Gold(III) chloride trihydrate

Name: Gold(III) chloride trihydrate
Brand: MedChemExpress
SKU: HY-W094581
Rating: 4.5 (1 reviews)

Cat. No.: HY-W094581 Purity: 99.9%: Data Sheet
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Gold (III) chloride trihydrate is a reducing agent. Gold (III) chromium trihydrate can be used for chemical synthesis of gold nanoparticles (NP) and spirochromene derivatives.

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Gold(III) chloride trihydrate Chemical Structure

CAS No. : 16961-25-4

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Description

Gold (III) chloride trihydrate is a reducing agent. Gold (III) chromium trihydrate can be used for chemical synthesis of gold nanoparticles (NP) and spirochromene derivatives^[1]^[2].

In Vitro

Gold nanoparticle synthesis method^[1]:
1. Prepare a 2.5 mM HAuCl₄·3H₂O solution by mixing 0.05 g of Gold(III) chloride trihydrate with 50 mL of deionized water.
2. Prepare a 6.6 mM sodium hydroxide (NaOH) solution by mixing 0.0264 g of NaOH with 100 mL of deionized water.
3. Control the pH of 10 mL of HAuCl₄·3H₂O solution by adding NaOH until the pH reaches 6.6. This process heats the solution to 85 °C for 30 minutes under vigorous stirring.
4. Prepare a 5 mM sodium citrate (C6H5Na3O7) solution by mixing 0.073 g of sodium citrate with 50 mL of deionized water.
5. Heat 10 mL of sodium citrate solution to about 85°C for about 20 minutes and add HAuCl₄·3H₂O solution after vigorous stirring to obtain a deep red gold nanoparticle solution.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

393.83

Formula

HAuCl₄.3H₂O

CAS No.

16961-25-4

Appearance

Solid

Color

Yellow to orange

SMILES

[H+].[Cl-][Au+3]([Cl-])([Cl-])[Cl-].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : ≥ 200 mg/mL (507.83 mM)

DMSO : 100 mg/mL (253.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5392 mL	12.6958 mL	25.3917 mL
5 mM	0.5078 mL	2.5392 mL	5.0783 mL
10 mM	0.2539 mL	1.2696 mL	2.5392 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (12.70 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (12.70 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.9%

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Data Sheet (270 KB) SDS (923 KB)

COA (243 KB)

Handling Instructions (2659 KB)

References

[1]. Ramos M, et al. Hardness and Elastic Modulus on Six-Fold Symmetry Gold Nanoparticles. Materials (Basel). 2013;6(1):198-205. Published 2013 Jan 14. [Content Brief]

[2]. Kidwai M, et al. Gold (III) chloride (HAuCl4• 3H2O) in PEG: A new and efficient catalytic system for the synthesis of functionalized spirochromenes[J]. Applied Catalysis A: General, 2012, 425: 35-43.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.5392 mL	12.6958 mL	25.3917 mL	63.4792 mL
	5 mM	0.5078 mL	2.5392 mL	5.0783 mL	12.6958 mL
	10 mM	0.2539 mL	1.2696 mL	2.5392 mL	6.3479 mL
	15 mM	0.1693 mL	0.8464 mL	1.6928 mL	4.2319 mL
	20 mM	0.1270 mL	0.6348 mL	1.2696 mL	3.1740 mL
	25 mM	0.1016 mL	0.5078 mL	1.0157 mL	2.5392 mL
	30 mM	0.0846 mL	0.4232 mL	0.8464 mL	2.1160 mL
	40 mM	0.0635 mL	0.3174 mL	0.6348 mL	1.5870 mL
	50 mM	0.0508 mL	0.2539 mL	0.5078 mL	1.2696 mL
	60 mM	0.0423 mL	0.2116 mL	0.4232 mL	1.0580 mL
	80 mM	0.0317 mL	0.1587 mL	0.3174 mL	0.7935 mL
	100 mM	0.0254 mL	0.1270 mL	0.2539 mL	0.6348 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.