential nutrient for many organisms, but it can also be toxic in high concentrations, so accurate measurement of copper levels is important to understand its impact on living systems. In terms of analysis, BCS is often used in environmental monitoring and water quality testing to detect copper pollution. It can detect copper even at very low concentrations, making it an invaluable tool for identifying potential sources of pollution and assessing the impact of industrial activities on aquatic ecosystems.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-D0889R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-P0263R
-
|
|
Bacterial
Fungal
Antibiotic
|
Infection
|
|
Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-107377R
-
-
-
- HY-B2219R
-
-
-
- HY-113365R
-
-
-
- HY-N7697R
-
|
|
Structural Classification
Polysaccharides
Microorganisms
Source classification
Saccharides
|
Others
|
|
Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.
|
-
-
- HY-N1495R
-
-
-
- HY-133668R
-
|
|
Other disease
Disease markers
Endogenous metabolite
|
Drug Metabolite
|
|
Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate .
|
-
-
- HY-N2518R
-
-
-
- HY-N0658AR
-
-
-
- HY-30151R
-
-
-
- HY-76316R
-
-
-
- HY-N2406R
-
-
-
- HY-W011303R
-
-
-
- HY-B0739AR
-
-
-
- HY-N2526R
-
-
-
- HY-B1131R
-
|
|
Structural Classification
Source classification
Endogenous metabolite
Steroids
|
Endogenous Metabolite
|
|
Zuclopenthixol (dihydrochloride) (Standard) is the analytical standard of Zuclopenthixol (dihydrochloride). This product is intended for research and analytical applications. Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia .
|
-
-
- HY-W017194R
-
-
-
- HY-B0739R
-
-
-
- HY-N7028R
-
-
-
- HY-N0034R
-
-
-
- HY-77995R
-
-
-
- HY-N0380R
-
-
-
- HY-N6257R
-
-
-
- HY-N0528R
-
-
-
- HY-W004049R
-
-
-
- HY-Y1004R
-
|
|
Microorganisms
Source classification
|
Biochemical Assay Reagents
|
|
1-Decanol (Standard) is the analytical standard of 1-Decanol. This product is intended for research and analytical applications. 1-Decanol is used in the production of lubricants, surfactants, plasticizers and solvents. It has also been used to study the thermal properties of polymeric monolithic stationary phases and to enhance homopolyglycine acceptor function. Used in cosmetics, daily flavors, and food flavors.
|
-
-
- HY-B1172R
-
-
-
- HY-122141R
-
-
-
- HY-N0842R
-
|
PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)
|
Triterpenes
Structural Classification
Terpenoids
Source classification
Myrtaceae
Plants
Syzygium aromaticum
|
Virus Protease
|
|
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].
|
-
-
- HY-W015883R
-
-
-
- HY-Y0946R
-
-
-
- HY-D0143AR
-
-
-
- HY-W010040R
-
-
-
- HY-N6996R
-
-
-
- HY-B0433AR
-
-
-
- HY-W007828R
-
-
-
- HY-Y0966R
-
-
-
- HY-A0152R
-
|
|
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Endogenous Metabolite
|
|
D-Thyroxine (Standard) is the analytical standard of D-Thyroxine (HY-A0152). This product is intended for research and analytical applications. D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. D-Thyroxine can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia .
|
-
-
- HY-B1695R
-
|
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Structural Classification
Natural Products
Microorganisms
Source classification
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Others
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Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .
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-
-
- HY-N1458R
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-
-
- HY-75087R
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-
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- HY-B0757AR
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-
-
- HY-B0143R
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-
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- HY-113071AR
-
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Structural Classification
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
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Endogenous Metabolite
|
|
Mevalonic acid (lithium salt) (Standard) is the analytical standard of Mevalonic acid (lithium salt). This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .
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- HY-17438R
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-
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- HY-16566R
-
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Kanamycin A (Standard)
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Microorganisms
Source classification
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Antibiotic
Bacterial
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Kanamycin (Standard) is the analytical standard of Kanamycin. This product is intended for research and analytical applications. Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].
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-
-
- HY-N0567R
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-
-
- HY-113315R
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-
-
- HY-W016009R
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-
-
- HY-125911R
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-
-
- HY-B1028R
-
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|
Structural Classification
Natural Products
Source classification
Endogenous metabolite
|
Endogenous Metabolite
SARS-CoV
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|
Pantethine (Standard) is the analytical standard of Pantethine. This product is intended for research and analytical applications. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .
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- HY-N2393R
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-
- HY-W012653R
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-
- HY-107469R
-
-
- HY-117235R
-
-
- HY-14608AR
-
-
- HY-N8423R
-
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Triterpenes
Structural Classification
other families
Terpenoids
Plants
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ERK
GSK-3
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α-Amyrin (Standard) is the analytical standard of α-Amyrin. This product is intended for research and analytical applications. α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission .
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- HY-N0246R
-
-
- HY-119358R
-
-
- HY-P0263R
-
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Structural Classification
Natural Products
Animals
Source classification
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Bacterial
Fungal
Antibiotic
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Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .
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- HY-N6703R
-
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(+)-ar-Turmerone (Standard)
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Structural Classification
Natural Products
Source classification
Plants
Curcuma longa
Zingiberaceae
|
Apoptosis
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|
ar-Turmerone (Standard) is the analytical standard of ar-Turmerone. This product is intended for research and analytical applications. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study.
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- HY-W010668R
-
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Source classification
Plants
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Flavivirus
Dengue Virus
Parasite
Potassium Channel
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Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM .
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- HY-16566AR
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-
- HY-N7513R
-
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Structural Classification
Monophenols
other families
Source classification
Phenols
Plants
|
TNF Receptor
Drug Metabolite
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|
Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .
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- HY-N1501R
-
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- HY-N0405R
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-
- HY-D0803R
-
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Quinones
Structural Classification
Nigella sativa L.
Ranunculaceae
Benzene Quinones
Plants
|
Apoptosis
VEGFR
PI3K
Akt
|
|
Thymoquinone (Standard) is the analytical standard of Thymoquinone. This product is intended for research and analytical applications. Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .
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- HY-B0573R
-
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Alkaloids
Other Alkaloids
Source classification
Endogenous metabolite
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Adrenergic Receptor
Bacterial
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Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
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- HY-N4095R
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- HY-A0066AR
-
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Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)
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Alkaloids
Other Alkaloids
Source classification
Alpinia officinarum Hance
Plants
Zingiberaceae
|
Adrenergic Receptor
|
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Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research .
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- HY-W013549R
-
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Human Gut Microbiota Metabolites
Microorganisms
Source classification
Endogenous metabolite
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Drug Metabolite
Bacterial
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6-Aminopenicillanic acid (Standard) is the analytical standard of 6-Aminopenicillanic acid. This product is intended for research and analytical applications. 6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses .
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- HY-B0215R
-
-
- HY-N2013R
-
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Aristololactam (Standard); Aristolactam (Standard)
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Structural Classification
Natural Products
other families
Source classification
Plants
|
Caspase
Apoptosis
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|
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .
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- HY-N1516R
-
|
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Triterpenes
Structural Classification
Microorganisms
Terpenoids
Polyporaceae
Source classification
Ganoderma lucidum (Leyss. Ex Fr.) Karst.
Plants
|
Apoptosis
|
|
3-Aminobenzoic acid (Standard) is the analytical standard of 3-Aminobenzoic acid. This product is intended for research and analytical applications. 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects .
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- HY-W015786R
-
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|
Structural Classification
Monophenols
Source classification
Phenols
Endogenous metabolite
|
Bacterial
|
|
L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .
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- HY-N0546R
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-
- HY-113224R
-
-
- HY-130462R
-
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Structural Classification
Natural Products
Microorganisms
Source classification
Plants
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Liposome
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|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers .
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- HY-B1907R
-
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Rifamycin SV (sodium) (Standard)
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Structural Classification
Microorganisms
Antibiotics
Source classification
Antibacterial
Disease Research
Other Antibiotics
|
Bacterial
Antibiotic
|
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Rifamycin (sodium) (Standard) is the analytical standard of Rifamycin (sodium). This product is intended for research and analytical applications. Rifamycin sodium (Rifamycin SV sodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .
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- HY-N1181R
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-
- HY-N0671R
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-
- HY-W012814R
-
-
- HY-113410R
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-
- HY-W014901R
-
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BPF (Standard); 4,4'-Dihydroxydiphenylmethane (Standard)
|
Orchidaceae
Galeola faberi Rolfe
Source classification
Phenols
Polyphenols
Plants
|
Reference Standards
Reactive Oxygen Species
Akt
GSK-3
Apoptosis
|
|
Bisphenol F (Standard) is the analytical standard of Bisphenol F (HY-W014901). This product is intended for research and analytical applications. Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) .
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- HY-D0889R
-
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|
Structural Classification
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Endogenous Metabolite
|
|
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
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- HY-W001160R
-
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Alkaloids
Structural Classification
Monophenols
Source classification
Phenols
Endogenous metabolite
Indole Alkaloids
|
Endogenous Metabolite
nAChR
Calcium Channel
|
|
5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160). This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT3 receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders .
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- HY-W010516R
-
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2-Methylpentanoic acid (Standard)
|
Structural Classification
other families
Ketones, Aldehydes, Acids
Source classification
Plants
Endogenous metabolite
|
Endogenous Metabolite
|
|
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
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- HY-N0667R
-
-
- HY-N2037AR
-
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Alkaloids
Structural Classification
Source classification
Phenols
Polyphenols
Plants
Lauraceae
Isoquinoline Alkaloids
Lindera aggregata (Sims) Kosterm.
|
MAP3K
MDM-2/p53
ROS Kinase
Apoptosis
|
|
Higenamine (hydrochloride) (Standard) is the analytical standard of Higenamine (hydrochloride). This product is intended for research and analytical applications. Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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- HY-W017443R
-
|
|
Structural Classification
Source classification
Amino acids
Endogenous metabolite
|
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
|
L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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- HY-N4314R
-
|
|
Structural Classification
Flavonoids
Flavones
Plants
Compositae
Genista maderensis (Webb & Berthel.) Lowe
|
Bacterial
COX
NO Synthase
NF-κB
|
|
Scutellarein tetramethyl ether (Standard) is the analytical standard of Scutellarein tetramethyl ether. This product is intended for research and analytical applications. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive compound extracted from Eupatorium odoratum. Scutellarein tetramethyl ether exhibits anti-inflammatory, antibacterial, pro-coagulant, and anti-tumor activities. Scutellarein tetramethyl ether exerts its anti-inflammatory effects by modulating the NF-κB pathway and regulates bacterial resistance through the inhibition of efflux pumps. Additionally, Scutellarein tetramethyl ether accelerates coagulation time via the endogenous coagulation pathway. Studies have shown that Scutellarein tetramethyl ether can effectively inhibit the growth of the liver cancer cell line HepG2 (IC50= 20.08 μg/mL) .
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- HY-B0927R
-
|
(-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)
|
Structural Classification
Alkaloids
Piperidine Alkaloids
Ranunculaceae
Plants
|
Reference Standards
Tyrosine Hydroxylase
Dopamine Receptor
OAT
|
|
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
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- HY-113469R
-
|
|
Structural Classification
Natural Products
Human Gut Microbiota Metabolites
Microorganisms
Source classification
Endogenous metabolite
|
STING
Endogenous Metabolite
|
|
Cyclic GMP (Standard) is the analytical standard of Cyclic GMP. This product is intended for research and analytical applications. Cyclic GMP is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases.
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-
- HY-40136R
-
-
- HY-N10319R
-
-
- HY-W015924R
-
|
|
Structural Classification
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Endogenous Metabolite
|
|
2-Hydroxyisobutyric acid (Standard) is the analytical standard of 2-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 pathway and the p38 MAPK pathway, which reduces reactive oxygen species (ROS) and fat accumulation in Caenorhabditis elegans. 2-Hydroxyisobutyric acid promotes β-oxidation and inhibits fatty acid synthesis by upregulating SKN-1/NRF2 and downregulating SREBP-1c transcription factors. 2-Hydroxyisobutyric acid has anti-aging and lipid-lowering effects, and can be used to study metabolic diseases such as obesity and diabetes. 2-Hydroxyisobutyric acid is also a renewable precursor of methacrylate through 2-HIB-CoA mutase-mediated biosynthesis[1][2].
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-
- HY-N7046R
-
|
Silibinin B (Standard)
|
Flavanonols
Structural Classification
Flavonoids
Glycine soya
Source classification
Phenols
Polyphenols
Cyamopsis tetragonoloba (L.) Taub.
Plants
Compositae
|
Reference Standards
JNK
Amyloid-β
p38 MAPK
Apoptosis
|
|
Silybin (Silibinin B) (Standard) is the analytical standard of Silybin B (HY-N7046). This product is intended for research and analytical applications. Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity .
|
-
- HY-N1420AR
-
|
L-Rhamnose monohydrate (Standard)
|
Structural Classification
Microorganisms
other families
Source classification
Plants
Saccharides
Monosaccharides
|
Endogenous Metabolite
MMP
Interleukin Related
PKA
|
|
Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
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-
- HY-N0440R
-
|
|
Structural Classification
Terpenoids
Sesquiterpenes
Source classification
Plants
Curcuma longa
Zingiberaceae
|
Influenza Virus
NF-κB
5 alpha Reductase
Keap1-Nrf2
Lactate Dehydrogenase
Apoptosis
|
|
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 influenza A viruses and the influenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .
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-
- HY-B1173R
-
|
D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)
|
Structural Classification
Other Monoterpenes
Terpenoids
Source classification
Plants
Lauraceae
Cinnamomum camphora
|
Bacterial
|
|
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .
|
-
- HY-113416R
-
|
DHEA sulfate (Standard); Prasterone sulfate (Standard)
|
Human Gut Microbiota Metabolites
Microorganisms
Source classification
Disease markers
Endocrine diseases
Nervous System Disorder
Endogenous metabolite
|
GABA Receptor
Sigma Receptor
iGluR
PPAR
NF-κB
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Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) (Standard) is the analytical standard of Dehydroepiandrosterone sulfate (HY-113416). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
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- HY-N0837R
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NSC17821 (Standard); NSC23880 (Standard)
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Alkaloids
Piperidine Alkaloids
Structural Classification
other families
Source classification
Plants
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PI3K
Akt
mTOR
Autophagy
Apoptosis
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Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .
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- HY-14608R
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Structural Classification
Microorganisms
Source classification
Disease markers
Endocrine diseases
Amino acids
Nervous System Disorder
Endogenous metabolite
Cardiovascular System Disorder
Cancer
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Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
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L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases .
IC50 & Target:DA .
In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus .
L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma .
In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice .
L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .
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- HY-W041470R
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Structural Classification
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
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Reference Standards
Endogenous Metabolite
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Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
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- HY-128483R
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Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
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TGF-beta/Smad
PI3K
NF-κB
Akt
Apoptosis
Dopamine β-hydroxylase
mTOR
Adrenergic Receptor
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Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .
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- HY-N1957R
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γ-Mangostin (Standard)
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Structural Classification
Xanthones
Guttiferae
Phenols
Polyphenols
Garcinia mangostana Linn.
Plants
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Reference Standards
5-HT Receptor
COX
Transthyretin (TTR)
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Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes .
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- HY-N0805R
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23-Acetylalismol B (Standard); 23-O-Acetylalisol B (Standard); Alisol B monoacetate (Standard)
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Triterpenes
Structural Classification
Alisma plantago-aquatica Linn.
Terpenoids
Source classification
Alismataceae
Plants
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Reference Standards
Apoptosis
Reactive Oxygen Species
CDK
MMP
PARP
FXR
Syk
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Alisol B 23-acetate (Standard) is the analytical standard of Alisol B 23-acetate (HY-N0805). This product is intended for research and analytical applications. Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .
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- HY-B0765R
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DHEA sulfate sodium (Standard); Prasterone sulfate sodium (Standard)
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Structural Classification
Source classification
Endogenous metabolite
Steroids
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GABA Receptor
Sigma Receptor
iGluR
PPAR
NF-κB
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Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt (Standard) is the analytical standard of Dehydroepiandrosterone sulfate sodium salt (HY-B0765). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .
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- HY-N1353R
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Flavonols
Structural Classification
Flavonoids
other families
Source classification
Phenols
Polyphenols
Plants
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Others
p38 MAPK
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Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
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- HY-125740R
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Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)
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Structural Classification
Anthocyans
Flavonoids
Source classification
Vitis vinifera cv. Zalema
Phenols
Polyphenols
Plants
Vitaceae
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Reference Standards
Interleukin Related
NO Synthase
NF-κB
TNF Receptor
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Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .
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- HY-N0534R
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Structural Classification
Flavonoids
other families
Flavones
Source classification
Phenols
Polyphenols
Plants
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DNA/RNA Synthesis
Apoptosis
PI3K
Akt
Caspase
SOD
Interleukin Related
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Vitexin-2"-O-rhamnoside (Standard) is the analytical standard of Vitexin-2"-O-rhamnoside (HY-N0534). This product is intended for research and analytical applications. Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. Vitexin-2"-O-rhamnoside inhibits Apoptosis, increases the phosphorylation levels of PI3K/Akt, inhibits caspase-3, SOD activity, and promotes cytokine (IL-2, IL-6, and IL-12) secretion. Vitexin-2"-O-rhamnoside strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. Vitexin-2"-O-rhamnoside enhances immune function and improves the absorption of active compounds. Vitexin-2"-O-rhamnoside has antioxidant activity. Vitexin-2"-O-rhamnoside is used in the study of cardiovascular disease and immune-related diseases .
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- HY-W015954R
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Structural Classification
Natural Products
Human Gut Microbiota Metabolites
Microorganisms
Source classification
Endogenous metabolite
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Endogenous Metabolite
Calcium Channel
Bacterial
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(2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La 3+)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC50 of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .
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- HY-N0696R
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Imperialine (Standard)
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Alkaloids
Piperidine Alkaloids
Structural Classification
Liliaceae
Source classification
Fritillaria ussuriensis Maxim.
Plants
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PI3K
NF-κB
Akt
NOD-like Receptor (NLR)
Pyroptosis
Ferroptosis
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Sipeimine (Standard) is the analytical standard of Sipeimine (HY-N0696R). Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .
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Product Name |
Chemical Structure |
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- HY-B1703S
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Nifursol- 13C6 is the 13C6 labeled Nifursol (HY-B1703). Nifursol (Standard) is the analytical standard of Nifursol (HY-B1703). This product is used for research and analytical applications. Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals .
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