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Results for "

adhesion receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adhesion G Protein-coupled Receptors (AGPCRs) (1) FAK (5) Akt (2) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (2) C-type Lectin-like Receptors (CTLRs) (1) Cannabinoid Receptor (1) CXCR (1) Drug Derivative (1) Drug Intermediate (1) EGFR (3) Endogenous Metabolite (3) ERK (3) Estrogen Receptor/ERR (2) Formyl Peptide Receptor (FPR) (1) G protein-coupled Bile Acid Receptor 1 (1) HIV (2) Integrin (8) Interleukin Related (1) Isotope-Labeled Compounds (2) Leukotriene Receptor (1) LXR (2) NO Synthase (2) p38 MAPK (1) Parasite (1) PI3K (2) PKC (2) PPAR (4) PROTACs (2) Reference Standards (3) SHP2 (2) Sirtuin (2) Src (2) STAT (2) TGF-β Receptor (1) Thrombin (1) TNF Receptor (1) Toll-like Receptor (TLR) (4) Urotensin Receptor (1) VEGFR (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (13) Endocrinology (2) Infection (2) Inflammation/Immunology (13) Metabolic Disease (7) Neurological Disease (5)

By Targets:

Adhesion G Protein-coupled Receptors (AGPCRs) (1)

FAK (5)

Akt (2)

Apoptosis (2)

Bacterial (2)

Biochemical Assay Reagents (2)

C-type Lectin-like Receptors (CTLRs) (1)

Cannabinoid Receptor (1)

CXCR (1)

Drug Derivative (1)

Drug Intermediate (1)

EGFR (3)

Endogenous Metabolite (3)

ERK (3)

Estrogen Receptor/ERR (2)

Formyl Peptide Receptor (FPR) (1)

G protein-coupled Bile Acid Receptor 1 (1)

HIV (2)

Integrin (8)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

Leukotriene Receptor (1)

LXR (2)

NO Synthase (2)

p38 MAPK (1)

Parasite (1)

PI3K (2)

PKC (2)

PPAR (4)

PROTACs (2)

Reference Standards (3)

SHP2 (2)

Sirtuin (2)

Src (2)

STAT (2)

TGF-β Receptor (1)

Thrombin (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (4)

Urotensin Receptor (1)

VEGFR (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (13)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (13)

Metabolic Disease (7)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Adhesion G Protein-coupled Receptors (AGPCRs) ALCAM/CD166 FAK VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10586A

Macrophage-activating lipopeptide 2 TFA MALP-2 TFA	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease Metabolic Disease
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-P1741

Fibrinogen-Binding Peptide 1 Publications Verification	Thrombin	Cardiovascular Disease
Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin .

HY-P1741A

Fibrinogen-Binding Peptide TFA 1 Publications Verification	Integrin	Cardiovascular Disease
Fibrinogen-Binding Peptide TFA (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide TFA binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin .

HY-P4651

H-Tyr-Ile-Gly-Ser-Arg-NH2	TGF-β Receptor	Others
H-Tyr-Ile-Gly-Ser-Arg-NH2 is a hexapeptide that is an essential fragment of laminin responsible for efficient cell adhesion and receptor binding. H-Tyr-Ile-Gly-Ser-Arg-NH2 promotes various epithelial cell adhesion activities .

HY-100197

Synaptamide 1 Publications Verification N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide	Cannabinoid Receptor	Neurological Disease
Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) .

HY-P9934

Abciximab 2 Publications Verification C7E3	Integrin	Cardiovascular Disease
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors .

HY-P3530

G-{d-Arg}-GDSP	Integrin	Others
G-{d-Arg}-GDSP is an RGD peptide analogue that binds to the adhesion receptor of integrins and inhibits cellular fibronectin attachment as well as osteoclast resorption .

HY-P10586

Macrophage-activating lipopeptide 2 MALP-2	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-E70716

FAK aa411-686 Recombinant Human Active Protein Kinase	FAK	Cancer
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase in the cytoplasm, couples with integrins and growth factor receptors to regulate cell adhesion, proliferation, migration, invasion, and metastasis. FAK is overexpressed and aberrantly activated in many cancer types, including triple negative breast cancer (TNBC). FAK aa411-686 Recombinant Human Active Protein Kinase is a recombinant FAK aa411-686 protein that can be used to study FAK aa411-686-related functions .

HY-164527

Si306	Src FAK EGFR	Cancer
Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM) .

HY-101483

Dihydromunduletone 1 Publications Verification	Drug Derivative	Neurological Disease Cancer
Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC ₅₀ of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs .

HY-10656

SB-657510	Urotensin Receptor	Inflammation/Immunology
SB-657510 is a selective *urotensin II (UII) receptor* (UT) antagonist. The K_i** values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells .

HY-N1990

Gypenoside XLIX 1 Publications Verification	PPAR	Cardiovascular Disease Inflammation/Immunology
Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective *peroxisome proliferator-activated receptor* (PPAR)-alpha** activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-NP070

Lotus tetragonolobus lectin LTL	Biochemical Assay Reagents	Inflammation/Immunology
Lotus tetragonolobus lectin (LTL) is a plant lectin, that can be extracted from Lotus tetragonolobus. Lotus tetragonolobus lectin recognizes and binds to fucose containing sugar structures, and can be used to study cell surface receptor recognition and cell adhesion processes. Lotus tetragonolobus lectin inhibits macrophage migration, and is involved in immunomodulatory processes .

HY-W159303

7-Hydroxy-2,2-dimethyl-4-chromanone	C-type Lectin-like Receptors (CTLRs)	Others
7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM . DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells .

HY-159179

α4 integrin receptor antagonist 3	Integrin	Inflammation/Immunology
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α₄integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α₄β₁/VCAM-1 and α₄β₇/MAdCAM-1, with IC₅₀ values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model .

HY-117971

BVT173187	CXCR Formyl Peptide Receptor (FPR)	Others
BVT173187 is a selective inhibitor of the neutrophil formyl peptide receptor FPR1, with activity that inhibits FPR1 activation. BVT173187 inhibits FPR1 agonist-induced activation in neutrophils, reduces adhesion molecule mobilization and superoxide anion production, and has inhibitory activity on FPR1 similar to that of earlier described peptide antagonists, but also has effects on C5aR and CXCR signaling.

HY-N1990R

Gypenoside XLIX (Standard)	Reference Standards PPAR	Cardiovascular Disease Inflammation/Immunology
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-W027751R

2-Methylanisole (Standard)	Drug Intermediate Reference Standards	Others
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-161633

PROTAC EGFR degrader 11	PROTACs EGFR FAK	Cancer
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC₅₀ <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a K_i of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC₅₀ <100 nM.

HY-P2975

Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) Mouse laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)	Endogenous Metabolite Biochemical Assay Reagents	Neurological Disease
Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural element in animal tissues, forming part of the scaffolding that supports tissue architecture. It interacts with type IV collagen through entactin and perlecan, connects to cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins, and contains functional domains that facilitate collagen binding, cell adhesion, heparin interaction, and promote neurite outgrowth.

HY-161632

PROTAC EGFR degrader 10	PROTACs EGFR FAK	Cancer
PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC₅₀ <100 nM. PROTAC EGFR degrader 10 binds CRBN-DDB1 with a K_i of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC₅₀ <150 nM .

HY-167686

Variabilin Homopisatin	Integrin	Cardiovascular Disease
Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg .

HY-147086

CAY10789	Leukotriene Receptor G protein-coupled Bile Acid Receptor 1 TNF Receptor	Metabolic Disease Inflammation/Immunology
CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC₅₀=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC₅₀=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases .

HY-P3444

CD31 PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P1110

AF12198 4 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-163712

17-Epiestriol	Estrogen Receptor/ERR	Endocrinology
17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-118792

AHR activator 1	Endogenous Metabolite	Cancer
AHR activator 1 is an aryl hydrocarbon receptor activator with activity regulating fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. AHR activator 1 prevents the formation of cellular branches by inhibiting AHR signaling. AHR activator 1 also associates with adhesion of dissociated linkers, suggesting the importance of dissociated linkers in the inhibition of branching by AHR agonists. Studies of AHR activator 1 reveal its functional role in mammary gland morphogenesis and play a role in inhibiting FGF-induced invasion .

HY-120200

YF-452	VEGFR	Cardiovascular Disease Cancer
YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research .

HY-148385

Ganglioside GM2	Endogenous Metabolite Integrin FAK Src ERK p38 MAPK	Neurological Disease Cancer
Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-P10365

VPM-p15	Adhesion G Protein-coupled Receptors (AGPCRs)	Others
Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members .

HY-163712S

17-Epiestriol-d5-1	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-152003S

Ganglioside GM2-d3 ammonium	Isotope-Labeled Compounds	Others
Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-18282

AZ876	LXR	Cardiovascular Disease Metabolic Disease Cancer
AZ876 is a selective, orally active agonist of liver X receptor (LXRα/β) (K_i=0.007 μM [LXRα, human], 0.011 μM [LXRβ, human]. AZ876 induces the expression of target genes such as ABCA1 and ABCG1, promotes reverse cholesterol transport (RCT) and regulates lipid metabolism and anti-inflammatory effects. AZ876 increases cardiac polyunsaturated fatty acid levels, reduces myocardial fibrosis, and reduces lesion area and monocyte adhesion in atherosclerosis models. AZ876 can be used in cardiovascular disease research, such as preventing and treating β-adrenergic-induced cardiac diastolic dysfunction and inhibiting the progression of atherosclerosis .

HY-18282R

AZ876 (Standard)	LXR	Cardiovascular Disease Metabolic Disease Cancer
AZ876 (Standard) is the analytical standard of AZ876. This product is intended for research and analytical applications. AZ876 is a selective, orally active agonist of liver X receptor (LXRα/β) (Ki=0.007 μM [LXRα, human], 0.011 μM [LXRβ, human]. AZ876 induces the expression of target genes such as ABCA1 and ABCG1, promotes reverse cholesterol transport (RCT) and regulates lipid metabolism and anti-inflammatory effects. AZ876 increases cardiac polyunsaturated fatty acid levels, reduces myocardial fibrosis, and reduces lesion area and monocyte adhesion in atherosclerosis models. AZ876 can be used in cardiovascular disease research, such as preventing and treating β-adrenergic-induced cardiac diastolic dysfunction and inhibiting the progression of atherosclerosis .

HY-N10534

Lewis X trisaccharide Lewis X	Parasite	Infection Inflammation/Immunology Cancer
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N2110R

Phellopterin (Standard)	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

HY-N2110

Phellopterin	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Inflammation/Immunology
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

Cat. No.	Product Name

HY-L016

Protein Tyrosine Kinase Compound Library	1,420 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1,420 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Protein Tyrosine Kinase Compound Library

1,420 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,420 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-P2975

Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) Mouse laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)	Native Proteins
Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural element in animal tissues, forming part of the scaffolding that supports tissue architecture. It interacts with type IV collagen through entactin and perlecan, connects to cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins, and contains functional domains that facilitate collagen binding, cell adhesion, heparin interaction, and promote neurite outgrowth.

Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)

Mouse laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane)

Native Proteins

Laminin (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural element in animal tissues, forming part of the scaffolding that supports tissue architecture. It interacts with type IV collagen through entactin and perlecan, connects to cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins, and contains functional domains that facilitate collagen binding, cell adhesion, heparin interaction, and promote neurite outgrowth.

HY-NP070

Lotus tetragonolobus lectin LTL	Native Proteins
Lotus tetragonolobus lectin (LTL) is a plant lectin, that can be extracted from Lotus tetragonolobus. Lotus tetragonolobus lectin recognizes and binds to fucose containing sugar structures, and can be used to study cell surface receptor recognition and cell adhesion processes. Lotus tetragonolobus lectin inhibits macrophage migration, and is involved in immunomodulatory processes .

Cat. No.	Product Name	Target	Research Area

HY-P10586A

Macrophage-activating lipopeptide 2 TFA MALP-2 TFA	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease Metabolic Disease
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-P1741

Fibrinogen-Binding Peptide 1 Publications Verification	Thrombin	Cardiovascular Disease
Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin .

HY-P1741A

Fibrinogen-Binding Peptide TFA 1 Publications Verification	Integrin	Cardiovascular Disease
Fibrinogen-Binding Peptide TFA (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide TFA binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin .

HY-P4651

H-Tyr-Ile-Gly-Ser-Arg-NH2	TGF-β Receptor	Others
H-Tyr-Ile-Gly-Ser-Arg-NH2 is a hexapeptide that is an essential fragment of laminin responsible for efficient cell adhesion and receptor binding. H-Tyr-Ile-Gly-Ser-Arg-NH2 promotes various epithelial cell adhesion activities .

HY-P10918

F11R peptide TFA	Peptides	Inflammation/Immunology
F11R peptide TFA is a F11 receptor molecule. F11R peptide TFA inhibits anti-F11R antibody-induced platelet aggregation, and inhibits the adhesion of platelets to cytokine (TNFα and INF-γ)-inflammed endothelial cells. F11R peptide TFA can be used for research of atherosclerotic plaques and associated thrombotic disease .

HY-P3444

CD31 PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P1110

AF12198 4 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-P3530

G-{d-Arg}-GDSP	Integrin	Others
G-{d-Arg}-GDSP is an RGD peptide analogue that binds to the adhesion receptor of integrins and inhibits cellular fibronectin attachment as well as osteoclast resorption .

HY-P10586

Macrophage-activating lipopeptide 2 MALP-2	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-P1711

L 366763	Peptides	Cardiovascular Disease
L 366763 is a potent peptide that acts as a fibrinogen receptor antagonist, preventing collagen-induced platelet aggregation and adhesion. L 366763 inhibits platelet deposition and maintains blood flow in a baboon thrombosis model, significantly prolonging bleeding time. L 366763 has antithrombotic efficacy, whereas recombinant LAPP does not have the same effect .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P10365

VPM-p15	Adhesion G Protein-coupled Receptors (AGPCRs)	Others
Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members .

Cat. No.	Product Name	Target	Research Area

HY-P9934

Abciximab 2 Publications Verification C7E3	Integrin	Cardiovascular Disease
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1990

Gypenoside XLIX 1 Publications Verification	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields	PPAR
Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective *peroxisome proliferator-activated receptor* (PPAR)-alpha** activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-N10534

Lewis X trisaccharide Lewis X	Infection Natural Products Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N2110

Phellopterin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

HY-N1990R

Gypenoside XLIX (Standard)	Triterpenes Terpenoids Source classification Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino	Reference Standards PPAR
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .

HY-167686

Variabilin Homopisatin	Natural Products Source classification Plants Dalbergia variabilis Fabaceae	Integrin
Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg .

HY-N2110R

Phellopterin (Standard)	Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

Species:	Human (16) Rhesus Macaque (1) Rat (1) Mouse (1) Cynomolgus (1)
Tag:	His (12) Tag Free (2) Avi (2) Fc (7)
Source:	HEK293 (18) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P76960

	GPR114 Protein, Human (HEK293, Fc) adhesion G-protein coupled receptor G5; G-protein coupled receptor 114; ADGRG5; PGR27	Human	HEK293
	GPR114, an adhesion G protein-coupled receptor (GPCR), crucially activates the adenylate cyclase pathway by coupling with G(s) subunit alpha. Isoform 1, displaying constitutive activity, elevates basal cyclic AMP (cAMP) levels and responds to mechanical stimulation, emphasizing GPR114's functional significance in intracellular signaling cascades and its role in cellular responses to mechanical cues. GPR114 Protein, Human (HEK293, Fc) is the recombinant human-derived GPR114 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76961

	GPR133 Protein, Human (HEK293, His) adhesion G-protein coupled receptor D1; G-protein coupled receptor 133; ADGRD1; PGR25	Human	HEK293
	GPR133 Protein, an orphan receptor, signals through the G(s)-alpha family of G-proteins, as indicated by studies. Its protumorigenic function, particularly in glioblastoma, suggests a potential role in tumorigenesis-associated pathological processes. GPR133 Protein, Human (HEK293, His) is the recombinant human-derived GPR133 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75369

	CD97 Protein, Human (HEK293, His) adhesion G protein-coupled receptor E5; CD97; ADGRE5	Human	HEK293
	CD97, a receptor crucial for leukocyte migration, participates in adhesion and signaling during early leukocyte activation. Forming a heterodimer with a large extracellular alpha subunit and a seven-transmembrane beta subunit, CD97 interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) specifically engages with chondroitin sulfate, showcasing its diverse roles in cellular processes. CD97 Protein, Human (HEK293, His) is the recombinant human-derived CD97 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75370

	CD97 Protein, Human (HEK293, hFc) adhesion G protein-coupled receptor E5; CD97; ADGRE5	Human	HEK293
	CD97, a receptor crucial for leukocyte migration, participates in adhesion and signaling during early leukocyte activation. Forming a heterodimer with a large extracellular alpha subunit and a seven-transmembrane beta subunit, CD97 interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) specifically engages with chondroitin sulfate, showcasing its diverse roles in cellular processes. CD97 Protein, Human (HEK293, hFc) is the recombinant human-derived CD97 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70948

	JAM-A/CD321 Protein, Human (HEK293, His) Junctional adhesion Molecule A; JAM-A; Junctional adhesion Molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM	Human	HEK293
	The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions, is present in early junction development, and recruits PARD3. Binding of the PARD6-PARD3 complex may hinder PARD3-JAM1 interaction, thereby impeding tight junction assembly. JAM-A/CD321 Protein, Human (HEK293, His) is the recombinant human-derived JAM-A/CD321 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72621

	ICAM-1/CD54 Protein, Human (HEK293, His) Intercellular adhesion Molecule 1; ICAM-1; Major Group Rhinovirus receptor; CD54; ICAM1	Human	HEK293
	The ICAM-1/CD54 protein plays a crucial role in cell interactions, acting as a ligand for the leukocyte adhesion protein LFA-1. It promotes leukocyte transendothelial migration by promoting the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. ICAM-1/CD54 Protein, Human (HEK293, His) is the recombinant human-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P79380

	BAI2 Protein, Human (HEK293, hFc) adhesion G protein-coupled receptor B2; ADGRB2; Brain-specific angiogenesis inhibitor 2; BAI2	Human	HEK293
	The BAI2 protein is an orphan G protein-coupled receptor involved in cell adhesion and possible cell-cell interactions. It activates the NFAT signaling pathway through the G protein GNAZ and contributes to transcriptional regulation. BAI2 Protein, Human (HEK293, hFc) is the recombinant human-derived BAI2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72622

	ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, Fc) Intercellular adhesion Molecule 1; ICAM-1; Major Group Rhinovirus receptor; CD54; ICAM1	Rhesus Macaque	HEK293
	The ICAM-1/CD54 protein is a ligand of the leukocyte adhesion protein LFA-1 and is critical for leukocyte transendothelial migration. Its involvement activates ARHGEF26/SGEF and RHOG, coordinating endothelial apical cup assembly. ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70507

	CD44 Protein, Human (HEK293, His) CD44 Antigen; CDw44; Epican; Extracellular Matrix receptor III; ECMR-III; GP90 Lymphocyte Homing/adhesion receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR	Human	HEK293
	CD44 Protein is a type of cell surface receptor protein. CD44 Protein mediates various signaling pathways, including protein kinases, changes in the cytoskeleton, intracellular pathways, proteases, and transcription factors, which promote cancer cell division, proliferation, invasion, angiogenesis, and metabolic changes. The expression level of CD44 Protein is positively correlated with the malignancy and invasiveness of glioblastoma. CD44 Protein, Human (HEK293, His) is a recombinant CD44 protein tagged with a C-6*His label, expressed by HEK293. CD44 Protein, Human (HEK293, His) consists of 200 amino acids and has a molecular weight of 38-50 kDa.

HY-P74735

	Nectin-2 Protein, Rat (HEK293, His) Nectin cell adhesion molecule 2; Poliovirus receptor-related 2; Pvrl2	Rat	HEK293
	Nectin-2/CD112 Protein, functioning as a laminin alpha-5 receptor, displays potential involvement in intracellular signaling, reflecting its similarity to related proteins. Nectin-2/CD112 Protein, Rat (HEK293, His) is the recombinant rat-derived Nectin-2/CD112 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75796

	GPR56 Protein, Human (HEK293, His) adhesion G-protein coupled receptor G1; ADGRG1 NT; ADGRG1; GPR56; TM7LN4; TM7XN1	Human	HEK293
	GPR56, a cell adhesion receptor, mediates cell-matrix adhesion in developing neurons and hematopoietic stem cells. It acts as a receptor for collagen III (COL3A1), influencing cortical development and hematopoietic stem cell maintenance. Additionally, GPR56 plays a pivotal role in cancer progression by inhibiting angiogenesis via PRKCA-mediated signaling and is essential for testis development. GPR56 Protein, Human (HEK293, His) is the recombinant human-derived GPR56 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704646

	GPR56 Protein-VLP, Human (HEK293) adhesion G-protein coupled receptor G1; ADGRG1 NT; ADGRG1; GPR56; TM7LN4; TM7XN1	Human	HEK293
	GPR56, a cell adhesion receptor, mediates cell-matrix adhesion in developing neurons and hematopoietic stem cells. It acts as a receptor for collagen III (COL3A1), influencing cortical development and hematopoietic stem cell maintenance. Additionally, GPR56 plays a pivotal role in cancer progression by inhibiting angiogenesis via PRKCA-mediated signaling and is essential for testis development. GPR56 Protein-VLP, Human (HEK293) is the recombinant human-derived GPR56 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P79135

	Stabilin-2 Protein, Human (His) Stabilin-2; STAB2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; Hyaluronan receptor for endocytosis; FEEL2; FELL; FEX2; HARE	Human	E. coli
	Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

HY-P700402

	CD44 Protein, Human (Biotinylated, HEK293, mFc-Avi) CD44 Antigen; CDw44; Epican; Extracellular Matrix receptor III; ECMR-III; GP90 Lymphocyte Homing/adhesion receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR	Human	HEK293
	CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag.

HY-P700439

	CD44 Protein, Macaca fascicularis (HEK293, His) CD44 Antigen; CDw44; Epican; Extracellular Matrix receptor III; ECMR-III; GP90 Lymphocyte Homing/adhesion receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR	Cynomolgus	HEK293
	The CD44 protein is characterized by a lack of conserved residues critical for annotation of propagation signatures. This defective residue in CD44 prevents the propagation of specific functional features associated with this protein. CD44 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived CD44 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P70083

	CADM3 Protein, Human (HEK293, His) rHuCell adhesion molecule 3/CADM3, His; Cell adhesion Molecule 3; Brain Immunoglobulin receptor; Immunoglobulin Superfamily Member 4B; IgSF4B; Nectin-Like Protein 1; NECL-1; Synaptic Cell adhesion Molecule 3; SynCAM3; TSLC1-Like Protein 1; TSLL1; CADM3; IGSF4B; NECL1; SYNCAM3; TSLL1	Human	HEK293
	CADM3 Protein is crucial for cell-cell adhesion through calcium-independent homophilic and heterophilic interactions with IGSF4, NECTIN1, and NECTIN3. It can regulate cell-cell junctions through its interaction with EPB41L1. CADM3 Protein forms homodimers and trans-heterodimers with NECTIN3, and interacts with EPB41L1, DLG3, PALS2, and CASK. CADM3 Protein, Human (HEK293, His) is the recombinant human-derived CADM3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705095

	Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, Fc) B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22; T-cell surface antigen Leu-14	Human	HEK293

HY-P72351

	Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His-Avi) B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22; T-cell surface antigen Leu-14	Human	HEK293
	The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P702717

	PTK2B Protein, Human (sf9) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	Sf9 insect cells
	PTK2B Protein, Human (sf9) is the recombinant human-derived PTK2B, expressed by Sf9 insect cells , with tag Free labeled tag. ,

HY-P70312

	L-selectin/CD62L Protein, Mouse (HEK293, hFc-His) rMuL-selectin, His; L-selectin; Sell; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LECAM1; Lymph node homing receptor; Lymphocyte antigen 22; CD62L	Mouse	HEK293
	L-selectin, a calcium-dependent lectin, binds to glycoproteins on adjacent cells, facilitating lymphocyte attachment to endothelial cells in peripheral lymph nodes.This interaction is essential for leukocyte rolling along the endothelium and requires L-selectin's binding to SELPLG/PSGL1 and PODXL2, dependent on glycan and sulfation modifications.Sulfation of 'Tyr-51' on SELPLG is particularly important for L-selectin binding.L-selectin/CD62L Protein, Mouse (HEK293, hFc-His) is the recombinant mouse-derived L-selectin/CD62L protein, expressed by HEK293 , with C-6*His, C-Fc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-163712S

17-Epiestriol-d5-1

17-Epiestriol-d₅-1 is the deuterium labeled 17-Epiestriol (HY-163712). 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα). 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase .

HY-152003S

Ganglioside GM2-d3 ammonium

Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81176

	CD11c Antibody Integrin alpha-X; integrin alpha-X precursor; ITGAX; SLEB6; CD11C (p150) alpha polypeptide; complement receptor 4; integrin aX; CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; leukocyte adhesion glycoprotein p150,95 alpha chain; ITAX_HUMAN.	FC, ELISA	Human, Rat
	CD11c Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CD11c.

HY-P83715M

	F4/80 Antibody (PE) (YA3452) adhesion G protein-coupled receptor E1; Adgre1; Cell surface glycoprotein F4/80; EGF-like module receptor 1; Adgre1; Emr1; Gpf480	FC	Mouse
	F4/80 Antibody (YA3452) is a rat-derived and phycoerythrin (PE) IgG2b monoclonal antibody, targeting to F4/80.

HY-P83743

	Nephrin Antibody (YA3472) CNF antibody; Nephrin antibody; Nephrosis 1 congenital Finnish type antibody; Nephrosis 1, congenital, Finnish type (nephrin) antibody; NPHN antibody; NPHN_HUMAN antibody; NPHS 1 antibody; Nphs1 antibody; Renal glomerulus specific cell adhesion receptor antibody; Renal glomerulus-specific cell adhesion receptor antibody	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	Nephrin Antibody (YA3472) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nephrin.

HY-P80602

	CD44 Antibody (YA801) CD44; LHR; MDU2; MDU3; MIC4; CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycopr	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	CD44 Antibody (YA801) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD44.

HY-P80502

	ICAM1/CD54 Antibody (YA725) ICAM1; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD antigen CD54	WB, IHC-P, ICC/IF, FC	Human
	ICAM1/CD54 Antibody (YA725) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to ICAM1/CD54.

HY-P80716

	ICAM1/CD54 Antibody (YA352) ICAM1; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD antigen CD54	WB, IHC-P, IP	Human
	ICAM1/CD54 Antibody (YA352) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

HY-P83280

	Junctional Adhesion Molecule 1 Antibody (YA3025) F11R; JAM1; JCAM; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321	WB, ICC/IF, IP	Human
	Junctional Adhesion Molecule 1 Antibody (YA3025) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Junctional Adhesion Molecule 1.

HY-P86708

	ICAM1/CD54 Antibody (YA6400) BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1(CD54), human rhinovirus receptor; major group rhinovirus receptor.	IHC-P, IHC-F, IF-Tissue	Human
	ICAM1/CD54 Antibody (YA6400) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

HY-P85119

	DDR1 Antibody (YA4811) DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2;	WB, ELISA	Human
	DDR1 Antibody (YA4811) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DDR1.

HY-P84957

	CD11c Antibody (YA4649) Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD antigen CD11c;
	CD11c Antibody (YA4649) is a non-conjugated antibody, targeting to CD11c.

HY-P81198

	Axl Antibody adhesion related kinase; AI323647; Ark; Axl; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming gene; AXL transforming sequence/gene; EC 2.7.10.1; JTK11; Oncogene AXL; Tyro7; Tyrosine protein kinase receptor UFO; Tyrosine-protein kinase receptor UFO; UFO; UFO_HUMAN.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	Axl Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Axl.

HY-P84956

	CD11b Antibody (YA4648) Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b;
	CD11b Antibody (YA4648) is a non-conjugated antibody, targeting to CD11b.

HY-P86309

	CD11b Antibody (YA6001) Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD antigen CD11b;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD11b Antibody (YA6001) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P81399

	CD97 Antibody (YA1144) ADGRE5; adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1	IHC-P	Human
	CD97 Antibody (YA1144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD97.

HY-P80877

	PYK2 Antibody (YA682) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
	PYK2 Antibody (YA682) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2.

HY-P85341

	PYK2 Antibody (YA5033) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB; IHC-P; ICC/IF; IF; FC; IHC-F	Human, Mouse, Rat
	PYK2 Antibody (YA5033) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PYK2.

HY-P85462

	PYK2 Antibody (YA5154) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB	Human, Mouse, Dog, Pig, Rabbit
	PYK2 Antibody (YA5154) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PYK2.

HY-P86140

	PYK2 Antibody (YA5832) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PYK2 Antibody (YA5832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PYK2.

HY-P80592

	CD11b Antibody (YA546) CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1	WB, IP	Mouse
	CD11b Antibody (YA546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P83690

	CD11b Antibody (YA3423) CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; CD11b; Leukocyte adhesion receptor MO1	WB, IHC-P, ICC/IF, IP, FC	Human
	CD11b Antibody (YA3423) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD11b.

HY-P81083

	F4/80 Antibody (YA920) F4/80 (mouse); adhesion G protein-coupled receptor E1; Cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; DD7A5 7; Egf like module containing mucin like hormone receptor like 1; Egf like module containing mucin like hormone receptor like sequence 1; EGF like module receptor 1; EGF TM7; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGFTM7; EMR 1; EMR1; EMR-1; EMR1 hormone receptor; EMR1_HUMAN; AGRE1_HUMAN; Gpf480; Ly71; Lymphocyte antigen 71; TM7LN3.	WB, IHC-P, IHC-F, ICC/IF	Mouse, Rat
	F4/80 Antibody (YA920) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to F4/80.

HY-P86695

	ADGRE1 Antibody (YA6387) F4/80; adhesion G protein-coupled receptor E1; Cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; DD7A5 7; Egf like module containing mucin like hormone receptor like 1; Egf like module containing mucin like hormone receptor like sequence 1; EGF like module receptor 1; EGF TM7; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGFTM7; EMR 1; EMR1; EMR-1; EMR1 hormone receptor; EMR1_HUMAN; AGRE1_HUMAN; Gpf480; Ly71; Lymphocyte antigen 71; TM7LN3.	FC, WB	Human
	ADGRE1 Antibody (YA6387) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADGRE1.

HY-P85085

	CD18 Antibody (YA4777) ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18	ICC/IF, ELISA	Human, Mouse
	CD18 Antibody (YA4777) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD18.

HY-P80795

	Phospho-CD18 (Ser745) Antibody (YA220) ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18	WB, IP	Human, Mouse, Rat
	Phospho-CD18 (Ser745) Antibody (YA220) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CD18 (Ser745).

HY-P81451

	Nectin 2 Antibody (YA1196) NECTIN2; HVEB, PRR2, PVRL2; CD112; Nectin-2; Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB); Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2	IHC-P	Human
	Nectin 2 Antibody (YA1196) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nectin 2.

HY-P81522

	CD22 Antibody (YA1267) CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22	IHC-P	Human
	CD22 Antibody (YA1267) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD22.

HY-P84975

	CD22 Antibody (YA4667) CD22; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD antigen CD22	FC, ELISA	Human
	CD22 Antibody (YA4667) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD22.

HY-P86463

	CD44 Antibody (YA6155) LHR antibody; BA-1 antibody; CD 44 antibody; CD44 antibody; CD44 antigen antibody; CD44 molecule; Indian blood group; antibody; CD44 molecule antibody; CD44_HUMAN antibody; CDw44 antibody; CDW44 antigen antibody; Cell surface glycoprotein CD44 antibody; chondroitin sulfate proteoglycan 8 antibody; CSPG8 antibody; ECMR-III antibody; Epican antibody; Extracellular matrix receptor III antibody; GP90 lymphocyte homing/adhesion receptor antibody	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD44 Antibody (YA6155) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD44.

HY-P80062

	CD44 Antibody (YA534) 1 Publications Verification LHR antibody; BA-1 antibody; CD 44 antibody; CD44 antibody; CD44 antigen antibody; CD44 molecule (Indian blood group) antibody; CD44 molecule antibody; CD44_HUMAN antibody; CDw44 antibody; Cell surface glycoprotein CD44 antibody; chondroitin sulfate proteoglycan 8 antibody; CSPG8 antibody; ECMR-III antibody; Epican antibody; Extracellular matrix receptor III antibody; GP90 lymphocyte homing/adhesion receptor antibody; HCELL antibody; hematopoietic cell E- and L-selectin ligand antibody; Heparan sulfate proteoglycan antibody; Hermes antigen antibody; homing function and Indian blood group system antibody; HSA antibody; HUTCH-I antibody; HUTCH1 antibody; Hyaluronate receptor antibody; IN antibody; MC56 antibody; MDU2 antibody; MDU3 antibody	WB, IHC-P, FC	Human, Mouse
	CD44 Antibody (YA534) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD44.