HN0037

Cat. No.: HY-163529 Purity: 99.46%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

HN0037 is a selective, orally active helicase-primase inhibitor. HN0037 is primarily metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by the UL5 (helicase), UL52 (primase), and UL8 (a scaffold protein that promotes primer synthesis) genes.

For research use only. We do not sell to patients.

HN0037 Chemical Structure

CAS No. : 2233566-79-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of HN0037:

(S)-HN0037 In-stock

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•Related Screening Libraries:

•Related Small Molecules:

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View All HSV Isoform Specific Products:

View All Isoforms

HSV-1 HSV-2 HSV

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

CYP3A4

Molecular Weight

428.53

Formula

C₂₀H₂₀N₄O₃S₂

CAS No.

2233566-79-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=NC(C)=C(S1)S(N)(=O)=O)C)[C@@H]2CC(C=CC(C3=CC=CC=N3)=C4)=C4C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.46%

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Data Sheet (267 KB) SDS (252 KB)

COA (249 KB) HNMR (242 KB) RP-HPLC (309 KB) LCMS (232 KB)

Handling Instructions (2659 KB)

References

[1]. Hou J, et al. Pharmacokinetics and Safety Study of HN0037, a Novel Anti-Human Herpes Simplex Virus Inhibitor, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2022 Dec;11(12):1467-1473. [Content Brief]

HN0037 Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HN00372233566-79-3HN 0037HN-0037HSVCytochrome P450Herpes simplex virusCYPshelicaseprimaseInhibitorinhibitorinhibit

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