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NP

" in MedChemExpress (MCE) Product Catalog:

95

Inhibitors & Agonists

1

Fluorescent Dye

6

Biochemical Assay Reagents

26

Peptides

1

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2

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7

Natural
Products

51

Recombinant Proteins

5

Isotope-Labeled Compounds

12

Antibodies

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129496

    Thrombin Cardiovascular Disease
    NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca 2+ inward flow .
    NP-313
  • HY-150270A

    P2X Receptor Neurological Disease Inflammation/Immunology
    NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions .
    NP-1815-PX sodium
  • HY-169996

    NOD-like Receptor (NLR) Neurological Disease Inflammation/Immunology
    NP3-253 is an NLRP3 inhibitor with oral activity and blood-brain barrier permeability, and NP3-253 can serve as a tool to further investigate the biological characteristics of NLRP3 in peripheral and neuroinflammatory model .
    NP3-253
  • HY-163159

    NOD-like Receptor (NLR) Inflammation/Immunology
    NP3-562 is a potent, orally active, tricyclic NLRP3 Inhibitor, with an IC50 of 214 nM. NP3-562 (30 mg/kg, p.o.) inhibits IL-1β release in a mouse acute peritonitis model .
    NP3-562
  • HY-B0370
    Tolnaftate
    2 Publications Verification

    NP-27

    Fungal Infection
    Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
    Tolnaftate
  • HY-163017

    Opioid Receptor Neurological Disease
    NP-5497-KA is a κ-opioid receptor agonist. NP-5497-KA has orally activity[1].
    NP-5497-KA
  • HY-P3981

    NP-3A; Corticostatin 1, rabbit

    Bacterial Melanocortin Receptor Neurological Disease
    Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity .
    Defensin NP-3A
  • HY-150270

    P2X Receptor Neurological Disease Inflammation/Immunology
    NP-1815-PX is a potent and selective P2X4R antagonist. NP-1815-PX has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions .
    NP-1815-PX
  • HY-19053

    Calcium Channel Cardiovascular Disease
    NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats .
    NP-252
  • HY-126810

    Fungal Infection
    NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections .
    NP213
  • HY-P991427

    Apoptosis Cancer
    NP137 is a human IgG1 monoclonal antibody (mAb) targeting Netrin-1. NP137 inhibits the binding of netrin-1 to its receptor UNC5H2 (IC50: 0.5 nM). NP137 activates caspase 3 to induce apoptosis. NP137 can be used in solid tumors and hematologic malignancies research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
    NP137
  • HY-163540

    Aminoacyl-tRNA Synthetase Fungal Infection
    NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC50 of 6.25 μM .
    NP-BTA
  • HY-148825

    iGluR Histamine Receptor Potassium Channel Cytochrome P450 Adrenergic Receptor Metabolic Disease Inflammation/Immunology Cancer
    NP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC50s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC50s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes .
    NP10679
  • HY-126810A

    Fungal Infection
    NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
    NP213 TFA
  • HY-NP137

    Complement System Others
    NP-PE (Phycoerythrin) is an immune complex. The formation and transport of NP-PE (Phycoerythrin) depends on the complement system, specifically through the complement receptors CR1 and CR2. These receptors are expressed on the surface of B cells and help B cells capture and transport immune complexes. NP-PE (Phycoerythrin) can be used to study the mechanisms by which B cells capture and transport immune complexes in lymph nodes .
    NP-PE (Phycoerythrin)
  • HY-B0370R

    NP-27 (Standard)

    Reference Standards Fungal Infection
    Tolnaftate (Standard) is the analytical standard of Tolnaftate. This product is intended for research and analytical applications. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
    Tolnaftate (Standard)
  • HY-125506
    NP-G2-044
    5 Publications Verification

    β-catenin Cancer
    NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response .
    NP-G2-044
  • HY-145087A

    NOD-like Receptor (NLR) Inflammation/Immunology
    NP3-146 sodium is a NLRP3 inflammasome inhibitor (WO2016131098 (N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2- l)furan-2-sulfonamide)) .
    NP3-146 sodium
  • HY-112353

    Endogenous Metabolite Others
    NP603 is a potent inhibitor of FGF receptor 1, exhibiting remarkable activity against endothelial proliferation in HUVEC cells stimulated by rhFGF-2, with a minimum effective dose of 0.4 microM.
    NP603
  • HY-P1812
    AUNP-12
    3 Publications Verification

    NP-12

    PD-1/PD-L1 Cancer
    AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .
    AUNP-12
  • HY-NP133A

    4-Hydroxy-3-nitrophenylacetyl-Keyhole Limpet Hemocyanin,Type II

    Biochemical Assay Reagents Inflammation/Immunology
    NP-KLH,Type II (4-Hydroxy-3-nitrophenylacetyl-Keyhole Limpet Hemocyanin,Type II) is a 4-Hydroxy-3-nitrophenylacetyl (NP) hapten. NP-KLH,Type II can be used for study as a carrier protein in immunological research .
    NP-KLH,Type II
  • HY-P1812A
    AUNP-12 TFA
    3 Publications Verification

    NP-12 TFA

    PD-1/PD-L1 Cancer
    AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .
    AUNP-12 TFA
  • HY-14872
    Tideglusib
    5+ Cited Publications

    NP031112

    GSK-3 Neurological Disease
    Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3β WT (1 h preincubation) and GSK-3β C199A (1 h preincubation), respectively.
    Tideglusib
  • HY-14462

    39-1B4

    Calcium Channel Cardiovascular Disease
    NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.
    NP118809
  • HY-NP141

    4-Hydroxy-3-nitrophenylacetyl-bovine serum albumin

    Biochemical Assay Reagents Inflammation/Immunology
    NP-BSA (4-Hydroxy-3-nitrophenylacetyl-bovine serum albumin) is an antigen-adjuvant conjugate of 4-Hydroxy-3-nitrophenylacetyl (NP) conjugated to bovine serum albumin (BSA), which is an immune complex. By conjugating antigens to protein adjuvants, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and can enhance cross-presentation and the generation of antigen-specific T cells .
    NP-BSA
  • HY-12882
    Ifenprodil
    5+ Cited Publications

    NP-120; RC-61-91

    iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus Infection Neurological Disease
    Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .
    Ifenprodil
  • HY-12882A
    Ifenprodil tartrate
    5+ Cited Publications

    NP-120 tartrate; RC-61-91 tartrate

    iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus Infection Neurological Disease
    Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .
    Ifenprodil tartrate
  • HY-P1571

    NP 396

    Arenavirus Inflammation/Immunology
    Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .
    Nucleoprotein (396-404)
  • HY-P1571A

    NP 396 TFA

    Arenavirus Inflammation/Immunology
    Nucleoprotein (396-404) TFA is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) TFA is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .
    Nucleoprotein (396-404) (TFA)
  • HY-11012
    TDZD-8
    Maximum Cited Publications
    12 Publications Verification

    GSK-3β Inhibitor I; NP 01139

    GSK-3 Cancer
    TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II, PKA, and PKC, with all IC50s of >100 μM.
    TDZD-8
  • HY-145087

    NLRP3-IN-5

    NOD-like Receptor (NLR) Inflammation/Immunology
    NLRP3-IN-5 is a NLRP3 inflammasome inhibitor (WO2016131098 (N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2- l)furan-2-sulfonamide)) .
    NP3-146
  • HY-12882AR

    NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)

    iGluR Potassium Channel Neurological Disease
    Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .
    Ifenprodil tartrate (Standard)
  • HY-W013523
    2-NP
    5 Publications Verification

    STAT JAK HSV Infection Cancer
    2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells .
    2-NP
  • HY-136444R

    Biochemical Assay Reagents Reference Standards Others
    2-NP-AOZ (Standard) is the analytical standard of 2-NP-AOZ. This product is intended for research and analytical applications. 2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (HY-W012982, a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues .
    2-NP-AOZ (Standard)
  • HY-136444S

    Isotope-Labeled Compounds Others
    2-NP-AOZ-d4 is a deuterium labeled 2-NP-AOZ. 2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues .
    2-NP-AOZ-d4
  • HY-P5502

    Influenza Virus Others
    Influenza NP (311-325) is a biologically active peptide derived from the influenza virus nucleoprotein (NP). The NP protein is an MHC class II restricted epitope that elicits host immune responses during viral infection. Influenza NP (311-325) elicits the most potent interferon gamma (IFN-γ) production without stimulating CD8 T cells in mice.
    Influenza NP (311-325)
  • HY-131019

    mGluR Neurological Disease
    JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .
    JF-NP-26
  • HY-136456R

    Drug Metabolite Reference Standards Others
    2-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ .
    2-NP-AMOZ (Standard)
  • HY-136457R

    Drug Metabolite Reference Standards Others
    2-NP-AHD (Standard) is the analytical standard of 2-NP-AHD. This product is intended for research and analytical applications. 2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .
    2-NP-AHD (Standard)
  • HY-136456S

    Isotope-Labeled Compounds Others
    2-NP-AMOZ-d5 is deuterium labeled 2-NP-AMOZ. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ .
    2-NP-AMOZ-d5
  • HY-136444

    Drug Derivative Others
    2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (HY-W012982, a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues .
    2-NP-AOZ
  • HY-146966S

    Isotope-Labeled Compounds Others
    2-NP-DNSAH- 13C6 is the 13C6 labeled 2-NP-DNSAH.
    2-NP-DNSAH-13C6
  • HY-136457S

    Isotope-Labeled Compounds Others
    2-NP-AHD- 13C3 is the 13C labled 2-NP-AHD (HY-136457) . 2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .
    2-NP-AHD-13C3
  • HY-145882

    Fluorescent Dye Others
    BOD-NH-NP is an activatable fluorescent probe for imaging endogenous nitric oxide via the eNOS enzymatic pathway .
    BOD-NH-NP
  • HY-P1762

    Influenza Virus Infection
    Influenza NP (147-155) is a K d restricted epitope from influenza nucleoprotein .
    Influenza NP (147-155)
  • HY-P1857

    Influenza Virus Infection
    CEF7, Influenza Virus NP (380-388) is a HLA-B *08 restricted influenza virus nucleoprotein epitope. Influenza virus NP functions as a key adapter molecule between virus and host cell processes .
    CEF7, Influenza Virus NP (380-388)
  • HY-136456

    Drug Metabolite Others
    2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ .
    2-NP-AMOZ
  • HY-P1762A

    Influenza Virus Infection
    Influenza NP (147-155) TFA is a K d restricted epitope from influenza nucleoprotein .
    Influenza NP (147-155) (TFA)
  • HY-W142008

    Amino Acid Derivatives Others
    Fmoc-Tyr(SO3nP)-OH is a tyrosine derivative .
    Fmoc-Tyr(SO3nP)-OH
  • HY-136457

    Drug Metabolite Others
    2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .
    2-NP-AHD

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