2. Autophagy Immunology/Inflammation
  3. Autophagy Cyclic GMP-AMP Synthase
  4. XQ2B

XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection.

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Custom Peptide Synthesis

XQ2B Chemical Structure

XQ2B Chemical Structure

CAS No. : 2104728-28-9

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Based on 1 publication(s) in Google Scholar

XQ2B Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection[1].

In Vitro

XQ2B (10 μM; 24 h) inhibits the expression of Ifnb1, Cxcl10 and Il6 in Trex1-/- BMDMs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XQ2B Related Antibodies
In Vivo

XQ2B (10 mg/kg; i.v.; 3  h) attenuates the host innate antiviral (HSV-1) response in WT mice[1].
XQ2B (10 mg/kg; i.v.; every other day; 7 days) suppresses systemic inflammation in Trex1-/- mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 Trex1-/- male mice (8-week-old) with autoimmune disease model[1]
Dosage: 10 mg/kg
Administration: Intravenous injection, every other day, 7-day cycle for evaluating anti-inflammatory effect and 11 - day cycle for survival analysis
Result: Attenuated the inflammation in heart, stomach, tongue, kidney, and skeletal muscle of Trex1-/- mice compared to untreated Trex1-/- mice (the 7-day cycle experiment).
Suppressed the mRNA level of Ifnb1, Cxcl10 and Il6 caused by Trex1 deficiency.
Showed no effect on mouse survival during the test period (the 11-day cycle experiment).
Molecular Weight

1201.46

Formula

C59H92N16O11
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cyclo({d-Phe}-Ala-Thr-Arg-Leu-{d-phe}-Pro-Val-Arg-Leu)
Sequence Shortening

Cyclo({d-Phe}-ATRL-{d-phe}-PVRL)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (83.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8323 mL 4.1616 mL 8.3232 mL
5 mM 0.1665 mL 0.8323 mL 1.6646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8323 mL 4.1616 mL 8.3232 mL 20.8080 mL
5 mM 0.1665 mL 0.8323 mL 1.6646 mL 4.1616 mL
10 mM 0.0832 mL 0.4162 mL 0.8323 mL 2.0808 mL
15 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
20 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0404 mL
25 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8323 mL
30 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
40 mM 0.0208 mL 0.1040 mL 0.2081 mL 0.5202 mL
50 mM 0.0166 mL 0.0832 mL 0.1665 mL 0.4162 mL
60 mM 0.0139 mL 0.0694 mL 0.1387 mL 0.3468 mL
80 mM 0.0104 mL 0.0520 mL 0.1040 mL 0.2601 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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XQ2B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XQ2B2104728-28-9AutophagyCyclic GMP-AMP SynthasecGAScGAS inhibitorInhibitorinhibitorinhibit

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