Search Result

Results for "

RANKL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RANKL/RANK (26) Akt (7) AMPK (1) Antibiotic (1) Apoptosis (7) Autophagy (4) Bacterial (5) Btk (1) Calcineurin (1) Caspase (1) COX (1) CXCR (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) ERK (3) FGFR (1) GLUT (2) Histone Methyltransferase (1) HIV (2) HMG-CoA Reductase (HMGCR) (1) Insulin Receptor (2) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (1) Macrophage migration inhibitory factor (MIF) (1) MALT1 (1) MEK (1) NF-κB (18) NO Synthase (1) Nuclear Factor of activated T Cells (NFAT) (6) Nucleoside Antimetabolite/Analog (1) p38 MAPK (7) Phosphatase (2) Phosphodiesterase (PDE) (1) PI3K (2) PIN1 (1) PPAR (1) Prostaglandin Receptor (4) PROTACs (1) Proton Pump (2) Reactive Oxygen Species (ROS) (1) Reference Standards (9) Small Interfering RNA (siRNA) (3) STAT (2) STING (1) TNF Receptor (5) Toll-like Receptor (TLR) (7) Wnt (7) β-catenin (7)
By Research Areas:	Cancer (27) Cardiovascular Disease (6) Endocrinology (6) Infection (9) Inflammation/Immunology (28) Metabolic Disease (22) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

*Anti-Mouse RANKL/CD254 Antibody (IK22/5)*	RANKL/RANK E1/E2/E3 Enzyme NF-κB	Inflammation/Immunology Cancer
Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse *RANKL/CD254* IgG2a monoclonal antibody. Anti-Mouse RANKL/CD254 Antibody (IK22/5) inhibits osteoclast formation and activity by specifically blocking the binding of RANKL and RANK. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can inhibit the expression of MuRF1/Trogin-1 and activation of NF-κB. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can be used for research on cancer such as melanoma or colon cancer and osteoporosis .

Denosumab 1 Publications Verification AMG-162	NF-κB Caspase Apoptosis RANKL/RANK	Endocrinology Cancer
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

NFATc1-IN-1 2 Publications Verification	Nuclear Factor of activated T Cells (NFAT)	Others
NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC₅₀ of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research .

8-Isoprostaglandin E2 iPE2-III	Prostaglandin Receptor	Cardiovascular Disease
8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

Ajudecunoid A	Others	Others
Ajudecunoid A is nature product that could be isolated from Ajuga decumbens. Ajudecunoid A inhibits RANKL-Induced osteoclastogenesis .

AS2690168 (freebase)	RANKL/RANK	Others
AS2690168 freebase is an orally active *RANKL* signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis .

AS2690168 hydrochloride	RANKL/RANK	Others
AS2690168 hydrochloride is an orally active *RANKL* signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis .

SH491	Others	Inflammation/Immunology
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC₅₀: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) .

Anti-osteoporosis agent-4	NF-κB PI3K	Inflammation/Immunology
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC₅₀ value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation .

1,3-Dibenzyl-5-fluorouracil	RANKL/RANK	Metabolic Disease
1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor of osteoclastogenesis. 1,3-Dibenzyl-5-fluorouracil inhibits the expression of osteoclast markers by downregulating the receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) signaling pathways. 1,3-Dibenzyl-5-fluorouracil can be used in the study of metabolic bone diseases .

Y2641	RANKL/RANK TNF Receptor	Inflammation/Immunology
Y2641, a etrahydro-β-carboline derivative, is an orally active dual *RANKL/TNF-α* inhibitor with K_d values of 3.984 μM and 18.59 μM for RANKL and TNF-α, respectively. Y2641 inhibits RANKL-induced osteoclastogenic and has anti-inflammatory and cartilage destruction. Y2641 can be used for study of osteoarthritis .

Peniditerpenoid A	Others	Metabolic Disease
Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis .

Denosumab (anti-TNFSF11) 1 Publications Verification	RANKL/RANK Apoptosis NF-κB	Neurological Disease Endocrinology Cancer
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

Anti-osteoporosis agent-8	RANKL/RANK p38 MAPK NF-κB	Endocrinology
Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for *RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC₅₀* is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model .

Aconine 2 Publications Verification Jesaconine	NF-κB	Inflammation/Immunology Cancer
Aconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced NF-κB activation.

Narlumosbart	RANKL/RANK	Cancer
Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor activator of nuclear factor-κB ligand (RANKL) .

Anti-osteoporosis agent-2	Others	Inflammation/Immunology
Anti-osteoporosis agent-2 (Compound 10) is an anti-osteoporosis agent. Anti-osteoporosis agent-2 inhibits differentiation on osteoclast induced by RANKL .

4-IPP 5+ Cited Publications 4-Iodo-6-phenylpyrimidine	Macrophage migration inhibitory factor (MIF)	Metabolic Disease
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF) .

Amakusamine	RANKL/RANK	Others
Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

2,3-Bis(3-indolylmethyl)indole	RANKL/RANK	Others
2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.

Napyradiomycin B4	MEK ERK	Others
Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis .

BCPA	PIN1	Metabolic Disease
BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research .

Sciadopitysin 2 Publications Verification	TNF Receptor NF-κB	Inflammation/Immunology
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

Halenaquinone	PI3K Apoptosis	Inflammation/Immunology Cancer
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells .

Phlorigidoside C	Others	Inflammation/Immunology
Phlorigidoside C, a natural iridoid glucoside, possesses anti-rheumatoid arthritis effect .

Niloticin	Akt NF-κB	Infection
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways .

GB-223	TNF Receptor	Cancer
GB-223 is a human monoclonal antibody (mAb) targeting *TNFSF11/RANKL/CD254*. GB-223 can be used in Giant cell tumour of bone and Postmenopausal osteoporosis research .

Cyanidin Chloride 4 Publications Verification IdB 1027	RANKL/RANK	Cancer
Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression .

Usnic acid sodium	Bacterial	Infection Cancer
Usnic acid sodium, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid sodium has excellent anticancer and antimicrobial properties. Usnic acid sodium significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1 .

Eudebeiolide B Plebeiolide D	NF-κB Akt Nuclear Factor of activated T Cells (NFAT) Phosphatase	Metabolic Disease
Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating *RANKL*-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research .

Eupenicisirenin C	STING NF-κB	Others
Eupenicisirenin C (compound 1) is a sirenin derivative. Eupenicisirenin C has strong NF-κB inhibitory activities. Eupenicisirenin C suppresses effects on cGAS-STING pathway. Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells .

TNFSF11 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFSF11 Rat Pre-designed siRNA Set A contains three designed siRNAs for TNFSF11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sciadopitysin (Standard)	TNF Receptor Reference Standards NF-κB	Inflammation/Immunology
Sciadopitysin (Standard) is the analytical standard of Sciadopitysin. This product is intended for research and analytical applications. Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

Ethyl gentisate Ethyl 2,5-dihydroxybenzoate	Phosphatase	Metabolic Disease
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process .

Vaccarin 1 Publications Verification	AMPK Akt ERK p38 MAPK NF-κB Nuclear Factor of activated T Cells (NFAT) JNK	Cardiovascular Disease Metabolic Disease
Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis .

FGFR1 inhibitor-11	FGFR	Metabolic Disease
FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity .

Sauristolactam Saurolactam	Others	Neurological Disease
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells . Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation .

Cyanidin Chloride (Standard) IdB 1027 (Standard)	Reference Standards RANKL/RANK	Cancer
Cyanidin (Chloride) (Standard) is the analytical standard of Cyanidin (Chloride). This product is intended for research and analytical applications. Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression .

LSD1-IN-32	Histone Methyltransferase	Metabolic Disease
LSD1-IN-32 (compound 11e) is a potent LSD1 inhibitor with an IC₅₀ value of 0.99 µM. LSD1-IN-32 inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation. LSD1-IN-32 has the potential for the research of osteoporosis .

Tnfsf11 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfsf11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfsf11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Penicisteck acid F	NF-κB	Others
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a NF-κB inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .

Sappanone A 5 Publications Verification	Phosphodiesterase (PDE) NF-κB Keap1-Nrf2 Reactive Oxygen Species (ROS) TNF Receptor Nuclear Factor of activated T Cells (NFAT) Akt ERK p38 MAPK NO Synthase Interleukin Related COX JNK	Cardiovascular Disease Inflammation/Immunology
Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .

Latanoprost acid 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .

Thonzonium bromide 5 Publications Verification	Bacterial Proton Pump	Infection
Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC₅₀=69 μM) .

Boldine (Standard) 1 Publications Verification	Reference Standards RANKL/RANK	Inflammation/Immunology
Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the *OPG/RANKL/RANK* signal pathway and may be a potential therapeutic agent for rheumatoid arthritis .

Usnic acid 1 Publications Verification	Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis	Infection Inflammation/Immunology Cancer
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

Cat. No.	Product Name	Target	Research Area

HY-P990165

*Anti-Mouse RANKL/CD254 Antibody (IK22/5)*	RANKL/RANK E1/E2/E3 Enzyme NF-κB	Inflammation/Immunology Cancer
Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse *RANKL/CD254* IgG2a monoclonal antibody. Anti-Mouse RANKL/CD254 Antibody (IK22/5) inhibits osteoclast formation and activity by specifically blocking the binding of RANKL and RANK. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can inhibit the expression of MuRF1/Trogin-1 and activation of NF-κB. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can be used for research on cancer such as melanoma or colon cancer and osteoporosis .

HY-P9958

Denosumab 1 Publications Verification AMG-162	NF-κB Caspase Apoptosis RANKL/RANK	Endocrinology Cancer
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

HY-P9958A

Denosumab (anti-TNFSF11) 1 Publications Verification	RANKL/RANK Apoptosis NF-κB	Neurological Disease Endocrinology Cancer
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

HY-P99966

Narlumosbart	RANKL/RANK	Cancer
Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor activator of nuclear factor-κB ligand (RANKL) .

HY-P991362

GB-223	TNF Receptor	Cancer
GB-223 is a human monoclonal antibody (mAb) targeting *TNFSF11/RANKL/CD254*. GB-223 can be used in Giant cell tumour of bone and Postmenopausal osteoporosis research .

Species:	Human (8) Mouse (5) Rat (1) Cynomolgus (2)
Tag:	His (7) Tag Free (3) Avi (2) Fc (5) Flag (2)
Source:	HEK293 (12) CHO (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73386

	RANKL/TNFSF11 Protein, Human (HEK293) 2 Publications Verification Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE	Human	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293) is a recombinant human RANKL (G64-D245) without any tag, which is produced in HEK293 cell.

HY-P73387

	RANKL/TNFSF11 Protein, Human (HEK293, hFc) Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE	Human	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293, hFc) is a recombinant human RANKL (G64-D245) with N-terminal hFc tag, which is produced in HEK293.

HY-P73388

	RANKL/TNFSF11 Protein, Mouse (HEK293, Fc) 1 Publications Verification Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE	Mouse	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Mouse (HEK293, Fc) is a recombinant mouse RANKL (R72-D316) with N-terminal hFc tag, which is produced in HEK293.

HY-P75999

	RANKL/TNFSF11 Protein, Cynomolgus (HEK293, Fc) Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE	Cynomolgus	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293, hFc) is a recombinant human RANKL (G63-D244) with N-terminal hFc tag, which is produced in HEK293.

HY-P7424

	RANKL/TNFSF11 Protein, Human Maximum Cited Publications 8 Publications Verification rHuRANK L/TNFSF11; TRANCE; CD254	Human	E. coli
	RANKL (TNFSF11), a type II transmembrane protein, is receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human is a recombinant human RANKL (I140-D317) without any tag, which is produced in E.coli.

HY-P7425

	RANKL/TNFSF11 Protein, Mouse 5+ Cited Publications rMuRANK L/TNFSF11; TRANCE; CD254	Mouse	E. coli
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Mouse is a recombinant mouse RANKL (Q137-D316) without tag, which is produced in E.coli.

HY-P73682

	RANK L/TNFSF11 Protein, Human (HEK293, mFc) Tumor necrosis factor ligand superfamily member 11; ODF; RANKL; CD254; TNFSF11	Human	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293, Fc) is a recombinant human RANKL (G63-D244) with N-terminal mFc tag, which is produced in HEK293 cell.

HY-P78376

	RANKL/TNFSF11 Protein, Human (HEK293, His-Flag) ODF; OPGL; RANKL; TRANCE; CD254; sOdf; TNFSF11; OPTB2	Human	HEK293
	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293, hFc) is a recombinant human RANKL (G63-D244) with N-terminal his and flag tag, which is produced in HEK293.

HY-P704252

	RANKL/TNFSF11 Protein, Human (HEK293, His) Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE	Human	HEK293
	RANKL/TNFSF11 Protein, Human (HEK293, His) is the recombinant human-derived RANKL/TNFSF11 protein, expressed by HEK293, with N-His tag.

HY-P704859

	RANKL/TNFSF11 Protein, Cynomolgus (HEK293, His) Tumor necrosis factor ligand superfamily member 11; RANKL; CD254; ODF; OPGL; TNFSF11; TRANCE	Cynomolgus	HEK293

HY-P700259

	RANKL/TNFSF11 Protein, Mouse (CHO, His) rMuRANKL/TNFSF11, His; TRANCE; CD254	Mouse	CHO
	RANKL/TNFSF11 Protein, Mouse (CHO) is a TNF-related activation-induced cytokine produced in CHO. Mouse and human RANK Ligand share 85% amino acid identity. RANK L/TNFSF11 Protein, Mouse (CHO, His) induces the activation of the c-jun N terminal kinase, enhances T cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis.

HY-P78817

	RANK L/TNFSF11 Protein, Human (Biotinylated, HEK293, Fc-Avi) RANKL; CD254; TRANCE; OPGL; ODF	Human	HEK293
	RANK L/TNFSF11 protein is a cytokine that binds to TNFRSF11B/OPG and TNFRSF11A/RANK and serves as a key regulator of osteoclast differentiation and activation. In addition, it is a factor that enhances the ability of dendritic cells to stimulate naive T cell proliferation, indicating its importance in regulating the interaction between T cells and dendritic cells, as well as its potential role in T cell-dependent immune responses. RANK L/TNFSF11 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived RANK L/TNFSF11 protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of RANK L/TNFSF11 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 182 a.a., with molecular weight of 55-60 kDa.

HY-P703819

	RANKL/TNFSF11 Protein, Mouse (247a.a, HEK293, His) rMuRANKL/TNFSF11, His; TRANCE; CD254	Mouse	HEK293
	RANKL/TNFSF11 Protein, Mouse (247a.a, HEK293, His) is the recombinant mouse-derived RANKL/TNFSF11 protein, expressed by HEK293, with C-His tag.

HY-P7425C

	RANKL/TNFSF11 Protein, Mouse (HEK293, His, Flag) soluble Receptor Activator of NF-kB Ligand; TNFSF11; TRANCE (TNF-Related Activation-induced Cytokine); OPGL; ODF (Osteoclast Differentiation Factor); CD254; sRNAK Ligand	Mouse	HEK293
	RANKL/TNFSF11 Protein, Mouse (HEK293, His, Flag) is the recombinant mouse-derived RANKL/TNFSF11, expressed by HEK293 , with C-Flag, C-6*His labeled tag. ,

HY-P705129

	RANK L/TNFSF11 Protein, Rat (Biotinylated, HEK293, His-Avi) Tnfsf11; TNF superfamily member 11; RANKL; tumor necrosis factor ligand superfamily member 11; ODF; OPGL; TNF-related activation-induced cytokine; TRANCE; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kapp	Rat	HEK293

HY-P7424AF

	*Animal-Free RANKL/TNFSF11 protein, Human* rHuRANK L/TNFSF11; TRANCE; CD254	Human

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-130304S

8-Isoprostaglandin E2-d4

8-Isoprostaglandin E2-d₄ (iPE2-III-d₄) is deuterium labeled 8-Isoprostaglandin E2. 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

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HY-P81124

	RANKL/CD254 Antibody OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.	WB, IHC-P, ELISA	Human, Mouse, Rat
	RANKL/CD254 Antibody is an unconjugated, approximately 35 kDa, rabbit-derived, anti-RANKL/CD254 polyclonal antibody. RANKL/CD254 Antibody can be used for: WB, IHC-P, ELISA expriments in human, mouse, rat background without labeling.

HY-P83811

	TNFSF11 Antibody (YA3508) CD254; ODF; OPGL; sOdf; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
	TNFSF11 Antibody (YA3508) is a mouse-derived and non-conjugated IgG1 antibody, targeting to TNFSF11. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey, rabbit.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS14821

TNFSF11 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
TNFSF11 Rat Pre-designed siRNA Set A contains three designed siRNAs for TNFSF11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14820

Tnfsf11 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tnfsf11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfsf11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14819

TNFSF11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFSF11 Human Pre-designed siRNA Set A contains three designed siRNAs for TNFSF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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