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Pathways Recommended:	Membrane Transporter/Ion Channel
Isoforms Recommended:	L-type calcium channel

Results for "

L-type calcium channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (93) Calmodulin (1) Potassium Channel (11) Adrenergic Receptor (3) Akt (6) AMPK (1) Antibiotic (2) Apoptosis (13) Autophagy (8) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (4) Drug Metabolite (5) Endogenous Metabolite (2) ERK (6) FKBP (1) Fluorescent Dye (1) Fungal (1) Glutathione S-transferase (3) Histamine Receptor (2) Interleukin Related (2) IRAK (6) Isotope-Labeled Compounds (16) JAK (1) JNK (6) MEK (1) Melatonin Receptor (1) Monoamine Oxidase (2) nAChR (2) Natriuretic Peptide Receptor (NPR) (2) NF-κB (9) NO Synthase (1) Opioid Receptor (6) Oxidative Phosphorylation (1) P-glycoprotein (6) Phosphodiesterase (PDE) (3) PPAR (1) Pyroptosis (1) Ras (2) Reactive Oxygen Species (11) Reference Standards (4) SOD (2) STAT (1) STING (2) TNF Receptor (1) Toll-like Receptor (TLR) (6)
By Research Areas:	Cancer (33) Cardiovascular Disease (58) Endocrinology (7) Infection (6) Inflammation/Immunology (16) Metabolic Disease (9) Neurological Disease (30)

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Calcium Channel (93)

Calmodulin (1)

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Akt (6)

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Autophagy (8)

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Biochemical Assay Reagents (1)

Caspase (4)

Drug Metabolite (5)

Endogenous Metabolite (2)

ERK (6)

FKBP (1)

Fluorescent Dye (1)

Fungal (1)

Glutathione S-transferase (3)

Histamine Receptor (2)

Interleukin Related (2)

IRAK (6)

Isotope-Labeled Compounds (16)

JAK (1)

JNK (6)

MEK (1)

Melatonin Receptor (1)

Monoamine Oxidase (2)

nAChR (2)

Natriuretic Peptide Receptor (NPR) (2)

NF-κB (9)

NO Synthase (1)

Opioid Receptor (6)

Oxidative Phosphorylation (1)

P-glycoprotein (6)

Phosphodiesterase (PDE) (3)

PPAR (1)

Pyroptosis (1)

Ras (2)

Reactive Oxygen Species (11)

Reference Standards (4)

SOD (2)

STAT (1)

STING (2)

TNF Receptor (1)

Toll-like Receptor (TLR) (6)

By Research Areas:

Cancer (33)

Cardiovascular Disease (58)

Endocrinology (7)

Infection (6)

Inflammation/Immunology (16)

Metabolic Disease (9)

Neurological Disease (30)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Calcium Channel C-type Lectin-like Receptors (CTLRs) CRAC Channel CaSR Scavenger Receptor Class B type I (SR-BI） Calmodulin PCSK9 Chloride Channel HCN Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126583

Nemadipine-A	Calcium Channel	Cancer
Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca ²⁺ channel . Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand .

HY-B0233

Isradipine PN 200-110	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (PN 200-110) is an orally active **L-type calcium channel** blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0984

Fendiline hydrochloride 1 Publications Verification	Calcium Channel Ras STING Autophagy	Infection Cardiovascular Disease Cancer
Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an **L-type calcium channel blocker (IC₅₀ of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC₅₀ of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING** agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .

HY-14462

NP118809 39-1B4	Calcium Channel	Cardiovascular Disease
NP118809 is a potent N-type calcium channel blocker, with an IC₅₀ of 0.11 μM; also less potently inhibits **L-type calcium channel with an IC₅₀** of 12.2 μM.

HY-12502

Efonidipine NZ-105; (±)-Efonidipine	Calcium Channel	Cardiovascular Disease
Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).

HY-B0233R

Isradipine (Standard)	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (Standard) is the analytical standard of Isradipine. This product is intended for research and analytical applications. Isradipine (PN 200-110) is an orally active **L-type calcium channel** blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0233S2

Isradipine-d7 PN 200-110-d₇	Calcium Channel Autophagy Isotope-Labeled Compounds	Cardiovascular Disease Neurological Disease
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active **L-type calcium channel** blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0984A

Fendiline	Calcium Channel Ras STING Autophagy	Infection Cardiovascular Disease Cancer
Fendiline, a diphenylalkylamine type of antianginal agent, is an **L-type calcium channel blocker (IC₅₀ of 17 µM). Fendiline is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline inhibits K-Ras plasma membrane localization (IC₅₀ of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline is a STING** agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .

HY-P3065

Calcicludine	Calcium Channel	Neurological Disease
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated **calcium channel*, especially L-type* **calcium channel** .

HY-12502B

Efonidipine hydrochloride NZ-105 hydrochloride	Calcium Channel	Cardiovascular Disease
Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).

HY-B0023S

Azelnidipine-d7 CS-905-d₇	Calcium Channel	Cardiovascular Disease
Azelnidipine-d₇ is deuterium labeled Azelnidipine, which is a L-type calcium channel blocker.

HY-12502A

Efonidipine hydrochloride monoethanolate NZ-105 hydrochloride monoethanolate	Calcium Channel	Cardiovascular Disease
Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).

HY-B0317

Amlodipine 5+ Cited Publications	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0317C

Amlodipine mesylate	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine **calcium channel** blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer .

HY-169333

1,4-Dihydropyridine 1,4-DHP	Calcium Channel	Cardiovascular Disease
1,4-Dihydropyridine is an inhibitor for **calcium channel*, that blocks the L-type* calcium channels, reduces the influx of calcium ions into cardiac and vascular smooth muscle cells, and thus reduces the contractility and heart rate of the heart, dilates blood vessels, and lowers blood pressure .

HY-B0317A

Amlodipine maleate 5+ Cited Publications	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine maleate is a dihydropyridine **calcium channel blocker, acts as an orally active antianginal agent*. Amlodipine maleate blocks the voltage-dependent L-type* calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-17611A1

Etripamil hydrochloride MSP-2017 hydrochloride; (-)-MSP-2017 hydrochloride	Calcium Channel	Neurological Disease
Etripamil (MSP-2017) hydrochloride is a short-acting, L-type calcium channel antagonist that can be used in the study of paroxysmal supraventricular tachycardia (PSVT). Etripamil hydrochloride inhibits calcium influx through slow calcium channels, thereby slowing atrioventricular node conduction and prolonging the atrioventricular node refractory period.

HY-B0317B

Amlodipine besylate 5+ Cited Publications Amlodipine benzenesulfonate	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer .

HY-N2077

Heteroclitin D	Calcium Channel	Metabolic Disease
Heteroclitin D is a lignin from Kadsura medicinal plants with anti-liqid peroxidation. Heteroclitin D inhibits L-type **calcium channels** .

HY-100750

Norverapamil hydrochloride 1 Publications Verification (±) -Norverapamil hydrochloride; D591 hydrochloride	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a **L-type calcium channel blocker and a P-glycoprotein (P-gp)** function inhibitor .

HY-135328

Norverapamil (±)-Norverapamil; D591	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a **L-type calcium channel blocker and a P-glycoprotein (P-gp)** function inhibitor .

HY-B0317R

Amlodipine (Standard)	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine (Standard) is the analytical standard of Amlodipine. This product is intended for research and analytical applications. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0317AS

Amlodipine-d4 maleate	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease Cancer
Amlodipine-d₄ (maleate) is the deuterium labeled Amlodipine maleate. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer[1][2][3].

HY-160980

Sornidipine	Calcium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Sornidipine is a **calcium channel** blocker. Sornidipine also reduces neurogenic inflammation. Sornidipine reduces the inflow of calcium ions into cells by blocking L-type calcium channels, thereby reducing the contraction of vascular smooth muscle, leading to vasodilation and decreased blood pressure. Sornidipine can be used to study the cardiovascular system especially in hypertension and related cardiovascular diseases .

HY-B1655

Fluspirilene 1 Publications Verification R 6218; Redeptin	Calcium Channel	Neurological Disease
Fluspirilene is a non-competitive antagonist of **L-type calcium channels with an IC₅₀** of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.

HY-103005R

Ramelteon metabolite M-II (Standard)	Melatonin Receptor Drug Metabolite	Neurological Disease Endocrinology
Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-B0317AS1

Amlodipine-d9 maleate	Calcium Channel Isotope-Labeled Compounds	Cardiovascular Disease
Amlodipine-d₉ maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine **calcium channel blocker, acts as an orally active antianginal agent*. Amlodipine maleate blocks the voltage-dependent L-type* calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-B0317AR

Amlodipine (maleate) (Standard)	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-B0317S1

Amlodipine-d4	Isotope-Labeled Compounds Calcium Channel	Cancer
Amlodipine-d₄ is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B1090

Cinnarizine	Calcium Channel Histamine Receptor	Cardiovascular Disease Endocrinology
Cinnarizine is an orally active, effective and selective inhibitor of L-type calcium channel Cav1.3 with an IC₅₀ of 1.5 μM (in vestibular hair cells). Cinnarizine can cross the blood-brain barrier and regulate calcium homeostasis and dopamine neurotransmission. Cinnarizine inhibits the influx of calcium ions into smooth muscle cells by blocking L-type calcium channels, thereby relaxing vascular smooth muscle, improving cerebral circulation and reducing blood viscosity, while antagonizing dopamine receptors. Cinnarizine can be used in the study of vestibular vertigo, Meniere's disease and cerebrovascular diseases .

HY-126763

ATI22-107	Phosphodiesterase (PDE) Calcium Channel	Others
ATI22-107 is a dual-pharmacophore compound designed to simultaneously inhibit cardiac phosphodiesterase (PDE-III) and L-type calcium channels (LTCC), with activity that has specific effects on calcium cycling and contractility in cat ventricular myocytes and trabeculae.

HY-B0317S

Amlodipine-1,1,2,2-d4 maleate	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease Cancer
Amlodipine-1,1,2,2-d₄ (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

HY-B0317BS

Amlodipine-d4 besylate Amlodipine benzenesulfonate-d₄ besylate	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease Cancer
Amlodipine-d₄ (besylate) is the deuterium labeled Amlodipine besylate. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3].

HY-15553A

Mibefradil dihydrochloride Ro 40-5967 dihydrochloride	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a **calcium channel** blocker with moderate selectivity for T-type Ca ²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) .

HY-108163A

SB-237376	Calcium Channel Potassium Channel	Neurological Disease
SB-237376 is a blocker of potassium and calcium channels. SB-237376 inhibits the rapidly activating delayed rectifier potassium current I(Kr) (IC50: 0.42 μM) and blocks the L-type calcium current I(Ca,L) at high concentrations .

HY-167203

AJG049 free base	Calcium Channel	Cardiovascular Disease
AJG049 free base is a calcium channel (Ca ²⁺ channel) antagonist. AJG049 free base regulates vascular relaxation, reduces cardiac load, and improves cardiac perfusion by binding to the binding site of L-type calcium channels, specifically Diltiazem (HY-B0632). AJG049 free base can be used in cardiovascular disease research .

HY-120411

Sadopine	Calcium Channel	Others
Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels .

HY-B0317BR

Amlodipine (besylate) (Standard) Amlodipine (benzenesulfonate) (Standard)	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine (besylate) (Standard) is the analytical standard of Amlodipine (besylate). This product is intended for research and analytical applications. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer .

HY-17611

Etripamil MSP-2017; (-)-MSP-2017	Calcium Channel	Cardiovascular Disease
Etripamil (MSP-2017) is a short-acting, **L-type calcium-channel** antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT) .

HY-15553

Mibefradil Ro 40-5967	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil (Ro 40-5967) is a **calcium channel** blocker with moderate selectivity for T-type Ca ²⁺ channels displaying IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively .

HY-B1440

Ethaverine hydrochloride	Calcium Channel Monoamine Oxidase	Cardiovascular Disease
Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type **calcium channel**. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease .

HY-B0023R

Azelnidipine (Standard)	Calcium Channel	Cardiovascular Disease
Azelnidipine (Standard) is the analytical standard of Azelnidipine. This product is intended for research and analytical applications. Azelnidipine (CS 905; Calblock) is a dihydropyridine derivative, an L-type calcium channel blocker, and can fight hypertension.

HY-B0023

Azelnidipine 2 Publications Verification CS 905	Calcium Channel MEK	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Azelnidipine (CS 905) is a dihydropyridine calcium channel blocker that is effective orally. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects .

HY-14744B

Levamlodipine hydrochloride (S)-Amlodipine hydrochloride; Levoamlodipine hydrochloride	Calcium Channel SOD	Cardiovascular Disease
Levamlodipine hydrochloride (Levoamlodipine hydrochloride) is a dihydropyridine **calcium channel** blocker. Levamlodipine hydrochloride reduces the inflow of calcium ions by blocking L-type **calcium channels** on vascular smooth muscle cells, thereby leading to vasodilation, lower blood pressure and lighten the burden on the heart. Levamlodipine hydrochloride has activity to lower blood pressure and relieve angina. The binding properties of Levamlodipine hydrochloride to human serum albumin (HSA) contribute to the study of drug transport and release mechanisms in the body .

HY-135328S

Norverapamil-d7 (±)-Norverapamil-d₇; D591-d₇	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-135328AS

Norverapamil-d7 hydrochloride (±)-Norverapamil-d₇ (hydrochloride); D591-d7 (hydrochloride)	Calcium Channel	Cardiovascular Disease
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-17402S

Nisoldipine-d6 BAY-k 5552-d₆	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-126401

Elgodipine IQB-875 free base	Calcium Channel	Cardiovascular Disease
Elgodipine (IQB-875 free base) is an orally active dihydropyridine calcium antagonist and an antianginal compound. Elgodipine inhibits both T- and L-type calcium channels (IC₅₀: 32 and 2.3 nM). Elgodipine lowers systemic vascular resistance and improves systolic cardiac function .

HY-D2266

FluoBar1	Fluorescent Dye	Neurological Disease
FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .

HY-B0632A

Diltiazem malate MK 793	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem malate is a potent and orally active **L-type calcium channel** inhibitor. Diltiazem malate shows antihypertensive and antiarrhythmic effects. Diltiazem malate can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

Cat. No.	Product Name	Type

HY-D2266

FluoBar1	Fluorescent Dyes/Probes
FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .

Cat. No.	Product Name	Type

HY-Y1267D

Magnesium sulfate, for cell culture	Buffer Reagents
Magnesium sulfate, suitable for cell culture, bioreagent. Magnesium sulfate is a calcium antagonist and a potent **L-type calcium channel** inhibitor. Magnesium sulfate has anti-inflammatory and an anticonvulsant activity. Magnesium sulfate is a tocolytic agent. Magnesium sulfate can be used for severe pre-eclampsis/eclampsia research .

Cat. No.	Product Name	Target	Research Area

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for *P-type* and Q-type Ca ²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels .

HY-P0003

Nesiritide Brain Natriuretic Peptide-32 human; BNP-32	Natriuretic Peptide Receptor (NPR) Calcium Channel	Cardiovascular Disease
Nesiritide (Brain Natriuretic Peptide-32 human) is a recombinant human B-type natriuretic peptide. Nesiritide is a NPRs agonist, with K_d values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide regulates V_1/2 activation/inactivation of the L-type **calcium channel**. Nesiritide shows vasodilatory, diuretic, and natriuretic activities. Nesiritide is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury .

HY-P3065

Calcicludine	Calcium Channel	Neurological Disease
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated **calcium channel*, especially L-type* **calcium channel** .

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for *P-type* and Q-type Ca ²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels .

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .

HY-P0003A

Nesiritide acetate Brain Natriuretic Peptide-32 human acetate; BNP-32 acetate	Natriuretic Peptide Receptor (NPR) Calcium Channel	Cardiovascular Disease
Nesiritide (Brain Natriuretic Peptide-32 human) acetate is a recombinant human B-type natriuretic peptide. Nesiritide acetate is a NPRs agonist, with K_d values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Nesiritide acetate regulates V_1/2 activation/inactivation of the L-type **calcium channel**. Nesiritide acetate shows vasodilatory, diuretic, and natriuretic activities. Nesiritide acetate is used in cardiovascular diseases such as heart failure and vascular remodeling after arterial injury .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2077

Heteroclitin D	other families Classification of Application Fields Source classification Lignans Metabolic Disease Phenylpropanoids Plants Disease Research Fields	Calcium Channel
Heteroclitin D is a lignin from Kadsura medicinal plants with anti-liqid peroxidation. Heteroclitin D inhibits L-type **calcium channels** .

HY-N7503

Psoralenoside	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Source classification Metabolic Disease Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields	Histamine Receptor Calcium Channel Calmodulin
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H₁, calmodulin, and voltage-gated L-type **calcium channels** (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-W001160

5-Hydroxyindole	Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite Calcium Channel nAChR
5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type **calcium channels**. 5-Hydroxyindole slows down the desensitization of 5-HT₃ receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type **calcium channels and Bcl-2 related apoptosis** genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses .

HY-P3065

Calcicludine	Structural Classification Natural Products Animals Source classification	Calcium Channel
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated **calcium channel*, especially L-type* **calcium channel** .

HY-N6687R

Calcimycin (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively .

HY-W001160R

5-Hydroxyindole (Standard)	Alkaloids Structural Classification Monophenols Source classification Phenols Endogenous metabolite Indole Alkaloids	Endogenous Metabolite nAChR Calcium Channel
5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160). This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type **calcium channels**. 5-Hydroxyindole slows down the desensitization of 5-HT₃ receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders .

Cat. No.	Compare	Product Name	Species	Source

HY-P72109

	CACNA2D1 Protein, Human (His-SUMO) CA2D1_HUMAN; CACN A2; CACNA2; Cacna2d1; CACNL2A; calcium channel L type alpha 2 polypeptide; calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1	Human	E. coli
	The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0317AS

Amlodipine-d4 maleate

Amlodipine-d₄ (maleate) is the deuterium labeled Amlodipine maleate. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer[1][2][3].

HY-B0317S1

Amlodipine-d4
Amlodipine-d₄ is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0317S

Amlodipine-1,1,2,2-d4 maleate
Amlodipine-1,1,2,2-d₄ (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-B0233S2

Isradipine-d7
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active **L-type calcium channel** blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0023S

Azelnidipine-d7
Azelnidipine-d₇ is deuterium labeled Azelnidipine, which is a L-type calcium channel blocker.

HY-B0317AS1

Amlodipine-d9 maleate

Amlodipine-d₉ maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-B0317BS

Amlodipine-d4 besylate

Amlodipine-d₄ (besylate) is the deuterium labeled Amlodipine besylate. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3].

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-17402S

Nisoldipine-d6
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-W699430

Norverapamil-d6 hydrochloride
Norverapamil-d₆ ((±)-Norverapamil-d₆) hydrochloride is deuterium labeled Norverapamil (hydrochloride). Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a **L-type calcium channel blocker and a P-glycoprotein (P-gp)** function inhibitor .

HY-B0233S1

Isradipine-d6
Isradipine-d₆ is the deuterium labeled Isradipine[1]. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[2][3][4].

HY-B0233S

Isradipine-d3

Isradipine-d₃ (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].

HY-17402S1

Nisoldipine-d4
Nisoldipine-d₄ (BAY-k 5552-d4) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-17402S2

Nisoldipine-d7
Nisoldipine-d₇ (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-B0347S3

Lacidipine-13C4

Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-111613S

Pinaverium bromide-d4
Pinaverium bromide-d₄ is deuterium labeled Pinaverium bromide. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].

HY-108974S

Drotaverine-d10 hydrochloride

Drotaverine-d₁₀ (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].

HY-W701464

N-Desalkylflurazepam-d4
N-Desalkylflurazepam-d₄ is a deuterated labeled N-Desalkylflurazepam (HY-106454). N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for Ca_v1.2 and Ca_v1.3, respectively .

HY-B0380S1

Trimebutine-d5 fumarate

Trimebutine-d₅ fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

HY-B0380S2

Trimebutine-d3 hydrochloride

Trimebutine-d₃ hydrochloride is deuterium labeled Trimebutine hydrochloride. Trimebutine hydrochloride is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine hydrochloride inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine hydrochloride also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine hydrochloride also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine hydrochloride also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

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