2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. STA-9584

STA-9584 is a potent vascular disrupting agent (VDA) that targets tubulin. STA-9584 exhibits potent antitumor activity in mouse xenograft model by selectively targeting microvasculature at both the center and periphery of tumors. STA-9584 can be used for research in prostate and breast cancer.

For research use only. We do not sell to patients.

STA-9584

STA-9584 Chemical Structure

CAS No. : 906481-23-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

STA-9584 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

STA-9584 is a potent vascular disrupting agent (VDA) that targets tubulin. STA-9584 exhibits potent antitumor activity in mouse xenograft model by selectively targeting microvasculature at both the center and periphery of tumors. STA-9584 can be used for research in prostate and breast cancer[1].

In Vivo

STA-9584 (4.5 mg/kg, i.v., weekly for 2-3 weeks) induces significant tumor regressions in mouse prostate and breast xenograft models by selectively disrupting tumor microvasculature at both the center and periphery[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (7-12 weeks old) subcutaneously implanted with EMT6 cells[1]
Dosage: 4.5 mg/kg
Administration: i.v., weekly for 2 weeks
Result: Completely blocked blood flow in highly perfused tumor subregions within 4 h of drug administration.
Completely arrested tumor growth over this period with a single dose for 24 h.
Exhibited far more extensive cellular destruction throughout the entire tumor, including areas of fibrosis and dramatically reduced viable rim or surviving tumor zones.
Resulted in no detectable viable rim tissue in many tumor sections.
Increased microvasculature destruction and consequent apoptosis in peripheral regions of tumors.
Induced widespread disruption of tumor microvessels, characterized by decreased, patchy CD31 expression, loss of integrity, and thrombosis.
Decreased CD31 endothelial cells in the viable rim by 77%.
Animal Model: Female BALB/c nude mice (7-12 weeks old) subcutaneously implanted with PC-3 cells[1]
Dosage: 4.5 mg/kg
Administration: i.v., weekly for 3 weeks
Result: Induced significantly tumor regression (40%) compared with the control group.
Was well tolerated with minimal loss of body weight during the course of treatment.
Animal Model: Female CB-17/ Icr-Prkdcscid (SCID) mice (7-12 weeks old) subcutaneously implanted with MDA-MB-231 cells[1]
Dosage: 4.5 mg/kg
Administration: i.v., weekly for 3 weeks
Result: Resulted in 60% tumor regression.
Molecular Weight

540.01

Formula

C28H30ClN3O6
CAS No.
SMILES

O=C(NC1=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)ON=C2)=CC=C1OC)[C@@H](N)CC4=CC=CC=C4.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

STA-9584 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STA-9584906481-23-0STA9584STA 9584Microtubule/TubulinVDAxenograftmicrovasculatureprostatebreastPC-3EMT6MDA-MB-231BALB/cCB-17/Icr-Prkdc scid (SCID)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
STA-9584
Cat. No.:
HY-111170
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.