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Collagen I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Collagen (4) Angiotensin Receptor (5) Apoptosis (8) Arginase (1) Bcr-Abl (1) Biochemical Assay Reagents (12) Calcium Channel (7) Cannabinoid Receptor (1) Cytochrome P450 (3) DNA/RNA Synthesis (7) Drug Derivative (1) Endogenous Metabolite (3) ERK (2) FGFR (1) FLT3 (1) Glutaminase (1) Glycosyltransferase (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (2) HIV Protease (2) Integrin (4) Interleukin Related (2) MDM-2/p53 (2) MMP (16) Monoamine Oxidase (1) NF-κB (3) P-glycoprotein (2) p38 MAPK (2) Parasite (7) PD-1/PD-L1 (1) PDGFR (1) Pim (1) Reactive Oxygen Species (ROS) (2) Reference Standards (5) SARS-CoV (2) Sodium Channel (7) STAT (1) TGF-beta/Smad (7) TGF-β Receptor (2) TNF Receptor (1) Toll-like Receptor (TLR) (3) Transmembrane Glycoprotein (1) TRP Channel (1) VEGFR (1) Wnt (1) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (20) Endocrinology (5) Infection (9) Inflammation/Immunology (34) Metabolic Disease (5) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

*Highly purified Type I collagen, from bovine skin* Bovine Type I Collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .

*Alpha 1(I) Collagen* (614-639), human**	MMP	Endocrinology
Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.

Recombinant Humanized Type I Collagen	Biochemical Assay Reagents	Others
Recombinant Humanized Type I Collagen is a recombinant humanized collagen protein with has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc .

*Anti-Human/Mouse denatured collagen* type-I Antibody (XL313)**	MMP Collagen PD-1/PD-L1	Inflammation/Immunology Cancer
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor .

*Highly purified Type I collagen, from canine skin* Canine Type I Collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

*Highly purified Type I collagen, from porcine skin* Porcine Type I Collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

*Highly purified Type I collagen, from rabbit skin* Rabbit Type I Collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

*Highly purified Type I collagen, from rat skin* Rat Type I Collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

*Highly purified type I collagen, from mouse skin* Mouse Type I Collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

*Highly purified Type I collagen, from chick skin* Chick type I Collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from chick skin (Chick type I collagen, immunization grade) is an immune grade collagen derived from chick skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

Collagen, Type I, from bovine achilles tendon	MMP	Inflammation/Immunology
Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. This product is enzymatically hydrolyzed collagen peptide .

Methacrylated Type I collagen Col1MA	MMP	Others
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen . Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.

*Type I Collagen, T Cell Grade, from Mouse*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Mouse has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .

*Type I Collagen, T Cell Grade, from Porcine*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Porcine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Porcine can be used as a stimulating antigen for T-cells in in vitro culture systems .

*Type I Collagen, T Cell Grade, from Human*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Human has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Human, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

*Type I Collagen, for cell culture, from Bovine*	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

*Type I Collagen, T Cell Grade, from Chick*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Chick has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Chick, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

*Type I Collagen, T Cell Grade, from Rat*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Rat has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Rat, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

*Type I Collagen, for cell culture, from Porcine*	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Porcine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Porcine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

*Type I Collagen, T Cell Grade, from Bovine*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Bovine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

C-telopeptide TFA	MMP	Inflammation/Immunology
C-telopeptide TFA, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD) .

ALK5-IN-82	TGF-β Receptor	Cardiovascular Disease
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC₅₀ value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .

Fibrostatin C P-23924C	HIF/HIF Prolyl-Hydroxylase	Others
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits *collagen* biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

Collagenase I, from Clostridium histolyticum	MMP	Metabolic Disease
Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation.

Neutral protease I Dispase I	Collagen	Others
Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin .

Collagenase, Type I 5+ Cited Publications EC 3.4.24.3	MMP	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

TC-I 15 1 Publications Verification	Integrin	Cardiovascular Disease
TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .

Prepro-von Willebrand factor (641-650) (bovine)	Biochemical Assay Reagents	Metabolic Disease
Prepro-von Willebrand factor (641-650) (bovine) is a fragment of Prepro-von Willebrand factor, which binds to type I collagen .

FT011 1 Publications Verification Asengeprast	MMP	Inflammation/Immunology
FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis . FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

C-telopeptide	MMP	Inflammation/Immunology
C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

P15	Collagen	Others
P15 is a collagen mimetic peptide with the sequence of GTPGPQGIAGQRGVV. P15 can mimic the cell-binding domain of human type I collagen. P15 is capable of promoting the adhesion, proliferation, and differentiation of osteoblasts. Biomaterials modified with P15 can be used in research related to bone regeneration .

Ziyuglycoside I	MDM-2/p53 Apoptosis	Cancer
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .

Ganodermaones B	Integrin	Inflammation/Immunology
Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .

Ziyuglycoside I (Standard)	Reference Standards MDM-2/p53 Apoptosis	Cancer
Ziyuglycoside I (Standard) is the analytical standard of Ziyuglycoside I. This product is intended for research and analytical applications. Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .

BTT-3034	Integrin	Cardiovascular Disease
BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC₅₀ of 160 nM and a corresponding E_maxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation .

Soybean Extract	Others	Endocrinology
Soybean Extract is a soybean extract, and its components include: Isoflavone. Soybean Extract has an increased content of isoflavone aglycones after biotransformation, which is an estrogen-like bioactive compound with effective type I collagen enhancement. .

PTD-DBM	β-catenin Wnt	Inflammation/Immunology
PTD-DBM is a competitive peptide that blocks the CXXC5-Dvl interaction and induces the expression of β-catenin, α-SMA, and type I collagen. PTD-DBM has skin wound healing activity .

Rilunermin alfa SCB-313	Drug Derivative Apoptosis	Cancer
Rilunermin alfa (SCB-313) is a recombinant fusion protein composed of the human C-propeptide of alpha1(I) collagen (Trimer-Tag) to the C-terminus of the mature human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; Apo2L). Rilunermin alfa has potential pro-apoptotic and antineoplastic activities .

Acetyl tetrapeptide-9 AcTP1	Biochemical Assay Reagents	Others
Caprooyl-tetrapeptide-9 (AcTP1) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

Xanthine oxidase-IN-6	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity .

ZM600	NF-κB	Inflammation/Immunology
ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis .

Arginase inhibitor 9	Arginase	Inflammation/Immunology
Arginase inhibitor 9 (Compound 12a) is an arginase inhibitor with IC₅₀ values of 9 μM and 55 μM for bovine and human arginase I, respectively. Arginase inhibitor 9 exhibits antioxidant activity and can scavenge free radicals. Additionally, Arginase inhibitor 9 can effectively regulate the levels of collagen and procollagen, exerting an anti-fibrotic effect .

TRPV1-IN-3	TRP Channel	Inflammation/Immunology
TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor that can be used for the research of idiopathic pulmonary fibrosis. TRPV1-IN-3 affects the expression of fibrosis markers collagen I and α-SMA by inhibiting the TGF-β/Smads and MAPK pathways, thereby exerting antifibrotic activity in vitro (IC₅₀=0.51 μM). TRPV1-IN-3 significantly inhibits collagen deposition in lung tissue, improves the alveolar structure, and also increases the survival rate of mice with pulmonary fibrosis induced by Bleomycin (HY-108345) .

Link N peptide	p38 MAPK	Others
Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .

NTU281	Glutaminase Apoptosis	Metabolic Disease Inflammation/Immunology
NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes .

BTT-3033	Integrin Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
BTT-3033 is an orally active conformation-selective inhibitor of α2β1 (EC50: 130 nM) by binding to the α2I domain. BTT-3033 inhibits platelet binding to collagen Ⅰ and cell proliferation, and induces cell apoptosis. BTT-3033 can be used in the research of prostate cancer, inflammation and cardiovascular disease .

Cat. No.	Product Name	Type

HY-NP101

Highly purified Type I collagen, from bovine skin

Bovine Type I Collagen, immunization grade

Native Proteins

Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .

HY-NP160

Recombinant Humanized Type I Collagen	Native Proteins
Recombinant Humanized Type I Collagen is a recombinant humanized collagen protein with has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc .

HY-P2738

Collagen, Type I, from bovine achilles tendon	Native Proteins
Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. This product is enzymatically hydrolyzed collagen peptide .

HY-158225

Methacrylated Type I collagen

Col1MA

3D Bioprinting

Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen . Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-NP127

*Highly purified Type I collagen, from canine skin* Canine Type I Collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP122

*Highly purified Type I collagen, from porcine skin* Porcine Type I Collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP128

*Highly purified Type I collagen, from rabbit skin* Rabbit Type I Collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP107

*Highly purified Type I collagen, from rat skin* Rat Type I Collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP109

*Highly purified type I collagen, from mouse skin* Mouse Type I Collagen, immunization grade	Native Proteins
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP112

*Highly purified Type I collagen, from chick skin* Chick type I Collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from chick skin (Chick type I collagen, immunization grade) is an immune grade collagen derived from chick skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP157C

*Type I Collagen, T Cell Grade, from Mouse*	Native Proteins
Type I Collagen, T Cell Grade, from Mouse has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP157D

*Type I Collagen, T Cell Grade, from Porcine*	Native Proteins
Type I Collagen, T Cell Grade, from Porcine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Porcine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP157B

*Type I Collagen, T Cell Grade, from Human*	Native Proteins
Type I Collagen, T Cell Grade, from Human has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Human, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP156

*Type I Collagen, for cell culture, from Bovine*	Native Proteins
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-NP157A

*Type I Collagen, T Cell Grade, from Chick*	Native Proteins
Type I Collagen, T Cell Grade, from Chick has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Chick, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP157E

*Type I Collagen, T Cell Grade, from Rat*	Native Proteins
Type I Collagen, T Cell Grade, from Rat has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Rat, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP156A

*Type I Collagen, for cell culture, from Porcine*	Native Proteins
Type I Collagen, for cell culture, from Porcine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Porcine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-NP157

*Type I Collagen, T Cell Grade, from Bovine*	Native Proteins
Type I Collagen, T Cell Grade, from Bovine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

Cat. No.	Product Name	Target	Research Area

HY-P1912

*Alpha 1(I) Collagen* (614-639), human**	MMP	Endocrinology
Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.

HY-P0284A

C-telopeptide TFA	MMP	Inflammation/Immunology
C-telopeptide TFA, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD) .

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .

HY-P11281

GYGGGP(GPP)5GFOGER(GPP)5GPC	Peptides	Inflammation/Immunology
GYGGGP(GPP)5GFOGER(GPP)5GPC is a type I collagen mimic that can bind to integrins and modify hydrogels .

HY-P4812

Prepro-von Willebrand factor (641-650) (bovine)	Biochemical Assay Reagents	Metabolic Disease
Prepro-von Willebrand factor (641-650) (bovine) is a fragment of Prepro-von Willebrand factor, which binds to type I collagen .

HY-P0284

C-telopeptide	MMP	Inflammation/Immunology
C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

HY-P11087

P15	Collagen	Others
P15 is a collagen mimetic peptide with the sequence of GTPGPQGIAGQRGVV. P15 can mimic the cell-binding domain of human type I collagen. P15 is capable of promoting the adhesion, proliferation, and differentiation of osteoblasts. Biomaterials modified with P15 can be used in research related to bone regeneration .

HY-P11112

PTD-DBM	β-catenin Wnt	Inflammation/Immunology
PTD-DBM is a competitive peptide that blocks the CXXC5-Dvl interaction and induces the expression of β-catenin, α-SMA, and type I collagen. PTD-DBM has skin wound healing activity .

HY-P3385

Rilunermin alfa SCB-313	Drug Derivative Apoptosis	Cancer
Rilunermin alfa (SCB-313) is a recombinant fusion protein composed of the human C-propeptide of alpha1(I) collagen (Trimer-Tag) to the C-terminus of the mature human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; Apo2L). Rilunermin alfa has potential pro-apoptotic and antineoplastic activities .

HY-P3164

Acetyl tetrapeptide-9 AcTP1	Biochemical Assay Reagents	Others
Caprooyl-tetrapeptide-9 (AcTP1) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-P3136A

TRV055 hydrochloride TRV120055 hydrochloride	Angiotensin Receptor	Cardiovascular Disease
TRV055 (TRV120055) (hydrochloride) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-P3136

TRV055 TRV120055	Angiotensin Receptor ERK	Cardiovascular Disease
TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-13948

Angiotensin II human Maximum Cited Publications 173 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948A

Angiotensin II human acetate Maximum Cited Publications 173 Publications Verification Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-13948B

Angiotensin II human TFA Maximum Cited Publications 173 Publications Verification Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

Cat. No.	Product Name	Target	Research Area

HY-P990251

*Anti-Human/Mouse denatured collagen* type-I Antibody (XL313)**	MMP Collagen PD-1/PD-L1	Inflammation/Immunology Cancer
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor .

HY-P990294

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)	Transmembrane Glycoprotein STAT Collagen Reactive Oxygen Species (ROS) Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis .

HY-P3385

Rilunermin alfa SCB-313	Drug Derivative Apoptosis	Cancer
Rilunermin alfa (SCB-313) is a recombinant fusion protein composed of the human C-propeptide of alpha1(I) collagen (Trimer-Tag) to the C-terminus of the mature human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; Apo2L). Rilunermin alfa has potential pro-apoptotic and antineoplastic activities .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P704237

	COL1A1 Protein, Human (HEK293, His) COL1A1; LCollagen alpha-1(I) chain; LAlpha-1 type I Collagen	Human	HEK293
	The procollagen alpha 1/COL1A1 protein is an important type I collagen component and forms a trimeric structure with alpha 2(I) and two alpha 1(I) chains. It interacts with MRC2, associates with MFAP4 in a Ca2+-dependent manner, and interacts with TRAM2. COL1A1 Protein, Human (HEK293, His) is the recombinant human-derived COL1A1 protein, expressed by HEK293, with N-His labeled tag.

HY-P704238

	Pro-COL1A1 Protein, Human (HEK293, His) COL1A1; LCollagen alpha-1(I) chain; LAlpha-1 type I Collagen	Human	HEK293
	The procollagen alpha 1/COL1A1 protein is an important type I collagen component and forms a trimeric structure with alpha 2(I) and two alpha 1(I) chains. It interacts with MRC2, associates with MFAP4 in a Ca2+-dependent manner, and interacts with TRAM2. Pro-COL1A1 Protein, Human (HEK293, His) is the recombinant human-derived Pro-COL1A1 protein, expressed by HEK293, with N-His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80627

	Collagen I alpha 2 Antibody Collagen alpha-2(I) chain (Alpha-2 type I Collagen)	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Collagen I alpha 2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen I alpha 2.

HY-P81227

	Collagen I Antibody 2 Publications Verification Collagen type I; Alpha 1 type I Collagen; Alpha 2 type I Collagen; COL1A1; COL1A2; Collagen I alpha 1 polypeptide; Collagen I alpha 2 polypeptide; Collagen Of Skin Tendon And Bone; Collagen Type 1; Collagen type I alpha 1; Collagen type I alpha 2; OI4; Osteogenesis Imperfecta Type IV; Pro alpha 1(I) Collagen; Type I proCollagen; CO1A1_HUMAN.	WB, IHC-P	Human, Mouse, Rat, Rabbit
	Collagen I Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen I.

HY-P85909

	Collagen I Antibody (YA5601) Alpha 1 Collagen type I; Alpha 1 type I Collagen; Alpha 1 type I proCollagen; Alpha 1; I; Collagen; Alpha 1; I; proCollagen; Alpha-1 type I Collagen; CO1A1_HUMAN; COL1A1; Collagen alpha 1; I; chain; Collagen alpha-1; I; chain; Collagen I alpha 1 polypeptide; Collagen of skin tendon and bone alpha 1 chain; Collagen type I alpha 1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Collagen I Antibody (YA5601) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Collagen I.

HY-P83998

	Collagen I alpha 2 Antibody (YA3695) OI4; EDSCV; EDSARTH2	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	Collagen I alpha 2 Antibody (YA3695) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Collagen I alpha 2.

HY-P81201

	Collagen IV Antibody Arresten; Canstatin; COL4A1; HANAC; ICH; POREN1; Collagen Alpha 1(IV) Chain; Collagen IV Alpha 1 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; Collagen alpha-1(IV) chain preproprotein; Collagen alpha-1(IV) chain preproprotein; Col4a1 protein; Collagen of basement membrane, alpha-1 chain; Collagen IV, alpha-1 polypeptide; Collagen alpha-1(IV) chain; COL4A1 NC1 domain; CO4A1_HUMAN; Collagen Ⅳ; Collagen Type Ⅳ.	ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	Collagen IV Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen IV.

HY-P85777

	Collagen I Antibody (YA5469) Collagen alpha-1; I; chain; Alpha-1 type I Collagen;	ICC/IF, IHC-P	Human, Mouse, Rat
	Collagen I Antibody (YA5469) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Collagen I.

HY-P86101

	Collagen I Antibody (YA5793) Alpha 1 Collagen type I; Alpha 1 type I Collagen; Alpha 1 type I proCollagen; Alpha 1; I; Collagen; Alpha 1; I; proCollagen; Alpha-1 type I Collagen; CO1A1_HUMAN; COL1A1; Collagen alpha 1; I; chain; Collagen alpha-1; I; chain; Collagen I alpha 1 polypeptide; Collagen of skin tendon and bone alpha 1 chain; Collagen type I alpha 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Collagen I Antibody (YA5793) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen I.