2. Autophagy Neuronal Signaling Metabolic Enzyme/Protease
  3. PINK1/Parkin Mitochondrial Metabolism
  4. FB231

FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease.

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FB231

FB231 Chemical Structure

CAS No. : 2166045-37-8

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FB231 Related Antibodies

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Description

FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease[1].

In Vitro

FB231 activates Parkin and enhances Parkin-mediated mitophagy induced by low-dose Oligomycin (HY-N6782)/Antimycin (O/A) (EC50 = 0.67 μM)[1].
FB231 (0.3125-20 μM, 6-24 h) reduces the threshold of O/A-induced mitophagy in YFP-Parkin/mt-Keima-expressing HeLa cells and SH-SY5Y cells with endogenous Parkin[1].
FB231 effectively chelates Fe2+ with an EC50 of 23.2 μM[1].
FB231 (6 h) increases mitochondrial oxygen consumption rate (OCR) and reduces cell sensitivity to the complex V inhibitor Oligomycin in WT HeLa cells[1].
FB231 (3.125-20μM, 24 h) reduces cell viability in HeLa and SH-SY5Y cells[1].
FB231 (10 μM, 16 h) induces the expression of ISR markers ATF3, ATF4, and IFRD1 in WT HeLa, YFP-Parkin HeLa, and PINK1-knockout HeLa cells [1].
FB231 (40 μM) stabilizes the HECT domain E3 ligase HERC4 and destabilizes the iron-responsive protein IREB2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FB231 Related Antibodies

Western Blot Analysis[1]

Cell Line: WT HeLa (no endogenous Parkin)
Concentration: 10 μM
Incubation Time: 16 h
Result: Increased ATF3, ATF4, and IFRD1 levels Promoted the accumulation of the full-length form of mitochondrial protein DELE1.
Activated the DELE1-HRI-EIF2α pathway.
Molecular Weight

411.46

Formula

C24H21N5O2
CAS No.
SMILES

CC1=C(C=CC=C1)C(NC2=NN(C(NC(C3=C(C=CC=C3)C)=O)=N2)C4=CC=CC=C4)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FB231 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FB2312166045-37-8FB 231FB-231PINK1/ParkinMitochondrial MetabolismPTEN-induced kinase 1/ParkinParkinMitochondrial stressMitochondrial toxinsMitophagyISRParkinson’s diseaseOligomycinAntimycinHeLaSH-SY5YATF3ATF4IFRD1Inhibitorinhibitorinhibit

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