2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. Ligritinib

Ligritinib (AB801) is an orally active AXL receptor tyrosine kinase inhibitor. Ligritinib blocks the downstream signaling pathway by inhibiting the kinase activity of AXL. Ligritinib can be used in cancer research, especially in combination with chemotherapy for non-small cell lung cancer (NSCLC).

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Ligritinib

Ligritinib Chemical Structure

CAS No. : 3024588-48-2

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Based on 1 publication(s) in Google Scholar

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Axl Mer Tyro3

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Description

Ligritinib (AB801) is an orally active AXL receptor tyrosine kinase inhibitor. Ligritinib blocks the downstream signaling pathway by inhibiting the kinase activity of AXL. Ligritinib can be used in cancer research, especially in combination with chemotherapy for non-small cell lung cancer (NSCLC)[1].

Molecular Weight

528.65

Formula

C33H32N6O
CAS No.
SMILES

CC(C=CC=N1)=C1C(C=N2)=CC=C2C3=NNC4=NC=C(C=C43)C5=CC6=C(C=C5)CC[C@@H](CC6)N7C8COCC7C8
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Ligritinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ligritinib3024588-48-2AB801AB 801AB-801TAM ReceptorTyro3AxlMerAXLHEK-293 cellsCD-1 miceSD ratsNu miceInhibitorinhibitorinhibit

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