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  4. Magnesium sulfate, for cell culture

Magnesium sulfate, for cell culture 

Cat. No.: HY-Y1267D Purity: ≥99.0%
COA
SDS
Handling Instructions Technical Support

Magnesium sulfate, for cell culture is a bioreagent. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.

For research use only. We do not sell to patients.

Magnesium sulfate, for cell culture

Magnesium sulfate, for cell culture Chemical Structure

CAS No. : 7487-88-9

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Magnesium sulfate, for cell culture Related Antibodies

Top Publications Citing Use of Products

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Phospholipase A PLD Phospholipase C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Magnesium sulfate, for cell culture is a bioreagent. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia[1][2][3][4][5][6].

In Vitro

Magnesium sulfate (3 mM) for cell culture inhibits phosphatidylinositol-4,5-bisphosphate-specific phospholipase C activity and subsequent calcium release in cultured myometrial cells[2].
Magnesium sulfate (20 mM; 6 h) for cell culture inhibits the LPS (HY-D1056)-induced inflammatory molecules production and NF-κB activation in RAW264.7 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Magnesium sulfate, for cell culture Related Antibodies

Real Time qPCR[3]

Cell Line: RAW264.7 cells treated with 100 ng/mL of LPS (HY-D1056)
Concentration: 20 mM
Incubation Time: 6 h
Result: Inhibtied the levels of iNOS and COX-2.
In Vivo

Magnesium sulfate (intraperitoneal injection; 270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg) for cell culture reduces LPS (HY-D1056)-induced inflammation-associated brain injury in fetal mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15[4]
Dosage: 270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
Administration: Intraperitoneal injection
Result: Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.
Molecular Weight

120.37

Formula

MgSO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Mg]=S(O[O])([O])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (830.77 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.3077 mL 41.5386 mL 83.0772 mL
5 mM 1.6615 mL 8.3077 mL 16.6154 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.3077 mL 41.5386 mL 83.0772 mL 207.6929 mL
5 mM 1.6615 mL 8.3077 mL 16.6154 mL 41.5386 mL
10 mM 0.8308 mL 4.1539 mL 8.3077 mL 20.7693 mL
15 mM 0.5538 mL 2.7692 mL 5.5385 mL 13.8462 mL
20 mM 0.4154 mL 2.0769 mL 4.1539 mL 10.3846 mL
25 mM 0.3323 mL 1.6615 mL 3.3231 mL 8.3077 mL
30 mM 0.2769 mL 1.3846 mL 2.7692 mL 6.9231 mL
40 mM 0.2077 mL 1.0385 mL 2.0769 mL 5.1923 mL
50 mM 0.1662 mL 0.8308 mL 1.6615 mL 4.1539 mL
60 mM 0.1385 mL 0.6923 mL 1.3846 mL 3.4615 mL
80 mM 0.1038 mL 0.5192 mL 1.0385 mL 2.5962 mL
100 mM 0.0831 mL 0.4154 mL 0.8308 mL 2.0769 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Magnesium sulfate, for cell culture Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magnesium sulfate, for cell culture7487-88-9Biochemical Assay ReagentsCalcium ChannelInterleukin RelatedNO SynthaseCOXNF-κBPhospholipaseCa2+ channelsCa channelsILNitric oxide synthasesNOSCyclooxygenaseNuclear factor-κBNuclear factor-kappaBInorganic saltmyometrial cellsRAW264.7 cellsLPSInhibitorinhibitorinhibit

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