PNPLA3

Patatin-like phospholipase domain-containing protein 3; Adiponutrin; iPLA2-epsilon; Calcium-independent phospholipase A2-epsilon; Acylglycerol O-acyltransferase

Patatin-like phospholipase domain-containing protein 3 (PNPLA3) is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. It is involved in the triacylglycerol hydrolysis in adipocytes and may play a role in energy metabolism.

PNPLA3 Related Products (5):

By Effects:	Inhibitors (2) Degrader (1) Modulators (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N1967

Dihydrocurcumin	Modulator	99.77%
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways.

HY-163959

PF-07853578	Degrader	99.08%
PF-07853578 (Example 11) is a PNPLA3 degrader with an EC₅₀ of 8 nM. PNPLA3 degrader-1 can be used in the study of cirrhosis and hepatocellular carcinoma.

HY-RS10794

PNPLA3 Human Pre-designed siRNA Set A	Inhibitor
PNPLA3 Human Pre-designed siRNA Set A contains three designed siRNAs for PNPLA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-173599

NUV-244	Inhibitor
NUV-244 is a PNPLA3 I148M degrader. NUV-244 reduces PNPLA3 I148M levels on lipid droplets via BFAR-mediated ubiquitin-proteasome degradation.

HY-159656

PNPLA3 modifier 1	Modulator
PNPLA3 modifier 1 (compound 10) is a Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifier, with a geometric mean EC₅₀ of 4.9 nM.

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