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  4. Anti-osteoporosis agent-12

Anti-osteoporosis agent-12 (Compound 18) is an orally active pyrazole-fused betulinic acid derivative with potent anti-osteoporosis activity. Anti-osteoporosis agent-12 exhibits a strong inhibitory effect on RANKL-induced osteoclastogenesis in RAW264.7 cells, with an IC50 of 7.96 nM. Anti-osteoporosis agent-12 can dose-dependently improve key micro-CT parameters of bone, reduce the level of serum bone resorption marker (CTx), and effectively prevent ovariectomy-induced bone loss. Anti-osteoporosis agent can be used for the study of osteoporosis.

For research use only. We do not sell to patients.

Anti-osteoporosis agent-12

Anti-osteoporosis agent-12 Chemical Structure

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Anti-osteoporosis agent-12 Related Antibodies

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Description

Anti-osteoporosis agent-12 (Compound 18) is an orally active pyrazole-fused betulinic acid derivative with potent anti-osteoporosis activity. Anti-osteoporosis agent-12 exhibits a strong inhibitory effect on RANKL-induced osteoclastogenesis in RAW264.7 cells, with an IC50 of 7.96 nM. Anti-osteoporosis agent-12 can dose-dependently improve key micro-CT parameters of bone, reduce the level of serum bone resorption marker (CTx), and effectively prevent ovariectomy-induced bone loss. Anti-osteoporosis agent can be used for the study of osteoporosis[1].

Molecular Weight

768.08

Formula

C45H73N3O7
SMILES

CC([C@@H]1CC[C@]2(C(OCCCCCC(NCCOCCOCCOCCO)=O)=O)CC[C@@]3(C)[C@]4(C)CCC5C(C)(C)C6=NNC=C6C[C@]5(C)C4CCC3C21)=C
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Room temperature in continental US; may vary elsewhere.
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Anti-osteoporosis agent-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-osteoporosis agent-12Drug DerivativeDrug derivativeOsteoporosisRAW264.7 cellsInhibitorinhibitorinhibit

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