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Results for "

E3 ligase ligand-linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (538) Ligands for E3 Ligase (6) PD-1/PD-L1 (1) Target Protein Ligand-Linker Conjugates (12) 17β-HSD (1) Androgen Receptor (2) Apoptosis (130) Autophagy (132) Btk (2) c-Myc (1) Casein Kinase (1) CDK (2) CRM1 (1) Epigenetic Reader Domain (8) Estrogen Receptor/ERR (1) FGFR (1) FKBP (1) FLT3 (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) JAK (1) Ligands for Target Protein for PROTAC (1) MAGL (1) Molecular Glues (1) NF-κB (1) PROTACs (24) Ras (1) RET (1) STAT (1) SWI/SNF Complex (1)
By Research Areas:	Cancer (558) Infection (2) Inflammation/Immunology (10)
Click Chemistry:	PROTAC Synthesis (3) Azide (25) Alkynes (5)

585

Inhibitors & Agonists

Click Chemistry

Targets Recommended: E3 Ligase Ligand-Linker Conjugates Ligands for E3 Ligase Target Protein Ligand-Linker Conjugates ADC Linker PROTAC-Linker Conjugates for PAC Drug-Linker Conjugates for ADC ByeTAC PD-1/PD-L1 E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-176138

*E3 Ligase* Ligand-linker Conjugate 185**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 185 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 185 can be used to synthesize RP03707 (HY-176134) .

HY-168659

*E3 Ligase* Ligand-linker Conjugate 130**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 130 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 130 can be used to synthesize YJ1206 (HY-16855) .

HY-168871

*E3 Ligase* Ligand-linker Conjugate 161**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 161 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 161 can be used to synthesize Tamoxifen-PEG-Clozapine (HY-168869) .

HY-168701

*E3 Ligase* Ligand-linker Conjugate 149**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 149 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 149 can be used to synthesize Setidegrasib (HY-148273) .

HY-172738

*E3 Ligase* Ligand-linker Conjugate 175**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 175 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 175 can be used to synthesize PROTAC SMARCA2 degrader-33 (HY-172735) .

HY-168866

*E3 Ligase* Ligand-linker Conjugate 160**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 160 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 160 can be used to synthesize FF2049 (HY-168863) .

HY-173358

*E3 Ligase* Ligand-linker Conjugate 174**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 174 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 174 can be used to synthesize TYD-68 (HY-173357) .

HY-168284

*E3 Ligase* Ligand-linker Conjugate 129**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 129 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 129 can be used to synthesize DD205-291 (HY-168282) .

HY-168256

*E3 Ligase* Ligand-linker Conjugate 128**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 128 (Intermediate 11) is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 128 can be used to synthesize PROTAC BRM/BRG1 degrader-4 (HY-168255) .

HY-173424

*E3 Ligase* Ligand-linker Conjugate 178**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 178 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 178 can be used to synthesize MS2133 (HY-173422) .

HY-176425

*E3 Ligase* Ligand-linker Conjugate 186**	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
E3 Ligase Ligand-linker Conjugate 186 is a CRBN *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 186 can be used to synthesize PROTAC SJ10542 (HY-145696) .

HY-176046

*E3 Ligase* Ligand-linker Conjugate 183**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 183 is an E3 ligase ligand-linker conjugate of PCSK9 autophagic degrader 2 (HY-176043). E3 Ligase Ligand-linker Conjugate 183 consists of LC3B ligand 2 (HY-176045) and the corresponding linker (HY-141373) .

HY-173415

*E3 Ligase* Ligand-linker Conjugate 177**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 177 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 177 can be used to synthesize STING PROTAC degrader ST9 .

HY-168612

*E3 Ligase* Ligand-linker Conjugate 125**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 125 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 125 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .

HY-176125

*E3 Ligase* Ligand-linker Conjugate 184**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 184 is a *E3 Ligase* Ligand-Linker Conjugates*, consisting of CDK2 ligand-2 (HY-176124) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 184 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete CDK2 degrader 2 (HY-163815) .

HY-168254

*E3 Ligase* Ligand-linker Conjugate 127**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 127 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 127 can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251) .

HY-169995

*E3 Ligase* Ligand-linker Conjugate 143**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 143 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of ACBI3 (HY-157228) .

HY-172949

*E3 Ligase* Ligand-linker Conjugate 187**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 187 is a CRBN *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 187 can be used to synthesize PROTAC SD-2301 (HY-172946) .

HY-169990

*E3 Ligase* Ligand-linker Conjugate 142**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 142 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of CFT8634 (HY-145925B) .

HY-169979

*E3 Ligase* Ligand-linker Conjugate 141**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 141 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of PROTAC ER Degrader-12 (HY-160264) .

HY-170305

*E3 Ligase* Ligand-linker Conjugate 145**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 145 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .

HY-159466

*E3 Ligase* Ligand-linker Conjugate 113**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 113 is an E3 ligase ligand-linker conjugate.

HY-163931

*E3 Ligase* Ligand-linker Conjugate 111**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 111 is an E3 ligase ligand-linker conjugate.

HY-172593

*E3 Ligase* Ligand-linker Conjugate 182**	E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-linker Conjugate 182 is a *E3 Ligase* Ligand-Linker Conjugates*. E3 Ligase* Ligand-linker Conjugate 182 consists of a CRBN ligand and a PROTAC linker. E3 Ligase Ligand-linker Conjugate 182 can be used to design PROTACs (such as LZ-07 (HY-172590)) .

HY-173127

*E3 Ligase* Ligand-linker Conjugate 171**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 171 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 171 can be used to synthesize FDU73 (HY-173125) .

HY-168696

*E3 Ligase* Ligand-linker Conjugate 148**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 148 is an *E3 Ligase* Ligand-linker Conjugate** for PROTAC synthesis. E3 Ligase Ligand-linker Conjugate 148 is compoused of an E3 Ligase Ligand (HY-W247437) and a linker (HY-W126831) .

HY-172739

*E3 Ligase* Ligand-linker Conjugate 176**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 176 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 176 can be used to synthesize BMS-986458 (HY-172736) .

HY-168684

*E3 Ligase* Ligand-linker Conjugate 136**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 136 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 136 can be used to synthesize c-Myc inhibitor 7 (HY-148837) .

HY-170673

*E3 Ligase* Ligand-linker Conjugate 156**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 156 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 156 can be used to synthesize PROTAC XPO1 degrader-1 (HY-170669) .

HY-KT001

*E3 Ligase* Ligand-Linker Conjugate Kit**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.

HY-159679

*E3 Ligase* Ligand-linker Conjugate 116**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 116 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 116 can be used to synthesize PROTAC SMARCA2/4-degrader-28 (HY-162835) .

HY-159683

*E3 Ligase* Ligand-linker Conjugate 117**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 117 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 117 can be used to synthesize PROTAC SMARCA2/4-degrader-29 (HY-162743) .

HY-159683A

*E3 Ligase* Ligand-linker Conjugate 119**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 119 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 119 can be used to synthesize PROTAC SMARCA2/4-degrader-31 (HY-162744) .

HY-159685

*E3 Ligase* Ligand-linker Conjugate 118**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 118 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 118 can be used to synthesize PROTAC SMARCA2/4-degrader-30 (HY-162748) .

HY-159677

*E3 Ligase* Ligand-linker Conjugate 115**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 115 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 115 can be used to synthesize PROTAC SMARCA2/4-degrader-27 (HY-162834) .

HY-162201

*E3 Ligase* Ligand-linker Conjugate 48**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 48 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-162188

*E3 Ligase* Ligand-linker Conjugate 15**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 15 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-157589

*E3 ligase* Ligand-Linker Conjugate 31**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 31 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-172956

*E3 Ligase* Ligand-linker Conjugate 188**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 188 is a E3 ligase ligand-linker conjugate, used for the synthesis of AZ'3137 (HY-162702) .

HY-176443

*E3 Ligase* Ligand-linker Conjugate 190**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 190 is a E3 ligase ligand-linker conjugate, used for the synthesis of BP-198 (HY-176440) .

HY-168228

*E3 Ligase* Ligand-linker Conjugate 123**	E3 Ligase Ligand-Linker Conjugates	Others
E3 Ligase Ligand-linker Conjugate 123 is the E3 ligand-linker part of PROTAC SMARCA2/4-degrader-35 (HY-168225). E3 Ligase Ligand-linker Conjugate 123 can be utilized in the synthesis of PROTACs .

HY-169976

*E3 Ligase* Ligand-linker Conjugate 140**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 140 (intermediate I-11) is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 140 can be used to synthesize PROTAC AR Degrader-6 (HY-156751) .

HY-170827

*E3 Ligase* Ligand-linker Conjugate 159**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 159 is an *E3 ligase* ligand-linker conjugate*. E3 Ligase* Ligand-linker Conjugate 159 can be used for the synthesis of SMD-3236 (HY-170824), a PRAOTAC that targets the degradation of SMARCA2, exhibiting long-lasting antitumor activity in vivo .

HY-173253

*E3 Ligase* Ligand-linker Conjugate 173**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 173 is an *E3 Ligase* Ligand-Linker Conjugate*. E3 Ligase* Ligand-linker Conjugate 173 can be used to synthesize YN14-H (HY-173250) to induce apoptosis and inhibits migration, and exert antitumor activity in vivo .

HY-161640

*E3 Ligase* Ligand-linker Conjugate 109**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 109 is a E3 ligase ligand-linker conjugate, used for the the synthesis of PROTAC SOS1 degrader (HY-161636) .

HY-161638

*E3 Ligase* Ligand-linker Conjugate 108**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 108 is a E3 ligase ligand-linker conjugate, used for the the synthesis of PROTAC SOS1 degrader (HY-161634) .

HY-W1006706

*E3 Ligase* Ligand-linker Conjugate 157**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 157 is the conjugate composed of the E3 ligase ligand and the linker. E3 Ligase Ligand-linker Conjugate 157 can be used for synthesis of PROTAC degrader KT-253 (HY-170451) .

HY-170980

*E3 Ligase* Ligand-linker Conjugate 166**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 166 is the conjugate composed of a E3 ligase ligand and a linker. E3 Ligase Ligand-linker Conjugate 166 can be used for synthesis of PROTAC CDK9 degrader-11 (HY-170978) .

HY-168233

*E3 Ligase* Ligand-linker Conjugate 124**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 124 is an E3 ubiquitinase ligand + linker conjugate. E3 Ligase Ligand-linker Conjugate 124 can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .

HY-162792

*E3 Ligase* Ligand-linker Conjugate 112**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 112 is a kind of E3 ubiquitinase ligand + linker conjugates. E3 Ligase Ligand-linker Conjugate 112 can be used to synthesize SMARCA2 degrader-10 (HY-162741) .

Cat. No.	Product Name		Classification

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase ligand-linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon ligand-linker Conjugates 4; E3 ligase ligand-linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon ligand-linker Conjugates 13; E3 ligase ligand-linker Conjugates 50		PROTAC Synthesis Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 ligand-linker Conjugates 1; E3 ligase ligand-linker Conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 VH032-PEG2-N3; VHL ligand-linker Conjugates 6; E3 ligase ligand-linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103601

(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3; VHL ligand-linker Conjugates 5; E3 ligase ligand-linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL ligand-linker Conjugates 9; E3 ligase ligand-linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL ligand-linker Conjugates 8; E3 ligase ligand-linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159801

*E3 Ligase* Ligand-linker Conjugate 122**		Azide
E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugation of the E3 ligase ligand and the linker, and can be used for synthesis of PROTAC degrader NR-11c (HY-159798) .

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the *E3 ligase* ligand-linker conjugate** used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-162948

(S,R,S)-AHPC-PEG2-C5-N3		Azide
(S,R,S)-AHPC-PEG2-C5-N3 is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-C5-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-161832

(S,R,S)-Me-AHPC-amide-C3-alkyne		Alkynes
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate used for the synthesis of JWZ-5-13 (HY-161828) .

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized *E3 ligase* ligand-linker conjugate** (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159165

Pomalidomide-cyclopentane-amide-Alkyne		Alkynes
Pomalidomide-cyclopentane-amide-Alkyne is an *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide (HY-10984) and the linker cyclopentane-amide-Alkyne. Pomalidomide-cyclopentane-amide-Alkyne is used to form PROTACs, such as RGB110 (HY-159087) .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-163964

Lenalidomide-C3-PEG3-N3		Azide
Lenalidomide-C3-PEG3-N3 is an E3 Ligase Ligand-Linker Conjugate. Lenalidomide-C3-PEG3-N3 can be used to synthesize L18I (HY-163962) .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-150251

SD-91 STAT3 degrader-2		PROTAC Synthesis
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a K_i of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		PROTAC Synthesis Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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