DBCO-PEG6-NHS ester

Cat. No.: HY-160773 Purity: ≥95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing an NHS ester that reacts specifically with primary amines, such as side chains of lysine residues or aminosilane-coated surfaces, under neutral or slightly alkaline conditions. , efficient reaction to form covalent bonds. DBCO-PEG6-NHS ester also contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG6-NHS ester Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DBCO-PEG6-NHS ester:

DBCO-C3-amide-PEG6-NHS ester In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

737.79

Formula

C₃₈H₄₇N₃O₁₂

Appearance

Liquid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (67.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3554 mL	6.7770 mL	13.5540 mL
5 mM	0.2711 mL	1.3554 mL	2.7108 mL
10 mM	0.1355 mL	0.6777 mL	1.3554 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.99%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (241 KB) HNMR (103 KB) RP-HPLC (239 KB) MS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3554 mL	6.7770 mL	13.5540 mL	33.8850 mL
	5 mM	0.2711 mL	1.3554 mL	2.7108 mL	6.7770 mL
	10 mM	0.1355 mL	0.6777 mL	1.3554 mL	3.3885 mL
	15 mM	0.0904 mL	0.4518 mL	0.9036 mL	2.2590 mL
	20 mM	0.0678 mL	0.3388 mL	0.6777 mL	1.6942 mL
	25 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3554 mL
	30 mM	0.0452 mL	0.2259 mL	0.4518 mL	1.1295 mL
	40 mM	0.0339 mL	0.1694 mL	0.3388 mL	0.8471 mL
	50 mM	0.0271 mL	0.1355 mL	0.2711 mL	0.6777 mL
	60 mM	0.0226 mL	0.1129 mL	0.2259 mL	0.5647 mL