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Results for "

HSV inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSV (120) Acetyl-CoA Carboxylase (2) Acyltransferase (2) Akt (4) AMPK (2) Androgen Receptor (1) Antibiotic (23) Apoptosis (25) Autophagy (17) Bacterial (32) Caspase (2) Cathepsin (2) CCR (1) CD3 (1) CDK (4) CMV (19) COX (3) CXCR (1) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (2) DNA/RNA Synthesis (21) Drug Metabolite (2) DYRK (1) EBV (1) Endogenous Metabolite (22) Enterovirus (2) ERK (5) FAK (1) Ferroptosis (4) FGFR (2) Filovirus (1) Flavivirus (2) Fungal (6) GSK-3 (2) HBV (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (3) HIV (16) HPV (2) HSP (1) Influenza Virus (4) Integrin (2) Interleukin Related (3) Isotope-Labeled Compounds (8) JNK (2) Mitophagy (2) MMP (2) Monoamine Oxidase (2) NF-κB (4) NO Synthase (1) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (21) Orthopoxvirus (10) p38 MAPK (2) Parasite (5) Phosphatase (2) PI3K (2) PKC (2) PPAR (3) Proton Pump (2) Reactive Oxygen Species (ROS) (4) Reference Standards (24) RSV (1) SARS-CoV (2) SGLT (1) Sirtuin (2) STAT (6) Tau Protein (2) Thymidylate Synthase (3) Toll-like Receptor (TLR) (2) Tyrosinase (2) VEGFR (3) Virus Protease (5) VSV (1) YB-1 (1)
By Research Areas:	Cancer (59) Cardiovascular Disease (2) Infection (130) Inflammation/Immunology (27) Metabolic Disease (11) Neurological Disease (9)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (2) Uridine (1) Antisense Oligonucleotides (2) Cholesterol (1)

141

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: HSV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-148852

PNU-183792	HSV	Infection
PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC₅₀ values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) .

HY-100272

B220	HSV CMV	Infection Cancer
B220 is an antiviral agent which can inhibit the growth of *HSV-1, HSV-2* and human cytomegalovirus (CMV).

HY-U00124B

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and *HSV-2* replication .

HY-163546

HSV-1-IN-1	HSV	Infection
HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus *HSV-1(IC₅₀*=0.5 nM) and *HSV-2(IC₅₀*=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting *HSV* infection .

HY-149023

HSV-1/HSV-2-IN-2	HSV	Infection
HSV-1/HSV-2-IN-2 is a *HSV-1, HSV-2* and VV inhibitor with EC₅₀ values of 6.8, 8.9 and 8.9 µM, respectively. HSV-1/HSV-2-IN-2 shows antiviral activity .

HY-149022

HSV-1/HSV-2-IN-1	HSV Orthopoxvirus	Infection
HSV-1/HSV-2-IN-1 (compound 7d) is a *HSV-1* and *HSV-2* inhibitor, with EC₅₀s of 7.6, 7.6, 4, and 12 μM for HSV-1 (KOS), HSV-2 (G), HSV-1 TK ^- KOS ACV ^r and vaccinia virus in human embryonic lung fibroblast cell cultures .

HY-176163

HSV-1-IN-2	HSV	Infection
HSV-1-IN-2 (compound 5i) is a potent Herpes simplex virus type 1 (HSV-1) inhibitor with an EC₅₀ of 1.95 μM. HSV-1-IN-2 inhibits apoptosis and improves herpes encephalitis model mouse survival .

HY-174429

HSV-1-IN-3	HSV	Infection
HSV-1-IN-3 (Compound A50) is a *HSV* inhibitor. HSV-1-IN-3 shows good antiviral efficacy against both Acyclovir (HY-17422) -sensitive and -resistant HSV strains .

HY-U00124

Tromantadine	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

HY-174252

HSV-1/HSV-2-IN-3	HSV	Infection
HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC₅₀ of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC₅₀ of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC₅₀ ≈ 2.9 µM for hCA II and > 35 µM for hCA I). HSV-1/HSV-2-IN-3 can be studied in anti-HSV research .

HY-15303B

Pritelivir mesylate hydrate 5+ Cited Publications AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-15303

Pritelivir 5+ Cited Publications AIC316; BAY 57-1293	HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-15303A

Pritelivir mesylate 5+ Cited Publications AIC316 mesylate; BAY 57-1293 mesylate	HSV	Infection
Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-N14446

Karalicin	HSV	Infection
Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC₅₀s (μg/mL) of 0.004, 0.008, 0.016 and 0.016 .

HY-15303R

Pritelivir (Standard)	HSV	Infection
Pritelivir (Standard) is the analytical standard of Pritelivir. This product is intended for research and analytical applications. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2 .

HY-15303AR

Pritelivir mesylate (Standard)	HSV	Infection
Pritelivir (mesylate) (Standard) is the analytical standard of Pritelivir (mesylate). This product is intended for research and analytical applications. Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2 .

HY-150306

Adibelivir IM-250	HSV	Infection
Adibelivir (IM-250) is an orally active helicase-primase inhibitor. Adibelivir is effective against *HSV* infection and reduces reactivation of latent HSV. Adibelivir inhibits HSV-1 infection in Vero cells (IC₅₀: ~20 nM). Adibelivir can be used for the study of recurrent herpes disease^[1][2]_.

HY-N10177

Peniterphenyl A	HSV	Infection
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits *HSV-1/2* virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-18944

FIT-039	CDK HSV CMV DNA/RNA Synthesis	Infection
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC₅₀ of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of *HSV-1* (IC₅₀ of 0.69 μM), *HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting* drug-resistant *HSVs* and other DNA viruses.

HY-131606

Cidofovir diphosphate	HSV CMV	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-15303S

Pritelivir-d4-1 AIC316-d4-1; BAY 57-1293-d4-1	Isotope-Labeled Compounds HSV	Infection
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-U00224

BRL44385	EBV HSV	Infection
BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and *HSV2*), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

HY-170547

DNA polymerase-IN-6	DNA/RNA Synthesis HSV Filovirus	Infection
DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, and inhibits HCMV, *HSV-1, HSV-2* and EBV with EC₅₀s of 0.33, 1.9, 0.76 and 0.066 µM, respectively .

HY-111801

Woodorien	HSV	Infection
Woodorien is a potent *HSV-1* inhibitor. Woodorien also is a glucoside that can be isolated from Woodwardia orientalis .

HY-131606B

Cidofovir diphosphate tri(triethylamine)	Drug Metabolite	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-177638A

ISIS 1082 sodium	HSV	Infection
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-177638

ISIS 1082	HSV	Infection
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-15486

Salubrinal 30+ Cited Publications	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against *HSV-1* and inhibits dephosphorylation of eIF2α mediated by the *HSV-1* protein ICP34.5 .

HY-18684

SIBA 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine	Nucleoside Antimetabolite/Analog HSV Parasite	Infection Metabolic Disease Cancer
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies .

HY-129861

5'-Ethynyl-2'-deoxycytidine	HSV	Infection Cancer
5'-Ethynyl-2'-deoxycytidine is an inhibitor for *HSV, that inhibits* the cytopathic effect of HSV-1 in primary rabbit kidney cell with a MIC of 0.2 μg/mL. 5'-Ethynyl-2'-deoxycytidine inhibits the proliferation of leukemia L1210 cell with an IC₅₀ of 64.5 μg/mL .

HY-122920

Soyasaponin II	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1	Infection Inflammation/Immunology
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-N1067

Xanthohumol 10+ Cited Publications	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-118122

Fialuridine FIAU; DRG-0098; NSC 678514	HSV HBV DNA/RNA Synthesis Orthopoxvirus Nucleoside Antimetabolite/Analog	Infection
Fialuridine (FIAU), a nucleoside analog, is a *HSV-1* and *HSV-2* inhibitor with K_is of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC₅₀ values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively .

HY-18944R

FIT-039 (Standard)	CDK HSV CMV DNA/RNA Synthesis	Infection
FIT-039 (Standard) is the analytical standard of FIT-039. This product is intended for research and analytical applications. FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.

HY-W002008

5-Nitrobarbituric acid	HSV	Infection Inflammation/Immunology
5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) .

HY-131606S

Cidofovir diphosphate-13C3	Isotope-Labeled Compounds HSV CMV	Infection
Cidofovir diphosphate- ¹³C₃ is the ¹³C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-15486R

Salubrinal (Standard)	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal (Standard) is the analytical standard of Salubrinal. This product is intended for research and analytical applications. Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5 .

HY-N1430

Oxyresveratrol 1 Publications Verification trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects .

HY-162069

Antiviral agent 47	HSV	Infection
Antiviral agent 47 (Compound 26) is an antiviral agent, which inhibits *HSV-1* with ID₅₀ of 16 μM, through suppression of herpes virus replication .

HY-123211

WAY-150138	HSV	Infection
WAY-150138 inhibits replication of herpes simplex virus type 1 (HSV-1) that acts by preventing the incorporation of DNA-packaging proteins into capsids as they are assembled

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-N1067R

Xanthohumol (Standard)	Reference Standards COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-N1430R

Oxyresveratrol (Standard) trans-Oxyresveratrol (Standard)	Reference Standards Tyrosinase HSV Autophagy	Others
Oxyresveratrol (Standard) is the analytical standard of Oxyresveratrol. This product is intended for research and analytical applications. Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-N2004

Isoborneol (±)-Isoborneol	HSV	Infection Neurological Disease
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 *(HSV-1)* .

HY-16592

Brefeldin A Maximum Cited Publications 126 Publications Verification BFA; Cyanein; Decumbin	Autophagy Mitophagy HSV Antibiotic Bacterial	Infection Cancer
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-120427

Cosalane 1 Publications Verification NSC 658586	CCR CXCR HIV HSV	Infection Inflammation/Immunology
Cosalane (NSC 658586) is a CCR7 (IC₅₀ = 2.43 μM) and CXCR2 antagonist (IC₅₀ = 0.66 μM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2, Rauscher murine leukemia virus, *HSV-1, HSV-2* and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4. Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT) .

HY-17422S1

Acyclovir-d4 Aciclovir-d₄; Acycloguanosine-d₄	Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic	Infection Cancer
Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-17425

Valacyclovir Valaciclovir	HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir (Valaciclovir) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir is a proagent of Aciclovir (HY-17422) .

Cat. No.	Product Name	Type

HY-B1773A

Sodium propionate

2 Publications Verification

Biochemical Assay Reagents

Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-14743R

Golotimod (Standard)	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

Cat. No.	Product Name	Target	Research Area

HY-P99147

Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)	CD3	Infection Inflammation/Immunology
Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) is an Armenian Hamster-derived IgG antibody inhibitor, targeting to mouse TCR V gamma 2. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) reacts with an epitope on the delta chain of the mouse Vγ2 TCR (V gamma 2 T cell receptor). Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can deplete γδ T cell. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can be used for the researches of infection and immunology, such as herpes simplex virus-1 (HSV-1) infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122920

Soyasaponin II	Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc.	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-N1067

Xanthohumol 10+ Cited Publications	Infection Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-N1430

Oxyresveratrol 1 Publications Verification trans-Oxyresveratrol	other families Stilbenes Classification of Application Fields Anti-aging Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects .

HY-N1067R

Xanthohumol (Standard)	Chalcones Flavonoids Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae	Reference Standards COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-N2004

Isoborneol (±)-Isoborneol	Natural Products Source classification Curcuma aromatica Salisb. cv. Wenyujin Plants Zingiberaceae	HSV
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 *(HSV-1)* .

HY-16592

Brefeldin A Maximum Cited Publications 126 Publications Verification BFA; Cyanein; Decumbin	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Disease Research Anticancer Disease Research Fields	Autophagy Mitophagy HSV Antibiotic Bacterial
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-N14446

Karalicin	Natural Products Microorganisms Source classification	HSV
Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC₅₀s (μg/mL) of 0.004, 0.008, 0.016 and 0.016 .

HY-N10177

Peniterphenyl A	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits *HSV-1/2* virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-111801

Woodorien	Blechnaceae Source classification Plants Woodwardia orientalis Sw. Saccharides Monosaccharides	HSV
Woodorien is a potent *HSV-1* inhibitor. Woodorien also is a glucoside that can be isolated from Woodwardia orientalis .

HY-N1430R

Oxyresveratrol (Standard) trans-Oxyresveratrol (Standard)	other families Stilbenes Source classification Phenols Polyphenols Plants	Reference Standards Tyrosinase HSV Autophagy
Oxyresveratrol (Standard) is the analytical standard of Oxyresveratrol. This product is intended for research and analytical applications. Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-17425A

Valacyclovir hydrochloride 1 Publications Verification Valaciclovir hydrochloride	Infection Classification of Application Fields Disease Research Fields	HSV Antibiotic Bacterial
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-16592R

Brefeldin A (Standard) BFA (Standard); Cyanein (Standard); Decumbin (Standard)	Microorganisms Macrolide Antibiotics Antibiotics Source classification Antiviral Disease Research Anticancer	Reference Standards Autophagy Mitophagy HSV Antibiotic Bacterial
Brefeldin A (Standard) (BFA (Standard)) is the analytical standard of Rutin. This product is intended for research and analytical applications. Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity.

HY-N11097

FK-3000	Alkaloids Piperidine Alkaloids Source classification Plants Stephania delavayi Diels Menispermaceae	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against *HSV-1* and HIV-1 .

HY-N2004R

Isoborneol (Standard) (±)-Isoborneol (Standard)	Natural Products Source classification Curcuma aromatica Salisb. cv. Wenyujin Plants Zingiberaceae	Reference Standards HSV
Isoborneol (Standard) is the analytical standard of Isoborneol. This product is intended for research and analytical applications. Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1) .

HY-117010

Kushenol K	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Sophora flavescens Aiton Disease Research Fields	Cytochrome P450 HSV SGLT
Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a K_i value of 1.35 μM . Kushenol K shows weak antiviral activity against *HSV-2* (EC₅₀ of 147 μM) . Kushenol K also inhibits the activity of SGLT1 and SGLT2 .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Infection Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Animals Source classification Marine natural products Eupatorium triplinerve Vahl. Pyridine Alkaloids Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against *HSV-1* .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against *HSV-1* .

HY-113289

Brassicasterol	Infection Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-13605

Cytarabine 75+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	Infection Natural Products Microorganisms Classification of Application Fields Marine natural products Source classification Sponge Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against *HSV*. Cytarabine shows anti-orthopoxvirus activity.

HY-N2812

Epipodophyllotoxin acetate 4-O-Epipodophyllotoxinyl acetate	Cupressaceae Source classification Lignans Phenylpropanoids Plants	HSV VSV
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits *HSV* and VSV, with IC₅₀s of 0.2 and 0.1 μg/mL, respectively .

HY-N15215

Antiviral agent 64	Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Enterovirus Influenza Virus RSV HSV
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, *HSV-1, and influenza virus H1N1, with EC₅₀* of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-128744

Phosphonoacetic acid 1 Publications Verification	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit *HSV* DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-B0275

Oxytetracycline 5+ Cited Publications	Classification of Application Fields Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields	Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B0275A

Oxytetracycline hydrochloride 5+ Cited Publications	Infection Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-13605R

Cytarabine (Standard) Cytosine β-D-arabinofuranoside (Standard); Cytosine Arabinoside (Standard); Ara-C (Standard)	Natural Products Microorganisms Marine natural products Source classification Sponge Endogenous metabolite	Reference Standards DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against *HSV*. Cytarabine shows anti-orthopoxvirus activity.

HY-B0275C

Oxytetracycline calcium	Infection Quinones Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity .

HY-B0275B

Oxytetracycline dihydrate 5+ Cited Publications	Infection Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .

HY-N0772

Isomangiferin 2 Publications Verification	Infection Liliaceae Xanthones Classification of Application Fields Source classification Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields	VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .

HY-B0275AR

Oxytetracycline hydrochloride (Standard)	Monophenols Microorganisms Antibiotics Source classification Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics	Reference Standards Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline (hydrochloride) (Standard) is the analytical standard of Oxytetracycline (hydrochloride). This product is intended for research and analytical applications. Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-B0275R

Oxytetracycline (Standard)	Monophenols Microorganisms Antibiotics Resistance Selection Source classification Animal Husbandry Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research	Reference Standards Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline (Standard) is the analytical standard of Oxytetracycline. This product is intended for research and analytical applications. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-128744R

Phosphonoacetic acid (Standard)	Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis
Phosphonoacetic acid (Standard) is the analytical standard of Phosphonoacetic acid (HY-128744). This product is intended for research and analytical applications. Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit *HSV* DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-N0772R

Isomangiferin (Standard)	Liliaceae Xanthones Source classification Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants	Reference Standards VEGFR NF-κB NOD-like Receptor (NLR) AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV
Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.

HY-N0414

Trigonelline 5 Publications Verification Trigenolline	Alkaloids Microorganisms other families Classification of Application Fields Leguminosae Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Trigonella foenum-graecum Linn. Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415

Trigonelline chloride 5 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Erythrophleum fordii Oliv. Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0469

L-Lysine 5+ Cited Publications	Microorganisms Classification of Application Fields Anti-aging Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Virus Protease HSV
L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of *HSV* infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation .

HY-B0275BR

Oxytetracycline dihydrate (Standard)	Monophenols Microorganisms Antibiotics Source classification Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics	Reference Standards Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .

HY-N7719

Oosporein	Quinones Microorganisms Classification of Application Fields Source classification Other Diseases Benzene Quinones Disease Research Fields	Endogenous Metabolite Bacterial Fungal Parasite Apoptosis Reactive Oxygen Species (ROS) Caspase HSV
Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity .

HY-N0414R

Trigonelline (Standard) Trigenolline (Standard)	Alkaloids Microorganisms other families Leguminosae Source classification Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal Reference Standards
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415R

Trigonelline chloride (Standard) Trigonelline hydrochloride (Standard)	Alkaloids Erythrophleum fordii Oliv. Labiatae Source classification Pyridine Alkaloids Plants	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal Reference Standards
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N7719R

Oosporein (Standard)	Quinones Microorganisms Source classification Benzene Quinones	Endogenous Metabolite Reference Standards Bacterial Fungal Parasite Apoptosis Reactive Oxygen Species (ROS) Caspase HSV
Oosporein (Standard) is the analytical standard of Oosporein (HY-N7719). This product is intended for research and analytical applications. Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity .

HY-N1992

Theaflavin 3,3'-digallate 5 Publications Verification TF-3; ZP10	Infection Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against *HSV* and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N1992R

Theaflavin 3,3'-digallate (Standard) TF-3 (Standard); ZP10 (Standard)	Flavonoids Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Reference Standards Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N2110R

Phellopterin (Standard)	Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

HY-N2110

Phellopterin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

HY-N0469R

L-Lysine (Standard)	Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite Virus Protease HSV
L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of *HSV* infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation . IC₅₀ & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium . L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity . In Vivo:L-lysine (10?mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model . L-lysine (5 or 10?mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model .

Cat. No.	Product Name	Chemical Structure

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-17425AS

Valacyclovir-d8 hydrochloride
Valacyclovir-d₈ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV .

HY-15303S

Pritelivir-d4-1
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-131606S

Cidofovir diphosphate-13C3
Cidofovir diphosphate- ¹³C₃ is the ¹³C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-17425AS1

Valacyclovir-d4 hydrochloride
Valacyclovir-d₄ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-B0275S

Oxytetracycline-d6
Oxytetracycline-d₆ is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-W755036

Oxytetracycline-13C,d3 hydrochloride

Oxytetracycline-13C,d3 hydrochloride is the 13C- and deuterium labeled Oxytetracycline hydrochloride (HY-B0275A). Oxytetracycline hydrochloride is an antibiotic that exhibits board-spectrum antibacterial activity. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-W766548

Floxuridine-13C,15N2

Floxuridine- ¹³C, ¹⁵N₂ (5-Fluorouracil 2'-deoxyriboside- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) .

Cat. No.	Product Name		Classification

HY-129861

5'-Ethynyl-2'-deoxycytidine		Alkynes
5'-Ethynyl-2'-deoxycytidine is an inhibitor for *HSV, that inhibits* the cytopathic effect of HSV-1 in primary rabbit kidney cell with a MIC of 0.2 μg/mL. 5'-Ethynyl-2'-deoxycytidine inhibits the proliferation of leukemia L1210 cell with an IC₅₀ of 64.5 μg/mL .

Cat. No.	Product Name		Classification

HY-W011079

5-Iodouridine 1 Publications Verification		Nucleoside Analogs Uridine
5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a K_i value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia .

HY-113289

Brassicasterol		Cholesterol
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-148169

2'-Deoxy-L-guanosine		Nucleoside Analogs Guanosine
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563) .

HY-177638A

ISIS 1082 sodium		Antisense Oligonucleotides
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-177638

ISIS 1082		Antisense Oligonucleotides
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

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