Search Result

Results for "

NSCs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADC Linker (1) Adenosine Kinase (1) Adenosine Receptor (1) Akt (6) Amino Acid Derivatives (1) Aminopeptidase (2) AMPK (4) Angiotensin Receptor (1) Antibiotic (19) Antifolate (3) Apoptosis (84) Arp2/3 Complex (2) Aryl Hydrocarbon Receptor (2) Atg4 (1) ATP Synthase (2) Autophagy (27) Bacterial (32) Bcl-2 Family (1) Bcr-Abl (3) BCRP (2) Biochemical Assay Reagents (8) c-Myc (2) Calcium Channel (8) Carbonic Anhydrase (1) Caspase (3) CCR (1) CDK (4) Checkpoint Kinase (Chk) (3) Chloride Channel (4) Claudin (2) COX (17) Cuproptosis (1) CXCR (1) Cytochrome P450 (3) Deubiquitinase (2) Dipeptidyl Peptidase (2) DNA Alkylator/Crosslinker (12) DNA Methyltransferase (5) DNA Stain (2) DNA/RNA Synthesis (30) Drug Derivative (5) Drug Intermediate (4) Drug Isomer (1) Drug Metabolite (3) E1/E2/E3 Enzyme (6) EGFR (5) Endogenous Metabolite (41) Epigenetic Reader Domain (2) ERK (1) Ferroptosis (8) FGFR (3) Fluorescent Dye (5) Fungal (14) Gli (1) GLUT (2) Glutamate Dehydrogenase (GLDH) (1) GSK-3 (1) HCV (2) HDAC (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (3) Histone Acetyltransferase (4) Histone Demethylase (2) Histone Methyltransferase (3) HIV (9) HPV (2) HSP (1) HSV (3) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Insecticide (1) Integrin (1) Interleukin Related (3) IRE1 (1) Isotope-Labeled Compounds (47) JAK (3) JNK (2) Keap1-Nrf2 (2) Kinesin (1) Ligands for Target Protein for PROTAC (2) LPL Receptor (1) MDM-2/p53 (8) Microtubule/Tubulin (3) MMP (2) mTOR (5) nAChR (2) Necroptosis (1) NF-κB (9) NO Synthase (1) NOD-like Receptor (NLR) (1) Notch (2) Nucleoside Antimetabolite/Analog (15) Orthopoxvirus (4) P-glycoprotein (4) P2Y Receptor (2) p38 MAPK (3) p97 (2) Parasite (13) PARP (1) PD-1/PD-L1 (1) PERK (1) PGC-1α (4) Phosphatase (7) PI3K (3) Pim (1) PKC (6) Potassium Channel (6) PROTACs (2) Proteasome (1) Quinone Reductase (2) Ras (6) Reactive Oxygen Species (7) Reference Standards (1) RET (1) Reverse Transcriptase (1) RUNX (1) SARS-CoV (4) Ser/Thr Kinase (1) Ser/Thr Protease (2) SGLT (2) SHP1 (2) SHP2 (2) SOS1 (2) Src (1) STAT (5) Stearoyl-CoA Desaturase (SCD) (1) Syk (1) TET Protein (3) TNF Receptor (2) Topoisomerase (10) VDAC (1) VEGFR (1) Virus Protease (1) Wnt (4) YAP (1) β-catenin (3)
By Research Areas:	Cancer (260) Cardiovascular Disease (11) Endocrinology (2) Infection (51) Inflammation/Immunology (57) Metabolic Disease (23) Neurological Disease (37)

By Targets:

5-HT Receptor (2)

ADC Linker (1)

Adenosine Kinase (1)

Adenosine Receptor (1)

Akt (6)

Amino Acid Derivatives (1)

Aminopeptidase (2)

AMPK (4)

Angiotensin Receptor (1)

Antibiotic (19)

Antifolate (3)

Apoptosis (84)

Arp2/3 Complex (2)

Aryl Hydrocarbon Receptor (2)

Atg4 (1)

ATP Synthase (2)

Autophagy (27)

Bacterial (32)

Bcl-2 Family (1)

Bcr-Abl (3)

BCRP (2)

Biochemical Assay Reagents (8)

c-Myc (2)

Calcium Channel (8)

Carbonic Anhydrase (1)

Caspase (3)

CCR (1)

CDK (4)

Checkpoint Kinase (Chk) (3)

Chloride Channel (4)

Claudin (2)

COX (17)

Cuproptosis (1)

CXCR (1)

Cytochrome P450 (3)

Deubiquitinase (2)

Dipeptidyl Peptidase (2)

DNA Alkylator/Crosslinker (12)

DNA Methyltransferase (5)

DNA Stain (2)

DNA/RNA Synthesis (30)

Drug Derivative (5)

Drug Intermediate (4)

Drug Isomer (1)

Drug Metabolite (3)

E1/E2/E3 Enzyme (6)

EGFR (5)

Endogenous Metabolite (41)

Epigenetic Reader Domain (2)

ERK (1)

Ferroptosis (8)

FGFR (3)

Fluorescent Dye (5)

Fungal (14)

Gli (1)

GLUT (2)

Glutamate Dehydrogenase (GLDH) (1)

GSK-3 (1)

HCV (2)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (2)

Histamine Receptor (3)

Histone Acetyltransferase (4)

Histone Demethylase (2)

Histone Methyltransferase (3)

HIV (9)

HPV (2)

HSP (1)

HSV (3)

iGluR (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (4)

Insecticide (1)

Integrin (1)

Interleukin Related (3)

IRE1 (1)

Isotope-Labeled Compounds (47)

JAK (3)

JNK (2)

Keap1-Nrf2 (2)

Kinesin (1)

Ligands for Target Protein for PROTAC (2)

LPL Receptor (1)

MDM-2/p53 (8)

Microtubule/Tubulin (3)

MMP (2)

mTOR (5)

nAChR (2)

Necroptosis (1)

NF-κB (9)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Notch (2)

Nucleoside Antimetabolite/Analog (15)

Orthopoxvirus (4)

P-glycoprotein (4)

P2Y Receptor (2)

p38 MAPK (3)

p97 (2)

Parasite (13)

PARP (1)

PD-1/PD-L1 (1)

PERK (1)

PGC-1α (4)

Phosphatase (7)

PI3K (3)

Pim (1)

PKC (6)

Potassium Channel (6)

PROTACs (2)

Proteasome (1)

Quinone Reductase (2)

Ras (6)

Reactive Oxygen Species (7)

Reference Standards (1)

RET (1)

Reverse Transcriptase (1)

RUNX (1)

SARS-CoV (4)

Ser/Thr Kinase (1)

Ser/Thr Protease (2)

SGLT (2)

SHP1 (2)

SHP2 (2)

SOS1 (2)

Src (1)

STAT (5)

Stearoyl-CoA Desaturase (SCD) (1)

Syk (1)

TET Protein (3)

TNF Receptor (2)

Topoisomerase (10)

VDAC (1)

VEGFR (1)

Virus Protease (1)

Wnt (4)

YAP (1)

β-catenin (3)

By Research Areas:

Cancer (260)

Cardiovascular Disease (11)

Endocrinology (2)

Infection (51)

Inflammation/Immunology (57)

Metabolic Disease (23)

Neurological Disease (37)

415

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120782

Yhhu-3792	Notch	Neurological Disease
Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction .

HY-15036

Diclofenac 15+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15038

Diclofenac potassium 15+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036A

Diclofenac diethylamine 15+ Cited Publications	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15037

Diclofenac Sodium 15+ Cited Publications GP 45840	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-101796

NSC-70220	Ras SOS1	Cancer
NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect .

HY-153719

NSC111552	SARS-CoV	Infection
NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM .

HY-120782A

Yhhu-3792 hydrochloride	Notch	Neurological Disease
Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Yhhu-3792 hydrochloride has the potential for the research of impairment of learning and memory associated DG dysfunction .

HY-15038R

Diclofenac (potassium) (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (potassium) (Standard) is the analytical standard of Diclofenac (potassium). This product is intended for research and analytical applications. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036R

Diclofenac (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (Standard) is the analytical standard of Diclofenac. This product is intended for research and analytical applications. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15036AR

Diclofenac (diethylamine) (Standard)	COX Apoptosis	Inflammation/Immunology Cancer
Diclofenac (diethylamine) (Standard) is the analytical standard of Diclofenac (diethylamine). This product is intended for research and analytical applications. Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-160638

NSC-311068	TET Protein	Cancer
NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1 .

HY-117481

NSC-639829	Apoptosis	Cancer
NSC-639829 is a Benzoylphenylurea (BPU) analogue which has antitumor activity. NSC-639829 is promising for research of refractory metastatic cancer .

HY-164402

NSC-124854	DNA/RNA Synthesis	Cancer
NSC-124854 is a DNA polymerase β (Pol-β) inhibitor with an IC₅₀ of 5.3 μM. NSC-124854 has antitumor activity .

HY-117831

NSC-79887	Bacterial Antibiotic Endogenous Metabolite	Infection
NSC-79887 is a nucleoside hydrolase (NH) inhibitor with activity against Bacillus anthracis. NSC-79887 is considered a good candidate inhibitor of nucleoside hydrolases for biological testing and further development. The pharmacokinetic (ADMET) prediction of NSC-79887 showed that all physicochemical parameters were within the acceptable range for human use .

HY-114557R

NSC 90469 (Standard)	Endogenous Metabolite	Metabolic Disease
NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 is an endogenous metabolite.

HY-B1476R

NSC 42196 (Standard)	Endogenous Metabolite	Metabolic Disease
NSC 42196 (Standard) is the analytical standard of NSC 42196. This product is intended for research and analytical applications. NSC 42196 is an endogenous metabolite.

HY-19539

NSC-658497	SOS1 Ras	Cancer
NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation .

HY-15432

*(E/Z)-NSC-687852* (E/Z)-b-AP15	Deubiquitinase	Cancer
(E/Z)-NSC-687852 is a isomer of NSC-687852 (HY-13989). NSC687852 (b-AP15) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 .

HY-123395

NSC-84096	Endogenous Metabolite	Neurological Disease
NSC-84096 is an endopeptidase activity inhibitor with the ability to inhibit the activity of botulinum neurotoxin type A light chain (rBoNT/A-LC). NSC-84096 is able to effectively inhibit the enzymatic activity of botulinum neurotoxin in vitro, indicating its potential in inhibiting botulism. The mechanism of action of NSC-84096 may provide hope for the development of small molecule compounds targeting these deadly toxins .

HY-134309

NSC 288387	Virus Protease	Infection
NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC₅₀ of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture .

HY-19387

Didox 10+ Cited Publications NSC-324360	DNA/RNA Synthesis	Cancer
Didox (NSC-324360) is a synthetic ribonucleotide reductase (RR) inhibitor.

HY-Y0124S

NSC 16590-d6 α,α-Dimethylglycine-d₆; α-Aminoisobutanoic acid-d₆	Isotope-Labeled Compounds Endogenous Metabolite	Others
NSC 16590-d₆ is the deuterium labeled NSC 16590. NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-122069

NSC177365 NSC 1	Bacterial	Infection Neurological Disease Cancer
NSC177365 (NSC 1) is a CcrM inhibitor. NSC177365 is a competitive DNA inhibitor and disrupts DNA binding. NSC177365 has antibacterial activity, with IC₅₀s of 2.3 and 14.6 μM for C. crescentus and M. lincolnii respectively. NSC177365 reverses several neurodegenerative disorders and serve as an anticancer agent .

HY-122258

NSC-370284	STAT TET Protein	Cancer
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 .

HY-Y0124R

NSC 16590 (Standard)	Endogenous Metabolite	Others
NSC 16590 (Standard) is the analytical standard of NSC 16590. This product is intended for research and analytical applications. NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-18594

NSC-41589	Drug Derivative	Others
NSC-41589 is N-[2-(methylsulfanyl) phenyl]acetamide.

HY-152168

NSC 295642	PERK Phosphatase	Cancer
NSC 295642 is a phosphatase inhibitor. NSC 295642 can significantly increase phospho-Erk cytonuclear differences in intact cells. NSC 295642 can be used for the research of cancer .

HY-16933

L-Alanosine 1 Publications Verification NSC-153353; SDX-102	Antibiotic DNA/RNA Synthesis	Infection Cancer
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP) .

HY-Y0219S1

1,2,4-Triazole-d3 s-Triazole-d₃; Pyrrodiazole-d₃	Isotope-Labeled Compounds	Others
NSC 83128-d₃ is the deuterium labeled NSC 83128 .

HY-Y0226S1

NSC 1940-d8	Isotope-Labeled Compounds	Others
NSC 1940-d₈ is the deuterium labeled NSC 1940 .

HY-Y1675S

NSC 65593-d4 m-Acetylanisole-d₄; m-Methoxyacetophenone-d₄	Isotope-Labeled Compounds	Others
NSC 65593-d₄ is the deuterium labeled NSC 65593 .

HY-Y0226S2

NSC 1940-d4	Isotope-Labeled Compounds	Others
NSC 1940-d₄ is the deuterium labeled NSC 1940 .

HY-Y0093S

NSC 5416-d14 α,ω-Nonanediol-d₁₄; 1,9-Dihydroxynonane-d₁₄; Nonamethylene Glycol-d₁₄	Isotope-Labeled Compounds	Others
NSC 5416-d₁₄ is the deuterium labeled NSC 5416 .

HY-Y0085S

NSC 190686-d3 3,4-Difluorobenzoic acid-d₃	Isotope-Labeled Compounds	Others
NSC 190686-d₃ is the deuterium labeled NSC 190686 .

HY-Y0251S

3-Nitrophthalic acid-d3 m-Nitrophthalic acid-d₃; o-Nitrophthalic acid-d₃	Isotope-Labeled Compounds	Others
NSC 3120-d₃ is the deuterium labeled NSC 3120 .

HY-52155S

NSC 89275-d12	Isotope-Labeled Compounds	Others
NSC 89275-d₁₂ is the deuterium labeled NSC 89275 .

HY-Y1630S

NSC 10281-d4 Para-fluoronitrobenzene-d₄; p-Fluoronitrobenzene-d₄; p-Nitrofluorobenzene-d₄	Isotope-Labeled Compounds	Others
NSC 10281-d₄ is the deuterium labeled NSC 10281 .

HY-145330

NSC639828	DNA/RNA Synthesis	Cancer
NSC639828 is a potent inhibitor of DNA polymerase α with an IC₅₀ of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease .

HY-122101

NSC114792	JAK Apoptosis	Cancer
NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5 .

HY-114658

Daunomycinone NSC-109351	Biochemical Assay Reagents	Cancer
Daunomycinone (NSC-109351) is a metabolite of daunomycin. Daunomycin is an antibiotic with antitumor activity .

HY-168602

NSC-217913	E1/E2/E3 Enzyme	Cancer
NSC-217913 is an inhibitor of WWP1 with an IC₅₀ value of 158.3 μM .

HY-144444

NSC381467	EGFR	Cancer
NSC381467 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC381467 has strong antiproliferative activities. NSC381467 has the potential for the research of cancer diseases .

HY-144445

NSC114126	EGFR	Cancer
NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases .

HY-15827

NSC 405020 2 Publications Verification	MMP	Cardiovascular Disease Cancer
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis .

HY-129666

NSC-65847	Influenza Virus	Neurological Disease
NSC-65847 is a groundbreaking dual inhibitor targeting both viral neuraminidase and Streptococcus pneumoniae neuraminidase.

HY-141687

NSC 107512	CDK Apoptosis	Cancer
NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors .

HY-12929

NSC756093 SU093	Pim	Cancer
NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research .

HY-164497

NSC 641396	DNA/RNA Synthesis Histone Methyltransferase	Cancer
NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC₅₀ value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity .

HY-122066

NSC47924	Others	Infection
NSC47924 is a laminin receptor (LR) inhibitor. NSC47924 affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein. NSC47924 can be used for testing prion diseases .

Cat. No.	Product Name

HY-L013

Neuronal Signaling Compound Library

3,194 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 3,194 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Cat. No.	Product Name	Type

HY-15907

BBD NSC240867; Benzylamino-NBD	Chromogenic Assays
BBD (NSC240867) is a biochemical reagent/chromogenic reagent.

HY-121986

Yellow AB Solvent yellow 5	Dyes
Yellow AB (Solvent yellow 5) is an azo dye that can be used as food dye .

HY-123533

Resorufin NSC 12097	Fluorescent Dyes/Probes
Resorufin (NSC 12097) is a highly fluorescent pink dye. Resorufin shows favorable properties such as water solubility, red-shifted absorption/emission signals. Resorufin is used for the detection of ROS/RNS and a second analyte .

HY-123533A

Resorufin sodium salt NSC 12097 sodium salt	Fluorescent Dyes/Probes
Resorufin sodium salt (NSC 12097) is a highly fluorescent pink dye. Resorufin sodium salt shows favorable properties such as water solubility, red-shifted absorption/emission signals. Resorufin sodium salt is used for the detection of ROS/RNS and a second analyte .

HY-D0221

2,4,6-Tri-2-pyridinyl-1,3,5-triazine NSC 112125; 2,4,6-Tipyidyl-s-tiazie	Dyes
2,4,6-Tri-2-pyridinyl-1,3,5-triazine (NSC 112125) is a colorimetric reagent for detecting iron. 2,4,6-Tri-2-pyridinyl-1,3,5-triazine forms a complex with Fe (II) and can be quantified as a measure of iron concentration by colorimetric detection at 594 nm .

HY-W011422

2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone

NSC 528

Fluorescent Dyes/Probes

2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone (NSC 528) is a colorimetric dye used for the detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone reacts with phenolic compounds at a pH of about 9.4 to produce an indigo dye. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has also been used in a colorimetric reaction for the quantitative colorimetric detection of aflatoxins, turning the colorless aflatoxins green with an absorption band at 673 nm.

Cat. No.	Product Name	Target	Research Area

HY-W039756

Boc-Ala-Ala-OH NSC 334362	Amino Acid Derivatives	Others
Boc-Ala-Ala-OH (NSC 334362) is an Alanine derivative. Boc-Ala-Ala-OH is used in the preparation of anti-bacterial agent .

HY-W010955

Z-Phe-Leu-OH NSC 334018	Biochemical Assay Reagents	Others
Z-Phe-Leu-OH (NSC 334018) is a substrate for carboxypeptidase Y (CPY). Z-Phe-Leu-OH is incubated with recombinant CPY to determine peptidase activity .

HY-P4663

Val-Gly-Ser-Glu NSC 350591	Peptides	Cancer
Val-Gly-Ser-Glu (NSC 350591) is an ECF-A tetrapeptide. Val-Gly-Ser-Glu dose-dependently increases the number of human eosinophils, but not neutrophils, rosetting with complement-coated sheep erythrocytes (EAC3b) .

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

HY-P4631

Tryptophylalanine NSC 97949	Peptides	Others
Tryptophylalanine (NSC 97949) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4647

Tryptophyltryptophan NSC 524592	Peptides	Others
Tryptophyltryptophan (NSC 524592) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4644

Tryptophylleucine NSC 286600	Peptides	Others
Tryptophylleucine (NSC 286600) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5024

Cbz-Ile-Pro-OH NSC 333754	Peptides	Others
Cbz-Ile-Pro-OH (NSC 333754) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5012

Cbz-Glu-Gly-OH NSC 186902	Peptides	Others
Cbz-Glu-Gly-OH (NSC 186902) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4711

N-β-Alanyl-β-alanine NSC 97926	Peptides	Others
N-β-Alanyl-β-alanine (NSC 97926) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Cat. No.	Product Name	Target	Research Area

HY-16189

Elliptinium acetate NSC 264137; Celiptium	DNA Stain	Cancer
Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4277

Methyl protogracillin NSC-698793	Other Terpenoids other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Methyl protogracillin (NSC-698793), isolated from the roots of Dioscorea opposite Thunb, exhibits strong anti-cancer activity .

HY-B1476

NSC 42196	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
NSC 42196 is an endogenous metabolite.

HY-Y0057

NSC 13138 Cinchoninic acid (6CI,7CI,8CI); 4-Carboxyquinoline	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 13138 is an endogenous metabolite.

HY-114557

NSC 90469 3,5-Diiodo-L-thyronine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 90469 is an endogenous metabolite.

HY-13555

β-Lapachone 5+ Cited Publications ARQ-501; NSC-26326	Quinones Structural Classification other families Classification of Application Fields Source classification Plants Naphthalene Quinones Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO) Topoisomerase Autophagy Apoptosis
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-13764

Tetrandrine 10+ Cited Publications NSC-77037; d-Tetrandrine	Stephania tetrandra S. Moore Alkaloids Structural Classification Classification of Application Fields Source classification Plants Menispermaceae Inflammation/Immunology Disease Research Fields Alkaloid Dimers	Calcium Channel Potassium Channel Parasite
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca ²⁺ current (ICa) and Ca ²⁺-activated K ⁺ current.

HY-Y1644

(E)-Crotonic acid (E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .

HY-114557R

NSC 90469 (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 is an endogenous metabolite.

HY-B1476R

NSC 42196 (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
NSC 42196 (Standard) is the analytical standard of NSC 42196. This product is intended for research and analytical applications. NSC 42196 is an endogenous metabolite.

HY-Y0124R

NSC 16590 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Pterocarpus soyauxii Taub. Source classification Plants Compositae Endogenous metabolite	Endogenous Metabolite
NSC 16590 (Standard) is the analytical standard of NSC 16590. This product is intended for research and analytical applications. NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-118724

Laetrile NSC103055; Mandelonitrile beta-glucuronide	Structural Classification Natural Products Source classification Rosaceae Plants Rosa multifoloraThunb	Others
Laetrile (NSC103055) is a natural product .

HY-B0504

Creatinine 5+ Cited Publications NSC13123	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Creatinine (NSC13123) is a breakdown product of creatine phosphate in muscles.

HY-Y0124

NSC 16590 α,α-Dimethylglycine; α-Aminoisobutanoic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Pterocarpus soyauxii Taub. Source classification Other Diseases Plants Compositae Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-N0004

Oridonin 15+ Cited Publications NSC-250682; Isodonol	Infection Structural Classification Classification of Application Fields Terpenoids Labiatae Diterpenoids Emilia sonchifolia (L.) DC. Plants Inflammation/Immunology Disease Research Fields	Akt Bacterial
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC₅₀s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

HY-N1903

NSC 648342 4-Hydroxysapriparaquinone	Quinones Structural Classification Labiatae Source classification Soroseris hookeriana (C. B. Clarke) Stebbins Plants Naphthalene Quinones	Others
NSC 648342 (4-Hydroxysapriparaquinone) is a product that can be isolated from .

HY-N1293

Serpentinine NSC72123	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Structural Classification Alkaloids Rauvolfia serpentina Source classification Plants Indole Alkaloids	Others
Serpentinine (NSC72123) is an alkaloid isolated from Rauwolfia serpentina Benth .

HY-13764R

Tetrandrine (Standard)	Stephania tetrandra S. Moore Alkaloids Structural Classification Source classification Plants Menispermaceae Alkaloid Dimers	Calcium Channel Potassium Channel Parasite
Tetrandrine (Standard) is the analytical standard of Tetrandrine. This product is intended for research and analytical applications. Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-N3738

Demethoxycentaureidin NSC 689466	Structural Classification Flavonoids Flavones Source classification Plants Compositae Dolichos trilobus Houtt.	Others
Demethoxycentaureidin (NSC 689466) is a natural product that can be isolated from Peucephyllum schottii .

HY-15733

Lucidin 1 Publications Verification NSC 30546	Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Rubiaceae Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Cancer	HPV Caspase Apoptosis
Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.

HY-N4284

Angelicolide NSC 382182	Structural Classification Natural Products Source classification Umbelliferae Plants Echinacea angustifolia DC.	Others
Angelicolide (NSC 382182) is a Phenols product that can be isolated from the herbs of Schisandra propinqua .

HY-N12219

Pyridindolol NSC 266530	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	Endogenous Metabolite
Pyridindolol (NSC 266530) is a β-galactosidase inhibitor. Pyridindolol can be produced by actinomycetes .

HY-N1297

Sesartemin NSC380470	Structural Classification Araceae Source classification Lignans Rhaphidophora decursiva (Roxb.) Schott Phenylpropanoids Plants	Others
Sesartemin (NSC380470) is a Xanthones product that can be isolated from the stem barks of Calophyllum inophyllum. .

HY-N3272

Methyl levulinate Methyl β-acetylpropionate; NSC 24874	Apocynaceae Structural Classification Natural Products Source classification Rauvolfia vomitoria Afzel. Plants	Others
Methyl levulinate (NSC 24874) is a Alkaloids product that can be isolated from the stems and leaves of Ervatamia hainanensis. .

HY-N3766

Diosbulbin G NSC 310635	Structural Classification Terpenoids Source classification Diterpenoids Plants Dioscorea bulbifera Linn. Dioscoreaceae	Others
Diosbulbin G (NSC 310635) is a Diterpenoids product that can be isolated from the barks of Pinus massoniana Lamb. .

HY-N3655

Cyclo(D-Phe-L-Pro) NSC 255998	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Others
Cyclo(D-Phe-L-Pro) (NSC 255998) is a flavonoid product that can be isolated from Rhododendron mucronulatum .

HY-19543

Brusatol Maximum Cited Publications 32 Publications Verification NSC 172924	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	Keap1-Nrf2 Apoptosis
Brusatol (NSC?172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

HY-N0004R

Oridonin (Standard)	Structural Classification Terpenoids Labiatae Diterpenoids Emilia sonchifolia (L.) DC. Plants	Akt Bacterial
Oridonin (Standard) is the analytical standard of Oridonin. This product is intended for research and analytical applications. Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Tournefortia argentea Linnaeus f. Source classification Plants Boraginaceae Disease Research Fields Cancer	Microtubule/Tubulin
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-N10687

Saprorthoquinone NSC 648341	Quinones Structural Classification Labiatae Source classification Plants Naphthalene Quinones Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells .

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis
Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.

HY-N1766

3',4',5',3,5,6,7-Heptamethoxyflavone NSC 684433	Structural Classification Flavonoids Flavones Source classification Rutaceae Plants Citrus sinensis (L.) Osbeck	Others
3',4',5',3,5,6,7-Heptamethoxyflavone (NSC 684433) is a product that can be isolated from .

HY-B0504R

Creatinine (Standard)	Infection Structural Classification Natural Products Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Creatinine (Standard) is the analytical standard of Creatinine. This product is intended for research and analytical applications. Creatinine (NSC13123) is a breakdown product of creatine phosphate in muscles.

HY-114502

Chrysanthemic acid NSC 11779	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Compositae Phaseolus lunatus Billb. ex Beurl.	Insecticide
Chrysanthemic acid (NSC 11779) is an organic compound that is associated with a variety of natural and synthetic insecticides for the prevention of insect-borne diseases, among others .

HY-N0837R

Veratramine (Standard) NSC17821 (Standard); NSC23880 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification other families Source classification Plants	PI3K Akt mTOR Autophagy Apoptosis
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy .

HY-B1777

Spermine 4 Publications Verification NSC 268508; Neuridine	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Influenza Virus
Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

HY-114772

Methyl reserpate NSC 81464; Me reserpate	Apocynaceae Structural Classification Alkaloids Source classification Rauvolfia vomitoria Afzel. Plants	Others
Methyl reserpate (NSC 81464) is a Yohimbine (HY-12715) type alkaloid, that can be isolated from Rauwolfia vomitoria roots and leaves .

HY-N4315

Pomiferin 1 Publications Verification NSC 5113	Classification of Application Fields Source classification Phenols Polyphenols Maclura pomifera (Raf.) Schneid. Plants Moraceae Disease Research Fields Cancer	HDAC mTOR
Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC₅₀ of 1.05 μM, and also potently inhibits mTOR (IC₅₀, 6.2 µM).

HY-105697

Protoveratrine A NSC 7526; Protalba; Protoveratrin	Structural Classification Alkaloids Piperidine Alkaloids Veratrum nigrum Linn. Liliaceae Source classification Plants	Glutamate Dehydrogenase (GLDH)
Protoveratrine A (NSC 7526; Protalba; Protoveratrin) is an alkaloid with strong cardiostimulant and vasoconstrictive effects, which can be used in the study of hypertension and other cardiovascular diseases .

HY-118166

Gentisein NSC 329491; 1,3,7-Trihydroxyxanthone	other families Xanthones Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	5-HT Receptor
Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC₅₀ value of 4.7 µM .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Steroids	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-N1393

2-Methoxybenzoic acid NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.

HY-15733R

Lucidin (Standard) NSC 30546 (Standard)	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Phenols Polyphenols Plants Rubia cordifolia L.	HPV Caspase Apoptosis
Lucidin (Standard) is the analytical standard of Lucidin. This product is intended for research and analytical applications. Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.

HY-79494

Glyoxalic acid (50% in water) 2 Publications Verification NSC 27785; Formylformic acid; Oxalaldehydic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glyoxalic acid (NSC 27785) (50% in water) is an organic compound that is both an aldehyde and a carboxylic acid. Glyoxalic acid (50% in water) induces fluorescence. Glyoxalic acid (50% in water) is used to study neurons .

HY-N1375

Qingyangshengenin	Monophenols Classification of Application Fields Source classification Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Cancer	Others
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-125461

Altersolanol A Stemphylin; NSC 173943	Quinones Structural Classification Taxaceae Source classification Benzene Quinones Plants Taxus wallichiana Zucc.	Bacterial
Altersolanol A (Stemphylin; NSC 173943) exhibits antimicrobial activities against Bacillus subtilis and Pseudomonas aeruginosa, with MIC of 25-100 μg/mL. Altersolanol A exhibits no phytotoxicity to Taxus (at dose of 4 μg/μL) .

HY-101413

Iberin 1 Publications Verification NSC 321801	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Bacterial
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC₅₀ of 2.3 μM in HL60 cell. Iberin induces apoptosis.

HY-B1777R

Spermine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Influenza Virus
Spermine (Standard) is the analytical standard of Spermine. This product is intended for research and analytical applications. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.

Cat. No.	Product Name	Chemical Structure

HY-Y1630S

NSC 10281-d4
NSC 10281-d₄ is the deuterium labeled NSC 10281 .

HY-Y0124S

NSC 16590-d6
NSC 16590-d₆ is the deuterium labeled NSC 16590. NSC 16590 inhibits the production of endogenous ethylene in the cotyledonary segments of cocklebur.

HY-Y0219S1

1,2,4-Triazole-d3
NSC 83128-d₃ is the deuterium labeled NSC 83128 .

HY-Y0226S1

NSC 1940-d8
NSC 1940-d₈ is the deuterium labeled NSC 1940 .

HY-Y1675S

NSC 65593-d4
NSC 65593-d₄ is the deuterium labeled NSC 65593 .

HY-Y0226S2

NSC 1940-d4
NSC 1940-d₄ is the deuterium labeled NSC 1940 .

HY-Y0093S

NSC 5416-d14
NSC 5416-d₁₄ is the deuterium labeled NSC 5416 .

HY-Y0085S

NSC 190686-d3
NSC 190686-d₃ is the deuterium labeled NSC 190686 .

HY-Y0251S

3-Nitrophthalic acid-d3
NSC 3120-d₃ is the deuterium labeled NSC 3120 .

HY-52155S

NSC 89275-d12
NSC 89275-d₁₂ is the deuterium labeled NSC 89275 .

HY-Y0219S

1,2,4-Triazole-13C2,15N3
NSC 83128- ¹³C₂, ¹⁵N₃ is the ¹³C and ¹⁵N labeled NSC 83128 .

HY-17393S

Carboplatin-d4
Carboplatin-d₄ is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

HY-W654342

Spermine-d20
Spermine-d₂₀ (NSC 268508-d₂₀) is deuterium labeled Spermine. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects .

HY-W017475S

4-Nitrobenzonitrile-d4
4-Nitrobenzonitrile-d₄ is the deuterium labeled NSC 88911 .

HY-W022039S

(Benzyloxy)benzene-d2
(Benzyloxy)benzene-d2 (NSC 77971-d2) is the deuterium labeled Benzyloxybenzene (HY-W022039) .

HY-123533S

Resorufin-d6
Resorufin-d₆ is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte .

HY-W016389S

9H-Fluoren-2-ol-d9
9H-Fluoren-2-ol-d₉ (NSC 31248-d₉) is a deuterium labeled compound.

HY-N0055S

Chlorogenic acid-13C3

Chlorogenic acid- ¹³C₃ (Heriguard- ¹³C₃; NSC-407296- ¹³C₃) is ¹³C- and ¹⁵N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .

HY-B0504S1

Creatinine-13C
Creatinine- ¹³C is the ¹³C-labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

HY-W779017

Thymidine-13C5
Thymidine- ¹³C₅ (DThyd- ¹³C₅; NSC 21548- ¹³C₅) is ¹³C-labeled Thymidine (HY-N1150) .

HY-B0504S2

Creatinine-d5
Creatinine-d₅ is the deuterium labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body .

HY-N5034S

Phosphorylethanolamine-d4
Phosphorylethanolamine-d₄ (Monoaminoethyl phosphate-d₄; NSC 254167-d₄) is a deuterium labeled Phosphorylethanolamine (HY-N5034). Phosphorylethanolamine is an endogenous metabolite.

HY-W050026S

Phenylacetylglutamine-d5 2 Publications Verification
Phenylacetylglutamine-d₅ (NSC 203800-d₅) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .

HY-B0246S3

Carbamazepine-(Ph)d8
Carbamazepine-(Ph)d8 (CBZ-(Ph)d8; NSC 169864-(Ph)d8) is the deuterium labeled Carbamazepine-(Ph) (HY-B0246) .

HY-W654270A

(rac)-Calcium N5-methyltetrahydrofolate-d3
(rac)-Calcium N5-methyltetrahydrofolate-d₃ ((rac)-NSC173328-d₃) is a deuterium labeled (rac)-Calcium N5-methyltetrahydrofolate.

HY-B0246S4

Carbamazepine-d4
Carbamazepine-d4 (CBZ-d4; NSC 169864-d4) is the deuterium labeled Carbamazepine-d4 (HY-B0246S4) .

HY-B0139S

Flucytosine-13C,15N2
Flucytosine- ¹³C, ¹⁵N₂ (NSC 103805- ¹³C, ¹⁵N₂; Ro 2-9915- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Flucytosine (HY-B0139).

HY-14655S

Sulfasalazine-d4
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-N1393S

2-Methoxybenzoic acid-13C6
2-Methoxybenzoic acid- ¹³C₆ is the ¹³C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.

HY-N1393S1

2-Methoxybenzoic acid-d3
2-Methoxybenzoic acid-d₃ (NSC 3778-d₃; O-Methylsalicylic acid-d₃; Salicylic acid methyl ether-d₃) is deuterium-labeled 2-Methoxybenzoic acid (HY-N1393) .

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-14655S1

Sulfasalazine-d3,15N
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-Y0484S

1-Indanamine-d9 hydrochloride
1-Indanamine-d₉ (1-Aminoindan-d₉; 1-Aminoindane-d₉; NSC 186227-d₉; 1-Aminoindane-d₉) hydrochloride is deuterium-labeled 1-Indanamine hydrochloride (HY-Y0484) .

HY-N1150S10

Thymidine-d14
Thymidine-d₁₄ (DThyd-d₁₄; NSC 21548-d₁₄) is deuterium labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-N1150S11

Thymidine-13C10
Thymidine- ¹³C₁₀ (DThyd- ¹³C₁₀; NSC 21548- ¹³C₁₀) is ¹³C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-17364S

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-13768S1

Topotecan-d6
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-N6703S

ar-Turmerone-d3

ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

HY-A0004S

Decitabine-13C5

Decitabine- ¹³C₅ (5-Aza-2'-deoxycytidine- ¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-B0678S

Metaxalone-d3

Metaxalone-d₃ is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-B0678S1

Metaxalone-d6

Metaxalone-d₆ is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-W653962

Triclosan-13C6

Triclosan- ¹³C₆ is ¹³C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-W747491

Triclosan-13C12

Triclosan- ¹³C₁₂ is ¹³C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

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