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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

IgG1κ monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (5) Antibody-Drug Conjugates (ADCs) (4) Anaplastic lymphoma kinase (ALK) (1) Antifolate (1) Apoptosis (2) Bacterial (3) c-Fms (1) c-Kit (1) c-Met/HGFR (2) C-type Lectin-like Receptors (CTLRs) (1) Cadherin (1) CCR (2) CD19 (2) CD22 (3) CD276/B7-H3 (2) CD3 (1) CD38 (2) CD47 (1) CD73 (3) CD74 (1) CTLA-4 (5) CXCR (1) EGFR (2) Fc Receptor (FcR) (3) Ferroptosis (1) FGFR (2) Filovirus (2) Glycoprotein VI (1) HIV (1) HSV (1) IFNAR (2) IGF-1R (2) Influenza Virus (5) Integrin (3) Interleukin Related (23) LAG-3 (2) LPL Receptor (2) MDM-2/p53 (1) MHC (1) Microtubule/Tubulin (2) Mucin (1) NAMPT (1) NF-κB (1) Notch (1) NTPDase (1) PD-1/PD-L1 (6) PSMA (1) RABV (2) Reactive Oxygen Species (ROS) (1) RET (1) RSV (4) SARS-CoV (8) Sodium Phosphate Cotransporter (1) STAT (1) Tau Protein (2) TGF-β Receptor (1) TNF Receptor (12) Toll-like Receptor (TLR) (1) Topoisomerase (2) Transferrin Receptor (2) Transmembrane Glycoprotein (14) Transthyretin (TTR) (1) TREM receptor (2) Trk Receptor (1) TSH Receptor (1) VEGFR (1) VISTA (2) Wnt (2)
By Research Areas:	Cancer (73) Cardiovascular Disease (2) Endocrinology (2) Infection (23) Inflammation/Immunology (75) Metabolic Disease (2) Neurological Disease (4)

By Targets:

ADC Antibody (5)

Antibody-Drug Conjugates (ADCs) (4)

Anaplastic lymphoma kinase (ALK) (1)

Antifolate (1)

Apoptosis (2)

Bacterial (3)

c-Fms (1)

c-Kit (1)

c-Met/HGFR (2)

C-type Lectin-like Receptors (CTLRs) (1)

Cadherin (1)

CCR (2)

CD19 (2)

CD22 (3)

CD276/B7-H3 (2)

CD3 (1)

CD38 (2)

CD47 (1)

CD73 (3)

CD74 (1)

CTLA-4 (5)

CXCR (1)

EGFR (2)

Fc Receptor (FcR) (3)

Ferroptosis (1)

FGFR (2)

Filovirus (2)

Glycoprotein VI (1)

HIV (1)

HSV (1)

IFNAR (2)

IGF-1R (2)

Influenza Virus (5)

Integrin (3)

Interleukin Related (23)

LAG-3 (2)

LPL Receptor (2)

MDM-2/p53 (1)

MHC (1)

Microtubule/Tubulin (2)

Mucin (1)

NAMPT (1)

NF-κB (1)

Notch (1)

NTPDase (1)

PD-1/PD-L1 (6)

PSMA (1)

RABV (2)

Reactive Oxygen Species (ROS) (1)

RET (1)

RSV (4)

SARS-CoV (8)

Sodium Phosphate Cotransporter (1)

STAT (1)

Tau Protein (2)

TGF-β Receptor (1)

TNF Receptor (12)

Toll-like Receptor (TLR) (1)

Topoisomerase (2)

Transferrin Receptor (2)

Transmembrane Glycoprotein (14)

Transthyretin (TTR) (1)

TREM receptor (2)

Trk Receptor (1)

TSH Receptor (1)

VEGFR (1)

VISTA (2)

Wnt (2)

By Research Areas:

Cancer (73)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (23)

Inflammation/Immunology (75)

Metabolic Disease (2)

Neurological Disease (4)

153

Inhibitors & Agonists

168

Inhibitory Antibodies

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99310

Perakizumab RG4934	Interleukin Related	Inflammation/Immunology
Perakizumab (RG4934) is a humanized IgG1κ monoclonal antibody against IL-17A (Interleukin Related). Perakizumab can be uesd for the research of autoimmune diseases, such as psoriatic arthritis .

HY-P99040

Onvatilimab JNJ-61610588; CI-8993; VSTB112	VISTA	Cancer
Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research .

HY-P99424

Afasevikumab RG 7624; RO 5553110; NI-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

HY-P99313

Quilizumab Anti-Human IGHE Recombinant antibody	Apoptosis	Inflammation/Immunology
Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed IGHE/IgE, leading to IGHE/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research .

HY-P99979

Rat IgG1 kappa, Isotype Control 1 Publications Verification	Fc Receptor (FcR)	Inflammation/Immunology
Rat IgG1 kappa, Isotype Control, a rat monoclonal antibody, is an isotype control for Rat IgG1κ antibody.

HY-P99316

Sirukumab CNTO-136	Interleukin Related	Inflammation/Immunology
Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis .

HY-P990780

Zeleciment	Transferrin Receptor	Inflammation/Immunology
Zeleciment is an anti-TFRC IgG1κ monoclonal antibody .

HY-P990689

Zifibancimig RO-7250284	VEGFR	Inflammation/Immunology
Zifibancimig is an anti-VEGFA/ANGPT2 IgG1κ monoclonal antibody .

HY-P99740

Mirzotamab	CD276/B7-H3 ADC Antibody	Cancer
Mirzotamab is an *IgG1κ* monoclonal antibody targeting to CD276/B7-H3 with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) .

HY-P99447

Atidortoxumab	Bacterial	Infection
Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin .

HY-P9909

Ustekinumab 3 Publications Verification Anti-Human IL-12/IL-23, Human antibody	Interleukin Related	Inflammation/Immunology Cancer
Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

HY-P99828

Cofetuzumab PF-06523435; hu24	RET	Others Cancer
Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is usually CHO (Chinese Hamster Ovary) cells .

HY-P99315

Ruplizumab BG 9588; Anti-Human CD40L Recombinant antibody; Hu5c8	TNF Receptor	Inflammation/Immunology
Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99778

Ontuxizumab MORAb-004	EGFR	Cancer
Ontuxizumab (MORAb-004) is a humanized IgG1/κ *anti-endosialin* (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer .

HY-P99181

Mupadolimab CPI-006	CD73	Infection Inflammation/Immunology Cancer
Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73 ^POS B cells .

HY-P990716

Sabestomig	PD-1/PD-L1	Inflammation/Immunology
Sabestomig is an anti-PDCD1/HAVCR2 Ig(G1-κ G1-λ2) monoclonal antibody .

HY-P9966

Enoblituzumab MGA271	CD276/B7-H3	Cancer
Enoblituzumab (MGA271) is a humanized *IgG1κ* monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators .

HY-P99368

Lacnotuzumab MCS110	c-Fms	Metabolic Disease Cancer
Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis .

HY-P990007

Tulisokibart PRA023; PRA-023	TNF Receptor	Inflammation/Immunology
Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis .

HY-P99591

Sontuzumab AS1402; huHMFG-1	Mucin	Cancer
Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a K_d of ~1 nM. Sontuzumab can be used for the research of breast cancer .

HY-P9901

Ipilimumab 4 Publications Verification MDX-010; BMS-734016	CTLA-4	Cancer
Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies .

HY-P99513

Zamerovimab CTB011	RABV	Infection
Zamerovimab (CTB011) is an anti-rabies humanized IgG1κ monoclonal antibody that binds to the non-overlapping epitopes on the rabies virus (RABV) glycoprotein. Zamerovimab targets residues at and near antigenic site III. Zamerovimab can be used in rabies studies .

HY-P99669

Iratumumab MDX-060	TNF Receptor	Cancer
Iratumumab (MDX-060) a human anti-CD30 IgG1κ monoclonal antibody. Iratumumab inhibits the growth of CD30-expressing tumor cells. Iratumumab can be used for research of Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) .

HY-P99727

Mazorelvimab CTB012	RABV	Infection
Mazorelvimab (CTB012) is an anti-rabies humanized IgG1κ monoclonal antibody that binds to the non-overlapping epitopes on the rabies virus (RABV) glycoprotein. Mazorelvimab binds to highly discontinuous conserved residues that are not in or near antigenic site III. Mezagitamab has potential application in the prevention of rabies .

HY-P99583

Suvratoxumab MEDI4893	Bacterial	Infection Inflammation/Immunology
Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .

HY-P99340

Sotrovimab 1 Publications Verification VIR 7831	SARS-CoV	Infection Cancer
Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .

HY-P99410

Ordesekimab AMG 714; PRV-015	Interleukin Related	Inflammation/Immunology
Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .

HY-P991595

HB-0017	Interleukin Related	Inflammation/Immunology
HB-0017 is a humanized IgG1κ monoclonal antibody inhibitor, targeting IL-17A. HB-0017 inhibits the IL-6 secretion induced by IL-17A with an IC₅₀ of 2.09 nM. HB-0017 significantly decreases ear thickness in Imiquimod (HY-B0180)-induced psoriasis-like mice model and alleviates inflammations in IL-17A-induced arthritis and air pouch mice model. The isotype control for the HB-0017 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P9995

Posdinemab JNJ-63733657	Tau Protein	Neurological Disease
Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease .

HY-P991566

KD6001	CTLA-4	Cancer
KD6001 is a humanized IgG1κ monoclonal antibody, targeting CTLA4. KD6001 significantly disrupts CTLA-4 interactions with CD80 (IC₅₀: 16 ng/mL) and CD86. KD6001 enhances IL-2 and IFNγ expression in PHA-activated human lymphocytes and exhibits potent antitumor effects. KD6001 effectively inhibits tumor growth in MC38, B16, and Hepa1-6 tumor mice model. KD6001 can be used for cancers research, such as advanced melanoma, hepatocellular carcinoma and liver cancer .

HY-P991567

VX5 VX5/5261	CXCR	Inflammation/Immunology Cancer
VX5 is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration (EC₅₀s for 105 and 253 nM for human tonsillar and pre-B-697-hCXCR5 cells, respectively). VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer .

HY-P991223

NC762	Transmembrane Glycoprotein TNF Receptor	Cancer
NC762 is a humanized IgG1κ monoclonal antibody that targets human B7-H4 (B7 homolog 4). NC762 has enhanced binding to CD16a (FcγRIIIa) after being Fc engineered with three point mutations (S239D/A330L/I332E; DLE) and demonstrate increased antibody-dependent cellular cytotoxicity (ADCC) activity. NC762 inhibits tumor growth in vivo through binding to tumor-expressing B7-H4. NC762 can be studies in research on cancer such as advanced or metastatic solid tumors .

HY-P991502

Armenian hamster IgG1 kappa, Isotype Control	Fc Receptor (FcR)	Inflammation/Immunology
Armenian hamster IgG1 kappa, Isotype Control, a Armenian hamster monoclonal antibody, is an isotype control for Armenian hamster IgG1 kappa antibody.

HY-P990749

Luvagrobart	Trk Receptor	Inflammation/Immunology
Luvagrobart is an anti-NGF human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991165

Trovostobart	Fc Receptor (FcR)	Others
Trovostobart is an anti-VSIR human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990734

Coramitug	Transthyretin (TTR)	Inflammation/Immunology
Coramitug is an anti-TTR human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990746

Lancastotug	Transmembrane Glycoprotein	Inflammation/Immunology
Lancastotug is an anti-TIGIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990754

Opelkibart	c-Kit	Inflammation/Immunology
Opelkibart is an anti-KIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990084

Veligrotug	IGF-1R	Cancer
Veligrotug is an IgG1-kappa, anti-IGF1R (insulin-like growth factor 1 receptor, CD221) chimeric monoclonal antibody .

HY-P990781

Suciraslimab SM03	CD22	Inflammation/Immunology
Suciraslimab is an anti-CD22 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990774

Verekitug	Interleukin Related	Inflammation/Immunology
Verekitug is an anti-CRLF2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990686

Ispectamab	TNF Receptor	Inflammation/Immunology
Ispectamab is an anti-TNFRSF17 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990697

Anvatabart ARX-788	EGFR	Inflammation/Immunology
Anvatabart is an anti-ERBB2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990728

Bezetabart	CD74	Inflammation/Immunology
Bezetabart is an anti-CD74 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990729

Budoprutug	CD19	Inflammation/Immunology
Budoprutug is an anti-CD19 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990764

Sigvotatug SGN-B6A antibody	Integrin	Inflammation/Immunology
Sigvotatug is an anti-ITGB6 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990747

Lumrotatug	CD38	Inflammation/Immunology
Lumrotatug is an anti-CD38 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990739

Evalstotug	CTLA-4	Inflammation/Immunology
Evalstotug is an anti-CTLA4 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990767

Solrikitug	Interleukin Related	Inflammation/Immunology
Solrikitug is an anti-CRLF2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991164

Torvutatug	Antifolate	Inflammation/Immunology
Torvutatug is an anti-FOLR1 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

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