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Alkaline

" in MedChemExpress (MCE) Product Catalog:

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2818E

Alkaline Phosphatase, Calf intestinal 1 Publications Verification Apase, Calf intestinal	Endogenous Metabolite Phosphatase	Inflammation/Immunology
Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase catalyzes the removal of phosphate group from various compounds that are phosphorylated. Intestinal Alkaline Phosphatase regulates intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial lipopolysaccharide, attenuation of intestinal inflammation. Alkaline Phosphatase with different origin may have differences in optimum pH values for hydrolysis of different substrates .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Endogenous Metabolite Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-P2818C

Alkaline phosphatase, microorganism 1 Publications Verification Apase, microorganism	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase, microorganism is a membrane-bound glycoprotein. It can hydrolyze monophosphate esters at alkaline pH, releasing inorganic phosphate. Alkaline phosphatase, microorganism is also capable of dephosphorylating proteins, and the balance between protein phosphorylation and dephosphorylation plays a key role in regulating various cellular functions. Alkaline phosphatase, microorganism can regulate cell proliferation and differentiation .

HY-P2818A

Alkaline phosphatase, Escherichia coli Apase, Escherichia coli	Endogenous Metabolite	Others
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-Y1422

Triacylglycerol lipase Alkaline lipase	Lipase	Metabolic Disease
Triacylglycerol lipase is an enzyme catalyzing the hydrolysis of triacylglycerol. Triacylglycerol lipase promotes fat decomposition, providing energy and lipid precursors for cells. Triacylglycerol lipase is used in the research of metabolic diseases such as diabetes and obesity .

HY-170768

Alkaline tryptase-IN-1	Parasite	Others
Alkaline tryptase-IN-1 (compound H-13) is an insecticide that targets alkaline tryptase. The LC50 of Alkaline tryptase-IN-1 inhibits Aphid graminearum, Schizaphis graminearum, Aphid natans, Aphid oleraceus, Aphid fusca, Aphid mariana, and Myzus persicae with concentrations of 8.72, 13.77, 14.17, 12.96, and 12.35 μg/mL, respectively .

HY-P2818B

Alkaline phosphatase, Chicken Intestine Apase, Chicken Intestine	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase, Chicken Intestine (Apase, Chicken Intestine) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values .

HY-E70359

Alkaline Phosphatase (ALP), Porcine Kidney ALP, Orthophosphoric-Monoester Phosphohydrolase	Others	Others
Alkaline Phosphatase (ALP), Porcine Kidney (ALP, Orthophosphoric-Monoester Phosphohydrolase) is a biological material or organic compound that can be used in life science research .

HY-E70382

*Shrimp Alkaline* Phosphatase**	Phosphatase Biochemical Assay Reagents	Others
Shrimp Alkaline Phosphatase (SAP), a nucleotide phosphatase, can catalyze the removal of 5′ phosphates from nucleic acid templates. Shrimp Alkaline Phosphatase is readily inactivated in the absence of chelators and is widely used phosphatases in molecular cloning .

HY-W554649

p-Aminophenyl phosphate	Phosphatase	Others
p-Aminophenyl phosphate is an alkaline phosphatase substrate, and can be used for the electrochemical measurement of alkaline phosphatase activity .

HY-170462

CSPD substrate	Biochemical Assay Reagents	Others
CSPD substrate is a chemiluminescent substrate of alkaline phosphatase. CSPD substrate provides the enhanced alkaline phosphatase sensitivity and a more simplified assay .

HY-78144

4-Methylsalicylic acid	Drug Derivative Drug Intermediate	Inflammation/Immunology
4-Methylsalicylic acid is a methyl derivative of Salicylic acid (HY-B0167). 4-Methylsalicylic acid derivatives inhibit the activity of alkaline phosphatases such as TNAP and IAP. 4-Methylsalicylic acid derivatives exhibit immunosuppressive activity .

HY-126606

Isochlortetracycline	Antibiotic	Infection
Isochlortetracycline is an inactive alkaline degradation product of the Chlortetracycline (HY-B1327A) (broad-spectrum antibiotic) .

HY-125409A

(S,R)-Lysinoalanine	Amino Acid Derivatives	Others
(S,R)-Lysinoalanine is an unnatural amino acid that can be formed in food submitted to thermal treatment, especially in alkaline conditions .

HY-D1208

CDP-Star	Biochemical Assay Reagents Phosphatase	Others
CDP-Star is a chemiluminescent substrate for alkaline phosphatase. CDP-Star can be used for enzyme-linked immunoassays .

HY-129276

N-Retinoyl phenylalanine	Phosphatase	Cancer
N-Retinoyl phenylalanine is a potent alkaline phosphatase isoenzymes inhibitor with cytotoxicity. N-Retinoyl phenylalanine is promising for research of cancers .

HY-D0994

4-Methylumbelliferyl phosphate 1 Publications Verification 4-MUP; MUP	Phosphatase	Others
4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate is also a nerve agent simulant .

HY-W141781

Cysteamine S-phosphate sodium Cystaphos sodium	Phosphatase	Metabolic Disease
Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant .

HY-D1491

Fast Red Violet LB	Fluorescent Dye	Others
Fast Red Violet LB is a dye for staining tartrate resistant acid phosphatase (TRAP). Fast Red Violet LB can be used for alkaline phosphatase (ALP) activity staining .

HY-D1491A

Fast Red Violet LB Zinc chloride	Fluorescent Dye	Others
Fast Red Violet LB Zinc chloride is a stain that stains tartrate-resistant acid phosphatase (TRAP) and Fast Red Violet LB Zinc chloride can be used to stain alkaline phosphatase (ALP) activity .

HY-149835

TTX-P	Fluorescent Dye	Others
TTX-P is a fluorescent probe. TTX-P responds in situ to the overexpressed alkaline phosphatase (ALP) in liver, imaging of diabetic liver injury in the near-infrared second-window (NIR-II) region .

HY-B2203

Monocalcium glycerophosphate	Phosphatase	Metabolic Disease
Monocalcium glycerophosphate is an inhibitor of *intestinal alkaline* phosphatase F3**, and it has anti-cavity properties. Monocalcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions, helps prevent the mineralization and development of bones from intravenous nutrition, and maintains the integrity of the intestinal epithelium .

HY-W127630

AMPSO	Biochemical Assay Reagents	Others
AMPSO is an alkaline transfer buffer that can be used to transfer strongly basic proteins from gels into nitrocellulose without reducing the transfer efficiency of other proteins. AMPSO can be used for Western Blot analysis, PCR amplification and many other applications .

HY-Y0319B

Acetic acid potassium 99%	Endogenous Metabolite	Infection
Acetic acid potassium 99% is a potassium salt employed to replenish electrolytes, for restoration of water-electrolyte balance. Acetic acid potassium 99% can employ in DNA and protein purification. Acetic acid potassium 99% has been used to prepare neutralizing solution for alkaline lysis of bacteria .

HY-21196A

Potassium perfluorohexanesulfonate	Phosphatase	Metabolic Disease
Potassium perfluorohexanesulfonate is an orally active surfactant found in sera of the general population. Potassium perfluorohexanesulfonate induces adaptive hepatocellular hypertrophy, decreases serum cholesterol and increases alkaline phosphatase in male mice .

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-167657

Tizolemide	Sodium Channel	Cardiovascular Disease
Tizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin .

HY-D1676

Thymolphthalein monophosphate disodium hydrate	Phosphatase	Others
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum .

HY-N12108

Forphenicine	Phosphatase	Infection Inflammation/Immunology Cancer
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-W151206

Hydroxy naphthol blue disodium	Fluorescent Dye	Others
Hydroxy naphthol blue disodium, an azo dye, is a metal indicator for calcium and a colorimetric reagent for alkaline earth metal ions ( λmax = 650 nm). In the pH range between 12 and 13, the solution of the indicator is reddish pink in the presence of calcium ion and to deep blue in the presence of disodium EDTA .

HY-N2511R

Trimyristin (Standard)	Reference Standards Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-157139

ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase Phosphatase	Inflammation/Immunology
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .

HY-Y1242

Choline hydroxide (44% in water)	Biochemical Assay Reagents	Others
Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .

HY-108531

ER 50891	RAR/RXR	Metabolic Disease
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

HY-D0220A

Toluidine Blue (purity 36%) 1 Publications Verification Toluidine Blue O (purity 36%)	Fluorescent Dye	Others Cancer
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-138821

BCIP potassium	Biochemical Assay Reagents	Others
BCIP (potassium) is a chromogenic substrate commonly used to detect the enzymatic activity of alkaline phosphatase. When dephosphorylated by alkaline phosphatase, BCIP produces a blue precipitate.

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Phosphatase	Metabolic Disease
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research .

HY-W009458

3-Indoxyl phosphate sodium 3-IP sodium	Phosphatase	Metabolic Disease
3-Indoxyl phosphate (3-IP) is a chromogenic and electrochemical substrate for alkaline phosphatase. Upon enzymatic cleavage by alkaline phosphatase, 3-indoxyl is released and subsequently oxidized to produce water-insoluble indigo, which can be quantified by colorimetric detection at 660 nm as a measure of alkaline phosphatase activity. 3-Indoxyl phosphate can also be converted to water-soluble leucoindigo by reduction of indigo in alkaline solution by sodium dithionite, which can be quantified by colorimetric detection at 415 nm or voltametric detection as a measure of alkaline phosphatase activity.2 3-Indoxyl phosphate has been used in ELISAs.

HY-112832

Lumigen APS-5	Phosphatase	Infection
Lumigen APS-5 is a substrate of alkaline phosphatase (ALP). Lumigen APS-5 can be used to assess the activity of alkaline phosphatase (ALP) .

HY-121066

Dehydrorotenone	Others	Others
Dehydrorotenone is a rotenone analog that is resistant to alkali decomposition. When treated with alkaline solution or alkaline solution containing zinc, dehydrorotenone can absorb 2 molecules of water and convert into acid solution.

HY-W322022

Disodium phenyl phosphate	Biochemical Assay Reagents	Others
Disodium Phenyl phosphate is a substrate for alkaline phosphatase .

HY-P1984

Alphostatin	Phosphatase	Others
Alphostatin is a bovine liver alkaline phosphatase inhibitor .

HY-W719646

Naphthol AS phosphate, 99%(TLC） 3-Hydroxy-2-naphthanilide phosphate, 99%(TLC）	Biochemical Assay Reagents	Others
Naphthol AS phosphate, 99%(TLC) is a histochemical substrate for acidic and alkaline phosphatases.

HY-19695

(-)-p-Bromotetramisole oxalate 1 Publications Verification L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate	Phosphatase	Cancer
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

HY-121932

Naphthol AS-BR	Phosphatase	Others
Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase .

HY-W328317

Fast garnet GBC sulfate salt, 90% Azoic diazo No. 4, 90%	Biochemical Assay Reagents	Others
Fast garnet GBC sulfate salt, 90% is a chromogenic substrate for alkaline phosphatase.

HY-W250315

Polypectate sodium pectate sodium	Glycosidase Bacterial Endogenous Metabolite	Others
Polypectate sodium is a major component of cell wall polysaccharides (pectins) and is used as a carbon source and inducer of polygalacturonase. Polypectate sodium can also be used to evaluate alkaline active and alkaline stable pectate lyases from Streptomyces spp. and to study the optimization of polygalacturonase production from Xanthophyllum spp. and reaction conditions .

HY-N14395

Formadicin A	Bacterial	Infection
Formadicin A has strong activity against kinds of Pseudomonas, Proteobacteria and Alkaline-producing bacilli .

HY-W008385R

H-HoArg-OH (Standard)	Endogenous Metabolite	Metabolic Disease
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-W008385

H-HoArg-OH	Endogenous Metabolite	Metabolic Disease
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite Glutathione Peroxidase Bacterial
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-N2511

Trimyristin	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-W008385

H-HoArg-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-N12108

Forphenicine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Phenols	Phosphatase
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-N2511R

Trimyristin (Standard)	Structural Classification Natural Products Microorganisms Source classification Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite	Reference Standards Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Source classification Phenols Polyphenols Agavaceae Plants	Phosphatase
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research .

HY-121066

Dehydrorotenone	Structural Classification Natural Products Tephrosia egregia Sandwith Source classification Plants Fabaceae	Others
Dehydrorotenone is a rotenone analog that is resistant to alkali decomposition. When treated with alkaline solution or alkaline solution containing zinc, dehydrorotenone can absorb 2 molecules of water and convert into acid solution.

HY-W250315

Polypectate sodium pectate sodium	Structural Classification Natural Products Polysaccharides Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides	Glycosidase Bacterial Endogenous Metabolite
Polypectate sodium is a major component of cell wall polysaccharides (pectins) and is used as a carbon source and inducer of polygalacturonase. Polypectate sodium can also be used to evaluate alkaline active and alkaline stable pectate lyases from Streptomyces spp. and to study the optimization of polygalacturonase production from Xanthophyllum spp. and reaction conditions .

HY-N14395

Formadicin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Formadicin A has strong activity against kinds of Pseudomonas, Proteobacteria and Alkaline-producing bacilli .

HY-W008385R

H-HoArg-OH (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-N14834

Formadicin B	Structural Classification Microorganisms Antibiotics Source classification Beta-lactam Antibiotics	Bacterial
Formadicin B has strong activity against kinds of pseudomonas, proteobacteria and alkaline-producing bacilli .

HY-W002339

3-Hydroxy-2-methylpyridine	Alkaloids Structural Classification other families Classification of Application Fields Leguminosae Source classification Other Diseases Pyridine Alkaloids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields	DNA/RNA Synthesis
3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine .

HY-N14491

Coumamidine γ2	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Coumamidine γ2 is a kind of alkaline sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa .

HY-N14490

Coumamidine γ1	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Coumamidine γ1 is a kind of alkaline sugar Cinodine antibiotic, which has broad spectrum antibacterial activity and also has effect on pseudomonas aeruginosa .

HY-N15220

Dipsacus saponin X	Structural Classification Polysaccharides Caprifoliaceae Source classification Dipsacus asper Wall. Plants Saccharides	Endogenous Metabolite Phosphatase
Dipsacus saponin X (compound 7) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM) .

HY-N2247

Guaiacin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Source classification Lignans Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zingiberaceae	Phosphatase
Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .

HY-N15231

Dipsacus saponin XII	Structural Classification Polysaccharides Caprifoliaceae Source classification Dipsacus asper Wall. Plants Saccharides	Endogenous Metabolite Phosphatase
Dipsacus saponin XII (compound 6) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM) .

HY-119539

Limocitrin	Structural Classification Flavonols Flavonoids Source classification Plants Platanaceae Platanus orientalis L.	Phosphatase
Limocitrin is a natural product that can be isolated from the buds of P. acerifolia and P. orientalis. Limocitrin suppresses estradiol-dependent proliferation of MCF7 cells weakly but estradiol-induced *AlkP (alkaline* phosphatase)** expression only marginally .

HY-N13110

23-Aldehyde-16-O-angeloybarringtogenol C	Triterpenes Structural Classification Terpenoids Source classification Camellia sinensis (L.) O. Ktze. Plants Theaceae	Others
23-Aldehyde-16-O-angeloybarringtogenol C (compound 7) is a tea seed saponin, an acid hydrolysis product obtained by oxidative alkaline degradation. Tea seed saponins have potential quinine oxidoreductase inducing activity .

HY-W661499

Orellanine	Structural Classification Natural Products Microorganisms Source classification	Phosphatase
Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC) .

HY-N8366

Alloisoimperatorin	Structural Classification Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt.	Phosphatase
Alloisoimperatorin (Compound 5) is a phytoestrogen that can be isolated from Angelica dahurica. Alloisoimperatorin can induce alkaline phosphatase (AP) activity with an EC₅₀ of 0.8 μg/mL. Alloisoimperatorin can be used in the study of hormone-dependent cancers and the alleviation of menopausal symptoms .

HY-N7427

2-(2',3',4'-Trihydroxybutyl)quinoxaline	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-(2',3',4'-Trihydroxybutyl)quinoxaline is a food metabolite. 2-(2',3',4'-Trihydroxybutyl)quinoxaline can be formed from homoglucans .

HY-N6663

3-Carene	Structural Classification Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	COX
3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .

HY-133108

Azadirachtin B	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Agricultural Research	EBV Parasite Phosphatase Influenza Virus
Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .

HY-N14549

Cycloepoxydon	Structural Classification Natural Products Microorganisms Source classification	Phosphatase
Cycloepoxydon inhibits the Phorbol 12-myristate 13-acetate (HY-18739) (PMA)-induced NF-KB and AP-1 mediated secreted alkaline phosphatase (SEAP) expression with IC₅₀s of 1-2 μg/mL (4.2-8.4 μM) and 3-5 μg/mL (12.6-21 μM), respectively .

HY-N0093

Ancitabine hydrochloride 1 Publications Verification Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C	Classification of Application Fields Disease Research Fields Cancer	Autophagy CMV DNA/RNA Synthesis
Ancitabine hydrochloride is the precursor of the anticancer agent Cytarabine (HY-13605), which targets targets related to cell metabolism and proliferation. Ancitabine hydrochloride can inhibit tumor cell proliferation, interfere with the DNA synthesis process of tumor cells, and prevent cell division. Under alkaline pH conditions, Ancitabine hydrochloride can be quantitatively converted into Cytarabine and can be used in the study of cancers such as colorectal cancer .

HY-N4119R

Neoeriocitrin (Standard)	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Reference Standards Cholinesterase (ChE)
Neoeriocitrin (Standard) is the analytical standard of Neoeriocitrin. This product is intended for research and analytical applications. Neoeriocitrin, isolated from Drynaria Rhizome,?shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor .

HY-N4119

Neoeriocitrin	Structural Classification Flavonoids other families Flavonones Source classification Phenols Polyphenols Plants	Cholinesterase (ChE)
Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor .

HY-N6663R

3-Carene (Standard)	Structural Classification Other Monoterpenes other families Terpenoids Source classification Plants	Reference Standards COX
3-Carene (Standard) is the analytical standard of 3-Carene. This product is intended for research and analytical applications. 3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .

HY-103701

L-Ascorbic acid 2-phosphate 4 Publications Verification 2-Phospho-L-ascorbic acid; LAA2P	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-103701B

L-Ascorbic acid 2-phosphate magnesium hydrate 2 Publications Verification 2-Phospho-L-ascorbic acid magnesium hydrate; LAA2P magnesium hydrate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-107837

L-Ascorbic acid 2-phosphate trisodium 4 Publications Verification 2-Phospho-L-ascorbic acid trisodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-103701A

L-Ascorbic acid 2-phosphate magnesium 4 Publications Verification 2-Phospho-L-ascorbic acid magnesium; LAA2P magnesium	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-N0123

Aloin-A Maximum Cited Publications 7 Publications Verification Barbaloin-A	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Cancer	Wnt
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-N0123R

Aloin-A (Standard) Barbaloin-A (Standard)	Quinones Structural Classification Liliaceae Anthraquinones Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants	Reference Standards Wnt
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-103701AR

L-Ascorbic acid 2-phosphate magnesium (Standard) 2-Phospho-L-ascorbic acid magnesium (Standard); LAA2P magnesium (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Reference Standards Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate (magnesium) (Standard) is the analytical standard of L-Ascorbic acid 2-phosphate (magnesium). This product is intended for research and analytical applications. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a?long-acting?vitamin?C?derivative?that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-107837R

L-Ascorbic acid 2-phosphate trisodium (Standard) 2-Phospho-L-ascorbic acid trisodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate (trisodium) (Standard) is the analytical standard of L-Ascorbic acid 2-phosphate (trisodium). This product is intended for research and analytical applications. L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

Cat. No.	Product Name	Chemical Structure

HY-18569S

3-Indoleacetic acid-d5 2 Publications Verification
3-Indoleacetic acid-d₅ is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid-d₅ can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates .

HY-W251598S

Bicarbonate-13C sodium

Bicarbonate- ¹³C sodium is the ¹³C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .

HY-W008385S

H-HoArg-OH-d4
H-HoArg-OH-d₄ is a deuterium labeled H-HoArg-OH (HY-W008385). H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-13632S5

Exemestane-13C,d2
Exemestane- ¹³C,d₂ is ¹³C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC₅₀s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .

HY-W008378S

5-Methoxy-2-benzimidazolethiol-d3
5-Methoxy-2-benzimidazolethiol-d₃ is the deuterium labeled 5-Methoxy-2-benzimidazolethiol . 5-Methoxy-2-benzimidazolethiol is a benzimidazole. The iodimetric determination of 5-Methoxy-2-benzimidazolethiol in alkaline media is studied .

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-B0324AS

Crystal Violet-d6
Crystal Violet-d₆ is the deuterium labeled Crystal Violet (HY-B0324A). Crystal Violet, also known as Gentian violet, methyl violet 10B, is a triphenyl-methane, an alkaline dye that binds to DNA in the nucleus of a cell, staining it a deep purple. It is often used for Gram staining to classify bacteria, or for cell or histological staining .

HY-W699846

5-(Methoxy-d3)-1H-benzo[d]imidazole-2-thiol
5-(Methoxy-d₃)-1H-benzo[d]imidazole-2-thiol is the deuterium labeled 5-Methoxy-2-benzimidazolethiol (HY-W008378). 5-Methoxy-2-benzimidazolethiol is a benzimidazole. The iodimetric determination of 5-Methoxy-2-benzimidazolethiol in alkaline media is studied .

HY-106827S1

Trimegestone-13C,d3

Trimegestone- ¹³C,d₃ is ¹³C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC₅₀ value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC₅₀=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .

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