2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Orphanin FQ(1-11)

Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice.

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Orphanin FQ(1-11) Chemical Structure

Orphanin FQ(1-11) Chemical Structure

CAS No. : 178249-41-7

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Based on 1 publication(s) in Google Scholar

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Orphanin FQ(1-11) Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

Orphanin FQ(1-11), a orphanin FQ or nociceptin (OFQ/N) fragment, is a potent NOP receptor (ORL-1; OP4) agonist, with a Ki of 55 nM. Orphanin FQ(1-11) has no affinity for μ, δ, κ1 and κ3 receptors (Ki>1000 nM). Orphanin FQ(1-11) is analgesic in CD-1 mice[1][2].

Molecular Weight

1098.21

Formula

C49H75N15O14
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

FGGFTGARKSA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (91.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9106 mL 4.5529 mL 9.1057 mL
5 mM 0.1821 mL 0.9106 mL 1.8211 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9106 mL 4.5529 mL 9.1057 mL 22.7643 mL
5 mM 0.1821 mL 0.9106 mL 1.8211 mL 4.5529 mL
10 mM 0.0911 mL 0.4553 mL 0.9106 mL 2.2764 mL
15 mM 0.0607 mL 0.3035 mL 0.6070 mL 1.5176 mL
20 mM 0.0455 mL 0.2276 mL 0.4553 mL 1.1382 mL
25 mM 0.0364 mL 0.1821 mL 0.3642 mL 0.9106 mL
30 mM 0.0304 mL 0.1518 mL 0.3035 mL 0.7588 mL
40 mM 0.0228 mL 0.1138 mL 0.2276 mL 0.5691 mL
50 mM 0.0182 mL 0.0911 mL 0.1821 mL 0.4553 mL
60 mM 0.0152 mL 0.0759 mL 0.1518 mL 0.3794 mL
80 mM 0.0114 mL 0.0569 mL 0.1138 mL 0.2846 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Orphanin FQ(1-11) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orphanin FQ(1-11)178249-41-7Opioid ReceptornociceptionNOPreceptoraffinityanalgesicneuropeptideInhibitorinhibitorinhibit

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