L-Selectin

L-Selectin; CD62L;

L-selectin (CD62L) is a type I transmembrane cell adhesion molecule expressed on most circulating leukocytes, including neutrophils. L-selectin recognizes sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant predominantly N-linked to L-selectin. L-selectin on human neutrophils is itself decorated with sLeX, it can act as a ligand for E-selectin. L-selectin engaged with endothelial-derived ligands initiates neutrophil tethering and rolling behavior along luminal walls of post-capillary venules, constituting the first step of the multi-step adhesion cascade. Blocking the shedding of L-selectin can profoundly alter cell polarity in monocytes entering the subendothelial space^[1].

References:

[1]. Aleksandar Ivetic, et al. A head-to-tail view of L-selectin and its impact on neutrophil behaviour. Cell Tissue Res. 2018 Jan 20;371(3):437–453.

L-Selectin Inhibitor (1)

L-Selectin Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-106139

Bimosiamose	Inhibitor	≥99.0%
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC₅₀s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

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