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Results for "

CD-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) CD1 (9) CD38 (1) P-glycoprotein (1) 15-PGDH (1) 5-HT Receptor (1) Adrenergic Receptor (1) Akt (1) Aminoacyl-tRNA Synthetase (1) Amyloid-β (1) Androgen Receptor (2) Angiotensin Receptor (1) Antibiotic (1) Antifolate (1) Apoptosis (7) Aryl Hydrocarbon Receptor (1) Aurora Kinase (1) Bacterial (2) Bcl-2 Family (1) Calcium Channel (2) Calmodulin (1) Carboxypeptidase (1) Caspase (1) Cholinesterase (ChE) (1) Cytochrome P450 (4) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (4) Dopamine Receptor (2) Drug Derivative (1) DYRK (2) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (4) Epigenetic Reader Domain (1) Epoxide Hydrolase (2) ERK (1) Fungal (3) HDAC (1) Histamine Receptor (1) Histone Methyltransferase (1) HIV (1) HIV Integrase (1) IFNAR (1) Influenza Virus (2) Interleukin Related (3) Isotope-Labeled Compounds (5) Lactate Dehydrogenase (1) LDLR (1) Liposome (1) mAChR (1) mGluR (1) MNK (1) Molecular Glues (1) nAChR (2) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (2) Parasite (3) PARP (1) PDI (2) Phosphodiesterase (PDE) (1) PKC (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) PROTACs (1) Ras (2) Reference Standards (2) SARS-CoV (1) Serotonin Transporter (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (7) Src (1) TAM Receptor (1) Tau Protein (1) Thyroid Hormone Receptor (1) TNF Receptor (1) Transmembrane Glycoprotein (2) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (4) Infection (14) Inflammation/Immunology (13) Metabolic Disease (8) Neurological Disease (11)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pegylated Lipids (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (5) siRNAs (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

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Targets Recommended: CD1 CD38 CD28 CD19 CD20 CD22 CD3 CD6 CD2 CD73 CD47 ALCAM/CD166 CD74 CD44 CD276/B7-H3 P-selectin Transferrin Receptor c-Kit L-Selectin LAG-3 CTLA-4 Neprilysin Tim3 E-Selectin Scavenger Receptor Class B type I (SR-BI） FLT3 Anaplastic lymphoma kinase (ALK) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155478

Androgen receptor-IN-6	Androgen Receptor	Cancer
Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC₅₀=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice ^[1].

HY-RS02200

CD1B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD1	Others
CD1B Human Pre-designed siRNA Set A contains three designed siRNAs for CD1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD1B Human Pre-designed siRNA Set A CD1B Human Pre-designed siRNA Set A

HY-RS02201

CD1C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD1	Others
CD1C Human Pre-designed siRNA Set A contains three designed siRNAs for CD1C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD1C Human Pre-designed siRNA Set A CD1C Human Pre-designed siRNA Set A

HY-RS02199

CD1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD1	Others
CD1A Human Pre-designed siRNA Set A contains three designed siRNAs for CD1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD1A Human Pre-designed siRNA Set A CD1A Human Pre-designed siRNA Set A

HY-P5813

Cd1a β-TRTX-CD1a; β-Theraphotoxin-CD1a	Calcium Channel	Neurological Disease
Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Ca_v2.2)(IC₅₀2.6 μM) and mouse sodium ion channels (Na_v1.7). Cd1a can be used in the development of peripheral pain treatment drugs ^[1].

HY-RS02203

CD1E Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD1E Human Pre-designed siRNA Set A contains three designed siRNAs for CD1E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD1E Human Pre-designed siRNA Set A CD1E Human Pre-designed siRNA Set A

HY-RS02202

CD1D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD1	Others
CD1D Human Pre-designed siRNA Set A contains three designed siRNAs for CD1D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD1D Human Pre-designed siRNA Set A CD1D Human Pre-designed siRNA Set A

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Endogenous Metabolite	Neurological Disease Metabolic Disease
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice ^[1].

HY-163797

WRN inhibitor 10	DNA/RNA Synthesis	Cancer
WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC₅₀ of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC₅₀ of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice ^[1].

HY-170832

Menin–KMT2A-IN-1	Epigenetic Reader Domain Potassium Channel	Cancer
Menin–KMT2A-IN-1 (Compound 20) is the inhibitor for menin–KMT2A that binds to menin with an IC₅₀ of 8 nM, and inhibits the interaction between menin and lysine methyltransferase 2A (KMT2A). Menin–KMT2A-IN-1 inhibits hERG with an IC₅₀ of 65 μM. Menin–KMT2A-IN-1 inhibits cell MV4-11 with an IC₅₀ of 74 nM. Menin–KMT2A-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mouse with an orally bioavailability of 74% ^[1].

HY-162492

Influenza A virus-IN-14	Influenza Virus	Infection
Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC₅₀ of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC₅₀ of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse ^[1].

HY-163799

PRMT5-MTA-IN-1	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC₅₀ of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice ^[1].

HY-163816

Antiproliferative agent-53-d3	Cytochrome P450	Cancer
Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2 ^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice ^[1].

HY-162484

GZNL-P36	SARS-CoV Virus Protease	Infection
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PL ^pro), with an IC₅₀ of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC₅₀ range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration C_max of 549 ng/mL, a half-life T_1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse ^[1].

HY-A0277

Cyproconazole	Fungal	Others
Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of fungal pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity ^[1] .

HY-A0277R

Cyproconazole (Standard)	Reference Standards Fungal	Others
Cyproconazole (Standard) is the analytical standard of Cyproconazole. This product is intended for research and analytical applications. Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of fungal pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity ^[1] .

HY-165425

KR31173	Angiotensin Receptor	Cardiovascular Disease
KR31173 is an *AT1* antagonist with an IC₅₀ of 3.27  nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice ^[1].

HY-160777

VNPP433-3β Galeterone 3β-imidazole	Molecular Glues Androgen Receptor MNK Apoptosis	Cancer
VNPP433-3β (Galeterone 3β-imidazole) is an orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase *Mnk1/2*.VNPP433-3β induces cell apoptosis. VNPP433-3β inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI₅₀ of 0.2, 0.3 and 0.31 μM. VNPP433-3β exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model. VNPP433-3β can be used for the study of castration resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC) ^[1].

HY-P1302

Orphanin FQ(1-11)	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent *NOP receptor (ORL-1; OP4)* agonist, with a K_i of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice ^[1] .

HY-P1302A

Orphanin FQ(1-11) TFA	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent *NOP receptor (ORL-1; OP4)* agonist, with a K_i of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice ^[1] .

HY-RS19855

Ky Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ky Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ky gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ky Mouse Pre-designed siRNA Set A Ky Mouse Pre-designed siRNA Set A

HY-158435

P-gp inhibitor 23	P-glycoprotein Cytochrome P450	Cancer
P-gp inhibitor 23 (compound 14F) is a potent inhibitor of P-gp and CYP3A4, with the EC₅₀ and IC₅₀ of 28 nM and 223 nM, respectively ^[1].

HY-W096171

D-Dopa 3-Hydroxy-D-tyrosine	Carboxypeptidase	Neurological Disease
D-Dopa is a non-competitive, allosteric inhibitor for glutamate carboxypeptidase II (GCPII) with an IC₅₀ of 200 nM. D-Dopa exhibits good pharmacokinetic characteristics, and low blood-brain barrier permeability in mouse model ^[1].

HY-158701

KRAS G12D inhibitor 23	Ras	Cancer
KRAS G12D inhibitor 23 (compound 46-3) is a potent inhibitor of KRAS G12D, with the IC₅₀ of 0.007 μM. KRAS G12D inhibitor 23 plays an important role in cancer research ^[1].

HY-169172

Bfl-1-IN-5	Bcl-2 Family Caspase	Cancer
Bfl-1-IN-5 (Compound (R,R,S)-26) is a selective inhibitor for *Bfl-1* with an IC₅₀ of 0.022 μM. Bfl-1-IN-5 promotes the caspase-3/7 activity with an EC₅₀ of 0.37 μM, and inhibits the cell viability of SU-DHL-1 with an EC₅₀ of 1.3 μM ^[1].

HY-RS16780

Ccnd1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccnd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccnd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccnd1 Mouse Pre-designed siRNA Set A Ccnd1 Mouse Pre-designed siRNA Set A

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors ^[1].

HY-106817

Amitivir LY 217896	Influenza Virus	Infection
Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses ^[1] .

HY-101017

Palmitoylcarnitine chloride 2 Publications Verification	Endogenous Metabolite Akt Calcium Channel	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca ²⁺ influx, and DHT-like effects ^[1].

HY-176241

DC-174	Others	Cardiovascular Disease
DC-174 is an orally active inhibitor of snake venom metalloproteinases (SVMP) with a broad spectrum of inhibitory activity against a variety of snake venom SVMPs. DC-174 acts directly on the active site of SVMPs via zinc-binding groups, inhibiting their enzymatic activity and procoagulant toxicity. DC-174 can significantly prolong the survival time of mice attacked by snake venom. DC-174 can be used in the study of first aid for snake bites ^[1].

HY-168905

SGC-CAMKK2-1	Calmodulin	Cancer
SGC-CAMKK2-1 is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC₅₀ of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC₅₀ of 1.6 µM ^[1].

HY-168439

HLB-0532259	PROTACs Aurora Kinase	Cancer
HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC₅₀ of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC₅₀ of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models ^[1]. (Pink: ligand for target protein (HY-168440); Black: linker (HY-W007957); Blue: ligand for E3 ligase Cereblon (HY-41547))

HY-W364575

Methyl-4-oxoretinoate	Drug Derivative	Cancer
Methyl-4-oxoretinoate is a derivative of Retinoic acid (HY-14649). Methyl-4-oxoretinoate inhibits TPA (HY-18739)-induced ornithine decarboxylase (ODC) activity, and carcinogen-induced papillomas in mouse skin ^[1].

HY-164478

G-631	Wnt PARP	Cancer
G-631 is a selective inhibitor for tankyrase. G-631 inhibits tankyrase auto-PARsylation (poly ADP ribosylation) with an IC₅₀ of 7 nM, and inhibits Wnt signaling pathway. G-631 exhibits good pharmacokinetic characteristics in mice ^[1].

HY-169394

5-HT1AR agonist 2	5-HT Receptor Serotonin Transporter Dopamine Receptor	Neurological Disease
5-HT_1AR agonist 2 (Compound 4f) is a 5-HT_1A receptor agonist (K_i: 10.0 nM). 5-HT_1AR agonist 2 also binds to the SERT, D₂ receptor and 5-HT₆ receptor (K_i: SERT, 2.8 nM; D₂, 23 nM; 5-HT₆, 192 nM). 5-HT_1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice ^[1].

HY-158706

SAE-IN-2	E1/E2/E3 Enzyme	Cancer
SAE-IN-2 (compound 6) is a potent inhibitor of sumo activating enzume (SAE), with the IC₅₀ of 27.8 nM ^[1].

HY-144012A

DPPE-PEG350 16:0 PEG350 PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] ammonium	Liposome CD1	Others
DPPE-PEG350 is a CD1d-dependent lipid antagonist thus blocking the ERK phosphorylation pathway in iNKT cells ^[1] . DPPE-PEG350 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles.

HY-W088065S1

Sodium formate-13C,d1	Isotope-Labeled Compounds	Others
Sodium formate- ¹³C,d₁ is the deuterium and ¹³C labeled Sodium formate[1].

HY-102022

α-Galactosylceramide 3 Publications Verification α-GalCer; KRN7000	Transmembrane Glycoprotein Interleukin Related CD1	Inflammation/Immunology Cancer
α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. α-Galactosylceramide is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide plus CD1d binds the NKT cell TCR (T cell antigen receptor) ^[1] .

HY-163540

NP-BTA	Aminoacyl-tRNA Synthetase Fungal	Infection
NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC₅₀ of 6.25 μM ^[1].

HY-137439

Fanotaprim VYR-006	Antifolate	Infection
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC₅₀s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim has the potential for the research of toxoplasmosis ^[1].

HY-162629

LDHA-IN-7	Lactate Dehydrogenase	Cancer
LDHA-IN-7 (compound 21) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA) and LDHB, with the IC₅₀s of 72 nM and 1.2 Μm, respectively ^[1].

HY-150628S

2-Oxobutanoic acid-13C,d1 sodium hydrate	Isotope-Labeled Compounds	Others
2-Oxobutanoic acid- ¹³C,d₁ sodium hydrate is the deuterium and ¹³C labeled 2-Oxobutanoic acid sodium hydrate.

HY-157193

Diacylglyceride	CD1	Inflammation/Immunology
Diacylglyceride, a natural scaffolding lipid, is a hapten that binds to CD1b. Diacylglyceride can be combined with carrier proteins and used in the design of antigens ^[1].

HY-160023

Elisrasib D3S-001	Ras	Cancer
Elisrasib is an orally active inhibitor for KRAS. Elisrasib inhibits the proliferation of KRAS ^G12C mutant H358 and MIA-PA-CA-2 with an IC₅₀ of 0.6 and 0.44 nM. Elisrasib exhibits good metabolic stability in hepatocytes, liver microsomes, plasma and whole blood in various species. D3S-001 exhibits good pharmacokinetic characteristics and antitumor efficacy in mice ^[1].

HY-A0106R

Levamisole (Standard) (-)-Tetramisole (Standard)	Reference Standards nAChR Parasite	Infection Inflammation/Immunology Cancer
Levamisole (Standard) is the analytical standard of Levamisole. This product is intended for research and analytical applications. Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC₅₀=300 μM) and α3β4 (EC₅₀=100 μM) subtype of nAChRs. Orally active ^[1] .

HY-A0106

Levamisole Maximum Cited Publications 6 Publications Verification (-)-Tetramisole	nAChR Parasite	Infection Inflammation/Immunology Cancer
Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC₅₀=300 μM) and α3β4 (EC₅₀=100 μM) subtype of nAChRs. Orally active ^[1] .

HY-101447

SI-2 EPH 116	Src Apoptosis	Cancer
SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) ^[1].

HY-116881

SCH 57790	mAChR	Neurological Disease
SCH 57790 is a selective antegonist for muscarinic M2 receptor, which increases acetylcholine release, and thus improves cognitive performance. SCH 57790 reverses Scopolamine (HY-N0296)-induced memory deficits in mice, without significant toxicity (100 mg/kg).

HY-170928

DA-0157	EGFR Anaplastic lymphoma kinase (ALK) Cytochrome P450	Cancer
DA-0157 is the orally active inhibitor for EGFR and ALK that overcomes drug-resistant mutations of EGFR C797S and ALK in NSCLC) cells. DA-0157 inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC₅₀ = 6.9 nM), Ba/F3-EGFR WT (IC₅₀ = 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC₅₀ = 5.5 nM), and Ba/F3-EML4-ALK (IC₅₀ = 7.4 nM). DA-0157 inhibits CYP2D6 with IC₅₀ of 5.26 μM. DA-0157 exhibits antitumor efficacy in mouse models ^[1].

Cat. No.	Product Name	Type

HY-144012A

DPPE-PEG350 16:0 PEG350 PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] ammonium	Drug Delivery
DPPE-PEG350 is a CD1d-dependent lipid antagonist thus blocking the ERK phosphorylation pathway in iNKT cells ^[1] . DPPE-PEG350 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles.

Cat. No.	Product Name	Target	Research Area

HY-P1302

Orphanin FQ(1-11)	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent *NOP receptor (ORL-1; OP4)* agonist, with a K_i of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice ^[1] .

HY-W096171

D-Dopa 3-Hydroxy-D-tyrosine	Carboxypeptidase	Neurological Disease
D-Dopa is a non-competitive, allosteric inhibitor for glutamate carboxypeptidase II (GCPII) with an IC₅₀ of 200 nM. D-Dopa exhibits good pharmacokinetic characteristics, and low blood-brain barrier permeability in mouse model ^[1].

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors ^[1].

HY-P5813

Cd1a β-TRTX-CD1a; β-Theraphotoxin-CD1a	Calcium Channel	Neurological Disease
Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Ca_v2.2)(IC₅₀2.6 μM) and mouse sodium ion channels (Na_v1.7). Cd1a can be used in the development of peripheral pain treatment drugs ^[1].

HY-P1302A

Orphanin FQ(1-11) TFA	Opioid Receptor	Neurological Disease
Orphanin FQ(1-11) TFA, a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent *NOP receptor (ORL-1; OP4)* agonist, with a K_i of 55 nM. Orphanin FQ(1-11) TFA has no affinity for μ, δ, κ1 and κ3 receptors (K_i>1000 nM). Orphanin FQ(1-11) TFA is analgesic in CD-1 mice ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P990287

*Anti-Mouse CD1d Antibody (19G11)*	Inhibitory Antibodies	Others
Anti-Mouse CD1d Antibody (19G11) is a rat-derived IgG1 type antibody inhibitor, targeting to mouse CD1d.

HY-P990006

Duvakitug TEV-48574	TNF Receptor	Inflammation/Immunology
Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to *TNFSF15*/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD) .

HY-P990273

Anti-Mouse CD38 Antibody (NIMR5)	CD38 ERK CD1 Apoptosis	Inflammation/Immunology Cancer
Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse CD38 IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of *CD1d* protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for research on cancer and immunology such as melanoma and colon cancer ^[1] .

HY-P990869

*Anti-CD1a Antibody (OKT-6)*	Inhibitory Antibodies	Others
Anti-CD1a Antibody (OKT-6) is a kind of mouse IgG1 chimeric antibody, targeting to human *CD1a. The recommend isotype control of Anti-CD1*a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-P990807

*Anti-Mouse CD1d Antibody (20H2 (HB323))*	Inhibitory Antibodies	Others
Anti-Mouse CD1d Antibody (20H2 (HB323)) is a kind of rat IgG1 kappa in vivo mouse antibody, targeting to *CD1d. The recommend isotype control of Anti-Mouse CD1*d Antibody (20H2 (HB323)): Rat IgG1 kappa, Isotype Control (HY-P99979).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101017

Palmitoylcarnitine chloride 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Akt Calcium Channel
Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca ²⁺ influx, and DHT-like effects ^[1].

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Other disease Disease markers Endogenous metabolite	Endogenous Metabolite
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice ^[1].

Species:	Human (6) Rhesus Macaque (3) Mouse (4) Cynomolgus (1)
Tag:	His (13) SUMO (1) Avi (1) Fc (2)
Source:	HEK293 (12) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76209

	CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) T-cell surface glycoprotein CD1b; CD1B; Beta-2-microglobulin; B2M	Rhesus Macaque	HEK293
	CD1B belongs to family 1 of the transmembrane glycoprotein CD1 family and plays a critical role in immune surveillance and response. As a key antigen-presenting molecule, CD1B protein has shown the ability to bind both self and non-self-lipid and glycolipid antigens. CD1B is a potential prognostic biomarker associated with tumor mutation burden and promotes antitumor immunity in lung adenocarcinoma. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1B-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~38-45 & 12 KDa.

HY-P76210

	CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) T-cell surface glycoprotein CD1c; CD1C; Beta-2-microglobulin; B2M	Rhesus Macaque	HEK293
	CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, mediating host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1C-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~44.7 (33.1+ 11.6) KDa.

HY-P76208

	CD1A-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) T-cell surface glycoprotein CD1a; CD1A; Beta-2-microglobulin; B2M	Rhesus Macaque	HEK293
	CD1A-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD1A-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag., has molecular weight of ~45.2 (33.6+11.6) KDa.

HY-P75438

	CD1B Protein, Human (HEK293, Fc) T-cell surface glycoprotein CD1b; CD1b; CD1B	Human	HEK293
	The CD1B protein is a key antigen-presenting molecule that binds self- and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T cells. As a B2M (beta-2-microglobulin) heterodimer, CD1B is crucially involved in immune surveillance and responses. CD1B Protein, Human (HEK293, Fc) is the recombinant human-derived CD1B protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75437

	CD1D Protein, Mouse (HEK293, His) Antigen-presenting glycoprotein CD1d; CD1D; R3G1	Mouse	HEK293
	CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD1D protein, expressed by HEK293 , with C-His labeled tag.

HY-P75436

	CD1D Protein, Mouse (HEK293, His-Fc) Antigen-presenting glycoprotein CD1d; CD1D; R3G1	Mouse	HEK293
	CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived CD1D protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P76778

	CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His) Antigen-presenting glycoprotein CD1d1; CD1d1; Beta-2-microglobulin	Mouse	HEK293
	CD1D protein, in partnership with B2M, functions as an antigen-presenting protein, binding self and non-self glycolipids. It presents these molecules to T-cell receptors on natural killer T-cells, playing a pivotal role in immune responses. CD1D also interacts with MHC II and CD74, contributing to the coordination of the adaptive immune system. CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D1-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~40-50 & 12 KDa, respectively.

HY-P76779

	CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) Antigen-presenting glycoprotein CD1d2; CD1d2; Beta-2-microglobulin	Mouse	HEK293
	The CD1D2 protein plays a crucial role as an antigen-presenting molecule, binding self and non-self glycolipids and presenting them to T-cell receptors on natural killer T-cells. In partnership with B2M, it mediates immune responses, and its interactions with MHC II and CD74 highlight its significance in the complex network of immune system regulation. CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D2-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag.

HY-P77624

	CD1A Protein, Human (HEK293, His) CD1a; CD1A; CD1; FCB6; HTA1; R4; T6	Human	HEK293
	The CD1A protein is a key antigen-presenting molecule that binds self and non-self lipid and glycolipid antigens and presents them to T cell receptors on natural killer T cells. CD1A, as a B2M (beta-2-microglobulin) heterodimer, plays a central role in immune surveillance and regulation. CD1A Protein, Human (HEK293, His) is the recombinant human-derived CD1A protein, expressed by HEK293 , with C-His labeled tag.

HY-P74327A

	CD1D Protein, Human (His-SUMO) Antigen-presenting glycoprotein CD1d; CD1.1; CD1A; CD1d; CD1D antigen; CD1D antigen d polypeptide; CD1d molecule; CD1D_HUMAN; CD1d1 ; differentiation antigen CD1 alpha 3 ; HMC class I antigen like glycoprotein CD1D ; Ly 38; MGC34622; R3; R3G1; T cell surface glycoprotein CD1d ; Thymocyte antigen CD1D	Human	E. coli
	The CD1D protein, a key antigen-presenting molecule, binds self and non-self glycolipids, presenting them to T-cell receptors on natural killer T-cells. Partnering with B2M, it centrally orchestrates immune responses, and its interactions with MHC II emphasize its significance in the intricate network of immune system regulation. CD1D Protein, Human (His-SUMO) is the recombinant human-derived CD1D, expressed by E. coli, with N-6His, N-SUMO labeled tag. The total length of CD1D Protein, Human (His-SUMO) is 282 a.a.*.

HY-P74326

	CD1D-B2M Heterodimer Protein, Human (HEK293, His) Antigen-presenting glycoprotein CD1d; CD1D; R3G1; Beta-2-microglobulin; B2M	Human	HEK293
	The CD1D protein, a key antigen-presenting molecule, binds self and non-self glycolipids, presenting them to T-cell receptors on natural killer T-cells. Partnering with B2M, it centrally orchestrates immune responses, and its interactions with MHC II emphasize its significance in the intricate network of immune system regulation. CD1D-B2M Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived CD1D-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1D-B2M Heterodimer Protein, Human (HEK293, His), has molecular weight of ~48 & 12 kDa, respectively.

HY-P705298

	CD1D-B2M Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) Antigen-presenting glycoprotein CD1d; CD1d; R3G1; Beta-2-microglobulin; B2M	Human	HEK293

HY-P77316

	CD1E-B2M Heterodimer Protein, Cynomolgus (HEK293, His) T-cell surface glycoprotein CD1e; hCD1e; R2G1; CD1E; Beta-2-microglobulin; B2M	Cynomolgus	HEK293
	TREM-2 Protein is an immune receptor expressed on immune and non-immune cells. It is an anti-inflammatory molecule and considered a marker for microglia activation. CD1E-B2M Heterodimer Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived CD1E-B2M Heterodimer protein, expressed by HEK293 , with N-His labeled tag.

HY-P72119

	CCND1 Protein, Human (His) AI327039; B cell leukemia 1; B-cell lymphoma 1 protein; BCL 1; BCL-1; BCL-1 oncogene; BCL1; BCL1 oncogene; ccnd1; CCND1/FSTL3 fusion gene; CCND1/FSTL3 fusion gene; included; CCND1/IGHG1 fusion gene; CCND1/IGLC1 fusion gene; CCND1_HUMAN; CD1; Cyl 1; D11S287E; G1/S specific cyclin D1; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31	Human	E. coli
	The CCND1 protein is a regulatory component of the cyclin D1-CDK4 complex that coordinates phosphorylation and RB family inhibition to regulate the G(1)/S transition. This promotes the dissociation of E2F from the RB/E2F complex and promotes the transcription of E2F target genes critical for G(1) phase progression. CCND1 Protein, Human (His) is the recombinant human-derived CCND1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W088065S1

Sodium formate-13C,d1
Sodium formate- ¹³C,d₁ is the deuterium and ¹³C labeled Sodium formate[1].

HY-B0389S20

D-Glucose-13C,d-1
D-Glucose- ¹³C,d-1 is the deuterium and ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si

HY-W102449S

4-Acetyl-N-methylaniline-13C,d3
4-Acetyl-N-methylaniline-13C,d3 (1-(4-(Methylamino)phenyl)ethanone-13C,d3) is a ¹³C and deuterated isotope of 4-Acetyl-N-methylaniline. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified ^[1].

HY-163816

Antiproliferative agent-53-d3

Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2 ^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice ^[1].

HY-150628S

2-Oxobutanoic acid-13C,d1 sodium hydrate
2-Oxobutanoic acid- ¹³C,d₁ sodium hydrate is the deuterium and ¹³C labeled 2-Oxobutanoic acid sodium hydrate.

HY-125818S2

Cytidine-5'-triphosphate-13C,d1 dilithium

Cytidine-5'-triphosphate- ¹³C,d₁ (Cytidine triphosphate- ¹³C,d₁ dilithium; 5'-CTP- ¹³C,d₁) dilithium is deuterium and ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-W042357S5

Ac-rC Phosphoramidite-13C,d1
Ac-rC Phosphoramidite- ¹³C,d₁ is deuterium and ¹³C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84241

	CD1C Antibody (YA3938) R7; CD1; CD1A; BDCA1	IHC-P, FC, ELISA	Human
	CD1C Antibody (YA3938) is a mouse-derived and non-conjugated IgG2b antibody, targeting to CD1C. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

HY-P83966

	CD1A Antibody (YA3663) R4; T6; CD1; FCB6; HTA1; CD1A	WB, IHC-P, ICC/IF, ELISA	Human
	CD1A Antibody (YA3663) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD1A. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P83967

	CD1A Antibody (YA3664) R4; T6; CD1; FCB6; HTA1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
	CD1A Antibody (YA3664) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD1A. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, monkey.

HY-P83241

	CD1C Antibody (YA2986) CD1C; T-cell surface glycoprotein CD1c; CD1c	WB	Human
	CD1C Antibody (YA2986) is a non-conjugated IgG antibody, targeting CD1C, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). CD1C Antibody (YA2986) can be used for WB experiment in human background.

HY-P83634

	CD1a Antibody (YA3379) CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD antigen CD1a	WB, IHC-P	Human
	CD1a Antibody (YA3379) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3379), targeting CD1a, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). CD1a Antibody (YA3379) can be used for WB, IHC-P experiment in human background.