Magnesium sulfate

Cat. No.: HY-Y1267 Assay: 99.07%: Data Sheet
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Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.

For research use only. We do not sell to patients.

Magnesium sulfate Chemical Structure

CAS No. : 7487-88-9

Size	Price	Stock	Quantity
50 g		In-stock	Estimated Time of Arrival: December 31
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Other Forms of Magnesium sulfate:

Magnesium sulfate heptahydrate, for cell culture In-stock
Magnesium sulfate, for cell culture In-stock
Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC Get quote
Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard Get quote
Magnesium sulfate heptahydrate, for molecular biology Get quote

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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nNOS iNOS eNOS

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Phospholipase A PLD Phospholipase C

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Magnesium sulfate (3 mM) inhibits phosphatidylinositol-4,5-bisphosphate-specific phospholipase C activity and subsequent calcium release in cultured myometrial cells^[2].
Magnesium sulfate (20 mM; 6 h) inhibits the LPS (HY-D1056)-induced inflammatory molecules production and NF-κB activation in RAW264.7 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[3]

Cell Line:	RAW264.7 cells treated with 100 ng/mL of LPS (HY-D1056)
Concentration:	20 mM
Incubation Time:	6 h
Result:	Inhibtied the levels of iNOS and COX-2.

In Vivo

Magnesium sulfate (intraperitoneal injection; 270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg) reduces LPS (HY-D1056)-induced inflammation-associated brain injury in fetal mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15^[4]
Dosage:	270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
Administration:	Intraperitoneal injection
Result:	Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.

CAS No.

7487-88-9

Appearance

Solid

Color

White to off-white

SMILES

[Mg]=S(O[O])([O])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.63%

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Data Sheet (277 KB) SDS (418 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Ramsey PS, et al. Magnesium sulfate as a tocolytic agent. Semin Perinatol. 2001;25(4):236-247. [Content Brief]

[2]. Hurd WW, et al. Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. Am J Obstet Gynecol. 2002 Aug;187(2):419-24. [Content Brief]

[3]. Lin CY, et al. L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth. 2010 Jan;104(1):44-51. [Content Brief]

[4]. Burd I, et al. Magnesium sulfate reduces inflammation-associated brain injury in fetal mice. Am J Obstet Gynecol. 2010 Mar;202(3):292.e1-9. [Content Brief]

[5]. Okusanya BO, et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016;123(3):356-366. [Content Brief]

[6]. Hunter LA, et al. Magnesium sulfate: past, present, and future. J Midwifery Womens Health. 2011 Nov-Dec;56(6):566-74. [Content Brief]