1. Gene
  2. Ager - advanced glycosylation end product-specific receptor Gene

Ager - advanced glycosylation end product-specific receptor Gene

Rattus norvegicus

Also known as RAGE

Gene ID: 81722 | Gene type: protein coding

About Ager

Summary

Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including bone disease (multiple); cardiovascular system disease (multiple); colorectal carcinoma; diabetic encephalopathy; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ager Products(1)

mRNA Protein Name
NM_053336.2 NP_445788.2 advanced glycosylation end product-specific receptor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables S100 protein binding IPI
IPI: Inferred from physical interaction
19910580 RGD
enables high mobility group box 1 binding IPI
IPI: Inferred from physical interaction
22740883 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7592757 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cell surface receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
11180401 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
22217518 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20054520 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
19885844 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
21807062 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22467055 RGD
involved in glycoprotein metabolic process IEP
IEP: Inferred from expression pattern
23348924 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
17343756 RGD
involved in negative regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
22301267 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
21872885 RGD
involved in negative regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
22301267 RGD
involved in negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
22301267 RGD
involved in negative regulation of osteoblast proliferation IEP
IEP: Inferred from expression pattern
23529231 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21743278 RGD
involved in neuron projection development IGI
IGI: Inferred from genetic interaction
7592757 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
7592757 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19910580 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
22293957 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19380826 RGD
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22301267 RGD
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
21743278 RGD
involved in positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
19959167 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
23053478 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21111711 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
22717618 RGD
involved in positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
23238794 RGD
involved in positive regulation of potassium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
23212096 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19885844 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19885844 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
23212096 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16368901 RGD
involved in positive regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21111711 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
23285277 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
21704028 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
21704028 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
17343756 RGD
involved in response to methylglyoxal IEP
IEP: Inferred from expression pattern
22425979 RGD
involved in response to selenite ion IEP
IEP: Inferred from expression pattern
22476978 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
22274401 RGD
involved in transdifferentiation IEP
IEP: Inferred from expression pattern
23403079 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
7592757 RGD
located in basal plasma membrane IDA
IDA: Inferred from direct assay
9846897 RGD
located in cell surface IDA
IDA: Inferred from direct assay
17959934 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16456142 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
7592757 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

advanced glycosylation end product-specific receptor

receptor for advanced glycosylation end products

Orthologs Information

Species Symbol Source ID
Homo sapiens Ager NCBI NCBI:177
Macaca fascicularis Ager NCBI NCBI:102121124
Mus musculus Ager NCBI NCBI:11596