Search Result

Results for "

M pro

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (7) Autophagy (1) Bacterial (1) Bcl-2 Family (2) c-Fms (1) Calcium Channel (1) Caspase (2) Cathepsin (6) Cholinesterase (ChE) (1) Collagen (1) COX (1) DNA/RNA Synthesis (3) Drug Intermediate (1) Drug Metabolite (1) EGFR (1) Ferroptosis (1) FLAP (2) HCV (2) HCV Protease (2) HDAC (2) HIV (1) IAP (1) IKK (1) Interleukin Related (2) Ligands for Target Protein for PROTAC (1) mAChR (3) MDM-2/p53 (1) Microtubule/Tubulin (1) MMP (1) Necroptosis (1) Neuropeptide Y Receptor (1) NF-κB (1) PDGFR (1) Phosphatase (1) Phospholipase (1) PROTACs (2) PTEN (1) Reactive Oxygen Species (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (62) Ser/Thr Protease (2) Src (1) Survivin (1) Thrombin (1) Topoisomerase (2) Transmembrane Glycoprotein (1) Virus Protease (21)
By Research Areas:	Cancer (17) Cardiovascular Disease (1) Infection (66) Inflammation/Immunology (19) Metabolic Disease (3) Neurological Disease (6)

By Targets:

Amyloid-β (1)

Apoptosis (7)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (2)

c-Fms (1)

Calcium Channel (1)

Caspase (2)

Cathepsin (6)

Cholinesterase (ChE) (1)

Collagen (1)

COX (1)

DNA/RNA Synthesis (3)

Drug Intermediate (1)

Drug Metabolite (1)

EGFR (1)

Ferroptosis (1)

FLAP (2)

HCV (2)

HCV Protease (2)

HDAC (2)

HIV (1)

IAP (1)

IKK (1)

Interleukin Related (2)

Ligands for Target Protein for PROTAC (1)

mAChR (3)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

MMP (1)

Necroptosis (1)

Neuropeptide Y Receptor (1)

NF-κB (1)

PDGFR (1)

Phosphatase (1)

Phospholipase (1)

PROTACs (2)

PTEN (1)

Reactive Oxygen Species (1)

Salt-inducible Kinase (SIK) (1)

SARS-CoV (62)

Ser/Thr Protease (2)

Src (1)

Survivin (1)

Thrombin (1)

Topoisomerase (2)

Transmembrane Glycoprotein (1)

Virus Protease (21)

By Research Areas:

Cancer (17)

Cardiovascular Disease (1)

Infection (66)

Inflammation/Immunology (19)

Metabolic Disease (3)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1130

M871 Galanin-(2-13)-Glu-His-(pro)3-(Ala-Leu)2-Ala-amide	Neuropeptide Y Receptor	Neurological Disease
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM and 420 nM for GalR2 and GalR1, respectively. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain) .

HY-152101

LY1	SARS-CoV	Infection
LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PL ^pro and M ^pro with K_d values of 1.5 μM and 2.3 μM for M ^pro C145A protein and PL ^pro C111A protein, respectively. LY1 potent against the viral proteases, with IC₅₀s of 0.12 μM and 0.99 μM against M ^pro and PL ^pro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme .

HY-144648

Mpro/PLpro-IN-1	SARS-CoV	Infection
Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of M ^pro/PL ^pro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus M ^pro (IC₅₀ = 1.72 μM) and submicromolar potency versus PL ^pro (IC₅₀ = 0.67 μM) .

HY-163389

Mpro/Cathepsin L-IN-1	SARS-CoV Cathepsin	Infection
Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M ^pro/hCatL inhibitor, with K_is of 5.54 μM and 0.701 μM respectively .

HY-172960

*SARS-CoV-2 Mpro-IN-44*	SARS-CoV Virus Protease	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-44 (Compound 25) is a broad-spectrum coronavirus main protease (Mpro) inhibitor. SARS-CoV-2 Mpro-IN-44 has inhibitory activity against a variety of high-risk coronaviruses (including SARS-CoV-2 and PEDV, etc.) (IC₅₀: < 0.6 μM). SARS-CoV-2 Mpro-IN-44 achieves broad-spectrum inhibition of coronaviruses by enhancing the interaction with the conserved sites of Mpro. SARS-CoV-2 Mpro-IN-44 can be used for anti-coronavirus drug development .

HY-161244

FGA145	SARS-CoV Cathepsin Virus Protease	Infection
FGA145 is a dual, selective inhibitor for M ^pro and human Cathepsin L, with K_is of 3.71 μM, 9.82 μM and 53 nM, for Mal-M ^pro, pET21-M ^pro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity .

HY-161245

FGA146	Virus Protease Cathepsin	Infection
FGA146 is a dual, selective inhibitor for M ^pro and human Cathepsin L, with K_is of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-M ^pro, pET21-M ^pro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2 .

HY-155136

NSC89641	SARS-CoV	Infection
NSC89641 inhibits MERS-CoV M ^pro, with an IC₅₀ value < 3.5 μM. NSC89641 exhibits the high inhibitory potency against SARS-CoV-2 M ^pro enzymatic activity, with an IC₅₀ of 3.05 μM .

HY-172965

*SARS-CoV-2 Mpro-IN-43*	SARS-CoV Virus Protease	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-43 (Compound 1) is a coronavirus main protease (Mpro) inhibitor (IC₅₀: 72 μM). SARS-CoV-2 Mpro-IN-43 interacts with key residues in the active site of Mpro via non-covalent binding, exerting its anti-coronavirus effect. SARS-CoV-2 Mpro-IN-43 exhibits moderate to low cytotoxicity, with CC₅₀ values of 13.24, 41.02, and 42.26 µM in HaCaT, HEK293T, and HepG2 cells, respectively. SARS-CoV-2 Mpro-IN-43 can be used in anti-SARS-CoV-2 research .

HY-154976

SARS-CoV-2-IN-50	SARS-CoV	Infection
SARS-CoV-2-IN-50 (Compound X77C) is a SARS-CoV-2 main protease (M ^Pro) inhibitor.. SARS-CoV-2-IN-50 has a high affinity to the catalytic site of M ^Pro .

HY-136298A

X77	SARS-CoV	Infection
X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-170598

HP211206	PROTACs SARS-CoV Virus Protease	Infection
HP211206 is a SARS-CoV-2 main protease (M ^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M ^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M ^pro. HP211206 has antiviral activity. (Pink: H117 (HY-170599); Black: linker (HY-B0236); Blue: E3 ligase ligand (HY-41547)) .

HY-P10858

UCI-1	SARS-CoV Virus Protease	Infection
UCI-1 is a SARS-CoV-2 main protease (M ^pro) cyclic peptide inhibitor with an IC₅₀ of 160 μM. UCI-1 shows no obvious cytotoxicity at the concentration of inhibiting M ^pro. UCI-1 can be used in the study of anti-COVID-19 drugs .

HY-136284

XP-59 1 Publications Verification	SARS-CoV	Infection
XP-59 is a potent inhibitor of the SARS-CoV M ^pro, with a K_i of 0.1 μM .

HY-N2949

Bonducellpin D	SARS-CoV	Infection Cancer
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M ^pro and MERS-CoV M ^pro, with an K_i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-136298

(Rac)-X77	SARS-CoV	Infection
(Rac)-X77?is a racemate of X77. X77 is a potent non-covalent inhibitor of the main protease of SARS-CoV-2 (SARS-CoV-2 M ^pro) . X77 binds to SARS-CoV-2 M ^pro with a K_d value of 0.057 μM .

HY-131096

L-Proline 4-methoxy-β-naphthylamide hydrochloride H-pro-4MβNA hydrochloride	Drug Intermediate	Cancer
L-Proline 4-methoxy-β-naphthylamide hydrochloride (H-Pro-4MβNA hydrochloride) can be used for Fap-activated anti-tumor compounds preparaction .

HY-170894

*SARS-CoV-2 Mpro-IN-37*	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-37 (compound 8r) is a SARS-CoV-2 main protease (M ^pro) inhibitor, with an IC₅₀ of 0.0199 μM. SARS-CoV-2 Mpro-IN-37 inhibits SARS-CoV-1 M ^pro and MERS-CoV M ^pro with IC₅₀s of 0.00945 and 0.111 μM, respectively. SARS-CoV-2 Mpro-IN-37 displays high antiviral activity in the nanomolar range without showing cellular toxicity .

HY-144062

INSCoV-614(1B)	SARS-CoV	Infection
INSCoV-614(1B) is a potent inhibitor of M ^pro (3CL ^pro). Proteases (PL ^pro and 3CL ^pro) are involved with transcription and replication of the virus. INSCoV-614(1B) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .

HY-144063

INSCoV-600K(1)	SARS-CoV	Infection
INSCoV-600K(1) is a potent inhibitor of M ^pro (3CL ^pro). Proteases (PL ^pro and 3CL ^pro) are involved with transcription and replication of the virus. INSCoV-600K(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .

HY-144061

INSCoV-601I(1)	SARS-CoV	Infection
INSCoV-601I(1) is a potent inhibitor of M ^pro (3CL ^pro). Proteases (PL ^pro and 3CL ^pro) are involved with transcription and replication of the virus. INSCoV-601I(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .

HY-162474

BZG2	SARS-CoV Virus Protease	Infection
BZG2 is an allosteric inhibitor for the SARS-CoV-2 main protease (M ^pro), with an IC₅₀ of 77 µM .

HY-P4593

*Z-Gly-Pro-Arg-4MβNA*	Thrombin	Others
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .

HY-155416

M56-S2 iodide	SARS-CoV	Infection
M56-S2 iodide is a SARS-CoV-2 M ^pro inhibitor (IC₅₀=4.0 μM). M56-S2 iodide showed good oral bioavailability and low toxicity in ADMET prediction. M56-S2 iodide has good drug potential and can be used in antiviral (such as SARS-CoV-2) research .

HY-169851

JANEX-1-M	Drug Metabolite	Others
JANEX-1-M is a metabolite of JANEX-1 (HY-15508). JANEX-1 is a JAK3 specific inhibitor, which can effectively inhibit mast cell degranulation and the release of pro-inflammatory mediators .

HY-139683

Antiviral agent 5	SARS-CoV	Infection
Antiviral agent 5 is an intermediate used in antiviral agents targeting 3C and 3CL proteases including SARS-CoV-2 M ^pro.

HY-N144101

*SARS-CoV MPro-IN-2*	SARS-CoV	Infection
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-173285

*SARS-CoV-2 Mpro-IN-38*	SARS-CoV Virus Protease	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-38 (2-5a) is a SARS-CoV‑2 M ^pro inhibitor, with an IC₅₀ of 0.0435 μM .

HY-168568

*SARS-CoV-2 Mpro-IN-28*	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-28 (Compound 1K) is an inhibitor of SARS-CoV-2 M ^pro with an EC₅₀ value of 24 μM .

HY-157145

SARS-CoV-2-IN-69	SARS-CoV	Infection
SARS-CoV-2-IN-69 (Compound 7E) is a non-covalent SARS-CoV-2 inhibitor with an EC₅₀ value of 7.4 μM. SARS-CoV-2-IN-69 is a potent inhibitor of SARS-CoV-2 main protease (M ^pro) and a non-covalent inhibitor of papain (PL ^pro) .

HY-153613

Ac-PLVE-FMK Ac-pro-Leu-Val-Glu(OMe)-CH2F	Cathepsin	Cancer
Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .

HY-155407

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

HY-151608

*SARS-CoV-2 Mpro-IN-3*	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-3 is a potent M ^pro inhibitor with an IC₅₀ value of ﹥5 μM. SARS-CoV-2 Mpro-IN-3 can be used in research of COVID-19 .

HY-N15268

Koenine	SARS-CoV Virus Protease	Infection
Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (M ^pro), which can be used in the research of anti-novel coronavirus drugs .

HY-155813

MPI60	SARS-CoV	Infection
MPI60 is a potent SARS-CoV-2 M ^Pro inhibitor with high antiviral potency, low cellular cytotoxicity, and high in vitro metabolic stability. MPI60 can be used for SARS-CoV-2 research .

HY-149774

GC-78-HCl	SARS-CoV	Infection
GC-78-HCl is an orally and nonpeptidic SARS-CoV-2 M ^pro inhibitor, with an IC₅₀ of 0.19 μM for enzyme. GC-78-HCl has excellent antiviral activity and favorable pharmacokinetic properties .

HY-155056

*SARS-CoV-2 Mpro-IN-7*	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-7 (compound 6g) is a potent inhibitor of M ^pro-SARS-CoV-2 (IC₅₀=8.8 μM, CC₅₀=10 μM) .

HY-110067

VO-OHPic	PTEN Apoptosis Autophagy	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC₅₀ of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy .

HY-P4905

*Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2*	MMP	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

HY-148387

SARS-CoV-2-IN-35	SARS-CoV	Infection
SARS-CoV-2-IN-35 is a potent and orally active SARS-CoV-2 M ^pro inhibitor with a K_i value of 12.1 nM. SARS-CoV-2-IN-35 can be used in research of COVID-19 .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-152224

SPR41	SARS-CoV	Infection
SPR41 is a potent SARS-CoV-2 main protease inhibitor with K_i values of 0.184, 0.252, 14.4 µM for SARS-CoV-2 M ^pro, hCatL, hCatB, respectively. SPR41 shows antiviral and cytotoxicity .

HY-152220

SPR39	SARS-CoV	Infection
SPR39 is a potent SARS-CoV-2 main protease inhibitor with K_i values of 0.252, 3.38, 7.88 µM for SARS-CoV-2 M ^pro, hCatL, hCatB, respectively. SPR39 shows antiviral and cytotoxicity .

HY-144647

SP inhibitor 1	SARS-CoV Virus Protease	Infection
SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC₅₀ of 3.26 μM, >25 μM, >25 μM for SP, M ^pro and PL ^pro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity .

HY-170886

*SARS-CoV-2 Mpro-IN-36*	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC₅₀ of 1.6 μM .

HY-170599

H117	Ligands for Target Protein for PROTAC SARS-CoV Virus Protease	Infection
H117 is a PROTAC target protein ligand that can be used to synthesize PROTAC HP211206 (HY-170598). H117 has competitive binding and inhibition ability on SARS-CoV-2 main protease (M ^pro) with an IC₅₀ of 151.3 nM .

HY-18234A

Leupeptin hemisulfate 35+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-153228

Pomotrelvir PBI-0451	SARS-CoV	Infection
Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (M ^pro), with an IC₅₀ of 24 nM for wild-type SARS-CoV-2 M ^pro. Pomotrelvir inhibits viral polyprotein processing, thereby preventing viral replication. Pomotrelvir has shown broad antiviral activity against multiple SARS-CoV-2 variants (including Omicron) in cell-based experiments, and has an additive effect when combined with nucleoside analogs that target viral RNA synthesis. Pomotrelvir is primarily used for the research and development of COVID-19 antiviral drugs, especially for infections caused by SARS-CoV-2 and its variants .

HY-147861

Topoisomerase II inhibitor 11	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC₅₀ of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC₅₀ of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and *pro-apoptotic* activity .

Cat. No.	Product Name

HY-L174

Macrophage Related Compound Library

198 compounds

Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance.

MCE designs a unique collection of 198 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P1130

M871 Galanin-(2-13)-Glu-His-(pro)3-(Ala-Leu)2-Ala-amide	Neuropeptide Y Receptor	Neurological Disease
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM and 420 nM for GalR2 and GalR1, respectively. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain) .

HY-P10089

TREM-1 inhibitory peptide M3	Peptides	Inflammation/Immunology
TREM-1 inhibitory peptide M3 is a ligand-dependent TREM-1 antagonist. TREM-1 inhibitory peptide M3 can inhibit systemic and pulmonary pro-inflammatory cytokine and chemokine production and attenuate acute lung injury .

HY-P3042

Chymostatin	SARS-CoV Virus Protease NF-κB Interleukin Related	Inflammation/Immunology
Chymostatin is a SARS-CoV-2 M ^pro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer .

HY-P10858

UCI-1	SARS-CoV Virus Protease	Infection
UCI-1 is a SARS-CoV-2 main protease (M ^pro) cyclic peptide inhibitor with an IC₅₀ of 160 μM. UCI-1 shows no obvious cytotoxicity at the concentration of inhibiting M ^pro. UCI-1 can be used in the study of anti-COVID-19 drugs .

HY-P4593

*Z-Gly-Pro-Arg-4MβNA*	Thrombin	Others
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .

HY-P4905

*Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2*	MMP	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

Cat. No.	Product Name	Target	Research Area

HY-P991217

EU-103	Transmembrane Glycoprotein	Cancer
EU-103 is a humanized monoclonal antibody targeting V-Set And Immunoglobulin Domain Containing 4 (VSIG4) with a K_D value ranging from 10 ⁻⁷ and 10 ⁻⁹. EU-103 blocks the interaction between VSIG4 and CD8+ T cells, promotes the conversion of M2 macrophages into M1 macrophages, induces the proliferation of CD8+ T cells and the secretion of pro-inflammatory cytokines, thereby inhibiting tumor growth. EU-103 is promising for research of cancers, such as bladder cancer, breast cancer, and colon cancer .

Species:	Human (3) Virus (5)
Tag:	His (5) SUMO (1) Tag Free (3) Avi (2) B2M (1)
Source:	HEK293 (1) Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P78275

	SARS-CoV-2 3CLpro/3C-like protease Protein 3C-like protease; 3CL protease; 3CL-Mpro; 3CL pro; COVID-19; M proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by E. coli , with tag free.

HY-P78275A

	SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) 3C-like protease; 3CL protease; 3CL-Mpro; 3CL pro; COVID-19; M proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is the recombinant virus-derived SARS-CoV-2 3CLpro/3C-like protease, expressed by E. coli , with tag Free labeled tag. ,

HY-P71584

	ALKAL1 Protein, Human (His, B2M) ALKAL1; FAM150A; UNQ9433/pro34745ALK and LTK ligand 1; Augmentor beta; AUG-beta; protein FAM150A	Human	E. coli
	ALKAL1 Protein, Human (His, B2M) is a potent activating ligand for human ALK that binds to the extracellular domain of ALK.

HY-P703978

	Serum Albumin/ALB Protein, Human (HEK293, V418M, T420A, E505G, V547A) Albumin; ALB; Serum albumin; ANALBA; FDAH; pro0883; pro0903; pro1341	Human	HEK293

HY-P76589

	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) 3CL protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P76590

	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) 3CL protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main protease; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by E. coli , with N-His, N-Avi labeled tag.

HY-P76591

	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) 3CL protease; 3CL proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M proteinase; Main protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells , with N-His, N-Avi labeled tag.

HY-P700260

	Aminopeptidase P1 Protein, Human (His-SUMO) Aminoacylproline aminopeptidase; aminopeptidase P, cytosolic; APP1; Cytosolic aminopeptidase P; RP11 451M19.1; sAmp; Soluble aminopeptidase P; soluble; X pro aminopeptidase 1; X prolyl aminopeptidase (aminopeptidase P) 1; X prolyl aminopeptidase (Aminopeptidase P) 1 soluble; X prolyl aminopeptidase 1; X prolyl aminopeptidase 1 soluble; X-pro aminopeptidase 1; X-prolyl aminopeptidase 1; Xaa pro aminopeptidase 1; Xaa-pro aminopeptidase 1; XPNPEP 1; XPNPEP; xpnpep1; XPNPEPL; XPNPEPL1; XPP1_HUMAN	Human	E. coli
	Aminopeptidase P1 Protein, a metalloaminopeptidase, crucially catalyzes the removal of penultimate prolyl residues from peptide N-termini, including substrates like Arg-Pro-Pro. This activity significantly contributes to specific peptide degradation, exemplified in bradykinin processing. Aminopeptidase P1's selective prolyl cleavage underscores its importance in modulating peptide structures and functions within biological systems. Aminopeptidase P1 Protein, Human (His-SUMO) is the recombinant human-derived Aminopeptidase P1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-P81482

	Obestatin Antibody (YA1227) GHRL; MTLRP; UNQ524/pro1066; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; protein M46; Ghrelin-27Ghrelin-28 (Ghrelin); Obestatin	IHC-P	Human
	Obestatin Antibody (YA1227) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1227), targeting Obestatin. Obestatin Antibody (YA1227) can be used for IHC-P experiment in human background.