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61

Inhibitors & Agonists

4

Screening Libraries

1

Fluorescent Dye

3

Biochemical Assay Reagents

5

Peptides

7

Natural
Products

3

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N8028
    Quercetin 3-O-sambubioside
    1 Publications Verification

    		 Others Cancer
    Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers. Quercetin-3-O-sambubioside promotes the stimulation of the nerve center. Antioxidant and anticancer activities .
    Quercetin 3-O-sambubioside
  • HY-116807
    Dihydrolipoic Acid
    1 Publications Verification

    DHLA

    		 Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology
    Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
    Dihydrolipoic Acid
  • HY-W011985
    H-Arg-NH2 hydrochloride

    		Biochemical Assay Reagents Others
    H-Arg-NH2 (hydrochloride) is a nucleophilic reagent that can be used in experiments related to enzyme activity center detection .
    H-Arg-NH2 hydrochloride
  • HY-143868
    HPK1-IN-27

    		MAP4K Cancer
    HPK1-IN-27 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-27 has the potential for the research of cancer diseases (extracted from patent WO2019016071A1, compound 38) .
    HPK1-IN-27
  • HY-143871
    HPK1-IN-30

    		MAP4K Cancer
    HPK1-IN-30 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-30 has the potential for the research of cancer diseases (extracted from patent WO2021175271A1, compound 3) .
    HPK1-IN-30
  • HY-116807R
    Dihydrolipoic Acid (Standard)

    DHLA (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology
    Dihydrolipoic Acid (Standard) is the analytical standard of Dihydrolipoic Acid. This product is intended for research and analytical applications. Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
    Dihydrolipoic Acid (Standard)
  • HY-N10516
    Bacteriopheophytin

    		Bacterial Others
    Bacteriopheophytin, a photosynthetic pigment, is a bacterial demagnetised chlorophyll composed of bacterial chlorophyll in which two hydrogen atoms replace the magnesium center. Bacteriopheophytin acts as an electron acceptor in the purple bacterial reaction center (RC) and is involved in electron transfer .
    Bacteriopheophytin
  • HY-W591325
    4-((5-Nitropyridin-2-yl)disulfanyl)pentanoic acid

    		Biochemical Assay Reagents Others
    4-((5-Nitropyridin-2-yl)disulfanyl)pentanoic acid is a synthetic building block with terminal nitro and carboxylic acid groups with a disulfide bond in the center.
    4-((5-Nitropyridin-2-yl)disulfanyl)pentanoic acid
  • HY-NP202B
    C4 Protein (human)

    		Complement System Inflammation/Immunology
    C4 Protein (human) is a naturally occurring glycosylated polypeptide with three disulfide-linked chains. C4 is the activation center of both the classical and lectin pathways of complement activation .
    C4 Protein (human)
  • HY-118593
    A2315A

    Madumycin II; Antibiotic A 2315A

    		 Antibiotic Infection
    A2315A (Madumycin II) is an alanine-containing streptogramin A antibiotic. A2315A is a potent peptidyl transferase center (PTC) inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation .
    A2315A
  • HY-107584
    BYK 191023 dihydrochloride

    		NO Synthase Metabolic Disease
    BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS .
    BYK 191023 dihydrochloride
  • HY-B1738
    Pralidoxime

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning .
    Pralidoxime
  • HY-B1200
    Pralidoxime chloride
    1 Publications Verification

    2-PAM chloride

    		 Cholinesterase (ChE) Neurological Disease
    Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .
    Pralidoxime chloride
  • HY-128974
    N-Dodecyl-β-D-maltoside
    4 Publications Verification

    Lauryl Maltoside

    		 DNA/RNA Synthesis Others
    N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .
    N-Dodecyl-β-D-maltoside
  • HY-122060
    BYK 191023

    		NO Synthase Metabolic Disease
    BYK 191023 is a selective and L-arginine competitive inducible nitric-oxide synthase inhibitor with an IC50 value of 86 nM, 17 µM, 162 µM for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) NO synthases respectively .
    BYK 191023
  • HY-B1738B
    Pralidoxime methanesulfonate

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime methanesulfonate reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime methanesulfonate is an antidote for organophosphate poisoning .
    Pralidoxime methanesulfonate
  • HY-W048718
    Fmoc-D-Tle-OH

    Fmoc-D-α-t-butylglycine

    		 Amino Acid Derivatives Others
    Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .
    Fmoc-D-Tle-OH
  • HY-B1738A
    Pralidoxime iodide

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .
    Pralidoxime iodide
  • HY-16908
    Lefamulin
    3 Publications Verification

    BC-3781

    		 Bacterial Antibiotic Infection
    Lefamulin (BC-3781) is an orally active antibiotic. Lefamulin inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin has anti-inflammatory activity. Lefamulin can be used in the research of bacterial infections, such as bacterial pneumonia .
    Lefamulin
  • HY-16908A
    Lefamulin acetate
    3 Publications Verification

    BC-3781 acetate

    		 Bacterial Antibiotic Infection Inflammation/Immunology
    Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia .
    Lefamulin acetate
  • HY-P1245A
    Neuropeptide SF (human) acetate

    Neuropeptide NPFF (human) acetate

    		 CRFR Others
    Neuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH .
    Neuropeptide SF (human) acetate
  • HY-P1245
    Neuropeptide SF (human)

    Neuropeptide NPFF (human)

    		 CRFR Others
    Neuropeptide SF human augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF human play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH .
    Neuropeptide SF (human)
  • HY-10053S
    Maropitant-d3

    		Isotope-Labeled Compounds Neurokinin Receptor Neurological Disease Endocrinology
    Maropitant-d3 is the deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .
    Maropitant-d3
  • HY-149035
    PAA4

    		Others Cancer
    PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model .
    PAA4
  • HY-149036
    PAA5

    		Ferroptosis Endogenous Metabolite Reactive Oxygen Species (ROS) Cancer
    PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .
    PAA5
  • HY-128974S
    N-Dodecyl-β-D-maltoside-d25

    Lauryl Maltoside-d25

    		 Isotope-Labeled Compounds DNA/RNA Synthesis Others
    N-Dodecyl-β-D-maltoside-d25 (Lauryl Maltoside-d25) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .
    N-Dodecyl-β-D-maltoside-d25
  • HY-D0020
    2,2'-Bipyridine
    1 Publications Verification

    		 Biochemical Assay Reagents Infection Endocrinology
    2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .
    2,2'-Bipyridine
  • HY-B1200R
    Pralidoxime chloride (Standard)

    2-PAM chloride (Standard)

    		 Reference Standards Cholinesterase (ChE) Neurological Disease
    Pralidoxime (chloride) (Standard) is the analytical standard of Pralidoxime (chloride). This product is intended for research and analytical applications. Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .
    Pralidoxime chloride (Standard)
  • HY-10053R
    Maropitant (Standard)

    		Reference Standards Neurokinin Receptor Neurological Disease Endocrinology
    Maropitant (Standard) is the analytical standard of Maropitant. This product is intended for research and analytical applications. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .
    Maropitant (Standard)
  • HY-10053S1
    Maropitant-13C,d3

    		Isotope-Labeled Compounds Neurokinin Receptor Neurological Disease Endocrinology
    Maropitant- 13C,d3 is the 13C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .
    Maropitant-13C,d3
  • HY-B1738AR
    Pralidoxime iodide (Standard)

    		Cholinesterase (ChE) Neurological Disease
    Pralidoxime (iodide) (Standard) is the analytical standard of Pralidoxime (iodide). This product is intended for research and analytical applications. Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .
    Pralidoxime iodide (Standard)
  • HY-16908AR
    Lefamulin acetate (Standard)

    BC-3781 acetate (Standard)

    		 Reference Standards Bacterial Antibiotic Infection Inflammation/Immunology
    Lefamulin (acetate) (Standard) is the analytical standard of Lefamulin (acetate). This product is intended for research and analytical applications. Lefamulin (BC-3781) acetate is an orally active antibiotic. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome. Lefamulin acetate has anti-inflammatory activity. Lefamulin acetate can be used in the research of bacterial infections, such as bacterial pneumonia[1].
    Lefamulin acetate (Standard)
  • HY-174738
    Human CD40 mRNA

    		mRNA Inflammation/Immunology
    Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
    Human CD40 mRNA
  • HY-W048682
    Fmoc-1-methyl-L-histidine

    		Amino Acid Derivatives Others
    Fmoc-1-methyl-L-histidine is a Fmoc protected amino acid and amino acid-containing building block. Fmoc-1-methyl-L-histidine can be used in the production of ε-nitrogen-ligated copper centers in copper nitrite reductases. Fmoc-1-methyl-L-histidine can also be used as an intermediate for peptide synthesis .
    Fmoc-1-methyl-L-histidine
  • HY-W582504
    Chlorotris(triphenylphosphine)copper

    CuCl(TPP)3

    		 DNA Stain Bacterial Fungal Infection Cancer
    Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents .
    Chlorotris(triphenylphosphine)copper
  • HY-W012885
    (S)-Methyl 3-hydroxybutanoate

    		Biochemical Assay Reagents Others
    (S)-Methyl 3-hydroxybutanoate consists of a chiral center, resulting in two enantiomers, where (S)-Methyl 3-hydroxybutanoate means that the hydroxyl group is located on the third carbon atom of the S-configuration carboxylic acid group stereoisomers. This compound is often used as a building block for the synthesis of various pharmaceuticals and natural products. Due to its fruity taste, it is also used as a flavor and fragrance ingredient.
    (S)-Methyl 3-hydroxybutanoate
  • HY-14507
    YK-4-279
    Maximum Cited Publications
    6 Publications Verification

    		 DNA/RNA Synthesis Apoptosis Cancer
    YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .
    YK-4-279
  • HY-162488
    Laccase-IN-3

    		Fungal Infection
    Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS .
    Laccase-IN-3
  • HY-162754
    LMP7/LMP2-IN-1

    		Proteasome Inflammation/Immunology
    LMP7/LMP2-IN-1 (Compound 19) is the orally active inhibitor for immunoproteasome subunits LMP7 and LMP2 with IC50 of 257 and 10 nM. LMP7/LMP2-IN-1 reduces the generation of antibody, downregulates the cells in spleen germinal center B and in plasma in NP-OVA-immunized mice, and can be used in research about autoimmune diseases .
    LMP7/LMP2-IN-1
  • HY-168705
    Anti-MRSA agent 20

    		Bacterial Infection
    Anti-MRSA agent 20 (Compound a4) is an anti-microbial agent (MIC: < 0.03125 μg/mL) against MRSA). Anti-MRSA agent 20 binds to the ribosomal peptidyl transferase center and inhibits bacterial survival by inhibiting MRSA toxin synthesis and bacterial division. Anti-MRSA agent 20 significantly reduces the MRSA load in the lungs and attenuates lung injury in the MRSA-infected mice (ED50 = 6.48 mg/kg) .
    Anti-MRSA agent 20
  • HY-W001222
    3-Furanboronic acid

    		Biochemical Assay Reagents Others
    3-Furanboronic acid is a 3-furanboronic acid, and furan is a π-electron heteroarene. In chemical synthesis, 3-Furanboronic acid and different 2-benzofuranboronic acids have good reactivity. 3-Furanboronic acid can successfully react with 3-bromothiophene, 2,3-bromopyridine, or 3-bromoquinoline with only a small amount of catalyst. Due to the coordination of heteroatoms with the palladium center, no poisoning effects were observed .
    3-Furanboronic acid
  • HY-D0020R
    2,2'-Bipyridine (Standard)

    		Biochemical Assay Reagents Reference Standards Infection Endocrinology
    2,2'-Bipyridine (Standard) is the analytical standard of 2,2'-Bipyridine. This product is intended for research and analytical applications. 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .
    2,2'-Bipyridine (Standard)
  • HY-167920
    Glutathione sulfonate

    S-Sulfoglutathione

    		 Endogenous Metabolite Cancer
    Glutathione sulfonate (S-Sulfoglutathione) is a multifunctional bioactive compound that inhibits angiogenesis and tumor growth. Glutathione sulfonate is a competitive inhibitor of glutathione S-transferase and is involved in the detoxification process and the binding of a variety of exogenous and endogenous compounds. Glutathione sulfonate acts in the substrate binding site of Escherichia coli glutathione S-transferase, affecting the catalytic mechanism. The structural characteristics of Glutathione sulfonate contribute to its inhibitory effect by hydrogen bonding in the active center of the enzyme .
    Glutathione sulfonate
  • HY-115733
    Cathepsin L-IN-2
    1 Publications Verification

    (Rac)-Z-Phe-Phe-FMK

    		 Cathepsin Cancer
    Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
    Cathepsin L-IN-2
  • HY-10943
    GNF-7
    2 Publications Verification

    		 Bcr-Abl Ack1 Cancer
    GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-Abl WT and Bcr-Abl T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies .
    GNF-7
  • HY-136926
    Candicidin A3

    FR-008I

    		 Fungal Infection
    Candicidin A3 (FR-008I) is an antifungal antibiotic with significant biological activity. Candicidin A3 can effectively inhibit the growth of fungi through its unique three-dimensional structure and seven-membered ring geometry. The absolute configuration of Candicidin A3 is a specific arrangement of multiple chiral centers, which may affect its biological activity and interaction with targets. Candicidin A3 can be used as a potential drug to inhibit fungal infections .
    Candicidin A3
  • HY-B1164A
    Bromopride hydrochloride

    		Dopamine Receptor Neurological Disease
    Bromopride hydrochloride is a selective, irreversible, competitive, and orally active dopamine D2 receptor antagonist. Bromopride hydrochloride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride hydrochloride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride hydrochloride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting) .
    Bromopride hydrochloride
  • HY-10427A
    iso-WAY-260022

    iso-NRI-022

    		 Serotonin Transporter Dopamine Transporter Cardiovascular Disease
    iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats .
    iso-WAY-260022
  • HY-163472
    PR280

    		Dihydroceramide Desaturase 1 (DES1) Metabolic Disease Cancer
    PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) (IC50=700 nM). PR280 forms hydrogen bonds with the amino acid residues of Des1, and its cyclopropenone group may form a coordination with the iron center, thus stabilizing the binding to the active site of Des1 and inhibiting the sphingosine lipid synthesis pathway of dihydroceramide (dhCer) to form ceramide. PR280 can be used in the study of diseases related to sphingosine lipid metabolism, such as cancer and metabolic diseases .
    PR280
  • HY-B1164
    Bromopride
    2 Publications Verification

    		 Dopamine Receptor Neurological Disease
    Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting) .
    Bromopride

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