Search Result
Results for "
mild
" in MedChemExpress (MCE) Product Catalog:
23
Biochemical Assay Reagents
18
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1796
-
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Fungal
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Infection
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Thymol iodide is a compound of Iodide and Thymol. Thymol iodide acts as a substitute for iodoform . Thymol iodide is an iodine derivative of Thymol (a phenol derived from thyme oil), which is mostly used as mild antiseptic and fungicide .
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-
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- HY-100046
-
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Desmethyldoxepin hydrochloride
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Drug Metabolite
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Neurological Disease
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Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
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-
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- HY-128901
-
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F 14679 fumarate
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5-HT Receptor
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Neurological Disease
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F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress .
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-
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- HY-B0629
-
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Glucocorticoid Receptor
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Metabolic Disease
Cancer
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Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
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-
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- HY-100046R
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Desmethyldoxepin hydrochloride (Standard)
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Reference Standards
Drug Metabolite
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Neurological Disease
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Nordoxepin (hydrochloride) (Standard) is the analytical standard of Nordoxepin (hydrochloride). This product is intended for research and analytical applications. Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
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-
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- HY-B0629R
-
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Reference Standards
Glucocorticoid Receptor
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Metabolic Disease
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Mometasone (Standard) is the analytical standard of Mometasone. This product is intended for research and analytical applications. Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
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-
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- HY-W274569
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-
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- HY-156634
-
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NYX-783
|
iGluR
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Neurological Disease
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Risevistinel (NYX-783) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease .
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- HY-156626
-
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NYX-458; NYX-3054
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iGluR
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Neurological Disease
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Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease .
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- HY-145535
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C24 3'-sulfo Galactosylceramide (d18:1/24:0)
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Endogenous Metabolite
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Metabolic Disease
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Tetracosanoyl-sulfatide is an endogenous metabolite present in Urine that can be used for the research of Mild Metachromatic Leukodystrophy .
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-
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- HY-122916
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-
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- HY-D0235
-
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Fluorescent Dye
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Others
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Alizarin yellow GG is a dye that exhibits corrosion inhibition effects on mild steel against concentrated H2SO4.
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-
-
- HY-B1191
-
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2,6-Lupetidine
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nAChR
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Cardiovascular Disease
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Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
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-
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- HY-108249
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-
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- HY-B1316
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-
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- HY-W133897
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Biochemical Assay Reagents
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Others
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tert-Butylamine borane is a mild reducing agent. tert-Butylamine borane involves in the selective reduction of aldehydes and ketones to the corresponding alcohols .
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- HY-I0020
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(-)-Narwedine; Narwedin
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Cholinesterase (ChE)
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Neurological Disease
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Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
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- HY-B1530
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(±)-Ammonium lactate
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Bacterial
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Infection
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Ammonium lactate is the ammonium salt of lactic acid, with mild anti-bacterial properties. Ammonium lactate can be used for the research of xerosis .
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- HY-E70612
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Biochemical Assay Reagents
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Others
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Nitril hydratase can convert nitriles to the corresponding higher-value amides under mild conditions. Nitril hydratase is an important catalyst .
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- HY-N10928
-
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Parasite
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Infection
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Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC50~20 μg/mL) .
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- HY-N2622
-
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(+)-Oxypeucedanin hydrate
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Others
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Cancer
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Oxypeucedanin hydrate ((+)-Oxypeucedanin hydrate) is a natural product isolated from D. anethifolia. Prangol exhibits mild toxicity on fibroblasts and parental lymphoma cells .
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- HY-N4000
-
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Others
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Cancer
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Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth . Digitonin is an natural detergent .
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- HY-B0892S2
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- HY-B0892S1
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- HY-10933
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CX516
2 Publications Verification
BDP 12
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iGluR
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Neurological Disease
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CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) .
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- HY-W012896
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Biochemical Assay Reagents
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Others
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2-Thiohydantoin acts as an inhibitor for the corrosion of mild steel in 0.1 M HCl and its inhibition efficiency is both concentration and immersion time dependent .
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- HY-129524
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Apoptosis
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Inflammation/Immunology
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Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs .
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- HY-B0575
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- HY-106000
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Histamine Receptor
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Neurological Disease
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GSK239512 is a potent and brain penetrated H3 receptor antagonist. GSK239512 can be used for the research of mild-to-moderate Alzheimer's disease (AD) .
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- HY-N3654
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Tyrosinase
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Others
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Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits a mild tyrosinase inhibitory effect .
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- HY-N5107
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(+)-epi-Magnolin
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Parasite
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Infection
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Epimagnolin A, a furfuran lignan, shows mild antiplasmodial activities (IC50=5.7 μg/mL) without noticeable toxicity on mammalian normal cells .
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- HY-W012896R
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Biochemical Assay Reagents
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Others
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2-Thiohydantoin acts as an inhibitor for the corrosion of mild steel in 0.1 M HCl and its inhibition efficiency is both concentration and immersion time dependent .
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- HY-113797
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Adrenergic Receptor
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Others
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RS-52367 is a potent syntex β-adrenergic antagonist. RS-52367 decreases intraocular pressure with a mild systemic effect in dogs .
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- HY-126460A
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Bacterial
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Others
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Myristoyl glutamic acid sodium is a common ingredient in cosmetics/creams. Myristoyl glutamic acid sodium, a surfactant belonging to the amino acid, has mild cleaning properties and is also foamy and mildly bacteriostatic .
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- HY-110014
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Cannabinoid Receptor
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Neurological Disease
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Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception .
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- HY-B0892R
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-
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- HY-N12426
-
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Endogenous Metabolite
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Metabolic Disease
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Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.
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- HY-E70422
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Biochemical Assay Reagents
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Others
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Cyclomaltodextrinase is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-W800830
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Biochemical Assay Reagents
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Others
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DMG-Nitrophenyl Carbonate is a short reagent featuring a DMG lipid headgroup and a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions.
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- HY-E70451
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Biochemical Assay Reagents
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Others
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Phosphopentomutase is an oxidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-145649A
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AD-85481 sodium; ALN-AGT sodium
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Angiotensin Receptor
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Cardiovascular Disease
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Zilebesiran sodium is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of syste
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- HY-E70429
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Biochemical Assay Reagents
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Others
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Ketohexokinases is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-B0892S5
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- HY-W017389
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Endogenous Metabolite
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Neurological Disease
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Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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- HY-W716321
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Drug Metabolite
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Inflammation/Immunology
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AN7602 is a metabolite of the anti-inflammatory agent/PDE4 inhibitor Crisaborole (HY-10978) and can be used for the study of mild to moderate atopic dermatitis (AD) .
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- HY-E70446
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Biochemical Assay Reagents
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Others
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Exolytic heparinase is a dehydrogenase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70448
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Biochemical Assay Reagents
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Others
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Thimet oligopeptidase is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-13005
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D-Fagomine
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Glycosidase
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Metabolic Disease
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Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.
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- HY-E70433
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Biochemical Assay Reagents
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Others
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SaCas9 is a nuclease. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-B1147
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Parasite
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Infection
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Diloxanide furoate is the proagent of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers .
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- HY-E70425
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Biochemical Assay Reagents
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Others
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Sucrose synthase is a glycosyltransferase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70438
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Biochemical Assay Reagents
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Others
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Endoproteinase Pro-C is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-146686
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Cholinesterase (ChE)
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Neurological Disease
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BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE with an IC50 of 8.3 nM. BuChE-IN-3 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .
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- HY-E70442
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Biochemical Assay Reagents
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Others
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Methionine aminopeptidase is a kinase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70428
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Biochemical Assay Reagents
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Others
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D-Xylose dehydrogenase is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-145649
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AD-85481; ALN-AGT
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Zilebesiran is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of systemic blood pressure.
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- HY-E70452
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MTG; MTGase; Protein-glutamine-γ-glutamyltransferase
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Biochemical Assay Reagents
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Others
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Microbial Transglutaminase (MTG) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70430
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Biochemical Assay Reagents
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Others
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N-Acylhexosamine oxidase is an isomerase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70445
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Biochemical Assay Reagents
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Others
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Chondroitinase AC II is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-W749852
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Biochemical Assay Reagents
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Neurological Disease
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Xanthine sodium, 98%, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, 98% also acts as an intermediate product on the pathway of purine degradation .
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- HY-110296
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- HY-E70423
-
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Biochemical Assay Reagents
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Others
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UDP-glucuronic acid decarboxylase is a decarboxylase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70431
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Biochemical Assay Reagents
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Others
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D-Xylonolactone lactonase is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-146687
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Cholinesterase (ChE)
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Neurological Disease
|
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BuChE-IN-4 (Compound C6) is a potent inhibitor of BuChE with an IC50 of 7.7 nM. BuChE-IN-4 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .
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- HY-E70444
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Biochemical Assay Reagents
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Others
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Chondroitinase ABC II is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70440
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Biochemical Assay Reagents
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Others
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L-Arabinose isomerase is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70426
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Biochemical Assay Reagents
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Others
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Polyphosphate kinase (RsPPK) is a kinase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70434
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Biochemical Assay Reagents
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Others
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Dipeptidyl peptidase III (human) is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70443
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Biochemical Assay Reagents
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Others
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Chondroitinase ABC I is a hydrolase with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .
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- HY-E70427
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Biochemical Assay Reagents
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Others
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Dipeptidyl peptidase IX (human) is a hydrolase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70432
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Biochemical Assay Reagents
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Others
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Dipeptidyl peptidase VII (human) is a peptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-108243
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- HY-123179
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Carbonic Anhydrase
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Cardiovascular Disease
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Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension .
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- HY-E70436
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TG1; TGase 1
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Biochemical Assay Reagents
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Others
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Human keratinocyte transglutaminase (TG1) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70454
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Neuronal Transglutaminase; TGy; TG6
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Biochemical Assay Reagents
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Others
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Human epidermal transglutaminase (Neuronal Transglutaminase) is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-W749852A
-
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Biochemical Assay Reagents
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Neurological Disease
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Xanthine sodium, for cell culture, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, for cell culture also acts as an intermediate product on the pathway of purine degradation .
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- HY-E70439
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TG3; TGase 3
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Biochemical Assay Reagents
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Others
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Human epidermal transglutaminase (TG3) is a transferase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70435
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PEP-Mx
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Biochemical Assay Reagents
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Others
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Prolylendopeptidase, myxococcus xanthus (PEP-Mx) is an endopeptidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-E70424
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Biochemical Assay Reagents
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Others
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Glucose-1-phosphate thymidyltransferase is an endoprotease. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-P2734
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Biochemical Assay Reagents
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Others
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Phosphopentomutase (EC 5.4.2.7) is an isomerase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-D2367
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Fluorescent Dye
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Others
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Rhodamine B NHS ester is a fluorophore featuring an NHS ester. Rhodamine B is a fluorescent dye which is used in fluorescence-based assays in vivo. NHS esters are highly reactive towards amines, forming amides under mild conditions.
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- HY-118751
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Bancol
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nAChR
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Others
Neurological Disease
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Bensultap (Bancol) is an insecticide, which can control Colorado beetle and some other insect pests. Bensultap is a modulator for nicotinic acetylcholine receptor (nAChR), and exhibits mild and temporary neuromodulatory efficacy on rat nervous system .
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- HY-151682
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ADC Linker
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Others
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H-L-Lys(Norbornene-methoxycarbonyl)-OH, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-N0377R
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- HY-151682A
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ADC Linker
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Others
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H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-B0892S
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- HY-108249R
-
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Histamine Receptor
Reference Standards
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Inflammation/Immunology
Cancer
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Tribenoside (Standard) is the analytical standard of Tribenoside. This product is intended for research and analytical applications. Tribenoside is a vasoprotective agent, can be used for the research of hemorrhoids. Tribenoside has mild anti-inflammatory, analgesic, and wound healing properties .
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- HY-I0020R
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Cholinesterase (ChE)
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Neurological Disease
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Galanthaminone (Standard) is the analytical standard of Galanthaminone. This product is intended for research and analytical applications. Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
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- HY-Z0478R
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(S)-(-)-Limonene (Standard)
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Reference Standards
Others
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Cardiovascular Disease
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(-)-Limonene (Standard) is the analytical standard of (-)-Limonene. This product is intended for research and analytical applications. (-)-Limonene ((S)-(-)-Limonene) is a monoterpene found in citrus plants like lemon, orange, and grape. (-)-Limonene can induce a mild bronchoconstrictive effect .
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- HY-N0285S
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- HY-P2728A
-
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Biochemical Assay Reagents
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Cardiovascular Disease
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Murine Antithrombin III is a blood coagulation inhibitory enzyme with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .
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- HY-17549
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CRL 40028
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Adrenergic Receptor
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Neurological Disease
Endocrinology
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Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist.
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- HY-B0575R
-
-
- HY-E70437
-
|
Tissue-type transglutaminase; TG2; TGase 2
|
Biochemical Assay Reagents
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Others
|
|
Guinea pig liver transglutaminase (Tissue-type transglutaminase) is an exoenzyme. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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-
- HY-W092176
-
|
|
Biochemical Assay Reagents
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Others
|
|
1,9-Bis-Boc-1,5,9-triazanonane is a linker containing two Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amines.
|
-
- HY-13708
-
|
|
5-HT Receptor
|
Cardiovascular Disease
|
|
SUN C5174 is an antagonist for 5-HT2 receptor with a mild sympathomimetic efficacy. SUN C5174 attenuates disorders in various experimental models of peripheral circulatory disturbance, and exhibits good pharmacokinetic properties .
|
-
- HY-B0575S
-
|
|
Sodium Channel
|
Metabolic Disease
|
|
Triamterene-d5 is deuterium labeled Triamterene (HY-B0575). Triamterene blocks epithelial Na + channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor.
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-
- HY-155500
-
|
|
Biochemical Assay Reagents
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Others
|
|
Digoxigenin NHS ester is an activated ester which readily reacts with amino groups under mild conditions, attaching the digoxigenin (HY-B1025) moiety to proteins or amino-. Digoxigenin NHS ester can be used to label proteins and oligonucleotides .
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-
- HY-149883
-
|
|
Others
|
Others
|
|
IZS-L is a amino acid-derived corrosion inhibitor. IZS-L exhibits corrosion inhibition performance for metal at longer immersion. IZSs, the series of corrosion inhibitors, inhibit mild steel corrosion through the formation of an inhibitor film on the metal surface .
|
-
- HY-W250170
-
|
Octyldecyl glucoside
|
Biochemical Assay Reagents
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Others
|
|
Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.
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-
- HY-P2950B
-
|
|
Biochemical Assay Reagents
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Others
|
|
α-(1-2,3,6) Mannosidase is a glycosidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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-
- HY-44370
-
|
|
ADC Linker
|
Cancer
|
|
(tert-Butoxycarbonyl)glycyl-glycyl-glycyl-glycyl-glycine is an ADC linker with a Boc group on the N terminus, and it is used for the development of antibody-drug conjugates (ADCs). The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W052066
-
|
|
Biochemical Assay Reagents
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Others
|
|
tert-Butyl (3-chloropropyl)carbamate is a compound with a t-butyl and a terminal choloride. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W019829
-
|
|
Tyrosinase
Parasite
|
Infection
|
|
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities .
|
-
- HY-W053842
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-134106
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-Boc-erythro-sphingosine is composed of t-butyl ester protected N-acetylsphingosine with a fatty acid tail. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl group can be deprotected under mild acidic conditions.
|
-
- HY-10933S
-
|
BDP 12-d10
|
Isotope-Labeled Compounds
iGluR
|
Neurological Disease
|
|
CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) .
|
-
- HY-B0892
-
|
Benzenemethanol
|
Cytochrome P450
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice .
|
-
- HY-W800660
-
|
|
Biochemical Assay Reagents
|
Others
|
|
endo-BCN-PEG4-Boc-amine is a PEG linker containing a BCN group and a Boc-protected amine. The protected amine can be deprotected under mild acidic conditions. The BCN group can react with azide-tagged biomolecules.
|
-
- HY-W598191
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl (3-azidopropyl)carbamate is a reagent containing an azide group and Boc-protected amino group. It is reactive with alkyne, BCN, DBCO via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-172511
-
|
|
Biochemical Assay Reagents
|
Others
|
|
m-PEG9-4-nitrophenyl carbonate serves as a PEG linker containing a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions. The PEG9 chain bolsters the water solublity of the compound.
|
-
- HY-N11019
-
|
|
Others
|
Others
|
|
Erinacine P (compoud 1) is a parental metabolite of luteolin. Erinacine P can be isolated from the mycelia of basidiomycetous Hericium erinaceum YB4-6237. Under mild conditions, Erinacine P is able to be chemically converted to Erinacine B and then to Erinacine A .
|
-
- HY-129524R
-
|
|
Apoptosis
|
Inflammation/Immunology
|
|
Ethylene dimethanesulfonate (Standard) is the analytical standard of Ethylene dimethanesulfonate. This product is intended for research and analytical applications. Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs .
|
-
- HY-144011
-
|
|
Liposome
|
Others
|
|
DSPE-PEG-Cyanur ammonium is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur ammonium can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur ammonium can be used for nanostructured lipid carrier .
|
-
- HY-P2797B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chitinase is a hydrolase that can convert chitin into N-acetyl-D-glucosamine. Enzymes have high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries .
|
-
- HY-50682A
-
|
TTP488 dihydrochloride; PF-04494700 dihydrochloride
|
Amyloid-β
|
Neurological Disease
Cancer
|
|
Azeliragon dihydrochloride (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon dihydrochloride also can cross the blood-brain barrier (BBB) .
|
-
- HY-158012
-
|
|
γ-secretase
|
Others
|
|
LY3056480 is a gamma-secretase inhibitor (GSI) that inhibits Notch signaling. LY3056480 improves mild to moderate sensorineural hearing loss and is safe and tolerable. Intratympanic administration of LY3056480 induces hair cell regeneration and partial hearing recovery in mammals .
|
-
- HY-50682
-
|
TTP488; PF-04494700
|
Amyloid-β
|
Neurological Disease
Cancer
|
|
Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .
|
-
- HY-W154175
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-DODA is a linker containing a Boc-protected amino group and a terminal amine. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
|
-
- HY-135531
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cefuzonam is an antibiotic, which exhibits antibacterial activity against gram positive bacteria, such as Staphylococcus, Streptococcus and Neisseria gonorrhoeae, with MIC ranginf from 0.63 to 2 μg/mL. Cefuzonam is an inhibitor for mild steel corrosion by increasing hydrophobicity of the metal surface to the acid solution .
|
-
- HY-143390
-
|
|
iGluR
|
Neurological Disease
|
|
NMDA receptor modulator 2 (Compound 1) is a potent NMDA receptor modulator. NMDA receptor modulator 2 can be used for neurological disorder research .
|
-
- HY-143396
-
|
|
iGluR
|
Neurological Disease
|
|
NMDA receptor modulator 5 (Compound 195) is a potent NMDA receptor modulator. NMDA receptor modulator 5 can be used for neurological disorder research .
|
-
- HY-143393
-
|
|
iGluR
|
Neurological Disease
|
|
NMDA receptor modulator 4 (Compound 169) is a potent NMDA receptor modulator. NMDA receptor modulator 4 can be used for neurological disorder research .
|
-
- HY-143391
-
|
|
iGluR
|
Neurological Disease
|
|
NMDA receptor modulator 3 (Compound 99) is a potent NMDA receptor modulator. NMDA receptor modulator 3 can be used for neurological disorder research .
|
-
- HY-143397
-
|
|
iGluR
|
Neurological Disease
|
|
NMDA receptor modulator 6 (Compound 183) is a potent NMDA receptor modulator. NMDA receptor modulator 6 can be used for neurological disorder research .
|
-
- HY-111081
-
|
|
Sigma Receptor
|
Neurological Disease
|
|
(±)-PPCC is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±)-PPCC has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .
|
-
- HY-W591971
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
|
-
- HY-109085
-
|
OPA-15406
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .
|
-
- HY-B1191S
-
|
2,6-Lupetidine-d2
|
Isotope-Labeled Compounds
nAChR
|
Cardiovascular Disease
|
|
Nanofin-d2 (2,6-Lupetidine-d2) is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
|
-
- HY-W071967
-
|
|
ADC Linker
|
Cancer
|
|
Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
|
-
- HY-B1192S
-
|
β-Estradiol 3-benzoate-d3; 17β-Estradiol 3-benzoate-d3
|
Estrogen Receptor/ERR
|
Neurological Disease
|
|
Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability .
|
-
- HY-B1191S1
-
|
2,6-Lupetidine-d5
|
Isotope-Labeled Compounds
nAChR
|
Cardiovascular Disease
|
|
Nanofin-d5 (2,6-Lupetidine-d5) is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
|
-
- HY-B1147R
-
|
|
Reference Standards
Parasite
|
Infection
|
|
Diloxanide furoate (Standard) is the analytical standard of Diloxanide furoate. This product is intended for research and analytical applications. Diloxanide furoate is the proagent of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers .
|
-
- HY-145576
-
|
|
Fluorescent Dye
|
Others
|
|
2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
|
-
- HY-B1191SA
-
|
2,6-Lupetidine-d2 hydrochloride
|
Isotope-Labeled Compounds
nAChR
|
Cardiovascular Disease
|
|
Nanofin-d2 (2,6-Lupetidine-d2) hydrochloride is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
|
-
- HY-161612
-
|
|
Tyrosinase
|
Others
|
|
Mycosporine 2 glycine is an inhibitor for tyrosinase-related protein 1 (TYRP1), that binds TYRP1 with good affinity and stability. Mycosporine 2 glycine stimulates mild to moderate skin and ocular irritancy. Mycosporine 2 glycine is utilized in sunscreen products to cure hyperpigmentation-related diseases .
|
-
- HY-W591973
-
|
|
Biochemical Assay Reagents
|
Others
|
|
OTs-C6-NHBoc is a six carbon linker containing a tosyl group and Boc-protected amine group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.
|
-
- HY-W092078
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl (4-iodobutyl)carbamate is a four carbon linker containing a Boc-protected amino group and an iodine group. The Boc group can be deprotected under mild acidic conditions to form the free amine. Iodine (I) is a very good leaving group for nucleophilic substitution reactions.
|
-
- HY-P99776
-
|
XmAb-13676
|
CD20
CD3
|
Cancer
|
|
Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 + expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo .
|
-
- HY-111081C
-
|
|
Sigma Receptor
|
Neurological Disease
|
|
(±)-PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±)-PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats .
|
-
- HY-W800828
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iodoacetamido-PEG3-NHS ester is a PEG reagent containing an Iodoacetamide group and a Boc-protected amino group. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-18715
-
|
(S)-Ornidazole; Levornidazole
|
Bacterial
Parasite
GABA Receptor
Drug Isomer
|
Infection
Neurological Disease
|
|
Levo-ornidazole ((S)-Ornidazole) is the L-isomer of Ornidazole. Ornidazole (Levo-) increases GAD 65/67 expression and decreases brain Glu/GABA ratio. Ornidazole (Levo-) has a mild sedative effect. Levo-ornidazole can be used in the research of anti-anaerobic and anti-parasitic agents .
|
-
- HY-W017389S1
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Xanthine- 15N2 is a 15N-labeled Xanthine (HY-W017389) . Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
|
-
- HY-32865
-
|
|
Bacterial
Drug Intermediate
|
Infection
|
|
tert-Butyl 2,2,2-trichloroacetimidate is a tert-butylation reagent. tert-Butyl 2,2,2-trichloroacetimidate achieves mild, nonreversible tert-butylation of alcohols and phenols. tert-Butyl 2,2,2-trichloroacetimidate is used in the synthesis of antimicrobial agents .
|
-
- HY-W259542
-
|
|
Biochemical Assay Reagents
|
Others
|
|
O-Proparagyl-N-Boc-ethanolamine is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.
|
-
- HY-W039729
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5-(Boc-amino)-1-pentanol is a linker containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W1048542A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542I
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W008864
-
|
β-Octaacetyllactose
|
Antibiotic
Fungal
|
Infection
|
|
Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
|
-
- HY-W127534
-
|
Trihexanoin
|
Biochemical Assay Reagents
|
Others
|
|
TricaproinIt is an organic compound belonging to the class of triacylglycerols. It consists of three molecules of caproic acid esterified to the glycerin backbone, with a mild fatty smell. TricaproinIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and surfactant in industrial settings.
|
-
- HY-156976A
-
|
|
Calcium Channel
Sodium Channel
|
Cardiovascular Disease
|
|
Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects .
|
-
- HY-W127377
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Butyl oleateIt is an organic compound belonging to esters. It is formed from the reaction of butanol and oleic acid and has a mild fruity smell. Butyl oleateIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and solvent in industrial settings.
|
-
- HY-W1048542C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-156976
-
|
|
Calcium Channel
Sodium Channel
|
Cardiovascular Disease
|
|
Sulcardine is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine has anti-arrhythmic effects .
|
-
- HY-W591964
-
|
|
Biochemical Assay Reagents
|
Others
|
|
t-Boc-Aminooxy-pentane-azide is a linker containing an azide group and Boc-protected amino group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-117059
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC50 of 1109 nM. SK609 hydrochloride has the potential for parkinson research .
|
-
- HY-W017389S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Xanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
|
-
- HY-W039454
-
|
|
Bacterial
SARS-CoV
|
Infection
|
|
2,4-Dichlorobenzyl alcohol is an orally active mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections. 2,4-Dichlorobenzyl alcohol exhibits prenatal developmental toxicity.2,4-Dichlorobenzyl alcohol can be used in the study of SARS-CoV .
|
-
- HY-164076
-
|
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-Epoxide is an activated polyethylene glycol (mPEG) derivative, which is achieved by converting the hydroxyl groups of mPEG into reactive epoxy groups. mPEG-Epoxide is a mild PEGylation reagent that reacts with amino groups in peptides and proteins to form stable secondary amine bonds. mPEG-Epoxide can be used in protein engineering and biomaterials research .
|
-
- HY-168639
-
|
|
Mitochondrial Metabolism
AMPK
|
Metabolic Disease
|
|
AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830)-induced lipid deposition in hepatocytes .
|
-
- HY-W127465
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Oleyl RicinoleateIt is an organic compound belonging to esters. It is formed from the reaction between oleyl alcohol and ricinoleic acid and has a mild fatty odor. Oleyl RicinoleateIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and plasticizer in industrial settings.
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- HY-W578278
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Biochemical Assay Reagents
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Others
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tert-Butyl (2-(pyridin-2-yldisulfanyl)ethyl)carbamate consists of a tert-butyl group, where the protected amine can be deprotected under mild acidic conditions, and the other part of the molecule may act as a thiol-specific labeling reagent, commonly used in reversibly binding cysteine residues on proteins.
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- HY-34619
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Biochemical Assay Reagents
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Others
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[Hydroxy(tosyloxy)iodo]benzene is a versatile reagent for the mild oxidation of aryl iodides at the iodine atom by ligand transfer. [Hydroxy(tosyloxy)iodo]benzene is an effective reagent for the one-step conversion of ketones to the corresponding α-tosyloxy ketones. [Hydroxy(tosyloxy)iodo]benzene is also a Bronsted acid and is expected to catalyze the enolization of ketones .
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![[Hydroxy(tosyloxy)iodo]benzene](//file.medchemexpress.eu/product_pic/hy-34619.gif)
- HY-E70310
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Lipase for biodiesel production
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Endogenous Metabolite
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Others
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Lipase (Immobilized,Used for biodiesel production) is a methanol-resistant lipase with high catalytic activity and can be used for the production of biodiesel. The reaction conditions of Lipase (Immobilized,Used for biodiesel production) are mild, which can avoid the oxidation of hydroxyl groups and the opening of double bonds, and prevent the production of by-products other than glycerol .
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- HY-E70447
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Biochemical Assay Reagents
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Others
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UDP-4-Keto-6-deoxy-D-glucose 3,5-epimerase/4-reductase (ApmUGER) is an epimerase/reductase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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- HY-W127437
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Octadecanoic acid, octadecyl ester
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Biochemical Assay Reagents
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Others
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Stearyl StearateIt is an organic compound belonging to esters. It is formed from the reaction between stearyl alcohol and stearic acid and has a mild fatty odor. Stearyl stearate has several applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and surfactant in industrial settings.
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- HY-149884
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Biochemical Assay Reagents
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Others
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IZS-P is an amino acid-derived corrosion inhibitor, based on the green chemistry principles. IZS-P inhibits mild steel corrosion via forming an inhibitor film on the metal surface. IZS series inhibitors following a corrosion inhibition performance as: IZS-P (82.46%) > IZS-M (67.19%) > IZS-L (24.77%) .
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- HY-W076556
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((Allyloxy)carbonyl)-L-valyl-L-alanine
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Biochemical Assay Reagents
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Others
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Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
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- HY-149885
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Amino Acid Derivatives
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Others
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IZS-M is an amino acid-derived corrosion inhibitor, based on the green chemistry principles. IZS-M inhibits mild steel corrosion via forming an inhibitor film on the metal surface. IZS series inhibitors following a corrosion inhibition performance as: IZS-P (82.46%) > IZS-M (67.19%) > IZS-L (24.77%) .
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- HY-50682R
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Amyloid-β
Reference Standards
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Neurological Disease
Cancer
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Azeliragon (Standard) is the analytical standard of Azeliragon. This product is intended for research and analytical applications. Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .
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- HY-W092344
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Biochemical Assay Reagents
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Others
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1,5-Bis-Boc-1,5,9-triazanonane is a linker containing two Boc-protected amino groups and a terminal amine. The Boc groups can be deprotected under mild acidic conditions to form the free amines. The terminal amine is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
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- HY-W457953
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Biochemical Assay Reagents
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Others
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tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W190953
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Biochemical Assay Reagents
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Others
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N1,N12-Di-boc-spermine is a spermine linker containing two a Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
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- HY-42213
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Biochemical Assay Reagents
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Others
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N1,N4-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-42222
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Biochemical Assay Reagents
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Others
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N1,N5-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W591977
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Biochemical Assay Reagents
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Others
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Boc-5-aminopentanoic NHS ester is a linker containing an NHS ester and a t-Boc protected amine group. The t-Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
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- HY-128784
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MDM-2/p53
Reactive Oxygen Species (ROS)
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Cancer
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PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .
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- HY-W460133
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Biochemical Assay Reagents
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Others
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tert-Butyl (2-(2-(2-iodoethoxy)ethoxy)ethyl)carbamate is a PEG linker containing a Boc protected amine and an iodine group. The protected amine can be deprotected under mild acidic conditions. Iodine (I) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
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- HY-WAA0302
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Biochemical Assay Reagents
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Others
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1,4-Bis-Boc-1,4,7-triazaheptane is a PEG derivative containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-155466
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Dopamine Receptor
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Neurological Disease
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Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC50=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells .
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- HY-W190908
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Biochemical Assay Reagents
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Others
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Desthiobiotin-PEG3-NHS ester is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin.
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- HY-109085R
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OPA-15406 (Standard)
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Reference Standards
Phosphodiesterase (PDE)
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Inflammation/Immunology
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Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .
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- HY-W190958
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Biochemical Assay Reagents
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Others
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Boc-NH-Tri-(carbonylethoxymethyl)-methane is a branched PEG linker with a Boc-protected amino and three terminal carboxilic acid groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W009004B
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Biochemical Assay Reagents
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Others
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Trilysine (TFA) is derived from lysine and rapidly undergoes polymerization with PEG esters to form a three-dimensional absorbable hydrogel. This process is mild to tissues, exothermic reaction-free, and causes minimal tissue response. Trilysine (TFA) and PEG esters form a hydrogel with strong mechanical adhesion, high cohesive strength, and flexibility, which adapts to the natural expansion and contraction of lung tissues .
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- HY-W101722
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PROTAC Linkers
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Cancer
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tert-Butyl (9-aminononyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W800712
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Biochemical Assay Reagents
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Others
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t-Boc-N-Amido-PEG11-Tos is a PEG linker containing a tosyl group and Boc-protected amine group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.
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- HY-W460275
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Biochemical Assay Reagents
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Others
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t-Boc-N-Amido-PEG5-Tos is a PEG linker containing a tosyl group and Boc-protected amine group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.
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- HY-151474
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SARS-CoV
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Cancer
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SARS-CoV-2-IN-31 is an effective COVID-19 inhibitor. SARS-CoV-2-IN-31 exhibits excellent to mild activity against various cancer cell lines with IC50 values range from 28.84 to 38.36 μM. SARS-CoV-2-IN-31 can be used for the research of cancer .
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- HY-19742A
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SRA-333 hydrochloride
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5-HT Receptor
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Neurological Disease
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Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research .
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- HY-174760
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mRNA
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Inflammation/Immunology
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Human CCL22 mRNA encodes the human C-C motif chemokine ligand 22 (CCL22) protein, a cytokine that displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. CCL22 also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes.
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- HY-W127491
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Elaidyl alcohol
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Biochemical Assay Reagents
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Others
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Trans-9-Octadecenol is an organic compound belonging to the group of alcohols. It has a mild fatty smell and is commonly found in a variety of foods, such as meat and dairy products. Trans-9-Octadecenol has several applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfumes, colognes and air fresheners. In addition, it has potential utility in inhibiting inflammation-related diseases and cancer.
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- HY-W127534R
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Trihexanoin (Standard)
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Biochemical Assay Reagents
Reference Standards
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Others
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Tricaproin (Standard) is the analytical standard of Tricaproin. This product is intended for research and analytical applications. TricaproinIt is an organic compound belonging to the class of triacylglycerols. It consists of three molecules of caproic acid esterified to the glycerin backbone, with a mild fatty smell. TricaproinIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and surfactant in industrial settings.
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- HY-126377
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Biochemical Assay Reagents
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Others
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Sulfobetaine 10, is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is commonly used to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Sulfobetaine 10 has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research.
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- HY-50682S
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TTP488-d9; PF-04494700-d9
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Isotope-Labeled Compounds
Amyloid-β
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Neurological Disease
Endocrinology
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Azeliragon-d9 (TTP488-d9) is the deuterium labeled Azeliragon (HY-50682). Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .
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- HY-145576B
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Fluorescent Dye
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Others
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2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
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- HY-17550
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DM-235
|
iGluR
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Neurological Disease
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Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD) .
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- HY-17368
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ENA 713 free base; SDZ-ENA 713 free base
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Cholinesterase (ChE)
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Neurological Disease
|
|
Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-W127621
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Biochemical Assay Reagents
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Others
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Sulfobetaine-8is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-8Often used as a mild surfactant because of its non-irritating and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
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- HY-W800813
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Biochemical Assay Reagents
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Others
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Carboxy-Amido-PEG5-N-Boc is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-167681
-
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Ro 12-4713
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Endogenous Metabolite
|
Cardiovascular Disease
|
|
Carprazidil (Ro 12-4713) is a potent vasodilator with activity in suppressing severe hypertension and mild heart failure. The use of carprazidil may lead to sodium retention and increased heart rate, requiring increased doses of diuretics or beta-blockers in some cases. Carprazidil and mecycline may both cause hirsutism, limiting their long-term use in women. Carprazidil did not cause adverse side effects on hematological parameters, liver, or kidney function .
|
-
- HY-P99103
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|
LY-3853113; LY-COV1404
|
SARS-CoV
|
Infection
|
|
Bebtelovimab a human IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19 ((the IC50 value for SARS-CoV-2/MT020880.1 virus is 9-22.1 ng/mL)). Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy .
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- HY-W005828
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PROTAC Linkers
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Cancer
|
|
9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-Z0478
-
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(S)-(-)-Limonene
|
Bacterial
Antibiotic
CaMK
|
Infection
Cardiovascular Disease
Metabolic Disease
|
|
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca 2+) and Ca 2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .
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- HY-W127620
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Biochemical Assay Reagents
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Others
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Sulfobetaine-12is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-12Often used as a mild surfactant due to its non-irritating properties and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
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- HY-W591982
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Biochemical Assay Reagents
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Others
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t-Boc-N-amido-PEG12-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W131541
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PROTAC Linkers
|
Cancer
|
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tert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. tert-Butyl (11-aminoundecyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W575291
-
|
N-Boc-oct-7-yn-1-amine
|
Biochemical Assay Reagents
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Others
|
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tert-Butyl oct-7-yn-1-ylcarbamate (N-Boc-oct-7-yn-1-amine) is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.
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- HY-119200
-
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Endogenous Metabolite
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Cancer
|
|
LY-195448 hydrochloride is a phenethanolamine that exhibits anti-tumour activity across various murine tumour models. LY-195448 hydrochloride acts by blocking cells at metaphase. LY-195448 hydrochloride has demonstrated a lack of "standard" side effects commonly associated with cancer treatments, such as myelosuppression and gastrointestinal toxicity. LY-195448 hydrochloride was evaluated in a phase I trial, where it showed only mild and reversible side effects like hypotension, tachycardia, and tremor.
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- HY-W591967
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PROTAC Linkers
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Cancer
|
|
N-Boc-15-aminopentadecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. N-Boc-15-aminopentadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-400361
-
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Biochemical Assay Reagents
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Others
|
|
BocNH-PEG2-CH2COONHS ester is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W017389R
-
|
|
Reference Standards
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Xanthine (Standard) is the analytical standard of Xanthine. This product is intended for research and analytical applications. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
In Vitro: A number of stimulants are derived from Xanthine including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme.
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-
- HY-11017
-
|
ENA 713; SDZ-ENA 713
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-W089232
-
|
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PROTAC Linkers
|
Cancer
|
|
Boc-10-Aminodecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-10-Aminodecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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-
- HY-W190720
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Biochemical Assay Reagents
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Others
|
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Fmoc-NH-PEG4-HZ-BOC is a PEG reagent containing an Fmoc-protected amine and a Boc-protected hydrazide. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups.
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-
- HY-W101723
-
|
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PROTAC Linkers
|
Cancer
|
|
Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-W012001
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-111259
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Ro 31-1118 Free base is a compound exhibiting weak antihypertensive activity in patients with mild hypertension. Ro 31-1118 Free base demonstrated a reduction in heart rates and blood pressure post-exercise at varying doses. Ro 31-1118 Free base exhibited linear pharmacokinetics within the 10-80 mg dose range. Ro 31-1118 Free base showed no significant impact on diastolic blood pressure or adverse effects during the study.
|
-
- HY-17368S1
-
|
(Rac)-ENA 713-d6 free base; (Rac)-SDZ-ENA 713-d6 free base
|
Isotope-Labeled Compounds
Cholinesterase (ChE)
|
Neurological Disease
|
|
(Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-P10540
-
|
|
Bacterial
|
Infection
|
|
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
|
-
- HY-W190905
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N4, N9-di-Boc-spermine is a spermine linker containing two a Boc-protected amino groups and two amine groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
|
-
- HY-148642
-
|
12-hydroxy-NVP; 12-OH-NVP
|
Drug Metabolite
|
Infection
|
|
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .
|
-
- HY-W190753
-
|
|
Biochemical Assay Reagents
|
Others
|
|
BocNH-PEG8-CH2CH2COONHS is a PEG linker containing an NHS ester and a Boc-protected amino group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
|
-
- HY-162904
-
|
|
Mitochondrial Metabolism
|
Cardiovascular Disease
|
|
BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent .
|
-
- HY-145414
-
|
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly .
|
-
- HY-178154
-
|
|
PINK1/Parkin
Mitochondrial Metabolism
|
Neurological Disease
|
|
FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease .
|
-
- HY-W654336
-
|
|
Isotope-Labeled Compounds
Cholinesterase (ChE)
|
Neurological Disease
|
|
(S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-42773
-
|
1-Boc-1,8-diaminooctane
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (8-aminooctyl)carbamate (1-Boc-1,8-diaminooctane) can be used as a PROTAC linker in the synthesis of PROTACs. tert-butyl (8-aminooctyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-107831
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
5-Acetylsalicylic acid is the derivate of Aspirin (HY-14654), with anti-inflammatory property. 5-Acetylsalicylic acid is the active metabolite of Sulfasalazine (HY-14655) and its production is regulated by beneficial bacteria in the gut but is confined to the intestinal tract. 5-Acetylsalicylic acid exhibits a mild cytotoxicity effect on B16F10 cells. 5-Acetylsalicylic acid can be used for the study of inflammatory bowel disease (IBD) such as ulcerative colitis (UC) .
|
-
- HY-W014394
-
|
|
TRP Channel
Parasite
|
Infection
Cardiovascular Disease
|
|
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether exhibits mutually inhibitory effects on mammalian TRPV1 and TRPM8 channels. Vanillyl butyl ether shows repellency activity against Tribolium castaneum, T. confusum and L. bostrychophila. Vanillyl butyl ether acts as a mild warming agent, providing a warming sensation and enhancing blood circulation .
|
-
- HY-W047688
-
|
1-Boc-1,10-diaminodecane
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (10-aminodecyl)carbamate (1-Boc-1,10-diaminodecane) can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. tert-Butyl (10-aminodecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-17368S2
-
|
ENA 713-d3 hydrochloride; SDZ-ENA 713-d3 hydrochloride
|
Cholinesterase (ChE)
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-131030
-
|
JF669, SE; JF669, NHS
|
Fluorescent Dye
|
Others
|
|
Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
|
-
- HY-17368R
-
|
ENA 713 free base(Standard); SDZ-ENA 713 free base(Standard)
|
Reference Standards
Cholinesterase (ChE)
|
Neurological Disease
|
|
Rivastigmine (Standard) is the analytical standard of Rivastigmine. This product is intended for research and analytical applications. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-W039454R
-
|
|
Reference Standards
Bacterial
SARS-CoV
|
Infection
|
|
2,4-Dichlorobenzyl alcohol (Standard) is the analytical standard of 2,4-Dichlorobenzyl alcohol (HY-W039454). This product is intended for research and analytical applications. 2,4-Dichlorobenzyl alcohol is an orally active mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections. 2,4-Dichlorobenzyl alcohol exhibits prenatal developmental toxicity.2,4-Dichlorobenzyl alcohol can be used in the study of SARS-CoV .
|
-
- HY-17550R
-
|
DM-235 (Standard)
|
Reference Standards
iGluR
|
Neurological Disease
|
|
Sunifiram (Standard) is the analytical standard of Sunifiram. This product is intended for research and analytical applications. Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD) .
|
-
- HY-W041856
-
|
Boc-8-aminooctanoic acid
|
PROTAC Linkers
|
Cancer
|
|
N-Boc-8-amino-octanoic acid (Boc-8-aminooctanoic acid) can be used as a PROTAC linker in the synthesis of PROTACs. N-Boc-8-amino-octanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-137312A
-
|
SKF 40383-A hydrochloride
|
Adrenergic Receptor
|
Inflammation/Immunology
|
|
Carbuterol (SKF 40383-A) hydrochloride is a selective β2-adrenergic receptor agonist that primarily targets bronchial smooth muscle, exhibiting significant bronchodilatory and anti-allergic activity. Carbuterol hydrochloride can directly inhibit the immunologically induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A), thereby alleviating allergic responses. In addition, it exerts mild β1-mediated cardiac stimulation and is applicable to studies related to respiratory and immune-related diseases such as asthma and allergic disorders .
|
-
- HY-175553
-
|
|
VEGFR
Apoptosis
|
Cancer
|
|
VEGFR-2-IN-72 is a selective VEGFR-2 inhibitor with an IC50 of 22.2 nM. VEGFR-2-IN-72 exhibits anticancer activity against HepG2 and Hep3B human HCC cell lines with IC50s of 15.7 and 2.4 μM. VEGFR-2-IN-72 can cause a mild blockage of the cell cycle and induce cell aopoptosis. VEGFR-2-IN-72 can used for the study of hepatocellular carcinoma (HCC) .
|
-
- HY-11017R
-
|
ENA 713 (Standard); SDZ-ENA 713 (Standard)
|
Reference Standards
Cholinesterase (ChE)
|
Neurological Disease
|
|
Rivastigmine (tartrate) (Standard) is the analytical standard of Rivastigmine (tartrate). This product is intended for research and analytical applications. Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-D1840
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products .
|
-
- HY-W654335
-
|
|
Isotope-Labeled Compounds
Cholinesterase (ChE)
|
Neurological Disease
|
|
Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-120144
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
SR-8993 is a highly selective nociceptin receptor agonist that can penetrate the blood-brain barrier and has the activity of reducing alcohol intake and relieving withdrawal anxiety. SR-8993 has shown mild anxiolytic effects in animal models and can effectively reverse anxiety caused by acute alcohol withdrawal. SR-8993 further reduces restricted drinking, operant responses for alcohol, and increased drinking induced by long-term intermittent exposure to alcohol. SR-8993 also reduces stress- and cue-related alcohol-seeking relapse .
|
-
- HY-E70843
-
|
|
MEK
|
Cancer
|
|
MAP2K1 encodes mitogen-activated protein kinase 1 (MEK1), which is a key component in the RAS-mitogen-activated protein kinase kinase (RAS/MAPK) signal transduction pathway. MAP2K1 P124L mutation is a mild mutation. MAP2K1 P124L Recombinant Human Active Protein Kinase is a recombinant MAP2K1 P124L protein that can be used to study MAP2K1 P124L-related functions .
|
-
- HY-117387
-
|
|
Endogenous Metabolite
|
Infection
|
|
BFE-37 is a yeast introduction with heat resistance activity. The survival rate change of BFE-37 after heating at 55 °C for 5 minutes was 6.53 log CFU/mL, showing its strong heat resistance in acidic orange juice. The dynamic behavior of BFE-37 at different temperatures showed a first-order logarithmic linear inactivation characteristic, which indicates its stability in heat treatment. The study of BFE-37 helps to understand the effect of mild heat treatment on juice and provide guidance for microbial control in the food industry .
|
-
- HY-B1032
-
|
(±)-Dropropizine; UCB-196
|
Others
|
Neurological Disease
|
|
Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .
|
-
- HY-N0265
-
-
- HY-118990
-
|
|
Histone Methyltransferase
|
Neurological Disease
|
|
Lobelane hydrochloride is a biologically active compound that has the activity of inhibiting vesicular monoamine transporter-2 (VMAT2). Lobelane hydrochloride has a low affinity for nicotinic acetylcholine receptors (nAChR), thereby enhancing its selectivity for VMAT2. Synthetic structural changes of lobelane hydrochloride have led to some related analogs that show mild changes in affinity for VMAT2. The most potent synthetic lobelane hydrochloride obtained after structural modification has a K(i) value of 630 nM, showing significant VMAT2 selectivity. The biological activity of lobelane hydrochloride suggests that it has the potential to be used in the development of compounds to inhibit methamphetamine abuse .
|
-
- HY-111167
-
|
|
Phosphodiesterase (PDE)
Interleukin Related
TNF Receptor
IFNAR
|
Inflammation/Immunology
|
|
AN-2898 is a selective PDE4 inhibitor with IC50 of 0.027 μM over other phosphodiesterase enzymes, such as PDE1A, PDE2A and PDE3A. AN-2898 also potently inhibits PDE4 subtypes (PDE4B1, PDE4A1A and PDE4D2). AN-2898 significantly inhibits the production of TNF-α, IL-2, IFN-γ, IL-5 and IL-10. AN-2898 can be used for mild to moderate atopic dermatitis (AD) and psoriasis research .
|
-
- HY-157936
-
|
|
iGluR
|
Neurological Disease
|
|
GluN2B-NMDAR antagonist-2 (compound S-58) is a potent, selective and cross the blood-brain barrier NMDAR-GluN2B antagonist with an IC50 value of 74.01, nM. GluN2B-NMDAR antagonist-2 shows mild cytotoxicity. GluN2B-NMDAR antagonist-2 decreases the cerebral infarction rates and neurologic deficit scores. GluN2B-NMDAR antagonist-2 has the potential for the research of stroke .
|
-
- HY-18698
-
|
|
iGluR
|
Neurological Disease
|
|
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity .
|
-
- HY-173217
-
|
|
PPAR
Phosphatase
|
Cardiovascular Disease
Metabolic Disease
|
|
PPARα agonist 5 is an orally available, selective partial agonist of PPARα (EC50: 3 nM). PPARα agonist 5 reduces lipid accumulation and upregulates key PPARα target genes, exerting anti-fatty liver effects. PPARα agonist 5 also exhibits significant hypolipidemic and hypoglycemic effects through partial PPARγ agonist activity and mild inhibition of protein tyrosine phosphatase 1B (PTP1B) (IC50: 79.1 μM). PPARα agonist 5 has a good safety profile and can be used in the study of type 2 diabetes with dyslipidemia .
|
-
- HY-138110
-
|
4-Methyldiphenhydramine
|
Endogenous Metabolite
iGluR
Histamine Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases .
|
-
- HY-P9995
-
|
JNJ-63733657
|
Tau Protein
|
Neurological Disease
|
|
Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease .
|
-
- HY-117247
-
|
|
DNA/RNA Synthesis
|
Infection
|
|
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase .
|
-
- HY-138110R
-
|
4-Methyldiphenhydramine (Standard)
|
Reference Standards
Endogenous Metabolite
iGluR
Histamine Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
Toladryl (Standard) is the analytical standard of Toladryl. This product is intended for research and analytical applications. Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases .
|
-
- HY-101481
-
|
|
COX
Apoptosis
MEK
ERK
PPAR
AMPK
NF-κB
Interleukin Related
TNF Receptor
STAT
Wnt
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Flurbiprofen axetil is a non-selective COX inhibitor and a nonsteroidal anti-inflammatory agent with anti-inflammatory and analgesic effects. Flurbiprofen axetil inhibits basal-like breast cancer metastasis by inhibiting the MEK/ERK signaling pathway. Flurbiprofen axetil can promote neuroprotection after focal cerebral ischemia in rats by partially activating PPAR-γ. Flurbiprofen axetil alleviates cerebral ischemia/reperfusion injury by reducing inflammation in a transient global cerebral ischemia/reperfusion rat model. Flurbiprofen axetil can alleviate inflammatory responses and cognitive function in a mild cognitive impairment (MCI) SD rat model through the AMPKα/NF-κB signaling pathway .
|
-
- HY-174395
-
|
|
Keap1-Nrf2
Interleukin Related
Heme Oxygenase (HO)
|
Neurological Disease
|
|
CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress (CUMS) mouse model. CD-10 can be used for the study of depression.
|
-
- HY-115857
-
|
|
GABA Receptor
|
Neurological Disease
|
|
SH-053-S-CH3-2'F is a selective positive allosteric modulator that produces mild to partial agonistic activity at α(1) GABA(A) receptors. SH-053-S-CH3-2'F showed anxiety-relieving effects at a dose of 30 mg/kg. SH-053-S-CH3-2'F completely avoids the memory impairment commonly caused by benzodiazepine site agonists. SH-053-S-CH3-2'F shows strong selectivity at GABA(A) receptors, which could potentially be used to develop more selective anti-anxiety drugs .
|
-
- HY-120974
-
|
|
GLUT
|
Metabolic Disease
|
|
α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes .
|
-
- HY-101481R
-
|
|
Reference Standards
COX
Apoptosis
MEK
ERK
PPAR
AMPK
NF-κB
Interleukin Related
TNF Receptor
STAT
Wnt
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Flurbiprofen axetil (Standard) is the analytical standard of Flurbiprofen axetil. This product is intended for research and analytical applications. Flurbiprofen axetil is a non-selective COX inhibitor and a nonsteroidal anti-inflammatory agent with anti-inflammatory and analgesic effects. Flurbiprofen axetil inhibits basal-like breast cancer metastasis by inhibiting the MEK/ERK signaling pathway. Flurbiprofen axetil can promote neuroprotection after focal cerebral ischemia in rats by partially activating PPAR-γ. Flurbiprofen axetil alleviates cerebral ischemia/reperfusion injury by reducing inflammation in a transient global cerebral ischemia/reperfusion rat model. Flurbiprofen axetil can alleviate inflammatory responses and cognitive function in a mild cognitive impairment (MCI) SD rat model through the AMPKα/NF-κB signaling pathway .
|
-
- HY-178020
-
|
|
FLT3
ERK
Akt
Apoptosis
|
Cancer
|
|
FLT3-IN-34 is a FLT3 inhibitor, with an IC50 value of 1.4 nM. FLT3-IN-34 blocks the phosphorylation of FLT3 and its downstream signaling molecules AKT and ERK1/2. FLT3-IN-34 induces concentration-dependent G0/G1 phase arrest and mild apoptosis in FLT3-ITD-positive MV4-11 cells. FLT3-IN-34 shows potent anti-proliferative activity against FLT3-ITD-positive MV4-11 cells (IC50 = 14.95 nM) and MOLM-13 (IC50 = 18.5 nM). FLT3-IN-34 can be used for the study of FLT3-positive acute myeloid leukemia (AML) .
|
-
- HY-132806
-
|
RG-7816; RO-7017773
|
GABA Receptor
|
Neurological Disease
|
|
Alogabat is a positive allosteric modulator (PAM) and agonist (Ki <100 nM) of the GABAA α5 receptor, targeting the α5β3γ2 subunit with a Ki of 8.7 nM. Alogabat increases the expression level of α5β3γ2 in oocytes (1.97-fold). GABAA has been implicated in cognitive impairment associated with central nervous system (CNS) disorders, brain cancer (including brain tumors such as medulloblastoma), and can be used in the study of mild cognitive impairment (MCI), amnestic MCI (aMCI), age-associated memory impairment (AAMI), age-related cognitive decline (ARCD), dementia, Alzheimer's disease (AD), prodromal AD, post-traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cognitive impairment associated with cancer treatment, mental retardation, Parkinson's disease (PD), autism spectrum disorder, fragile X, Rett syndrome, obsessive-compulsive behavior, and substance addiction .
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-
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HY-L0118V
-
|
|
942 compounds
|
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A unique set of molecules containing mild electrophilic moieties that covalently interact with amino acid residues in the target protein. The diversity of our compounds for covalent drug discovery ranges from natural product-like scaffolds to macrocycles, creating multiple opportunities in hit generation for a selected target.
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| Cat. No. |
Product Name |
Type |
-
- HY-D2367
-
|
|
Dyes
|
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Rhodamine B NHS ester is a fluorophore featuring an NHS ester. Rhodamine B is a fluorescent dye which is used in fluorescence-based assays in vivo. NHS esters are highly reactive towards amines, forming amides under mild conditions.
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-
- HY-D1840
-
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Dyes
|
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Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). TSA Technology is based on a tyrosinase labeling system that reacts a tyrosine-labeled antibody with a fluorescently labeled tyramide using peroxidase to form a highly amplified fluorescent signal. For example, horseradish peroxidase (HRP) can catalyze the reaction of tyrosine and hydrogen peroxide under milder conditions to generate epoxy groups. Epoxy groups promote the binding of tyramide to adjacent amino acids to form fluorescently labeled products .
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-
- HY-D0235
-
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Dyes
|
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Alizarin yellow GG is a dye that exhibits corrosion inhibition effects on mild steel against concentrated H2SO4.
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- HY-131030
-
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JF669, SE; JF669, NHS
|
Fluorescent Dyes/Probes
|
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Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
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| Cat. No. |
Product Name |
Type |
-
- HY-W250170
-
|
Octyldecyl glucoside
|
Biochemical Assay Reagents
|
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Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.
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- HY-W008864
-
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β-Octaacetyllactose
|
Cell Assay Reagents
|
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Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
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-
- HY-W274569
-
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Surfactants
|
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Hexyl-β-D-glucopyranoside, 98% is typically used as a mild nonionic detergent.
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- HY-W749852
-
|
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Enzyme Substrates
|
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Xanthine sodium, 98%, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, 98% also acts as an intermediate product on the pathway of purine degradation .
|
-
- HY-W749852A
-
|
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Enzyme Substrates
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Xanthine sodium, for cell culture, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, for cell culture also acts as an intermediate product on the pathway of purine degradation .
|
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- HY-144011
-
|
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Drug Delivery
|
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DSPE-PEG-Cyanur ammonium is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur ammonium can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur ammonium can be used for nanostructured lipid carrier .
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- HY-W1048542A
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Drug Delivery
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Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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-
- HY-W1048542D
-
|
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Drug Delivery
|
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Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542I
-
|
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Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542E
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W127534
-
|
Trihexanoin
|
Biochemical Assay Reagents
|
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TricaproinIt is an organic compound belonging to the class of triacylglycerols. It consists of three molecules of caproic acid esterified to the glycerin backbone, with a mild fatty smell. TricaproinIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and surfactant in industrial settings.
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-
- HY-W127377
-
|
|
Drug Delivery
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Butyl oleateIt is an organic compound belonging to esters. It is formed from the reaction of butanol and oleic acid and has a mild fruity smell. Butyl oleateIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and solvent in industrial settings.
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-
- HY-W1048542C
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542H
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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-
- HY-W127465
-
|
|
Drug Delivery
|
|
Oleyl RicinoleateIt is an organic compound belonging to esters. It is formed from the reaction between oleyl alcohol and ricinoleic acid and has a mild fatty odor. Oleyl RicinoleateIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and plasticizer in industrial settings.
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- HY-34619
-
|
|
Gene Sequencing and Synthesis
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[Hydroxy(tosyloxy)iodo]benzene is a versatile reagent for the mild oxidation of aryl iodides at the iodine atom by ligand transfer. [Hydroxy(tosyloxy)iodo]benzene is an effective reagent for the one-step conversion of ketones to the corresponding α-tosyloxy ketones. [Hydroxy(tosyloxy)iodo]benzene is also a Bronsted acid and is expected to catalyze the enolization of ketones .
|
-
- HY-W127437
-
|
Octadecanoic acid, octadecyl ester
|
Drug Delivery
|
|
Stearyl StearateIt is an organic compound belonging to esters. It is formed from the reaction between stearyl alcohol and stearic acid and has a mild fatty odor. Stearyl stearate has several applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and surfactant in industrial settings.
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-
- HY-W127491
-
|
Elaidyl alcohol
|
Drug Delivery
|
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Trans-9-Octadecenol is an organic compound belonging to the group of alcohols. It has a mild fatty smell and is commonly found in a variety of foods, such as meat and dairy products. Trans-9-Octadecenol has several applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfumes, colognes and air fresheners. In addition, it has potential utility in inhibiting inflammation-related diseases and cancer.
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-
- HY-W127534R
-
|
Trihexanoin (Standard)
|
Biochemical Assay Reagents
|
|
Tricaproin (Standard) is the analytical standard of Tricaproin. This product is intended for research and analytical applications. TricaproinIt is an organic compound belonging to the class of triacylglycerols. It consists of three molecules of caproic acid esterified to the glycerin backbone, with a mild fatty smell. TricaproinIt has a variety of applications in the cosmetic and personal care industries, especially as an emollient and conditioning agent in skin and hair care products. Additionally, it is used as a lubricant and surfactant in industrial settings.
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-
- HY-126377
-
|
|
Surfactants
|
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Sulfobetaine 10, is a zwitterionic surfactant commonly used in biochemistry and biophysics. It is commonly used to dissolve membrane proteins and other hydrophobic molecules in aqueous solutions. Sulfobetaine 10 has both positively and negatively charged groups in its structure, which allows it to maintain a neutral charge in solution and reduces its tendency to denature proteins. It is considered a mild, non-denaturing surfactant and is widely used in protein research.
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-
- HY-W127621
-
|
|
Surfactants
|
|
Sulfobetaine-8is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-8Often used as a mild surfactant because of its non-irritating and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
|
-
- HY-W127620
-
|
|
Surfactants
|
|
Sulfobetaine-12is a zwitterionic surfactant, which means it has both positive and negative charges in its molecules. It is used as a detergent in various industries, including pharmaceuticals, cosmetics, and personal care products. Sulfobetaine-12Often used as a mild surfactant due to its non-irritating properties and ability to stabilize emulsions. Plus, it has antistatic properties that can be used to clean electronics and other static-prone surfaces.
|
-
- HY-W782399
-
|
Sodium boranocarbonate
|
Biochemical Assay Reagents
|
|
CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-W009004B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Trilysine (TFA) is derived from lysine and rapidly undergoes polymerization with PEG esters to form a three-dimensional absorbable hydrogel. This process is mild to tissues, exothermic reaction-free, and causes minimal tissue response. Trilysine (TFA) and PEG esters form a hydrogel with strong mechanical adhesion, high cohesive strength, and flexibility, which adapts to the natural expansion and contraction of lung tissues .
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-
- HY-P10540
-
|
|
Bacterial
|
Infection
|
|
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
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-
- HY-K1002
-
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|
|
MCE NP-40 Lysis Buffer is a relatively mild reliable buffers used to lyse cells from animal, plant tissue and fungi, bacteria etc.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99776
-
|
XmAb-13676
|
CD20
CD3
|
Cancer
|
|
Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 + expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo .
|
-
- HY-P99103
-
|
LY-3853113; LY-COV1404
|
SARS-CoV
|
Infection
|
|
Bebtelovimab a human IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19 ((the IC50 value for SARS-CoV-2/MT020880.1 virus is 9-22.1 ng/mL)). Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy .
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-
- HY-P9995
-
|
JNJ-63733657
|
Tau Protein
|
Neurological Disease
|
|
Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B0892S2
-
|
|
|
Benzyl alcohol-d5 is the deuterium labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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-
-
- HY-B0892S1
-
|
|
|
Benzyl alcohol-d7 is the deuterium labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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-
-
- HY-B0575S
-
|
|
|
Triamterene-d5 is deuterium labeled Triamterene (HY-B0575). Triamterene blocks epithelial Na + channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor.
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-
-
- HY-B1192S
-
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|
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Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability .
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-
-
- HY-B0892S5
-
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|
Benzyl alcohol- 13C is the 13C labeled Benzyl alcohol (HY-B0892). Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor .
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-
-
- HY-B0892S
-
|
|
|
Benzyl alcohol-α- 13C-α,α-d2 is the 13C-labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
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-
-
- HY-N0285S
-
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|
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Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria .
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-
-
- HY-10933S
-
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CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) .
|
-
-
- HY-B1191S
-
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|
|
Nanofin-d2 (2,6-Lupetidine-d2) is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
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-
-
- HY-B1191S1
-
|
|
|
Nanofin-d5 (2,6-Lupetidine-d5) is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
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-
-
- HY-B1191SA
-
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|
|
Nanofin-d2 (2,6-Lupetidine-d2) hydrochloride is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
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-
-
- HY-W017389S1
-
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|
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Xanthine- 15N2 is a 15N-labeled Xanthine (HY-W017389) . Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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-
-
- HY-W017389S
-
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|
|
Xanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Xanthine (HY-W017389). Xanthine is a plant alkaloid with mild stimulant activity of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation .
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-
-
- HY-50682S
-
|
|
|
Azeliragon-d9 (TTP488-d9) is the deuterium labeled Azeliragon (HY-50682). Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .
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-
-
- HY-17368S1
-
|
|
|
(Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
-
- HY-W654336
-
|
|
|
(S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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-
-
- HY-17368S2
-
|
|
|
Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
-
- HY-W654335
-
|
|
|
Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W457953
-
|
|
|
Azide
|
|
tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. tert-Butyl N-(4-azidobutyl)carbamate can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.
|
-
- HY-151682
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
H-L-Lys(Norbornene-methoxycarbonyl)-OH, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
|
-
- HY-151682A
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride can be used for the mild and selective modification of proteins in a copper-free click reaction .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-B0892
-
|
Benzenemethanol
|
|
Preservatives
Solvents
|
|
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice .
|
-
- HY-145649A
-
|
AD-85481 sodium; ALN-AGT sodium
|
|
siRNAs
siRNA drugs
|
|
Zilebesiran sodium is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of syste
|
-
- HY-145649
-
|
AD-85481; ALN-AGT
|
|
siRNAs
|
|
Zilebesiran is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of systemic blood pressure.
|
-
- HY-144011
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG-Cyanur ammonium is a PEG derivative containing cyanur functional group. DSPE-PEG-Cyanur ammonium can be used for PEGylation of protein under mild basic conditions. DSPE-PEG-Cyanur ammonium can be used for nanostructured lipid carrier .
|
-
- HY-174760
-
|
|
|
mRNA
|
|
Human CCL22 mRNA encodes the human C-C motif chemokine ligand 22 (CCL22) protein, a cytokine that displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. CCL22 also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes.
|
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