Search Result
Results for "
B viruses
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
27
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-112543
-
|
|
Influenza Virus
|
Infection
|
|
S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV) .
|
-
-
- HY-121513
-
|
2'-Deoxy-L-cytidine; L-dC
|
HBV
|
Infection
|
|
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment .
|
-
-
- HY-W892911
-
|
|
Influenza Virus
|
Infection
|
|
AV-5080 is an orally active neuraminidase inhibitor. AV-5080 can be used for the research of influenza A and B viruses .
|
-
-
- HY-P4042
-
|
hepatitis B peptide 4980
|
HBV
|
Infection
Inflammation/Immunology
|
|
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .
|
-
-
- HY-P4051
-
-
-
- HY-163659
-
|
|
Influenza Virus
|
Infection
|
|
Anti-Influenza agent 6 (compound 19b) shows inhibitory activity against A/WSN/33/H1N1 (EC50 = 0.015 μM) and influenza B virus Yamagata/16/88 (EC50 = 0.073 μM) and Victotis/2/87 (EC50 = 0.067 μM) .
|
-
-
- HY-126033
-
|
|
HBV
RSV
|
Infection
|
|
Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL .
|
-
-
- HY-P4045
-
|
|
HBV
|
Infection
|
|
HBV Seq2 aa:208-216, a HBsAg derived CD8 epitope peptide, is studied as part of Large envelope protein from Hepatitis B virus .
|
-
-
- HY-173278
-
|
|
HBV
Potassium Channel
|
Infection
|
|
AIC263282 is a potent Hepatitis B Virus (HBV) capsid assembly modulator with an EC50 of 3.8 nM. AIC263282 shows an IC50 of 61 nM for hERG. AIC263282 exhibits activity against viral replication and hepatitis B surface antigen (HBsAG) on primary human hepatocytes .
|
-
-
- HY-156578
-
|
|
DGK
HIV
|
Infection
Cancer
|
|
DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC50=22.491 nM; EC50=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection .
|
-
-
- HY-125719
-
|
L-FMAU-TP
|
HBV
|
Infection
Cancer
|
|
Clevudine triphosphate is a thymidine analog. Clevudine triphosphate has anti-human hepatitis B virus (HBV) activity .
|
-
-
- HY-114314
-
|
|
HBV
|
Infection
|
|
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B .
|
-
-
- HY-148201
-
|
|
HBV
|
Infection
|
|
Oleana-2,12-dien-28-oic acid is an HBV-DNA inhibitor, HBsAg and HBeAg inhibitor. Oleana-2,12-dien-28-oic acid can be used in hepatitis B virus infection disease research .
|
-
-
- HY-133721
-
|
|
HBV
|
Infection
Inflammation/Immunology
|
|
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities .
|
-
-
- HY-126970
-
|
|
HBV
|
Infection
|
|
HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis .
|
-
-
- HY-W011518
-
|
|
Nucleoside Antimetabolite/Analog
Influenza Virus
|
Infection
|
|
2′-Deoxy-2′-fluoroguanosine is a nucleoside analog and potent influenza virus inhibitor with an EC90 value of <0.35 μM against influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine inhibits influenza virus replication in the upper respiratory tract, thereby ameliorating fever and nasal inflammation .
|
-
-
- HY-W352344
-
|
|
HBV
|
Infection
|
|
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV) .
|
-
-
- HY-P4046
-
|
|
HIV
|
Inflammation/Immunology
|
|
HBV Seq2 aa:179-186 serve as effective motifs for CTL response in H-2b system after in vitro restimulation of the primed T cells. HBV Seq2 aa:179-186 is a novel epitope identified on the surface antigen of hepatitis B virus .
|
-
-
- HY-Y0073
-
|
P-hydroxyacetophenone
|
HBV
Myosin
|
Infection
Inflammation/Immunology
Cancer
|
|
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .
|
-
-
- HY-113512
-
|
|
Influenza Virus
|
Inflammation/Immunology
|
|
17-HDHA is a DHA-derived specialized proresolving mediator (SPM). 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27 + CD38 + antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells .
|
-
-
- HY-119691
-
|
LY582563; MCC-478
|
HBV
|
Infection
|
|
Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect .
|
-
-
- HY-19447
-
|
LB80331
|
HBV
|
Infection
|
|
Besifovir (LB80331), a parent agent converted by LB80380 (HY-19447A), further metabolizes to its active form, LB80317 (HY-106235). Besifovir is an orally active, novel antiviral agent against hepatitis B virus (HBV) .
|
-
-
- HY-116999
-
|
|
HBV
|
Infection
|
|
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease . HBx: hepatitis B virus X protein.
|
-
-
- HY-126970R
-
|
|
HBV
|
Infection
|
|
HBF-0259 (Standard) is the analytical standard of HBF-0259. This product is intended for research and analytical applications. HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis .
|
-
-
- HY-162242
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC50 = 12.26 nM) .
|
-
-
- HY-Y0073R
-
|
P-hydroxyacetophenone (Standard)
|
Reference Standards
HBV
Myosin
|
Infection
Inflammation/Immunology
Cancer
|
|
4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .
|
-
-
- HY-B1537
-
|
2',3',5'-Tri-O-acetyl-6-azauridine
|
Virus Protease
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research .
|
-
-
- HY-145713
-
|
HBV-IN-19
|
HBV
|
Infection
|
|
GS-8873 is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC50 of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys .
|
-
-
- HY-143744
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-3 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-3 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-3 has the potential for the research of influenza A and influenza B infection (extracted from patent WO2019141179A1, compound VI-1) .
|
-
-
- HY-145713A
-
|
HBV-IN-19 TFA
|
HBV
|
Infection
|
|
GS-8873 TFA is the TFA salt form of GS-8873 (HY-145713). GS-8873 TFA is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC50 of 4 nM. GS-8873 TFA exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 TFA causes neurofunctional deficits in rats and cynomolgus monkeys .
|
-
-
- HY-174856
-
|
|
PROTACs
HBV
|
Infection
|
|
PROTAC HBeAg degrader-1 is a PROTAC targeting degradation agent for HBeAg. PROTAC HBeAg degrader-1 recruits the VHL E3 ligase but degrades HBV protein HBeAg through VHL-independent mechanism. PROTAC HBeAg degrader-1 decreases levels of secreted and intracellular HBeAg. PROTAC HBeAg degrader-1 can be used for the research of hepatitis B virus (HBV) . (Structure Note: Pink: HBeAg ligand (HY-174857); Blue: VHL Ligand (HY-125845); Black: linker; E3-linker (HY-135045))
|
-
-
- HY-P1774
-
|
|
HBV
|
Infection
|
|
Hepatitis B Virus Core (128-140) is a peptide of hepatitis B virus core protein.
|
-
-
- HY-177300
-
|
|
Toll-like Receptor (TLR)
HBV
IFNAR
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM). TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus .
|
-
-
- HY-146004
-
|
|
Influenza Virus
|
Infection
|
|
Influenza A virus-IN-4 (compound 23b), an Oseltamivir derivative, is a potent inhibitor of neuraminidase. Influenza A virus-IN-4 exerts powerful inhibitions on influenza viruses .
|
-
-
- HY-P1857
-
|
|
Influenza Virus
|
Infection
|
|
CEF7, Influenza Virus NP (380-388) is a HLA-B *08 restricted influenza virus nucleoprotein epitope. Influenza virus NP functions as a key adapter molecule between virus and host cell processes .
|
-
-
- HY-174297
-
|
|
HBV
|
Infection
|
|
HBV/HDV-IN-5 (example 4) is an inhibitor of hepatitis B virus (HBV) and hepatitis D virus (HDV) .
|
-
-
- HY-P4038
-
|
|
HCV Protease
|
Infection
|
|
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
|
-
-
- HY-N15389
-
|
|
Influenza Virus
|
Infection
|
|
Noformicin has inhibitory effect on mumps virus and Newcastle disease virus in chicken embryo. Noformicin also extended the survival of mice infected with swine, influenza A (PR8) and influenza B (Lee) viruses .
|
-
-
- HY-N6025
-
|
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities .
|
-
-
- HY-W753521
-
|
BI 207127 sodium
|
Endogenous Metabolite
|
Infection
|
|
Deleobuvir sodium (BI 207127 sodium) is a non-nucleoside hepatitis C virus NS5B polymerase inhibitor with anti-hepatitis C virus activity .
|
-
-
- HY-168165
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Adefovir diphosphate is an antiviral compound with activity against hepatitis B virus (HBV). Adefovir diphosphate blocks the replication of HBV by inhibiting reverse transcriptase. Adefovir diphosphate has also shown activity against other viruses such as herpes viruses and human immunodeficiency virus. Adefovir diphosphate is used as an effective inhibitory option in the suppression of chronic hepatitis B. The mechanism of action of Adefovir diphosphate involves blocking the autophosphorylation of growth factor receptors, thereby potentially reducing the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B .
|
-
-
- HY-N14300
-
-
-
- HY-N14299
-
-
-
- HY-N14296
-
-
-
- HY-N14297
-
-
-
- HY-N14298
-
-
-
- HY-14775
-
|
HCV-796
|
HCV
|
Infection
|
|
Nesbuvir is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase.
|
-
-
- HY-109168
-
|
JNJ-6379; JNJ-56136379
|
HBV
|
Infection
|
|
Bersacapavir (JNJ-6379) is a novel Hepatitis B Virus capsid assembly modulator. Bersacapavir interferes with the assembly process of the hepatitis B virus nucleocapsid by binding to the hydrophobic pocket at the dimer-dimer interface of hepatitis B core protein (HBc) subunits. Bersacapavir inhibits the replication of HBV. Bersacapavir is mainly used in the research of chronic hepatitis B .
|
-
-
- HY-W012738
-
|
|
Influenza Virus
GABA Receptor
|
Infection
|
|
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action .
|
-
-
- HY-N3861
-
|
|
HBV
|
Infection
|
|
Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor .
|
-
- HY-170646
-
|
|
Influenza Virus
|
Infection
|
|
Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum inhibitor of influenza A viruses with acceptable cytotoxicity (IC50: 0.88-6.33 μM). Influenza A virus-IN-15 can inhibit the transcription and replication of viral RNA and is used in research for its antiviral effects against influenza A viruses (IAV) .
|
-
- HY-112564
-
JNJ-632
2 Publications Verification
|
HBV
|
Infection
|
|
JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM).
|
-
- HY-106233B
-
|
AM188 hydrochloride
|
HBV
|
Infection
|
|
Tiviciclovir (AM188) hydrochloride is an antiviral guanosine analog and a hepatitis B virus inhibitor .
|
-
- HY-106233
-
|
AM188
|
HBV
|
Infection
|
|
Tiviciclovir (AM188) is an antiviral guanosine analog and a hepatitis B virus inhibitor .
|
-
- HY-138543
-
-
- HY-N14265
-
|
|
Influenza Virus
|
Infection
|
|
Kistamicin B has antiviral effect, and its ID50s against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 μg/mL and 30 μg/mL .
|
-
- HY-P1835
-
|
|
Influenza Virus
|
Inflammation/Immunology
|
|
CEF8, Influenza Virus NP (383-391), an influenza A virus nucleoprotein containing residues 383 to 391, is the most important HLA-B *2705-restricted epitope in the nucleoprotein of influenza A viruses and is associated with escape from cytotoxic T lymphocytes-mediated immunity .
|
-
- HY-132286
-
|
|
Protein Arginine Deiminase
|
Infection
|
|
2-PADQZ is an antiviral compound with activity against influenza viruses. 2-PADQZ specifically binds to the influenza A virus RNA promoter and forms a binding site at the internal loop. 2-PADQZ has a significant inhibitory effect on H1N1 and H3N2 influenza A viruses and influenza B viruses .
|
-
- HY-122486
-
|
Lophirochalcone
|
EBV
|
Cancer
|
|
Lophirachalcone (Lophirochalcone) is an inhibitor of the activation of EB virus (EBV) induced by tumor promoter teleocidin B-4. Lophirachalcone has antitumor activity .
|
-
- HY-100029
-
|
|
HBV
|
Infection
|
|
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-112684
-
|
|
Influenza Virus
|
Infection
|
|
RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.
|
-
- HY-13318
-
|
GS 4071; Ro 64-0802; Oseltamivir carboxylate
|
Influenza Virus
Drug Metabolite
|
Infection
|
|
Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses .
|
-
- HY-P4049
-
|
|
HBV
|
Infection
|
|
HBV Seq1 aa:63-71 is the fragment of hepatitis B virus (HBV) .
|
-
- HY-P99699
-
-
- HY-161956
-
|
|
Filovirus
|
Infection
|
|
Antiviral agent 59 (compound 58) is an antiviral agent with selective and drug-like properties that inhibits a broad spectrum of filoviruses. Antiviral agent 59 exhibits low off-target activity and inhibition against replication-competent Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV/b>) .
|
-
- HY-19643
-
|
|
HCV Protease
|
Infection
|
|
JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC50 value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) .
|
-
- HY-N8873
-
|
|
Others
|
Cancer
|
|
Silychristin B is an antitumor promoter. Silychristin B inhibits TPA induced Epstein-Barr virus early antigen (EBV-EA) induction. Silychristin B can be isolated from milk thistle .
|
-
- HY-P1920
-
|
|
EBV
|
Inflammation/Immunology
|
|
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition .
|
-
- HY-119213
-
|
|
Influenza Virus
|
Infection
|
|
BMY-27709 is an influenza virus growth inhibitor with an IC50 value of 3-8 μM against A/WSN/33 virus growth, and also exhibits inhibitory activity against some subtypes of influenza viruses. BMY-27709 acts early in the course of H1 and H2 virus infections, and exhibits antiviral activity through inhibition of hemagglutinin proteins. However, BMY-27709 has no effect on H3 subtype viruses and influenza B/Lee/40 viruses .
|
-
- HY-109137
-
|
GS-9688
|
Toll-like Receptor (TLR)
HBV
|
Infection
|
|
Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection .
|
-
- HY-P99342
-
|
REGN10987
|
SARS-CoV
|
Infection
|
|
Imdevimab (REGN10987) is a human monoclonal antibody that targets SARS-CoV-2 virus. Imdevimab can be used in combination with Casirivimab (HY-P99341) to reduce viral load and transiently increases anti-receptor-binding domain IgG titers. Imdevimab maintains most of its neutralization activity against viruses with B.1.1.7, B.1.351 and mink cluster 5 spike proteins .
|
-
- HY-117151
-
-
- HY-P990825
-
|
|
Flavivirus
CHIKV
|
Infection
|
|
Anti-Chikungunya virus E2 Antibody (CHK-265) is mouse-derived IgG2c κ type antibody inhibitor, targeting to Chikungunya virus E2. Anti-Chikungunya virus E2 Antibody (CHK-265) reacts with a conserved epitope on the B domain of the E2 glycoprotein of chikungunya virus. Anti-Chikungunya virus E2 Antibody (CHK-265) can block viral entry and egress. Anti-Chikungunya virus E2 Antibody (CHK-265) can be used for the research of infection, such as Chikungunya virus (CHIKV), Mayaro (MAYV) and O’nyong’nyong virus (ONNV) .
|
-
- HY-N14318
-
|
|
Fungal
|
Infection
|
|
Feigrisolide B is a lactone found in Streptomyces griseus. Feigrisolide B has the activity of resisting Sporobolomyces ochreata and inhibiting CoxsacKie virus B3. Feigrisolide B also has moderate inhibitory activity of 3α-hydroxysterol dehydrogenase .
|
-
- HY-177555
-
|
|
Influenza Virus
Endonuclease
|
Infection
|
|
AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections .
|
-
- HY-103487
-
|
IDX21437; MK-3682
|
HCV
|
Infection
|
|
Uprifosbuvir is an antiviral agent. Uprifosbuvir is a NS5b inhibitor developed for the research of chronic hepatitis C virus .
|
-
- HY-P99693
-
|
GC1102
|
HBV
|
Infection
|
|
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection .
|
-
- HY-N14564
-
|
|
Antibiotic
HSV
|
Infection
|
|
Cycloviracin B2 is an antibiotic with antiviral activity. Cycloviracin B2 has a strong inhibitory activity against herpes simplex virus type 1 (HSV-1) .
|
-
- HY-123475A
-
|
RV521 hydrochloride
|
RSV
|
Infection
|
|
Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice .
|
-
- HY-123475
-
|
RV521
|
RSV
|
Infection
|
|
Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice .
|
-
- HY-169815
-
|
|
Virus Protease
HCV
|
Infection
|
|
HCV NS5B polymerase-IN-2 (Compound 298) is a Ns5b polymerase inhibitor. HCV NS5B polymerase-IN-2 is promising for research of hepatitis C virus (HCV) infections .
|
-
- HY-12732
-
|
|
HCV
|
Infection
|
|
PTC 725 is a potent, selective and orally active Hepatitis C Virus NS4B Protein inhibitor. PTC 725 inhibits HCV 1b (Con1) replicons .
|
-
- HY-155110
-
|
|
Influenza Virus
|
Infection
|
|
Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC50 value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research .
|
-
- HY-N3093
-
|
(+)-Periglaucine B
|
HBV
|
Infection
|
|
Periglaucine B ((+)-Periglaucine B) is an alkaloid and an HBsAg inhibitor. Periglaucine B can be isolated from Pericampylus glaucus. Periglaucine B inhibits the secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in Hep G2.2.15 cells with an IC50 of 0.47 mM .
|
-
- HY-B0017
-
|
Epavudine; L-Thymidine; NV 02B
|
HBV
|
Infection
|
|
Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .
|
-
- HY-N10543
-
|
|
HBV
|
Infection
|
|
5-O-(E)-p-Coumaroylquinic acid, a quinic acid derivative, is a potent phytochemical agent against hepatitis B virus .
|
-
- HY-122261
-
|
DU-34569 maleate
|
Influenza Virus
|
Infection
|
|
Spiroamantadine (DU-34569 maleate) is a compound related to Amantadine (HY-B0402) with anti-influenza virus activity .
|
-
- HY-148560
-
ccc_R08
1 Publications Verification
|
HBV
DNA/RNA Synthesis
|
Infection
|
|
ccc_R08 is a non-cytotoxic and orally active cccDNA inhibitor that reduces cccDNA levels in the liver of HBV-infected mice. ccc_R08 can be used in the study of HBV virus (hepatitis B virus) infection .
|
-
- HY-13318S
-
|
GS 4071-d3; Ro 64-0802-d3; Oseltamivir carboxylate-d3
|
Influenza Virus
|
Infection
|
|
Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses .
|
-
- HY-N14110
-
|
|
Bacterial
HIV
|
Infection
|
|
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .
|
-
- HY-178455
-
|
|
Influenza Virus
|
Infection
|
|
Influenza virus-IN-10 is a dual-target antiviral agents for influenza that targets both PAC (KD = 8.9 μM) and NP (KD = 52.5 μM) simultaneously. Influenza virus-IN-10 exhibits an EC50 values of 1.64 μM) against influenza A virus (H1N1, A/WSN/33) and broad-spectrum activity against other influenza strains, including influenza B virus and multiple subtypes of influenza A .
|
-
- HY-14775R
-
|
|
HCV
|
Infection
|
|
Nesbuvir (Standard) is the analytical standard of Nesbuvir. This product is intended for research and analytical applications. Nesbuvir is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase.
|
-
- HY-12634
-
|
BI 207127
|
HCV
|
Infection
|
|
Deleobuvir (BI 207127), a chemical probe, is a potent non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor.
|
-
- HY-116154
-
|
|
Reverse Transcriptase
HBV
|
Infection
|
|
Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity .
|
-
- HY-175796
-
|
|
Influenza Virus
|
Infection
|
|
Antiviral agent 70 (Compound 12b) is an antiviral agent. Antiviral agent 70 has a superior binding capacity to to Neuraminidaseb. Antiviral agent 70 has potent antiviral activity against influenza A/H1N1 virus with an IC50 of 2.9 μM. Antiviral agent 70 can be used for influenza virus infections research .
|
-
- HY-163318
-
-
- HY-156048
-
|
TFMT
|
Influenza Virus
|
Infection
|
|
Trifluoromethyl-tubercidin (TFMT) is an inhibitor of 2'-O-ribose methyltransferase 1 (MTr1). Trifluoromethyl-tubercidin can inhibit the replication of influenza A and B viruses by interfering with the cap-snatching process of the influenza virus. Trifluoromethyl-tubercidin has antiviral activity and low toxicity .
|
-
- HY-14818B
-
|
R 125489 TFA
|
Influenza Virus
|
Infection
|
|
Laninamivir TFA (R 125489 TFA) is an antiviral compound with inhibitory and prophylactic activity against influenza A and B viruses. Laninamivir TFA is a long-acting neuraminidase inhibitor administered by nasal inhalation. Laninamivir TFA has shown good safety and efficacy in the inhibition of influenza viruses .
|
-
- HY-148171
-
-
- HY-B2226R
-
|
|
Reference Standards
HIV
Influenza Virus
|
Infection
|
|
Sodium copper chlorophyllin B (Standard) is the analytical standard of Sodium copper chlorophyllin B. This product is intended for research and analytical applications. Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV with IC50s of 50 to 100 μM for both of them.
|
-
- HY-B2226
-
|
|
HIV
Influenza Virus
|
Infection
|
|
Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV with IC50s of 50 to 100 μM for both of them.
|
-
- HY-P4050
-
|
|
HBV
|
Infection
|
|
HBV Seq1 aa:18-27 is a hepatitis B virus (HBV) core antigen 18-27 peptide fragment .
|
-
- HY-100029A
-
|
|
HBV
|
Infection
|
|
BAY 41-4109 racemate is the racemate of BAY 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-127014
-
|
|
Bacterial
|
Infection
Cancer
|
|
Julimycin B2 has anti-Gram-positive bacteria and anti-virus activity and it has effects on ehrman ascites carcinoma in mice .
|
-
- HY-P4048
-
|
|
HBV
|
Infection
|
|
HBV Seq1 aa:93-100 is a hepatitis B virus (HBV) core antigen 93-100 peptide fragment .
|
-
- HY-I0736
-
|
|
Drug Metabolite
Drug Intermediate
|
Infection
|
|
Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus .
|
-
- HY-P10056
-
|
Human ezrin peptide (324-337)
|
HIV
HCV
HPV
Influenza Virus
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .
|
-
- HY-118932
-
|
|
HCV
|
Infection
|
|
HCV-IN-45 (Compound EI-1) is an inhibitor for hepatitis C virus (HCV), that inhibits 1a and 1b HCV pseudoparticles with EC50 of 0.134 and 0.027 μM. HCV-IN-45 inhibits 1a/2a and 1b/2a cell culture-adapted HCV (HCVcc), with EC50 of 0.024 and 0.012μM. HCV-IN-45 inhibits the entry of the virus into hepatocyte, and blocks the cell-cell spread .
|
-
- HY-119375
-
|
|
Bacterial
|
Infection
|
|
Syncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively .
|
-
- HY-13318R
-
|
GS 4071 (Standard); Ro 64-0802 (Standard); Oseltamivir carboxylate (Standard)
|
Reference Standards
Influenza Virus
Drug Metabolite
|
Infection
|
|
Oseltamivir acid (Standard) is the analytical standard of Oseltamivir acid. This product is intended for research and analytical applications. Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses .
|
-
- HY-N15076
-
|
|
Src
Antibiotic
Bacterial
|
Infection
Cancer
|
|
Herbimycin B is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Herbimycin B has herbicidal effect on most monocotyledons and dicotyledons, inhibits the activity of tobacco Mosaic virus (TMV), HeLa cells and Ehrlich cells .
|
-
- HY-120233
-
|
|
HCV
|
Infection
|
|
MK-8876 is an inhibitor of HCV NS5b site D, which can be used in the research of hepatitis C virus .
|
-
- HY-111003
-
|
NZ-4
|
HBV
|
Infection
|
|
Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation .
|
-
- HY-156272
-
|
|
HBV
|
Infection
|
|
HBV-IN-41 (compound 45) is a potent and orally active Hepatitis B Virus (HBV) inhibitor, with an EC50 of 0.027μM .
|
-
- HY-136266
-
|
|
HCV
|
Cancer
|
|
HCV-IN-29 is a hepatitis C virus (HCV) inhibitor exacted from patent US8329159B2, compound 1e .
|
-
- HY-168510
-
|
|
Influenza Virus
|
Infection
|
|
ATV03 is an anti-influenza virus agent with excellent anti-influenza A and B virus activity. ATV03 inhibits anti-influenza A (H3N2) and anti-influenza B with EC50 values of 0.78 nM and 2.02 nM, respectively. ATV03 exerts anti-influenza activity by inhibiting polymerase acidic protein (PA) and RNA-dependent RNA polymerase (RdRp), as well as disrupting nuclear protein .
|
-
- HY-124600
-
|
|
HBV
|
Infection
|
|
NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity .
|
-
- HY-124600R
-
|
|
HBV
|
Infection
|
|
NVR 3-778 (Standard) is the analytical standard of NVR 3-778. This product is intended for research and analytical applications. NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity .
|
-
- HY-N2006
-
|
|
EBV
HIV Protease
|
Infection
Inflammation/Immunology
|
|
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM) .
|
-
- HY-P99756
-
|
MEDI8897
|
RSV
|
Infection
|
|
Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections .
|
-
- HY-N0854
-
|
|
HBV
|
Infection
|
|
Alisol F is a triterpene isolated from Alisma orinentale, has immunosuppressive and anti-virus functions. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the HepG2.2.15 cell line with an IC50 of 0.6 μM .
|
-
- HY-147255A
-
|
(S)-ZM-H1505R
|
HBV
|
Infection
|
|
(S)-Canocapavir is the isomer of Canocapavir (HY-147255A). Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B .
|
-
- HY-147255
-
|
ZM-H1505R
|
HBV
|
Infection
|
|
Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B. .
|
-
- HY-106817
-
|
LY 217896
|
Influenza Virus
|
Infection
|
|
Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses .
|
-
- HY-111204
-
|
|
HCV
|
Infection
|
|
MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a .
|
-
- HY-169125
-
|
|
HBV
|
Infection
|
|
HBV-IN-49 is an anti-hepatitis B virus (HBV) agent that inhibits HBV replication. HBV-IN-49 can be utilized in infection research .
|
-
- HY-14844
-
|
MIV-210
|
HBV
|
Infection
|
|
Lagociclovir (FLG) is a nucleoside analogue that inhibits wild-type hepatitis B virus (HBV) replication in a human hepatoma cell line permanently expressing HBV .
|
-
- HY-149468
-
|
|
HBV
|
Infection
|
|
Antiviral agent 38 (compound 2.1-1) is a potent antiviral agent. Antiviral agent 38 can be used for hepatitis B virus (HBV) research .
|
-
- HY-13317S
-
|
|
Influenza Virus
|
Infection
|
|
Oseltamivir-d3 is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
- HY-139602
-
|
|
Flavivirus
Dengue Virus
Virus Protease
|
Infection
|
|
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models .
|
-
- HY-13317S3
-
|
|
Influenza Virus
|
Infection
|
|
Oseltamivir-d5 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
- HY-N2006R
-
|
|
EBV
Reference Standards
HIV Protease
|
Infection
Inflammation/Immunology
|
|
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM) .
|
-
- HY-162327
-
|
|
PROTACs
HBV
|
Infection
|
|
PROTAC PAPD5 degrader 1 (compound 12b) inhibits both hepatitis A (HAV) and hepatitis B virus (HBV) in vitro and in vivo , with IC50 and CC50 of 10.59 μM and ＞ 50 μM, respectively in Huh7 cells .
|
-
- HY-I0719
-
|
|
Drug Metabolite
|
Others
|
|
Sofosbuvir impurity B is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-169993
-
|
|
HBV
|
Infection
|
|
ALG-000184, a prodrug of the potent Hhepatitis B virus (HBV) capsid assembly modulator ALG-001075, has the potential for the research of HBV infection research .
|
-
- HY-P4043
-
|
|
HBV
|
Infection
Inflammation/Immunology
|
|
Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg .
|
-
- HY-N14563
-
|
|
Bacterial
HSV
|
Infection
|
|
Cycloviracin B1 has anti-herpes simplex virus Type I (HSV-1) activity and has weak anti-Gram-positive bacterial activity .
|
-
- HY-163088
-
|
|
CHIKV
Flavivirus
|
Infection
|
|
CHIKV-IN-4 (compound 31b) is a potent and selective CHIKV inhibitor. CHIKV-IN-4 inhibits the Chikungunya virus with the EC50 value of 0.6 μM .
|
-
- HY-133108
-
|
|
EBV
Parasite
Phosphatase
Influenza Virus
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .
|
-
- HY-144062
-
|
|
SARS-CoV
|
Infection
|
|
INSCoV-614(1B) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-614(1B) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
|
-
- HY-144066
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A) .
|
-
- HY-148172
-
|
|
HIV
HBV
Nucleoside Antimetabolite/Analog
|
Infection
|
|
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC50=1.5 μM) and anti-hepatitis B virus (HBV) (EC50=1.7 μM) activity. L-Fd4A has low cytotoxicity .
|
-
- HY-144067
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-23 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-23 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-23 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8A or 8B) .
|
-
- HY-19447A
-
|
LB80380 maleate
|
HBV
|
Infection
|
|
Besifovir Dipivoxil maleate (LB80380 maleate) is an oral proagent of LB80317. Besifovir Dipivoxil maleate (LB80380 maleate) is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients in preliminary studies [2]
|
-
- HY-B0017S
-
|
Epavudine-d4; L-Thymidine-d4; NV 02B-d4
|
Isotope-Labeled Compounds
HBV
|
Infection
|
|
Telbivudine-d4 is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .
|
-
- HY-109025
-
|
S-033188; RG 6152
|
Influenza Virus
|
Infection
Cancer
|
|
Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
|
-
- HY-N12483
-
|
|
HBV
|
Infection
|
|
Catenulopyrizomicin A has a thiazolyl pyridine moiety. Catenulopyrizomicin A can be isolated from the fermentation broth of rare actinomycete Catenuloplanes sp. Catenulopyrizomicin A has anti-Hepatitis B virus activity .
|
-
- HY-15602B
-
|
GS-5885 D-tartrate
|
HCV
|
Infection
|
|
Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
|
-
- HY-146418
-
|
|
Flavivirus
|
Infection
|
|
Antiviral agent 20 (Compound 17b) is a selective inhibitor against Zika virus infection with an EC50 of 4.5 µM. Antiviral agent 20 has low cytotoxicity .
|
-
- HY-13317S4
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Oseltamivir-d3 hydrochloride is the deuterium-labeled Oseltamivir (HY-13317) . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
- HY-13317S1
-
|
|
Influenza Virus
|
Infection
|
|
Oseltamivir-d3-1 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
- HY-109035
-
|
SB9200; GS-9992
|
HCV
HBV
|
Infection
|
|
Inarigivir soproxil (SB9200) is an agonist of innate immunity and shows potent antiviral activity against resistant HCV variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. Inarigivir soproxil, an orally bioavailable proagent of SB 9000, has broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, respiratory syncytial virus and influenza and HBV .
|
-
- HY-147763
-
|
|
HCV
|
Infection
|
|
HCV-IN-39 (Compound 18a) is a potent hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.644, 0.952 and 0.154 μM against GT1a, GT1b and GT1b CES1 replicons .
|
-
- HY-B0420AR
-
|
ABOB hydrochloride (Standard)
|
Influenza Virus
HCV
HSV
Apoptosis
Caspase
|
Infection
|
|
Moroxydine (ABOB) hydrochloride (Standard) is the analytical standard of Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels.
|
-
- HY-100029B
-
|
|
HBV
|
Infection
|
|
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-111296
-
|
|
RSV
|
Infection
|
|
YM 53403 is an anti-respiratory syncytial virus (RSV) agent, with an EC50 of 0.20 μM. YM 53403 potently inhibits the replication of RSV strains belonging to both A and B subgroups .
|
-
- HY-12731
-
|
|
HCV
|
Infection
|
|
GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively .
|
-
- HY-148560A
-
|
|
HBV
|
Infection
|
|
trans-ccc_R08 (compound 1-B) is a potent cccDNA (covalently closed circular DMA) inhibitor. trans-ccc_R08 inhibits HBeAg level with an IC50 value of 0.08 µM. trans-ccc_R08 has the potential for the research of Hepatitis B Virus infection (HBV) .
|
-
- HY-P5997
-
|
|
Autophagy
Cyclic GMP-AMP Synthase
|
Inflammation/Immunology
|
|
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .
|
-
- HY-12429
-
|
BMS-791325
|
HCV
|
Infection
|
|
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM .
|
-
- HY-168015
-
|
|
Drug Isomer
|
Infection
|
|
5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4 (HY-130497) with antiviral activity. 5-Oxo leukotriene B4 is promising for research of viral infections caused by human and animal enveloped RNA viruses .
|
-
- HY-N6939
-
-
- HY-P5947
-
|
|
HIV
|
Neurological Disease
|
|
Tat-HA-NR2B9 contains a fragment of the cellmembrane transduction domain of HIV-1 Tat, a influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c). Tat-HA-NR2B9 reduces infarct size and improves neurological functions in ischemia-induced cerebral injury in the rats
|
-
- HY-P4044
-
|
|
HBV
|
Infection
|
|
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .
|
-
- HY-147764
-
|
|
HCV
|
Infection
|
|
HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons .
|
-
- HY-B0017R
-
|
Epavudine (Standard); L-Thymidine (Standard); NV 02B (Standard)
|
Reference Standards
HBV
|
Infection
|
|
Telbivudine (Standard) is the analytical standard of Telbivudine. This product is intended for research and analytical applications. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .
|
-
- HY-123767
-
|
|
HBV
|
Infection
|
|
HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers .
|
-
- HY-155831
-
|
|
HCV
|
Infection
|
|
HCV-IN-43 (compound 2) is an HCV NS5B protein inhibitor that can effectively inhibit the replication of HCV virus. HCV-IN-43 can be used for the study of HCV infection .
|
-
- HY-155832
-
|
|
HCV
|
Infection
|
|
HCV-IN-44 (compound 28) is an HCV NS5B protein inhibitor that can effectively inhibit the replication of HCV virus. HCV-IN-44 can be used for the study of HCV infection .
|
-
- HY-W713297
-
|
ABOB hydrochloride-d8
|
Influenza Virus
Isotope-Labeled Compounds
HCV
HSV
Apoptosis
Caspase
|
Infection
|
|
Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
- HY-149050
-
|
|
Influenza Virus
SARS-CoV
|
Infection
|
|
Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells .
|
-
- HY-N6939R
-
-
- HY-P991200
-
|
|
Claudin
HCV
|
Infection
|
|
OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (Kd = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection .
|
-
- HY-12429A
-
|
BMS-791325 hydrochloride
|
HCV
|
Infection
|
|
Beclabuvir (BMS-791325) hydrochloride is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM .
|
-
- HY-150600
-
|
|
Virus Protease
Flavivirus
|
Infection
|
|
NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells .
|
-
- HY-P3070
-
|
|
MHC
|
Infection
Others
|
|
H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). H2-D b restricted epitopes VSV Nucleoprotein (52-59) binds to MHC class I molecules and presents itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs), which can recognize and kill cells expressing the corresponding antigen. H2-D b restricted epitopes VSV Nucleoprotein (52-59) can be used in the development of CTL vaccines against Ebola virus .
|
-
- HY-177299
-
|
|
HCV
|
Infection
|
|
HCV NS5B polymerase-IN-3 (Compound 30a) is an inhibitor of the HCV NS5B polymerase. HCV NS5B polymerase-IN-3 exhibits anti-HCV activity in the Huh7 replicon cell line with an EC50 of 0.23 μM and shows no obvious cytotoxicity. HCV NS5B polymerase-IN-3 can be used in research related to the hepatitis C virus .
|
-
- HY-145579
-
|
RG7907; RO7049389
|
HBV
Apoptosis
|
Infection
Inflammation/Immunology
|
|
Linvencorvir (RG7907) is an orally active Hepatitis B virus core protein allosteric modulator. Linvencorvir induces Apoptosis. Linvencorvir has antiviral activity against HBV .
|
-
- HY-13784
-
|
R77975
|
Enterovirus
|
Infection
|
|
Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes. Pirodavir is very potent in a virus yield reduction assay (IC90=2.3 nM).
|
-
- HY-15789
-
|
MK-8742
|
HCV
|
Infection
|
|
Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
|
-
- HY-P10668
-
|
|
Dengue Virus
Flavivirus
|
Infection
|
|
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate corresponding to the P6-P1 segment amino-terminal to the NS2B-NS3 cleavage site but with a more reactive, hydrolytically cleavable, para-nitroanilide at the P1’ position. Ac-EVKKQR-pNA is promising for research of dengue 2 virus and flavivirus virus infection .
|
-
- HY-144612
-
|
|
Flavivirus
Dengue Virus
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate .
|
-
- HY-10468
-
NM107
1 Publications Verification
2'-C-Methylcytidine
|
HCV
|
Infection
|
|
NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM .
|
-
- HY-N14095
-
|
|
Bacterial
HIV
|
Infection
Cancer
|
|
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .
|
-
- HY-13317
-
|
GS 4104
|
Influenza Virus
|
Infection
Cancer
|
|
Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively .
|
-
- HY-P990015
-
|
VIR-3434
|
HBV
|
Infection
|
|
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) .
|
-
- HY-129150
-
|
|
Influenza Virus
|
Infection
|
|
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC50 values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .
|
-
- HY-W705873
-
|
EUDR-d5
|
Isotope-Labeled Compounds
Virus Protease
|
Infection
|
|
Edoxudine-d5 (EUDR-d5) is the deuterium labeled Edoxudine (HY-B1011). Edoxudine is an antiviral active molecule and thymidine analog. Edoxudine is effective against herpes simplex virus .
|
-
- HY-148560B
-
|
|
HBV
|
Infection
|
|
cis-ccc_R08 (compound 1) is a flavonoid derivative that can be used in the study of hepatitis B virus (HBV) infection. cis-ccc_R08 is a cccDNA (covalently closed circular DNA) inhibitor .
|
-
- HY-113806
-
|
(±)-Oleracein E
|
Bacterial
Influenza Virus
Apoptosis
|
Infection
Inflammation/Immunology
|
|
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis .
|
-
- HY-176433
-
|
|
Flavivirus
|
Infection
|
|
NSC-323241 is a potent STT3A-mediated mega protein complex assembly inhibitor. NSC-323241 disrupts he endoplasmic reticulum (ER) mega complex nucleated by STT3A during dengue virus (DENV) and Zika virus (ZIKV) infection. NSC-323241 targets the binding of STT3A subcomplex with viral nonstructural proteins (e.g., NS2B, NS3) and host translocon proteins, disrupting the formation of viral replication microenvironment. NSC-323241 is promising for research of flavivirus infection, such as dengue fever and Zika virus .
|
-
- HY-145052
-
|
|
HBV
|
Infection
|
|
HBV-IN-9 is a potent HBsAg (HBV Surface antigen) inhibitor (IC50=10 nM) and HBV DNA production inhibitor (IC50=0.15 nM in HepG2.2.15 cells) . From patent WO2018001952A1, example 20.
|
-
- HY-15602D
-
|
GS-5885 (diacetone)
|
HCV
|
Infection
|
|
Ledipasvir diacetone (GS-5885 diacetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
|
-
- HY-P1571
-
|
NP 396
|
Arenavirus
|
Inflammation/Immunology
|
|
Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .
|
-
- HY-15602A
-
|
GS-5885 (acetone)
|
HCV
|
Infection
|
|
Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
|
-
- HY-105395
-
|
|
Influenza Virus
|
Infection
|
|
BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model .
|
-
- HY-13998A
-
|
ABT-333 sodium
|
HCV
DNA/RNA Synthesis
|
Infection
|
|
Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively .
|
-
- HY-P99608
-
|
|
HBV
|
Infection
|
|
Exbivirumab is a monoclonal antibody directed against highly conserved HBsAg epitopes. Exbivirumab enhances the antiviral activity of hepatitis B immunoglobulin (HBIG). Exbivirumab combined with Libivirumab (HY-P99703) decreases circulating HBsAg and hepatitis B virus (HBV) DNA levels in a chronically infected chimpanzee. Exbivirumab can be used for HBV re-infection in liver transplant .
|
-
- HY-134910
-
|
|
Virus Protease
|
Infection
|
|
SID-852843 is a WNV NS2B-NS3 proteinase inhibitor. SID-852843 can inhibit WNV NS2B-NS3 proteinase activity with IC50 value of 0.105 μM. SID-852843 can be used for the research of virus infection .
|
-
- HY-162795
-
|
|
HBV
|
Infection
|
|
HBV-IN-47 (compound 4a) is a capsid assembly regulator with inhibitory activity against hepatitis B virus (HBV). HBV-IN-47 exhibits strong anti-HBV activity in HepAD38 cells with low toxicity (EC50=0.24 μM). HBV-IN-47 can be used for the study of chronic hepatitis B (CHB) .
|
-
- HY-149158
-
|
|
HBV
|
Inflammation/Immunology
|
|
CCC-0975 is a hepatitis B virus (HBV) inhibitor (EC50=10 μM). CCC-0975 interferes with the conversion of relaxed circular DNA (rcDNA) to cccDNA, synchronously reducing cccDNA and its precursor deproteinized rcDNA (DP-rcDNA) without promoting their intracellular degradation. CCC-0975 is promising for research of chronic hepatitis B .
|
-
- HY-13998
-
|
ABT-333
|
HCV
DNA/RNA Synthesis
|
Infection
|
|
Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively .
|
-
- HY-102038
-
PC786
1 Publications Verification
|
RSV
|
Infection
|
|
PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM) .
|
-
- HY-I0736S
-
-
- HY-P11083
-
|
|
HBV
|
Cancer
|
|
Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .
|
-
- HY-112047
-
|
GSK2878175
|
HCV
|
Infection
|
|
GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons .
|
-
- HY-P1571A
-
|
NP 396 TFA
|
Arenavirus
|
Inflammation/Immunology
|
|
Nucleoprotein (396-404) TFA is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) TFA is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .
|
-
- HY-100029AR
-
|
|
Reference Standards
HBV
|
Infection
|
|
Bay 41-4109 (racemate) (Standard) is the analytical standard of Bay 41-4109 (racemate). This product is intended for research and analytical applications. BAY 41-4109 racemate is the racemate of BAY 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-135330
-
|
|
HIV
Reverse Transcriptase
|
Infection
|
|
Lamivudine- 13C, 15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .
|
-
- HY-I0736R
-
|
|
Reference Standards
Drug Metabolite
Drug Intermediate
|
Infection
|
|
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid (HY-I0736). This product is intended for research and analytical applications. Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus .
|
-
- HY-15591
-
|
|
HCV
|
Infection
|
|
TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV) .
|
-
- HY-B0250
-
|
BCH-189
|
HIV
Reverse Transcriptase
HBV
|
Infection
Cancer
|
|
Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-112254
-
-
- HY-135646
-
|
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .
|
-
- HY-162485
-
|
|
Dengue Virus
Virus Protease
|
Infection
|
|
DV-B-120 is a competitive inhibitor for dengue virus (DENV) with IC50s of 5.35, 7.39, 10.49 and 8.58 μM, for DENV-1, DENV-2, DENV-3 and DENV-4, respectively, by inhibiting NS2B-NS3 protease. DV-B-120 exhibits antiviral activity through inhibition of DENV replication .
|
-
- HY-147266A
-
|
VIR-2218
|
HBV
Small Interfering RNA (siRNA)
|
Infection
|
|
Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections .
|
-
- HY-147266
-
|
VIR-2218 sodium
|
Small Interfering RNA (siRNA)
HBV
|
Infection
|
|
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .
|
-
- HY-13317R
-
|
GS 4104 (Standard)
|
Reference Standards
Influenza Virus
|
Infection
|
|
Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively .
|
-
- HY-W070093
-
|
|
HBV
|
Infection
|
|
KKJ00626 is an inhibitor for Hepatitis B virus (HBV) with an IC50 of 0.12~0.23 μM. KKJ00626 inhibits the interaction between HBV core protein and the surface protein PreS region, prevents the maturation and secretion of HBV particles, and exhibits antiviral efficacy .
|
-
- HY-120632
-
|
|
RSV
|
Infection
|
|
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease .
|
-
- HY-W754691
-
|
|
HBV
|
Infection
|
|
Glaziovine is an antiviral agent found in Hypserpa nitida. Glaziovine exhibits significant inhibitory activity against HBV, capable of suppressing hepatitis B virus surface antigen (HBsAg) secretion in Hep G2.2.15 cells transfected with HBV, with an IC50 of 8 nM .
|
-
- HY-101954
-
|
ORI-9020; SB-9000
|
HBV
|
Infection
|
|
Inarigivir (ORI-9020) is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as a RIG-I agonist to activate cellular innate immune responses .
|
-
- HY-B0250A
-
|
BCH-189 salicylate
|
HIV
Reverse Transcriptase
HBV
|
Infection
Cancer
|
|
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine salicylate can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-120632A
-
|
|
RSV
|
Infection
|
|
BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease .
|
-
- HY-11098
-
|
R170591
|
RSV
|
Infection
|
|
JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ 2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg .
|
-
- HY-B0250S
-
|
BCH-189-15N,d2
|
HBV
HIV
Reverse Transcriptase
Isotope-Labeled Compounds
|
Infection
Cancer
|
|
Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-124191
-
|
PPI-668 hydrochloride
|
HCV
|
Infection
|
|
Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats .
|
-
- HY-159987
-
|
|
HBV
|
Infection
|
|
AB-161 is an orally active HBV RNA destabilizer and a PAPD5/7 inhibitor, with its primary action focused in the liver. AB-161 treats Hepatitis B Virus (HBV) infection by lowering the levels of Hepatitis B surface antigen (HBsAg), with an EC50 value of 2.2 nM for HBsAg. AB-161 can be used in the field of HBV infection research .
|
-
- HY-116683
-
116-9e
2 Publications Verification
MAL2-11B
|
HSP
DNA/RNA Synthesis
|
Infection
Cancer
|
|
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70 .
|
-
- HY-143781
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains .
|
-
- HY-109025R
-
|
S-033188 (Standard); RG 6152 (Standard)
|
Reference Standards
Influenza Virus
|
Infection
|
|
Baloxavir marboxil (Standard) is the analytical standard of Baloxavir marboxil. This product is intended for research and analytical applications. Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
|
-
- HY-109025A
-
|
Baloxavir acid; S-033447
|
Influenza Virus
|
Infection
Cancer
|
|
Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
- HY-W128400
-
|
|
DNA/RNA Synthesis
HCV
|
Infection
|
|
3′-Deoxy-3′-fluoroguanosine exhibits antiviral activity against tick-borne encephalitis virus (TBEV), through interaction with NS5B RdRp of HCV, resulting in suppression of viral RNA synthesis by disruption of further extension of the replicating viral RNA .
|
-
- HY-15591A
-
|
|
HCV
|
Infection
|
|
TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV) .
|
-
- HY-P1791
-
|
Lactoferricin B; Lfcin B
|
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities .
|
-
- HY-W060316
-
|
3-Hydroxy-5-isopropyltropolone
|
HBV
DNA/RNA Synthesis
|
Infection
|
|
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC50 values of 5.9 and 2.3 μM, respectively .
|
-
- HY-P1791B
-
|
Lactoferricin B acetate; Lfcin B acetate
|
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities .
|
-
- HY-W003943
-
|
|
Biochemical Assay Reagents
|
Infection
|
|
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors .
|
-
- HY-P0323
-
|
|
Arenavirus
|
Infection
|
|
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D b molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM .
|
-
- HY-19577
-
|
PTT119
|
DNA Alkylator/Crosslinker
|
Infection
Cancer
|
|
Ambamustine (PTT119) is a new bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities .
|
-
- HY-B0434S1
-
-
- HY-153810
-
|
JNJ-1802
|
Virus Protease
Flavivirus
Dengue Virus
|
Infection
|
|
Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates .
|
-
- HY-145579R
-
|
RG7907 (Standard); RO7049389 (Standard)
|
Antibiotic
Reference Standards
|
Infection
Inflammation/Immunology
|
|
Bendiocarb (Standard) is the analytical standard of Bendiocarb. This product is intended for research and analytical applications. Linvencorvir (RG7907) is an orally active Hepatitis B virus core protein allosteric modulator. Linvencorvir induces Apoptosis. Linvencorvir has antiviral activity against HBV .
|
-
- HY-15602C
-
|
GS-5885 hydrochloride
|
HCV
SARS-CoV
|
Infection
|
|
Ledipasvir (GS-5885) hydrochloride is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir hydrochloride is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
|
-
- HY-15602
-
|
GS-5885
|
HCV
SARS-CoV
|
Infection
|
|
Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
|
-
- HY-15789R
-
|
MK-8742 (Standard)
|
Reference Standards
HCV
|
Infection
|
|
Elbasvir (Standard) is the analytical standard of Elbasvir. This product is intended for research and analytical applications. Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
|
-
- HY-P4209A
-
|
|
Virus Protease
|
Others
|
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
-
- HY-19921
-
|
|
HCV
|
Infection
|
|
JTK-853 is a novel, non-nucleoside Hepatitis C Virus (HCV) polymerase inhibitor which shows effective antiviral activity in HCV replicon cells with EC50s of 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, respectively.
|
-
- HY-147885
-
|
|
HCV
|
Infection
|
|
HCV-IN-41 (compound 4) is a highly potent hepatitis C virus (HCV) inhibitor with an EC50 value of 0.006762 nM, 5.183 nM, 1.365 nM and 142.2 nM for HCV genotype 1b, 2a, 3a and 4a, respectively. HCV-IN-41 reduces HCV RNA replication .
|
-
- HY-117383
-
|
ML414
|
Virus Protease
|
Cancer
|
|
NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B . NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability .
|
-
- HY-13998R
-
|
ABT-333 (Standard)
|
Reference Standards
HCV
DNA/RNA Synthesis
|
Infection
|
|
Dasabuvir (Standard) is the analytical standard of Dasabuvir. This product is intended for research and analytical applications. Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively .
|
-
- HY-P990828
-
|
|
PD-1/PD-L1
|
Infection
|
|
Anti-PD-L1/B7-H1 Antibody (29E.2A3) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human PD-L1/B7-H1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can block the binding of PD-1 to PD-L1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can be used for the research of infection, such as hepatitis C virus (HCV) .
|
-
- HY-P1862
-
|
|
HSV
|
Infection
|
|
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope .
|
-
- HY-W779404
-
|
Ribasphere-13C2
|
Isotope-Labeled Compounds
RSV
HCV
Antibiotic
Orthopoxvirus
|
Cancer
|
|
Ribavirin- 13C2 (Ribasphere- 13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-101954A
-
|
ORI-9020 ammonium; SB-9000 ammonium
|
HBV
|
Infection
Inflammation/Immunology
|
|
Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses .
|
-
- HY-15602AS
-
|
GS-5885-d6 hydrochloride
|
HCV
Isotope-Labeled Compounds
|
Infection
|
|
Ledipasvir-d6 hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
|
-
- HY-B1192
-
|
β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate
|
Estrogen Receptor/ERR
HBV
Bcl-2 Family
|
Neurological Disease
|
|
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .
|
-
- HY-151526
-
|
|
Virus Protease
Flavivirus
|
Infection
|
|
LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death .
|
-
- HY-B0272S3
-
|
Rifampin-d11; Rifamycin AMP-d11
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Influenza Virus
Orthopoxvirus
|
Others
|
|
Rifampicin-d11 (Rifampin-d11; Rifamycin AMP-d11) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .
|
-
- HY-10468R
-
|
2'-C-Methylcytidine (Standard)
|
Reference Standards
HCV
|
Infection
|
|
NM107 (Standard) is the analytical standard of NM107. This product is intended for research and analytical applications. NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM .
|
-
- HY-15298C
-
|
MK-5172 sodium salt
|
HCV
HCV Protease
SARS-CoV
|
Infection
|
|
Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir sodium salt inhibits SARS-CoV-2 3CL pro activity .
|
-
- HY-15298B
-
|
MK-5172 hydrate
|
HCV
HCV Protease
SARS-CoV
|
Infection
|
|
Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity .
|
-
- HY-15298
-
|
MK-5172
|
HCV Protease
HCV
SARS-CoV
|
Infection
|
|
Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL pro activity .
|
-
- HY-131603
-
|
3TCTP
|
Reverse Transcriptase
HCV
HBV
SARS-CoV
|
Infection
|
|
Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the Reverse Transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA .
|
-
- HY-15298A
-
|
MK-5172 potassium salt
|
HCV
HCV Protease
SARS-CoV
|
Infection
|
|
Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL pro activity .
|
-
- HY-B1404
-
|
Buphenine hydrochloride
|
iGluR
Influenza Virus
|
Infection
Cardiovascular Disease
Inflammation/Immunology
|
|
Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects .
|
-
- HY-169281
-
|
|
COX
|
Infection
|
|
Antiviral agent 61 (compound Z40) is a potent antiviral agent. Antiviral agent 61 shows anti tomato spotted wilt virus (TSWV) activity with an EC50 value of 252 μg/mL. Antiviral agent 61 increases the RNA expression of Ndufb9，COX6B，7.1.2.2，E，COX5B，Ndufs4，and SDHB，decreases the RNA expression of Ndufb7，Ndufa5，and G .
|
-
- HY-B1404R
-
|
Buphenine hydrochloride (Standard)
|
Reference Standards
iGluR
Influenza Virus
|
Infection
Cardiovascular Disease
Inflammation/Immunology
|
|
Nylidrin (hydrochloride) (Standard) is the analytical standard of Nylidrin hydrochloride (HY-B1404). This product is intended for research and analytical applications. Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects .
|
-
- HY-N15365
-
|
|
Virus Protease
SARS-CoV
|
Infection
|
|
Antcin B is a SARS-CoV-2 3-chymotrypsin-like protease (3CL Pro) inhibitor. Antcin B binds to multiple key amino acid residues of 3CL Pro(such as Leu141, Asn142, Glu166, His163, etc.) through hydrogen bonds, salt bridges, and hydrophobic interactions, thereby inhibiting the activity of 3CL Pro, blocking the cleavage process of viral polyproteins, and suppressing the replication of the SARS-CoV-2 virus in host cells. Antcin B is promising for research of COVID-19 .
|
-
- HY-109195
-
|
ABI-H0731
|
HBV
|
Infection
Inflammation/Immunology
|
|
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM .
|
-
- HY-W399940
-
|
|
Antibiotic
Influenza Virus
Drug Intermediate
|
Infection
|
|
Actiphenol is an antibiotic against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 µg/mL, respectively). Actiphenol is also an aromatic ketone that exhibits weak eukaryotic translation inhibiton activity, which is found in Streptomyces species. Actiphenol can be used as a key intermediate to synthesize Cycloheximide (HY-12320) .
|
-
- HY-B0434G
-
|
Ribasphere; ICN-1229
|
Antibiotic
RSV
HCV
Orthopoxvirus
|
Infection
|
|
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-15602S
-
|
GS-5885-d6
|
HCV
SARS-CoV
|
Infection
|
|
Ledipasvir-d6 is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM .
|
-
- HY-P0323A
-
|
|
Arenavirus
|
Infection
|
|
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D b molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM .
|
-
- HY-B0250R
-
|
BCH-189 (Standard)
|
Reference Standards
HIV
Reverse Transcriptase
HBV
|
Infection
Cancer
|
|
Lamivudine (Standard) is the analytical standard of Lamivudine. This product is intended for research and analytical applications. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-109025AS
-
|
Baloxavir acid-d5; S-033447-d5
|
Isotope-Labeled Compounds
Influenza Virus
|
Infection
|
|
Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
- HY-106685
-
|
CI 935
|
Influenza Virus
|
Infection
|
|
Selenazofurin is an antiviral compound used against influenza A and influenza B viruses. Selenazofurin shows antiviral activity in cells against Measles, Para-3, Mumps, VV, HSV-2 with the ED50s of 3.7 μg/ml, 1.3 μg/ml, 8.0 μg/ml, 3.4 μg/ml, 4.3 μg/ml .
|
-
- HY-120137
-
|
|
Histone Methyltransferase
|
Cancer
|
|
CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected .
|
-
- HY-139111
-
|
|
Cathepsin
SARS-CoV
|
Infection
|
|
Oxocarbazate is an inhibitor of human cathepsin L with the IC50 values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into 293T cells .
|
-
- HY-B0421S
-
|
Mycophenolate-d3
|
Bacterial
Apoptosis
Fungal
Antibiotic
Endogenous Metabolite
Isotope-Labeled Compounds
Flavivirus
|
Others
|
|
Mycophenolic acid-d3 (Mycophenolate-d3) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
- HY-109025AR
-
|
Baloxavir acid (Standard); S-033447 (Standard)
|
Reference Standards
Influenza Virus
|
Infection
|
|
Baloxavir (Standard) is the analytical standard of Baloxavir. This product is intended for research and analytical applications. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
- HY-143274
-
|
|
Flavivirus
Dengue Virus
HIV
DNA/RNA Synthesis
|
Infection
|
|
DENV-IN-5 (Compound 4b) is a dengue virus (DENV) inhibitor with EC50s of 1.47, 9.23, 7.08 and 8.91 μM against DENV-I ∼ IV replication, respectively. DENV-IN-5 also inhibits HIV-1IIIB strain with an EC50 of 0.1512 μM .
|
-
- HY-100028
-
AT-130
2 Publications Verification
|
HBV
DNA/RNA Synthesis
|
Infection
Cancer
|
|
AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells .
|
-
- HY-12993
-
RSV604
2 Publications Verification
A-60444
|
RSV
|
Infection
|
|
RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM) .
|
-
- HY-163546
-
|
|
HSV
|
Infection
|
|
HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1(IC50=0.5 nM) and HSV-2(IC50=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection .
|
-
- HY-112041
-
|
PTC596
|
BMI1
Apoptosis
|
Cancer
|
|
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .
|
-
- HY-162073
-
|
|
Influenza Virus
|
Infection
|
|
ZIKV-IN-8 (Compound 9b) is a noncompetitive Zika virus (ZIKV) inhibitor. ZIKV-IN-8 shows the best anti-ZIKV activity with a selectivity index of 22.4. ZIKV-IN-8 has significant inhibition of ZIKV with an IC50 value of 25.6 μM. ZIKV-IN-8 can be used for the research of ZIKV infection .
|
-
- HY-W654247
-
|
|
HBV
|
Infection
Cancer
|
|
Lamivudine- 13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-129555
-
|
|
Bacterial
HSV
Antibiotic
|
Infection
|
|
Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .
|
-
- HY-14920
-
|
Reverset; d-d4FC
|
Reverse Transcriptase
HIV
|
Infection
|
|
Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent .
|
-
- HY-172835
-
|
JH-B10
|
HBV
|
Infection
|
|
Rapavir (JH-B10) is a selective and potent sodium taurocholate cotransporting polypeptide (NTCP) inhibitor with an IC50 value of 1.8 nM for the uptake of taurocholic acid-d4 (TCA-d4). Rapavir exerts antiviral activity by directly binding to NTCP and blocking the entry of the virus into cells during the HBV infection phase. Rapavir is promising for research of HBV infections .
|
-
- HY-111073
-
|
Y101
|
HBV
|
Infection
Inflammation/Immunology
|
|
Bentysrepinine (Y101) is an orally active HBV inhibitor with anti-hepatitis B virus infection activity. Bentysrepinine exhibits favorable pharmacokinetic characteristics, with absolute bioavailability of 44.9%, 43.1%, and 19.2% in rats, dogs, and monkeys, respectively, and it does not accumulate in monkeys after 90 days of oral administration. Bentysrepinine is under research in the antiviral and hepatitis fields .
|
-
- HY-N0639
-
|
|
HBV
Pyroptosis
Carbonic Anhydrase
|
Infection
Inflammation/Immunology
|
|
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .
|
-
- HY-N0063
-
|
|
SARS-CoV
HBV
|
Infection
Metabolic Disease
Cancer
|
|
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .
|
-
- HY-N12105
-
|
|
HBV
|
Infection
|
|
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside is an anti-hepatitis B virus (anti-HBV) agent. Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside inhibits HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line, with IC50 values of 1.67 and >2.15 mM, respectively .
|
-
- HY-12725
-
|
|
Histone Demethylase
HSV
CMV
|
Cancer
|
|
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .
|
-
- HY-N6771
-
|
|
Calcium Channel
5-HT Receptor
MDM-2/p53
Apoptosis
RSV
|
Infection
|
|
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B [1][4][5].
|
-
- HY-143750
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-7 Inhibits the synthesis of viral mRNA and eventually inhibits virus proliferation. Cap-dependent endonuclease-IN-7 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2020177715A1, compound 5)
|
-
- HY-B0250S1
-
|
BCH-189-13C,15N2,d2
|
Isotope-Labeled Compounds
HBV
Reverse Transcriptase
HIV
|
Infection
|
|
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .
|
-
- HY-151134
-
|
|
HBV
|
Infection
|
|
HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity .
|
-
- HY-125371
-
|
|
HCV
|
Infection
Inflammation/Immunology
|
|
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis .
|
-
- HY-15602S1
-
|
GS-5885-d16
|
Isotope-Labeled Compounds
HCV
SARS-CoV
|
Infection
|
|
Ledipasvir-d16 (GS-5885-d16) is deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
|
-
- HY-174521
-
|
|
mRNA
|
Inflammation/Immunology
|
|
Human TLR7 mRNA encodes the human toll like receptor 7 (TLR7) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells.
|
-
- HY-136575
-
|
|
Virus Protease
|
Infection
|
|
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .
|
-
- HY-136574
-
|
|
Virus Protease
|
Infection
|
|
2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .
|
-
- HY-15256A
-
|
BI 201335 sodium
|
HCV Protease
|
Infection
|
|
Faldaprevir sodium is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with Ki values of 2.6 and 2.0 nM, respectively. Faldaprevir sodium inhibits HCV RNA replication, with EC50 values of 6.5 and 3.1 nM, respectively. Faldaprevir sodium has potent antiviral activity against chronic HCV infection .
|
-
- HY-N0440
-
|
|
Influenza Virus
NF-κB
5 alpha Reductase
Keap1-Nrf2
Lactate Dehydrogenase
Apoptosis
|
Infection
Neurological Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 influenza A virus and the influenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .
|
-
- HY-N1992
-
|
TF-3; ZP10
|
Virus Protease
HSV
HIV
Flavivirus
|
Infection
Cancer
|
|
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .
|
-
- HY-B0421S2
-
|
Mycophenolate-13C17
|
Isotope-Labeled Compounds
Flavivirus
|
Cancer
|
|
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
- HY-136573
-
|
|
Virus Protease
|
Infection
|
|
5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .
|
-
- HY-B1192R
-
|
β-Estradiol 3-benzoate (Standard); 17β-Estradiol 3-benzoate (Standard)
|
Reference Standards
Estrogen Receptor/ERR
HBV
Bcl-2 Family
|
Neurological Disease
|
|
Estradiol benzoate (Standard) is the analytical standard of Estradiol benzoate. This product is intended for research and analytical applications. Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .
|
-
- HY-15256
-
|
BI 201335
|
HCV Protease
|
Infection
|
|
Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with Ki values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC50 values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection .
|
-
- HY-B0250S2
-
|
BCH-189-13C,15N3
|
Isotope-Labeled Compounds
Reverse Transcriptase
HIV
HBV
|
Infection
Cancer
|
|
Lamivudine- 13C, 15N3 (BCH-189- 13C, 15N3) is 13C and 15N labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-118122
-
|
FIAU; DRG-0098; NSC 678514
|
HSV
HBV
DNA/RNA Synthesis
Orthopoxvirus
Nucleoside Antimetabolite/Analog
|
Infection
|
|
Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively .
|
-
- HY-B0510S3
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Antifolate
Influenza Virus
|
Others
|
|
Trimethoprim- 13C3 is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
|
-
- HY-16278A
-
|
LCQ 908 sodium
|
Acyltransferase
BCRP
OAT
|
Infection
Metabolic Disease
|
|
Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .
|
-
- HY-16278
-
|
LCQ-908
|
Acyltransferase
BCRP
OAT
|
Infection
Metabolic Disease
|
|
Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .
|
-
- HY-147974
-
|
|
HSP
Influenza Virus
|
Infection
|
|
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .
|
-
- HY-N0063R
-
|
|
Reference Standards
SARS-CoV
HBV
|
Infection
Metabolic Disease
Cancer
|
|
Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .
|
-
- HY-N0639R
-
|
|
Reference Standards
HBV
Pyroptosis
Carbonic Anhydrase
|
Infection
Inflammation/Immunology
|
|
Punicalin (Standard) is the analytical standard of Punicalin. This product is intended for research and analytical applications. Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .
|
-
- HY-14920R
-
|
|
Reverse Transcriptase
HIV
|
Infection
|
|
Dexelvucitabine (Standard) is the analytical standard of Dexelvucitabine. This product is intended for research and analytical applications. Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent .
|
-
- HY-178856
-
|
Oseltamivir carboxylate
-C2-cholesterol
|
Influenza Virus
|
Infection
|
|
Cholesterol-conjugated OC prodrug (Compound 1b) is an orally active cholesterol-bound prodrug of Oseltamivir carboxylate (HY-13318). Cholesterol-conjugated OC prodrug has a protective effect against influenza virus infection. The Oseltamivir carboxylate released by the Cholesterol-conjugated OC prodrug has a longer duration of circulation than the Oseltamivir carboxylate released from Oseltamivir (HY-13317). Cholesterol-conjugated OC prodrug can be used in influenza research .
|
-
- HY-13318S1
-
|
GS 4071-13C,d3; Ro 64-0802-13C,d3; Oseltamivir carboxylate-13C,d3
|
Isotope-Labeled Compounds
Drug Metabolite
Influenza Virus
|
Infection
|
|
Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections .
|
-
- HY-143757
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1) .
|
-
- HY-116633
-
|
|
Endogenous Metabolite
|
Infection
|
|
BCM-599 is a HBV (hepatitis B virus) capsid assembly inhibitor with the activity of inhibiting HBV capsid assembly. BCM-599 showed an IC50 value of 0.88μM and a CC50 value of 144μM in HepG2.2.15 cells. When used in combination with lamivudine, BCM-599 showed a synergistic inhibitory effect on viral concentration. BCM-599 can be used as an effective combined inhibition option for HBV infection .
|
-
- HY-B1607R
-
|
|
Reference Standards
Histamine Receptor
SARS-CoV
Filovirus
Parasite
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Chlorphenoxamine (Standard) is the analytical standard of Chlorphenoxamine (HY-B1607). This product is intended for research and analytical applications. Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease.
|
-
- HY-10238
-
|
ITMN-191; R7227; RO5190591; RG7227
|
HCV Protease
HCV
SARS-CoV
|
Infection
|
|
Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM) . Danoprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 0.05 μM .
|
-
- HY-114216
-
|
|
Endogenous Metabolite
|
Infection
|
|
DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A .
|
-
- HY-117085
-
|
|
Phosphatase
TMV
Lipoxygenase
|
Cancer
|
|
Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
|
-
- HY-N1992R
-
|
TF-3 (Standard); ZP10 (Standard)
|
Reference Standards
Virus Protease
HSV
HIV
Flavivirus
|
Infection
Cancer
|
|
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .
|
-
- HY-16278R
-
|
|
Acyltransferase
BCRP
OAT
|
Infection
Metabolic Disease
|
|
Pradigastat (Standard) is the analytical standard of Pradigastat. This product is intended for research and analytical applications. Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .
|
-
- HY-124645
-
|
|
Flavivirus
Dengue Virus
Btk
MNK
|
Infection
Cancer
|
|
QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies .
|
-
- HY-17015
-
-
- HY-17015A
-
|
RWJ-270201; BCX-1812
|
IKK
JNK
STAT
p38 MAPK
ERK
|
Infection
Inflammation/Immunology
|
|
Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19 .
|
-
- HY-N0440R
-
|
|
Reference Standards
Influenza Virus
NF-κB
5 alpha Reductase
Keap1-Nrf2
Lactate Dehydrogenase
Apoptosis
|
Infection
Neurological Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 influenza A viruses and the influenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .
|
-
- HY-N0058
-
|
Isochlorogenic acid C
|
HBV
Endogenous Metabolite
Apoptosis
Glycosidase
|
Infection
|
|
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .
|
-
- HY-W751835
-
|
Baloxavir acid-d4; S-033447-d4
|
Isotope-Labeled Compounds
|
Others
Cancer
|
|
Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
- HY-163670
-
|
|
Toll-like Receptor (TLR)
|
Infection
|
|
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections .
|
-
- HY-146126
-
|
|
HCV Protease
|
Infection
|
|
NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a . NS5A-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-P990794
-
|
|
TNF Receptor
Dengue Virus
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor .
|
-
- HY-144668
-
|
|
Influenza Virus
|
Infection
|
|
RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice .
|
-
- HY-B1422S
-
|
Aminacrine-13C6
|
Bacterial
HIV
Isotope-Labeled Compounds
|
Infection
|
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-N0110B
-
-
- HY-N0110
-
-
- HY-N0110A
-
-
- HY-163532
-
|
|
Sirtuin
|
Infection
|
|
FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC50 of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication .
|
-
- HY-P990236
-
|
|
Transmembrane Glycoprotein
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .
|
-
- HY-P990142
-
|
|
MHC
|
Infection
Inflammation/Immunology
|
|
Anti-Mouse Vβ4 TCR Antibody (KT4) is an anti-mouse Vβ4 TCR IgG2b monoclonal antibody. Anti-Mouse Vβ4 TCR Antibody (KT4) can reduce the proportion of Vβ4 + T cells without affecting their function. Anti-Mouse Vβ4 TCR Antibody (KT4) can be used for research on immunology and infection conditions such as virus infection. Anti-Mouse Vβ4 TCR Antibody (KT4) is often used in flow cytometry .
|
-
- HY-N0110R
-
-
- HY-B1422
-
|
Aminacrine
|
Bacterial
HIV
|
Infection
|
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-N0058R
-
|
Isochlorogenic acid C (Standard)
|
Reference Standards
HBV
Endogenous Metabolite
Apoptosis
Glycosidase
|
Infection
|
|
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .
|
-
- HY-P990804
-
|
|
Transmembrane Glycoprotein
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection .
|
-
- HY-B1422R
-
|
Aminacrine (Standard)
|
Reference Standards
Bacterial
HIV
|
Infection
|
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-148089
-
|
|
Transthyretin (TTR)
|
Neurological Disease
|
|
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .
|
-
- HY-148089A
-
|
|
Transthyretin (TTR)
|
Neurological Disease
|
|
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .
|
-
- HY-P990187
-
|
|
MHC
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .
|
-
-
-
HY-L113
-
|
|
180 compounds
|
|
Increasing research have shown that Traditional Chinese Medicine (TCM) possess antiviral activities against various viral strains, such as herpes simplex virus, influenza virus, hepatitis B and C viruses, and SARS-CoV. To date, dozens of Chinese herbs and hundreds of natural TCM ingredients have been reported to exhibit good antiviral activities. Active components from TCM are one of the important sources for antiviral drugs discovery.
MCE designs a unique collection of 180 active compounds of antiviral Chinese Herbal Medicines. MCE Antiviral Traditional Chinese Medicine Active Compound Library is a useful tool for discovery antiviral drugs from TCM.
|
| Cat. No. |
Product Name |
Type |
-
- HY-B1422
-
|
Aminacrine
|
Fluorescent Dyes/Probes
|
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-B0434G
-
|
Ribasphere (GMP); ICN-1229 (GMP)
|
Fluorescent Dye
|
|
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-B1422R
-
|
Aminacrine (Standard)
|
Fluorescent Dyes/Probes
|
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
| Cat. No. |
Product Name |
Type |
-
- HY-B0434G
-
|
Ribasphere (GMP); ICN-1229 (GMP)
|
Biochemical Assay Reagents
|
|
Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1774
-
|
|
HBV
|
Infection
|
|
Hepatitis B Virus Core (128-140) is a peptide of hepatitis B virus core protein.
|
-
- HY-P4042
-
|
hepatitis B peptide 4980
|
HBV
|
Infection
Inflammation/Immunology
|
|
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .
|
-
- HY-P4051
-
-
- HY-P4045
-
|
|
HBV
|
Infection
|
|
HBV Seq2 aa:208-216, a HBsAg derived CD8 epitope peptide, is studied as part of Large envelope protein from Hepatitis B virus .
|
-
- HY-P4046
-
|
|
HIV
|
Inflammation/Immunology
|
|
HBV Seq2 aa:179-186 serve as effective motifs for CTL response in H-2b system after in vitro restimulation of the primed T cells. HBV Seq2 aa:179-186 is a novel epitope identified on the surface antigen of hepatitis B virus .
|
-
- HY-P1857
-
|
|
Influenza Virus
|
Infection
|
|
CEF7, Influenza Virus NP (380-388) is a HLA-B *08 restricted influenza virus nucleoprotein epitope. Influenza virus NP functions as a key adapter molecule between virus and host cell processes .
|
-
- HY-P4038
-
|
|
HCV Protease
|
Infection
|
|
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
|
-
- HY-P4041
-
|
|
Peptides
|
Others
|
|
[Ala127] Hepatitis B Virus Pre-S Region (120-131) is a peptide with the sequence of MQWNSTAFHQT. [Ala127] Hepatitis B Virus Pre-S Region (120-131) can be used in the activity enhancement study .
|
-
- HY-P1835
-
|
|
Influenza Virus
|
Inflammation/Immunology
|
|
CEF8, Influenza Virus NP (383-391), an influenza A virus nucleoprotein containing residues 383 to 391, is the most important HLA-B *2705-restricted epitope in the nucleoprotein of influenza A viruses and is associated with escape from cytotoxic T lymphocytes-mediated immunity .
|
-
- HY-P4049
-
|
|
HBV
|
Infection
|
|
HBV Seq1 aa:63-71 is the fragment of hepatitis B virus (HBV) .
|
-
- HY-P1920
-
|
|
EBV
|
Inflammation/Immunology
|
|
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition .
|
-
- HY-P4050
-
|
|
HBV
|
Infection
|
|
HBV Seq1 aa:18-27 is a hepatitis B virus (HBV) core antigen 18-27 peptide fragment .
|
-
- HY-P4048
-
|
|
HBV
|
Infection
|
|
HBV Seq1 aa:93-100 is a hepatitis B virus (HBV) core antigen 93-100 peptide fragment .
|
-
- HY-P10056
-
|
Human ezrin peptide (324-337)
|
HIV
HCV
HPV
Influenza Virus
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .
|
-
- HY-P5364
-
|
|
Peptides
|
Others
|
|
B8R 20-27 is a biological active peptide. (This is amino acids 20 to 27 fragment of B8R, a vaccinia virus (VV) gene that encodes a secreted protein related to gamma interferon receptor. B8R binding to IFN-g neutralizes its antiviral activity.)
|
-
- HY-P4043
-
|
|
HBV
|
Infection
Inflammation/Immunology
|
|
Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg .
|
-
- HY-P5997
-
|
|
Autophagy
Cyclic GMP-AMP Synthase
|
Inflammation/Immunology
|
|
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .
|
-
- HY-P5947
-
|
|
HIV
|
Neurological Disease
|
|
Tat-HA-NR2B9 contains a fragment of the cellmembrane transduction domain of HIV-1 Tat, a influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c). Tat-HA-NR2B9 reduces infarct size and improves neurological functions in ischemia-induced cerebral injury in the rats
|
-
- HY-P4044
-
|
|
HBV
|
Infection
|
|
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .
|
-
- HY-P10662
-
|
|
Peptides
|
Infection
Inflammation/Immunology
|
|
HLA-B*0801-binding EBV peptide is an Epstein-Barr virus (EBV) epitope FLRGRAYGL. HLA-B*0801-binding EBV peptide can bind to the HLA-B*0801 molecule. HLA-B*0801-binding EBV peptide can be presented to CD8+ T cells through HLA-B*0801 to activate a specific immune response .
|
-
- HY-P3070
-
|
|
MHC
|
Infection
Others
|
|
H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). H2-D b restricted epitopes VSV Nucleoprotein (52-59) binds to MHC class I molecules and presents itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs), which can recognize and kill cells expressing the corresponding antigen. H2-D b restricted epitopes VSV Nucleoprotein (52-59) can be used in the development of CTL vaccines against Ebola virus .
|
-
- HY-P10668
-
|
|
Dengue Virus
Flavivirus
|
Infection
|
|
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate corresponding to the P6-P1 segment amino-terminal to the NS2B-NS3 cleavage site but with a more reactive, hydrolytically cleavable, para-nitroanilide at the P1’ position. Ac-EVKKQR-pNA is promising for research of dengue 2 virus and flavivirus virus infection .
|
-
- HY-P1571
-
|
NP 396
|
Arenavirus
|
Inflammation/Immunology
|
|
Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .
|
-
- HY-P11083
-
|
|
HBV
|
Cancer
|
|
Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .
|
-
- HY-P1571A
-
|
NP 396 TFA
|
Arenavirus
|
Inflammation/Immunology
|
|
Nucleoprotein (396-404) TFA is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) TFA is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .
|
-
- HY-P1791
-
|
Lactoferricin B; Lfcin B
|
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities .
|
-
- HY-P1791B
-
|
Lactoferricin B acetate; Lfcin B acetate
|
Bacterial
Fungal
Apoptosis
|
Infection
Cancer
|
|
Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities .
|
-
- HY-P4209
-
|
|
Peptides
|
Others
|
|
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
-
- HY-P0323
-
|
|
Arenavirus
|
Infection
|
|
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D b molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM .
|
-
- HY-P4209A
-
|
|
Virus Protease
|
Others
|
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
-
- HY-P1862
-
|
|
HSV
|
Infection
|
|
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope .
|
-
- HY-P0323A
-
|
|
Arenavirus
|
Infection
|
|
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D b molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99699
-
-
- HY-P99342
-
|
REGN10987
|
SARS-CoV
|
Infection
|
|
Imdevimab (REGN10987) is a human monoclonal antibody that targets SARS-CoV-2 virus. Imdevimab can be used in combination with Casirivimab (HY-P99341) to reduce viral load and transiently increases anti-receptor-binding domain IgG titers. Imdevimab maintains most of its neutralization activity against viruses with B.1.1.7, B.1.351 and mink cluster 5 spike proteins .
|
-
- HY-P990825
-
|
|
Flavivirus
CHIKV
|
Infection
|
|
Anti-Chikungunya virus E2 Antibody (CHK-265) is mouse-derived IgG2c κ type antibody inhibitor, targeting to Chikungunya virus E2. Anti-Chikungunya virus E2 Antibody (CHK-265) reacts with a conserved epitope on the B domain of the E2 glycoprotein of chikungunya virus. Anti-Chikungunya virus E2 Antibody (CHK-265) can block viral entry and egress. Anti-Chikungunya virus E2 Antibody (CHK-265) can be used for the research of infection, such as Chikungunya virus (CHIKV), Mayaro (MAYV) and O’nyong’nyong virus (ONNV) .
|
-
- HY-P99693
-
|
GC1102
|
HBV
|
Infection
|
|
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection .
|
-
- HY-P99756
-
|
MEDI8897
|
RSV
|
Infection
|
|
Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections .
|
-
- HY-P990015
-
|
VIR-3434
|
HBV
|
Infection
|
|
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) .
|
-
- HY-P99608
-
|
|
HBV
|
Infection
|
|
Exbivirumab is a monoclonal antibody directed against highly conserved HBsAg epitopes. Exbivirumab enhances the antiviral activity of hepatitis B immunoglobulin (HBIG). Exbivirumab combined with Libivirumab (HY-P99703) decreases circulating HBsAg and hepatitis B virus (HBV) DNA levels in a chronically infected chimpanzee. Exbivirumab can be used for HBV re-infection in liver transplant .
|
-
- HY-P990828
-
|
|
PD-1/PD-L1
|
Infection
|
|
Anti-PD-L1/B7-H1 Antibody (29E.2A3) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human PD-L1/B7-H1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can block the binding of PD-1 to PD-L1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can be used for the research of infection, such as hepatitis C virus (HCV) .
|
-
- HY-P990794
-
|
|
TNF Receptor
Dengue Virus
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) is a rat-derived IgG1 antibody inhibitor, targeting to TNF-alpha/TNFSF2. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) neutralizes of TNF-alpha. Anti-Mouse TNF-alpha/TNFSF2 Antibody (XT3.11) can be used for the researches of cancer, infection and immunology, such as dengue virus and B16K1 tumor .
|
-
- HY-P991200
-
|
|
Claudin
HCV
|
Infection
|
|
OM-7D3-B3 is a monoclonal antibody targeting human claudin-1 (CLDN1) (Kd = 4 nM). OM-7D3-B3 blocks the process in which CLDN1 is involved in the entry of hepatitis C virus (HCV) into cells. OM-7D3-B3 is promising for research of HCV infection .
|
-
- HY-P990236
-
|
|
Transmembrane Glycoprotein
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .
|
-
- HY-P990142
-
|
|
MHC
|
Infection
Inflammation/Immunology
|
|
Anti-Mouse Vβ4 TCR Antibody (KT4) is an anti-mouse Vβ4 TCR IgG2b monoclonal antibody. Anti-Mouse Vβ4 TCR Antibody (KT4) can reduce the proportion of Vβ4 + T cells without affecting their function. Anti-Mouse Vβ4 TCR Antibody (KT4) can be used for research on immunology and infection conditions such as virus infection. Anti-Mouse Vβ4 TCR Antibody (KT4) is often used in flow cytometry .
|
-
- HY-P990804
-
|
|
Transmembrane Glycoprotein
|
Infection
Inflammation/Immunology
Cancer
|
|
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection .
|
-
- HY-P990187
-
|
|
MHC
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-133721
-
-
-
- HY-Y0073
-
-
-
- HY-Y0073R
-
|
P-hydroxyacetophenone (Standard)
|
Monophenols
Ketones, Aldehydes, Acids
Source classification
Phenols
Plants
Compositae
Artemisia capillaris Thunb.
|
Reference Standards
HBV
Myosin
|
|
4-Hydroxyacetophenone (Standard) is the analytical standard of 4-Hydroxyacetophenone. This product is intended for research and analytical applications. 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer .
|
-
-
- HY-N6025
-
-
-
- HY-126033
-
-
-
- HY-N15389
-
-
-
- HY-N14300
-
-
-
- HY-N14299
-
-
-
- HY-N14296
-
-
-
- HY-N14297
-
-
-
- HY-N14298
-
-
-
- HY-N3861
-
-
-
- HY-N14265
-
-
-
- HY-N8873
-
-
-
- HY-N14318
-
-
-
- HY-N14564
-
-
-
- HY-N3093
-
-
-
- HY-N10543
-
-
-
- HY-N14110
-
-
-
- HY-127014
-
-
-
- HY-I0736
-
-
-
- HY-N15076
-
-
-
- HY-N2006
-
-
-
- HY-N0854
-
-
-
- HY-N2006R
-
-
-
- HY-N14563
-
-
-
- HY-133108
-
-
-
- HY-N12483
-
-
-
- HY-N6939
-
-
-
- HY-N6939R
-
|
|
Pinaceae
Terpenoids
Diterpenoids
Plants
|
Reference Standards
HBV
Fungal
Apoptosis
Autophagy
Ferroptosis
HIF/HIF Prolyl-Hydroxylase
Interleukin Related
|
|
Pseudolaric Acid B (Standard) is the analytical standard of Pseudolaric Acid B. This product is intended for research and analytical applications. Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2 .
|
-
-
- HY-N14095
-
-
-
- HY-129150
-
-
-
- HY-113806
-
-
-
- HY-I0736R
-
-
-
- HY-135646
-
-
-
- HY-W754691
-
-
-
- HY-W060316
-
-
-
- HY-B1192
-
-
-
- HY-N15365
-
|
|
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Virus Protease
SARS-CoV
|
|
Antcin B is a SARS-CoV-2 3-chymotrypsin-like protease (3CL Pro) inhibitor. Antcin B binds to multiple key amino acid residues of 3CL Pro(such as Leu141, Asn142, Glu166, His163, etc.) through hydrogen bonds, salt bridges, and hydrophobic interactions, thereby inhibiting the activity of 3CL Pro, blocking the cleavage process of viral polyproteins, and suppressing the replication of the SARS-CoV-2 virus in host cells. Antcin B is promising for research of COVID-19 .
|
-
-
- HY-W399940
-
-
-
- HY-129555
-
-
-
- HY-N0639
-
-
-
- HY-N0063
-
-
-
- HY-N12105
-
-
-
- HY-N6771
-
-
-
- HY-N0440
-
-
-
- HY-N1992
-
-
-
- HY-N0063R
-
|
|
Punica granatum L.
Source classification
Phenols
Polyphenols
Punicaceae
Plants
|
Reference Standards
SARS-CoV
HBV
|
|
Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .
|
-
-
- HY-N0639R
-
|
|
Punica granatum L.
Source classification
Phenols
Polyphenols
Punicaceae
Plants
|
Reference Standards
HBV
Pyroptosis
Carbonic Anhydrase
|
|
Punicalin (Standard) is the analytical standard of Punicalin. This product is intended for research and analytical applications. Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .
|
-
-
- HY-N1992R
-
|
TF-3 (Standard); ZP10 (Standard)
|
Flavonoids
Flavanols
Source classification
Phenols
Polyphenols
Camellia sinensis (L.) O. Ktze.
Plants
Theaceae
|
Reference Standards
Virus Protease
HSV
HIV
Flavivirus
|
|
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .
|
-
- HY-N0440R
-
|
|
Terpenoids
Sesquiterpenes
Source classification
Plants
Curcuma longa
Zingiberaceae
|
Reference Standards
Influenza Virus
NF-κB
5 alpha Reductase
Keap1-Nrf2
Lactate Dehydrogenase
Apoptosis
|
|
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 influenza A viruses and the influenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .
|
-
- HY-N0058
-
-
- HY-N0110B
-
-
- HY-N0110
-
-
- HY-N0110A
-
-
- HY-N0110R
-
-
- HY-N0058R
-
|
Isochlorogenic acid C (Standard)
|
Ketones, Aldehydes, Acids
Source classification
Phenols
Polyphenols
Bowdichia virgilioides
Plants
Compositae
Endogenous metabolite
|
Reference Standards
HBV
Endogenous Metabolite
Apoptosis
Glycosidase
|
|
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-13318S
-
|
|
|
Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses .
|
-
-
- HY-13317S
-
|
|
|
Oseltamivir-d3 is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
-
- HY-I0736S
-
|
|
|
Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid (HY-I0736). Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus .
|
-
-
- HY-13317S3
-
|
|
|
Oseltamivir-d5 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
-
- HY-B0017S
-
|
|
|
Telbivudine-d4 is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .
|
-
-
- HY-13317S4
-
|
|
|
Oseltamivir-d3 hydrochloride is the deuterium-labeled Oseltamivir (HY-13317) . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
-
- HY-13317S1
-
|
|
|
Oseltamivir-d3-1 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .
|
-
-
- HY-W713297
-
|
|
|
Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
-
- HY-W705873
-
|
|
|
Edoxudine-d5 (EUDR-d5) is the deuterium labeled Edoxudine (HY-B1011). Edoxudine is an antiviral active molecule and thymidine analog. Edoxudine is effective against herpes simplex virus .
|
-
-
- HY-135330
-
|
|
|
Lamivudine- 13C, 15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus .
|
-
-
- HY-B0250S
-
|
|
|
Lamivudine- 15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
-
- HY-B0434S1
-
|
|
|
Ribavirin- 15N, d2 is 15N and deuterated labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
-
- HY-W779404
-
|
|
|
Ribavirin- 13C2 (Ribasphere- 13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
-
- HY-15602AS
-
|
|
|
Ledipasvir-d6 hydrochloride is deuterated labeled Ledipasvir acetone (HY-15602A). Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.
|
-
-
- HY-B0272S3
-
|
|
|
Rifampicin-d11 (Rifampin-d11; Rifamycin AMP-d11) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .
|
-
-
- HY-15602S
-
|
|
|
Ledipasvir-d6 is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM .
|
-
-
- HY-109025AS
-
|
|
|
Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
-
- HY-B0421S
-
|
|
|
Mycophenolic acid-d3 (Mycophenolate-d3) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
-
- HY-W654247
-
|
|
|
Lamivudine- 13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
-
- HY-B0250S1
-
|
|
|
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .
|
-
-
- HY-15602S1
-
|
|
|
Ledipasvir-d16 (GS-5885-d16) is deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM .
|
-
-
- HY-B0421S2
-
|
|
|
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
-
- HY-B0250S2
-
|
|
|
Lamivudine- 13C, 15N3 (BCH-189- 13C, 15N3) is 13C and 15N labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
-
- HY-B0510S3
-
|
|
|
Trimethoprim- 13C3 is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .
|
-
-
- HY-13318S1
-
|
|
|
Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections .
|
-
-
- HY-W751835
-
|
|
|
Baloxavir-d4 (Baloxavir acid-d4; S-033447-d4) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d4 (Baloxavir-d4 acid), derived from the proagent Baloxavir-d4 marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d4 inhibits viral RNA transcription and replication and has potently antiviral activity .
|
-
-
- HY-B1422S
-
|
|
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-121513
-
|
2'-Deoxy-L-cytidine; L-dC
|
|
Nucleoside Analogs
Cytidine
|
|
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment .
|
-
- HY-W352344
-
|
|
|
Nucleoside Analogs
Adenosine
|
|
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV) .
|
-
- HY-147266
-
|
VIR-2218 sodium
|
|
siRNAs
siRNA drugs
|
|
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .
|
-
- HY-148089
-
|
|
|
Antisense Oligonucleotides
|
|
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .
|
-
- HY-148089A
-
|
|
|
Antisense Oligonucleotides
|
|
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .
|
-
- HY-148171
-
|
|
|
Nucleoside Analogs
Cytidine
|
|
L-2'-Fd4C, is an l-nucleoside analogue. L-2'-Fd4C has anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity .
|
-
- HY-148172
-
|
|
|
Nucleoside Analogs
Adenosine
|
|
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC50=1.5 μM) and anti-hepatitis B virus (HBV) (EC50=1.7 μM) activity. L-Fd4A has low cytotoxicity .
|
-
- HY-174521
-
|
|
|
mRNA
|
|
Human TLR7 mRNA encodes the human toll like receptor 7 (TLR7) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells.
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent:
