7-Hydroxy-2,2-dimethyl-4-chromanone

Cat. No.: HY-W159303 Purity: ≥97.0%: Data Sheet
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7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells.

For research use only. We do not sell to patients.

7-Hydroxy-2,2-dimethyl-4-chromanone Chemical Structure

CAS No. : 17771-33-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
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50 g	Get quote

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Purity & Documentation
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Description

7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM^[1]. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells^[2].

IC₅₀ & Target

DC-SIGN

Molecular Weight

192.21

Formula

C₁₁H₁₂O₃

CAS No.

17771-33-4

Appearance

Solid

Color

Off-white to pink

SMILES

O=C1CC(C)(C)OC2=C1C=CC(O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (520.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2026 mL	26.0132 mL	52.0264 mL
5 mM	1.0405 mL	5.2026 mL	10.4053 mL
10 mM	0.5203 mL	2.6013 mL	5.2026 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: ≥97.0%

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Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) HNMR (210 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 2009 Mar;11(3):321-7. [Content Brief]

[2]. Aaftaab Sethi, et al. Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins. Eur J Med Chem. 2021 Oct 15:222:113561. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2026 mL	26.0132 mL	52.0264 mL	130.0661 mL
	5 mM	1.0405 mL	5.2026 mL	10.4053 mL	26.0132 mL
	10 mM	0.5203 mL	2.6013 mL	5.2026 mL	13.0066 mL
	15 mM	0.3468 mL	1.7342 mL	3.4684 mL	8.6711 mL
	20 mM	0.2601 mL	1.3007 mL	2.6013 mL	6.5033 mL
	25 mM	0.2081 mL	1.0405 mL	2.0811 mL	5.2026 mL
	30 mM	0.1734 mL	0.8671 mL	1.7342 mL	4.3355 mL
	40 mM	0.1301 mL	0.6503 mL	1.3007 mL	3.2517 mL
	50 mM	0.1041 mL	0.5203 mL	1.0405 mL	2.6013 mL
	60 mM	0.0867 mL	0.4336 mL	0.8671 mL	2.1678 mL
	80 mM	0.0650 mL	0.3252 mL	0.6503 mL	1.6258 mL
	100 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL