BAI2 Protein, Human (HEK293, hFc)

The BAI2 protein is an orphan G protein-coupled receptor involved in cell adhesion and possible cell-cell interactions. It activates the NFAT signaling pathway through the G protein GNAZ and contributes to transcriptional regulation. BAI2 Protein, Human (HEK293, hFc) is the recombinant human-derived BAI2 protein, expressed by HEK293 , with C-hFc labeled tag.

The BAI2 Protein, an orphan G-protein coupled receptor, plays a significant role in cell adhesion and likely participates in cell-cell interactions. By activating the NFAT-signaling pathway through the G-protein GNAZ, BAI2 contributes to transcriptional regulation, highlighting its involvement in diverse cellular processes. Additionally, BAI2 is implicated in angiogenesis inhibition. Notably, the receptor activity of BAI2 is subject to regulation through proteolytic processing. The long N-terminal region exerts an inhibitory effect on constitutive signaling activity, and removal of this region induces an increase in receptor activity. These intricate regulatory mechanisms underscore the versatility of BAI2 in modulating cellular responses and provide insights into its potential as a key player in cellular communication and angiogenic processes.

Measured by its binding ability in a functional ELISA. When Recombinant Human C1qL3 is immobilized at 2 μg/mL can bind Biotinylated Recombinant Human BAI2. The ED₅₀ for this effect is 82.33 ng/mL.

Human

HEK293

C-hFc

O60241-3 (F21-D911)

576  [NCBI]

Partial

Approximately 128-150 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.